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Institute of Bioengineering



"Molecular Biomechanics and Mechanobiology" by Prof. Cheng Zhu, Chair in Engineering at the Georgia Institute of Technology and Emory University.


Date: 3 June 2016   Time: 13:00 - 14:00

Molecular mechanics studies mechanics of biomolecules and uses mechanics to study biology at the molecular level. Molecular mechanobiology studies mechanotransduction at the molecular level. Mechanical factors can cause and/or regulate molecular deformation, conformational change, and receptor-ligand binding/unbinding. Information can be encoded and transferred through the molecular structure mechanically, and decoded remotely to be transduced into biological signal. In this talk, Dr. Cheng Zhu will use three examples from the work of his laboratory to illustrate molecular Biomechanics and mechanobiology: 1) measurements of molecular stiffness and use of stiffness measurements to determine molecular conformation; 2) concurrent visualization of conformational changes of single molecules on living cells and intracellular calcium in real-time; and 3) biophysical regulation of receptor-ligand kinetics and protein unfolding.

Location:  PP1, People Palace, Mile End Campus