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Institute of Bioengineering

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Development of diffuse optical tomography for imaging the newborn infant brain, with Prof. Jeremy C. Hebden

Date(s): 20 March 2019
Time: 15:00 - 16:00
Location: PP1 People's Palace, Mile End Campus, Queen Mary University of London
Prof. Jeremy C. Hebden
Prof. Jeremy C. Hebden
The use of near-infrared light to interrogate biological tissues is attractive because light penetration into tissue is relatively high, and the absorption is sensitive to the oxygenation status of haemoglobin. However, light is very highly scattered in tissue, and consequently imaging requires new types of instruments and sophisticated image reconstruction techniques. Diffuse optical tomography (DOT), a 3D imaging methodology has emerged as an increasingly prevalent research tool, and the technological barriers to successful clinical translation are being overcome. UCL’s Biomedical Optics Research Laboratory (BORL) has played a major role in the development of DOT technology for many years, and has pioneered a range of applications in functional imaging of the adult and infant brain. This talk will focus on the application of DOT to imaging of newborn infants, specifically those at risk of permanent brain damage resulting from extreme prematurity.

Professor Hebden is Director of the UCL Biomedical Optics Research Laboratory (BORL) and Head of the Department of Medical Physics & Biomedical Engineering. His research has largely concerned the development of systems for diffuse optical tomography (DOT), and he has pioneered the development of time-domain techniques in particular. Applications of the technology have focussed on imaging of the newborn infant brain, and especially the assessment of hypoxic ischemic encephalopathy and perinatal arterial ischaemic stroke. His group has been responsible for generating the first whole-brain functional images of newborn infants using optical techniques, and the first full-scalp maps of cortical haemodynamic changes during seizures. Recently, the group has been exploring the development of fibreless wearable DOT technology.
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