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New Directions in Regenerative Engineering, with Dr Adam Perriman, Reader in Biomaterials, University of Bristol

Image: Dr Adam Perriman
Dr Adam Perriman

Date: 3 October 2018   Time: 15:00 - 16:00

Reengineering cells to operate effectively in biological systems invariably involves the assembly of multiple components, which can only be integrated when compatible interfaces are built into the design. This can be achieved through the synthesis of hybrid materials comprising highly cooperative biological and synthetic constituents that can be used to amplify or attenuate cell-host tissue interactions. The systems methodology that underpins this design approach provides a gateway to the development of non-traditional approaches to regenerative medicine. Accordingly, I describe three emerging research programmes that span the fields of synthetic biology, biomaterials, and regenerative engineering: Stem Cell Painting (1), where artificial membrane binding proteins undergo spontaneous assembly at the plasma membrane of stem cells; Cell Paintballing (2), where microdroplet vectors are controlled optically to deliver bimolecular payloads to specific membranous regions of individual cells; and 3D Bioprinting (3), where a new hybrid microporous bioink is used to print stem cell laden tissue-like constructs.

1. Armstrong et al., Nature Communications 2015, 6, 7405.
2. Armstrong et al., Chemical Science 2015, 6, 6106.
3. Armstrong et al., Advanced Healthcare Materials 2016, 5, 1724.

Location:  PP1 People's Palace, Mile End Campus, Queen Mary University of London
Website:  http://www.bris.ac.uk/chemistry/people/adam-w-perriman/index.html