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Institute of Bioengineering



Prof. Richard Oreffo. Bridging the gap - harnessing skeletal stem cells, nanotopography and environmental niches for bone repair.

Image: Prof. Richard Oreffo
Prof. Richard Oreffo

Date: 1 April 2015   Time: 15:00 - 17:00

Medical advances have led to a welcome increase in world population demographics. However, increased aging populations pose new challenges and emphasize the need for innovative approaches to augment and repair tissue lost through trauma or disease.

We have developed protocols for the isolation, expansion and translational application of skeletal stem cell populations with cues from developmental biology, nanotopography and nanoscale architecture as well as biomimetic niche development informing our skeletal tissue engineering approaches. We have developed ex vivo approaches to bone formation evaluation and analysis and central are large animal in vivo translational studies to examine the efficacy of skeletal stem and cell populations in innovative scaffold compositions for orthopaedics. The talk will also highlight current clinical translational studies to examine the efficacy of skeletal populations for orthopaedic application. Advances in our understanding of skeletal stem cells and their role in bone development and repair, offer the potential to open new frontiers in bone regeneration and offer exciting opportunities to improve the quality of life of many.

Location:  David Sizer & DS Foyer, Bancroft Building, Mile End.