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Smoking found to reduce risk of developing Parkinson’s disease

The association between smoking and a decreased risk of Parkinson’s
The association between smoking and a decreased risk of Parkinson’s
Dr Valentina Gallo
Dr Valentina Gallo
People who smoke, or are passively exposed to cigarette smoke, are less likely to develop Parkinson’s disease, according to a study led by Queen Mary University of London of more than 220,000 people.

The analysis suggests that people who have smoked are 20 per cent less likely to develop Parkinson’s disease, and for those who are still smoking the risk is halved. A person’s risk also decreases the more cigarettes that are smoked and the longer one smokes.

The researchers warn that the findings do not imply health benefits from smoking, and should instead be used for further research into the active agent in tobacco, which could in the future be used as a preventive treatment.

New link found with passive smoking
It is also the first study to show an association with exposure to passive smoking, finding that people exposed to passive smoking were 30 per cent less likely to develop the disease compared to the non-exposed.

Lead researcher Dr Valentina Gallo from Queen Mary’s Blizard Institute said: “Our discovery is incredibly important from a scientific point of view and should prompt basic science research aimed at identifying the agent responsible for this effect found in tobacco. Hopefully this will give insight for preventive treatment options.

“However, no-one would ever be advised to use smoking as a preventive treatment for Parkinson’s based on this research, because of the disastrous effects we know smoking has on people’s general health.”

Around 145,000 people in the UK are diagnosed with Parkinson's disease - a condition in which parts of the brain become progressively damaged over many years, leading to involuntary shaking (tremor), muscle stiffness and slow movement, among other symptoms.

Association or causation?
The study also involved researchers from Imperial College London and University of Campania Luigi Vanvitelli, Italy, and was published in the International Journal of Epidemiology. The researchers analysed data from 220,494 European individuals in eight countries (including a total of 715 cases of Parkinson’s disease) and looked at their exposure to cigarette smoke.

The association between smoking and a decreased risk of Parkinson’s has been under discussion for a long time, but it has been difficult to determine whether smoking actually reduces the risk of Parkinson’s disease through a causal effect.

Although the data from this study is observational, the researchers employed certain statistical methods to infer a causal link, by ruling out a number of alternative explanations for the association that was seen.

More information
Research paper: ‘Exploring causality of the association between smoking and Parkinson’s disease’ by Gallo et al. International Journal of Epidemiology (link is below)

News date: 26 November 2018
Contact: Dr Valentina Gallo
Email: v.gallo@qmul.ac.uk
Website: https://academic.oup.com/ije/advance-article/doi/10.1093/ije...

Updated by: Colin Rainey

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