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Institute of Bioengineering

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Dr Nick Evans. Mechanics, nanoparticles and growth factors in tissue regeneration.

Date: 3 December 2014   Time: 15:00 - 16:00

During development and wound healing, tissues rapidly change in size, shape, composition, and in their mechanical characteristics. Cells within these tissues are exposed to a variety of forces, including tension, compression and shear, which are known to have profound effects on their behaviour. But in addition cells can detect and respond to the static, mechanical properties of the material to which they adhere, which influences how they move, grow and differentiate. We are currently interested in how the stiffness of extracellular matrix affect cells that form epithelial, such as embryonic stem cells and keratinocytes. We hypothesise that groups of cells, acting collectively, are able to mechanosense heterogeneities in extracellular matrices at greater length scales than isolated cells, and that this can affect their function. This talk will introduce some of our past and recent work on developing methods to investigate these ideas, and how they may be important in processes such as skin wound healing and in early embryonic development.

Location:  David Sizer Lecture Theatre , Bancroft Building