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Institute of Bioengineering



IoB Seminar Series: Dr Deborah Mason, Repurposing glutamate receptor antagonists to prevent and treat osteoarthritis: A voyage of discovery using cell, animal and human models

Image: Dr Deborah Mason
Dr Deborah Mason

Date: 7 November 2017   Time: 15:00 - 16:00

This talk described how we have used animal (load-induced osteogenesis, antigen induced arthritis, menisectomy, anterior cruciate ligament rupture), cell (mechanically-loaded 3D osteocyte/osteoblastco-culture) and human models (high tibial osteotomy, total knee replacement, focal cartilage defects) to understand the role of glutamate signaling in the skeleton, and how this has revealed a potential therapeutic opportunity for prevention/treatment of osteoarthritis. Challenges of interdisciplinary research and translation of basic science discoveries to the clinic will also be addressed.

Location:  David Sizer Lecture Theatre, Bancroft Building, Mile End
Contact:  Dr Deborah Mason