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Institute of Bioengineering

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'Functionalized polymer-based building blocks for constructing spatially organized biomaterials' with Dr Lesley W. Chow, Lehigh University, Bethlehem, USA

Date(s): 24 May 2018
Time: 10:00 - 11:00
Location: SEMS Seminar Room, 3/F, Engineering Building, Queen Mary University of London
Dr Lesley W. Chow
Dr Lesley W. Chow
The spatial organization of multiple components in biological tissues is intimately linked to the tissue’s function in the body. Disrupting this organization affects normal tissue function and properties, even if the overall composition remains the same. Inspired by native tissues, our lab focuses on developing strategies to combine and organize different components within a continuous construct to achieve new levels of functionality. The overarching goal is to create biomaterials that template native tissue organization and function. We previously developed a versatile class of end-functionalized polymer conjugates that can be spatially organized by exploiting advanced fabrication techniques. Specific functional groups, such as bioorthogonal chemistries, peptides, or polymer initiators, emerge on the surface during fabrication to generate functionalized materials in a single processing step. For example, peptide-functionalized polymer conjugates can be sequentially electrospun to form fibrous materials with multiple peptide gradients.

These same molecular conjugates can also be 3D printed to independently and simultaneously control the physical and biochemical organization within a single biomaterial. This talk will discuss the how our modular platform can be easily tailored by modifying the conjugate chemistry and fabrication methods to create constructs with spatially organized properties that resemble native tissues.
Contact: Dr Helena Azevedo
Tel: 020 7882 5502
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