'Investigating the roles of inflammation in skin repair and cancer' by Prof. Paul Martin, University of Bristol
We model wound healing in several genetically tractable model organism from the fruitfly, Drosophila, through to mice. Of particular interest to us is the wound inflammatory response which we have shown to be causal of scarring at the wound site. Our current goal is to use a mix of live imaging and genetic studies to determine how recruited innate immune cells direct aberant deposition of collagen at sites of tissue damage. Recently, we have also begun investigating parallels between wound healing and cancer. We use translucent zebrafish to model cancer surgery, in particular investigating how the wound inflammatory response impacts on immune cell recruitment to nearby transformed cells and what might be the downstream consequences of this.
News date: 5 November 2015
Updated by: David Lockwood