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IoB Seminar Series: Prof. Matthias Lutolf, Engineering hydrogels to control stem cell self-organisation

Image: Prof. Matthias Lutolf
Prof. Matthias Lutolf

Date: 5 April 2017   Time: 11:00 - 12:00

The earliest steps of development are characterized by cellular reorganization and differentiation within a three-dimensional (3D) microenvironment. This 3D context allows for a complex spatial interplay between biochemical and mechanical signals, and governs important cellular rearrangements leading to morphogenesis. In vitro approaches have attempted to capture key features of these processes, and it has now become possible to generate an increasing variety of self- organizing multicellular tissue constructs termed ‘organoids’. While these approaches are incredibly promising, a number of limitations exist that preclude their reliable use. In particular, the poor reproducibility, dependency on ill-defined matrices, and current inability to scale these assays need to be addressed to make organoid models useful for drug discovery and personalized medicine. In this talk, I will highlight recent efforts in my lab to grow organoids in well-defined synthetic microenvironments.

Location:  Seminar Room, 3rd floor Engineering Building, Mile End
Contact:  Prof. Matthias Lutolf