'Structured and Amphiphilic PEGs for Bio-related Chemistry' by Assoc. Prof. Takahiro Muraoka
Date: 15 March 2016 Time: 12:00 - 13:00
Poly(ethylene glycol) (PEG) is a versatile functional polyether with charge-free, flexible, water-soluble and thermo-responsive properties as well as high biocompatibility, which enrich the value of PEG in bio-related applications and materials development. Our group has been pursuing an investigation of the topological effects of PEG, where it was figured out as a significant example that triangle PEG forms self-assembly upon heating and shows suppression of protein thermal aggregation.
The hydrophilicity and structural flexibility makes PEG useful to design functional amphiphiles. Multi-block amphiphiles consisting of iterative PEG chains and hydrophobic aromatic moieties form folded conformations by an intramolecular hydrophobic interaction in aqueous media. Such foldamers can be inserted into a bilayer membrane to form supramolecular ion channels. By an elaborated design with a ligand-binding pocket, reversible ligand-gated opening and closing of the channels have been successfully demonstrated.
|Location:||Nanoforce seminar room, Mile End Campus|