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Institute of Bioengineering



"HipSci Cell Phenotyping: building imaging platforms to characterise human induced pluripotent stem cell lines" By Dr Davide Danovi, King's College

Image: Dr Danovi
Dr Danovi

Date: 9 March 2016   Time: 15:00 - 16:00

Induced pluripotent stem cells (iPSCs) provide invaluable opportunities for future cell therapies as well as for studying human development, modelling diseases and discovering therapeutics. In order to realise the potential of iPSCs, it is crucial to comprehensively characterise cells generated from large cohorts of healthy and diseased individuals. The human iPSC initiative (HipSci) is assessing a large panel of cell lines to define cell phenotypes, dissect inter- and intra-line and donor variability and identify its key determinant components. We discuss the development of high-content imaging platforms for phenotypic analysis of human iPSC lines. Our aim is to deliver robust quantification of phenotypic diversity within complex cell populations facilitating future identification of the genetic, biological and technical determinants of variance. These approaches can be used to benchmark iPSCs from multiple donors and create novel platforms that can readily be tailored for disease modelling and drug discovery.

Location:  Blizard Institute, Perrin Lecture Theatre, Whitechapel