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Institute of Bioengineering

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"Mechanical and regulatory roles of the nuclear lamina" by Dr Joe Swift, University of Manchester

Image: Dr Joe Swift
Dr Joe Swift

Date: 30 November 2015   Time: 12:45 - 13:45

How cells receive and decipher mechanical inputs, by feeling the compliance of their surroundings or by being subject to deformation, is a key area of research in the field of mechanobiology. Cells in mature tissue must be appropriately regulated to meet the mechanical demands of their daily functions, with cells in stiff and mechanically loaded tissues requiring more robust cellular structures. I will discuss my work in the Discher laboratory, showing the composition of the nuclear lamina ? the protein meshwork that lines the inner nuclear envelope ? to be a key factor in tuning the mechanical properties of the nucleus, performing functional and regulatory roles while providing physical protection to chromatin. I will also present new efforts, extending these ideas beyond the nucleus to understand how cells and their surrounding extracellular matrices are regulated to be robust to stress and strain.

Location:  Derek Willoughby Lecture Theatre, Charterhouse Square