Prof. Stephen Mann. Synthetic cellularity via protocell design and construction.
Date: 14 May 2014 Time: 15:00 - 16:00
The design and construction of compartmentalized chemical ensembles for modelling complex biological systems, exploring the origin of life, and advancing future living technologies is attracting considerable interest in a wide range of research communities. In this talk, I will review some recent experiments undertaken in my laboratory that provide steps towards synthetic cellularity. I will discuss three new protocell models based on; (i) nanoparticle self-assembly (colloidosomes) , (ii) interfacial assembly of protein-polymer nanoconjugates (proteinosomes) , and (iii) micro-droplet formation (coacervation) . In each case, the underlying concepts and emerging properties will be discussed.
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. Huang X, et al., Interfacial Assembly of Protein-polymer Nano-conjugates into Stimulus-Responsive Biomimetic Protocells. Nature Communications 4, 2239 (2013) DOI: 10.1038/ncomms3239, 1-9 (2013).
. Koga, S., et al., Peptide–nucleotide microdroplets as a step towards a membrane-free protocell model. Nature Chem. 3, 720-724 (2011).