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Bio-inspired peptidic nanotubes: from atomic structures to applications, with Dr Franck Artzner, Biomimetic Self-assemblies Group, Soft Matter Department, Institute of Physics - Rennes

Image: Dr Franck Artzner
Dr Franck Artzner

Date: 5 March 2018   Time: 15:00 - 16:00

Two peptide nanotubes with well-defined organization resolved at molecularor atomic scale will be presented. Lanreotide is an octapeptide that self-assembles in water into highly monodisperse supramolecular nanotubes, the diameter and wall thickness of which are 244Å and 18Å respectively [Valery et al PNAS 2003]. These amyloid nanotubes can be used as a template to produce micron-long, bilayered silica nanotubes having a monodisperse diameter [Pouget et al, Nature Mat. 2007].

The diameter of these nanotubes can be tuned by a single mutation of the peptides [Taraboutetal, PNAS 2011]. We recently studied a self-assembling pH-sensitive peptide that forms either crystalline bundles of small nanotubes of 10nm width (pH<6.5) or large nanotubes of 50nm width (pH>7.5). By solving both self-assembled structures, we deduced the mechanism of the peptide conformational changes at the origin of the transition between small and large nanotubes. We report on the subangström peptide structure at basic pH that highlights a specific histidine H-bond together with histidine-aromatic packing [Valery et al, Nature Comm. 2015].

Location:  LG01, People’s Palace, Mile End Campus
Contact:  Dr Helena Azevedo, FRSC, FHEA
Telephone:  020 7882 5502