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Institute of Bioengineering

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Imaging with Multimode Fibers and Phase contrast imaging of the retina, with Prof. Christophe Moser, Laboratory of Applied Photonics Devices (LAPD), Lausanne, Switzerland

Date(s): 28 March 2018
Time: 15:00 - 16:00
Location: David Sizer Lecture Theatre, Bancroft Building, Mile End
Prof Christophe Moser
Prof Christophe Moser
Techniques for addressing image distortion through wavefront shaping and computational optics could pave the way for a new generation of extremely thin, high-resolution endoscopes for medical imaging. Because of the fibre’s ability to transmit multiple spatial modes of light simultaneously, MMFs could, in principle, replace the millimeters-thick bundles of fibers currently used in endoscopes with a single fiber only a few hundred microns thick. That, in turn, could potentially open up new, less invasive forms of endoscopy to perform high-resolution imaging of tissues out of reach of current conventional endoscopes.

The evaluation and monitoring of cells' health in the human retina is crucial for understanding retinal diseases. Towards this goal, a major challenge is to image retina neuronal cells in human eyes in a non-invasive manner in order to detect abnormalities well before physiological and pathological changes occur and also monitor sub-clinical therapeutic effects to evaluate the efficacy of new drugs. However, in vivo imaging of many of these cells is still elusive despite the phenomenal advances in Optical Coherence Tomography (OCT) and Adaptive Optics systems. We will present a method capable of visualising these elusive cells with high contrast. The technique is based on transcleral illumination and phase contrast.
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