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Dr. Yanlan Mao. Getting in Shape: in vivo and in silico studies of tissue mechanics in growth control

Image: Dr Yanlan Mao
Dr Yanlan Mao

Date: 25 March 2015   Time: 15:00 - 17:00

How tissue size and shape are controlled is a fundamental biological question that remains remarkably ill understood. Tissues can grow in a particular direction by controlling the orientation of cell divisions. Using a combination of genetics, live imaging, experimental biophysics and computational modeling, we show that tissue mechanical forces can have an instrumental role in controlling cell shape patterns and cell division orientations. The first part of the presentation will discuss how planar polarization of an atypical myosin, Dachs, can polarize junctional tension to orient cell divisions, while the second part will focus on how differential proliferation rates can generate global patterns of mechanical tension to orient tissue growth in a self perpetuating and self organizing manner. Novel techniques for automated image analysis, and for mechanically manipulating tissues, will be discussed.

Location:  Clark-Kennedy Lecture Theatre, Whitechapel, (not in the QM Innovation Building, but next to it. )