Dr Christoph Ballestrem. Vinculin a mechanotansducing adaptor proteins in control of cell adhesion and migration.
Date: 7 May 2014 Time: 15:00 - 16:00
My lab is interested in how cells sense mechanical and biochemical stimuli. Sensing of such stimuli is directed by adhesion receptors (integrins) that transduce the information of the extracellular environment via focal adhesion proteins to the actomyosin machinery. Coupling and uncoupling events between the integrins and the actin cytoskeleton and the coordinated recruitment and release of focal adhesion components are essential for polarized cell migration. In my talk I will present data where we use a variety of imaging techniques and Atomic force spectroscopy to elucidate molecular mechanisms of cell adhesion and migration. I will present how the adaptor protein vinculin is involved in the transduction of forces and how it coordinates the assembly and disassembly of adhesion complexes.