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Institute of Bioengineering

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Nanoscale analysis of immune cell communication, with Professor Michael L. Dustin

Date(s): 27 February 2019
Time: 15:00 - 16:00
Location: PP1 People's Palace, Mile End Campus, Queen Mary University of London
Professor Michael Dustin
Professor Michael Dustin
Professor Dustin was trained in Tim Springer’s lab at Harvard Medical School and Stuart Kornfeld’s lab at Washington University in St Louis. He started his Lab at Washington University in St Louis using supported lipids bilayers to study dynamics of the immunological synapse. Work at NYU School of Medicine focused on in vivo analysis of immune cell function in multiple tissues with a focus on tolerance, cancer and infection models. In Oxford he has focused on the immune T cell immunological synapse and the formation of nanoscale extracellular vesicles. This is a unique form of communication that allows the T cell to send out particles with a combination of antigen specificity and effector function. The system is also amenable to analysis by nanofabrication methods. In work started at NYU and continued at Oxford. Professor Dustin has used 3D nano position of T cell receptor ligands to determine the role of phosphatase exclusion in control of T cell responses.
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