'Biomimetic Approaches to Growing Biological Rubber Bands' by Assoc. Prof. Anand Ramamurthi, Cleveland Clinic
Date: 16 March 2016 Time: 10:00 - 11:00
This seminar will summarize my laboratory’s efforts to develop matrix-engineering technologies directed at biomimetic regeneration and repair of elastic fibers and fiber networks. We seek to apply these methods to growing elastic tissues in vitro and for effecting regenerative matrix repair in tissues impaired by disruption of their structural extracellular matrix. Restoring the elastic matrix is crucial since its absence, malformation, or pathological disruption can adversely impact tissue recoil properties and cell behavior and health. At this time, we focus on regenerating complex matrix structures vital to cardiovascular homeostasis since these tissues have a capacity for self-repair that is far less effective than tissue-engineering principles demand. A major challenge contributing to this deficiency is the lack of suitable tissue engineering tools to overcome very poor elastin precursor synthesis by stable adult cell types and their poor ability replicate the biocomplexity of developmental elastogenesis. This seminar will provide an overview of our multifaceted approach to overcoming these critical challenges via the design and integration of innovative tools (e.g., biomolecular agents, biomaterial scaffolds, nanotherapeutics and stem cells) and more specifically discuss their application as a minimally-invasive, non-surgical treatment modality to arrest or reverse growth of abdominal aortic aneurysms (AAAs), localized and irreversible expansions of the aorta wall.
|Location:||PP2, People Palace, Mile End|