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Institute of Bioengineering



Prof. John Girkin. Looking deeply in living biology

Image: Prof. John Girkin
Prof. John Girkin

Date: 11 March 2015   Time: 15:00 - 17:00

Since its invention around 400 years ago optical microscopy has played a crucial role in biology, as observation is the key component of all science. In many cases the ultimate test is to observe sub-cellular events in vivo and this clearly creates challenges; namely sample movement and the distortion of the images as one observes ever more deeply within the sample. This presentation will explore the recent advances in imaging methods to overcome these issues. Work will be presented in which live beating Zebrafish hearts have been imaged in real time with micron resolution through novel methods of optical gating. Using a single plane illumination microscope combined with adaptive optics (more normally used in optical telescopes) we have been able to image at depth within a range of live samples with both high spatial and temporal resolution. Using a novel micro-endoscope imaging of endothelial cells in intact and pressurised blood vessels will be linked with a mathematical simulations to explain the effect of hypertension on individual and cell networks responses.

Location:  Derek Willioughby Lecture Theatre, John Vane Science Centre, Charterhouse Square.