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Institute of Bioengineering

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Oil-core chitosan based nanocapsules and their influence on 'life networks'

Image: Prof. Francisco Goycoolea
Prof. Francisco Goycoolea

Date: 24 January 2018   Time: 15:00 - 16:00

with Prof. Francisco Goycoolea, University of Leeds

Chitosan-based nanocapsules (d.~200 nm; ?-potential~+60 mV) form by spontaneous emulsification and self assembly, under a phase separation-driven process. These “soft matter” systems are amenable to be loaded with lipophilic phytochemicals, namely capsaicin, cinnamaldehyde, curcumin, and flavonoids (namely quercetin and baicalein). Enhanced permeability, motility and cytoprotective effects, have all been evidenced on different mammalian cell lines forming epithelial monolayer networks1,2. These nanocapsules are also taken up avidly by mammalian cells. In parallel, we have shown that the nanocapsules bind “stoichiometrically” to E. coli bacteria3 and that the quorum sensing response is reduced. The potential application of these findings in functional food and pharmacy is to be fully realised.

References
1. Kaiser M., Pereira S., Pohl L., Ketelhut S., Kemper B., Gorzelanny C., Galla H.-J., Moerschbacher B.M., Goycoolea F.M. Scientific Reports. 5, 10048 DOI: 10.1038/srep10048
2. Kaiser M, Pohl L, Ketelhut S, Kastl L, Gorzelanny C, Götte M, Schnekenburger J., Goycoolea F.M., Kemper B. (2017) PLoS ONE 12(11):e0187497.
3. Qin X., Engwer C., Desai S., Vila-Sanjurjo C., Goycoolea F.M. Colloids and Surfaces B: Biointerfaces.149, 358-368. DOI:10.1016/j.colsurfb.2016.10.031

Location:  David Sizer Lecture Theatre, Bancroft Building, Mile End Campus
Contact:  Dr Julien Gautrot