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Institute of Bioengineering

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Prof Amrita Ahluwalia

Professor of Vascular Pharmacology

Department William Harvey Research Institute
 Centre for Clinical Pharmacology, John Vane Science Centre, Charterhouse Square
Telephone +44 (0)20 7882 8377
Email a.ahluwalia@qmul.ac.uk
Homepage http://www.qmul.ac.uk/whri/people/academic-staff/items/ahluwaliaamrita.html

Research Interests

Vascular Pharmacology Group
The main research focus of the group is exploration of the investigation of the impact of inflammation on cardiovascular function and the mechanisms involved in this phenomenon. The group has  4 key areas of interest:

  1. Effects of nitrite and nitrate on the cardiovascular system in health and disease. A major research focus of the group is study of the bioactivity of the reductive nitrate-to nitrite to NO pathway in humans, often dubbed the enterosalivary circuit of inorganic nitrate.  We made the first demonstrations of the protective effects of inorganic nitrite against myocardial ischemia-reperfusion injury implicating two enzymes in the conversion of nitrite to NO: xanthine oxidoreductase and eNOS. More recently, the vasodilator activity of nitrite has attracted much attention. In 2008 we published our findings that a dietary nitrate load, in the form of beetroot juice, reduces blood pressure and improves platelet and endothelial function in healthy volunteers. We are currently investigating the effect of a similar inorganic nitrate load in hypertensive and hypercholesterolemic patients and with Anthony Mathur the potential of intracoronary nitrite in patients suffering an acute myocardial infarction.
  2. Role of the kinin B1 receptor in cardiovascular disease. Ahluwalia & Perretti  in 1996 published findings demonstrating the key role of the inducible kinin B1 receptor in neutrophil recruitment to a site of inflammation. Our research has focussed on the molecular pathways involved in this response and we have identified two particular pathways that play a role i.e. B1-induced endothelial chemokine generation and sensory C-fibre activation. Our most recent studies have demonstrated that laminar shear stress plays a major role in regulating endothelial kinin B1 receptor expression and that this regulation implicates the receptor in atherosclerosis.
  3. Sex differences in cardiovascular function and susceptibility to cardiovascular disease. In 2005 Ahluwalia and Hobbs published the findings demonstrating that endothelium-dependent relaxation of the resistance arteries of females is predominantly mediated by the endothelial factor endothelium-derived hyperpolarising factor, EDHF, whereas in the resistance vessels of males NO and the prostaglandin PGI2 are the primary endothelial factors. We also demonstrated that this propensity to express EDHF protected females from genetically-induced hypertension and protects females from inflammation. We have speculated that these differences may have a role to play in the reduced susceptibility of females to cardiovascular disease. We are currently investigating the pathways involved in this sex-specific upregulation of EDHF and reduced inflammatory responses in healthy volunteers to determine the relevance of our findings in pre-clinical models to humans.
  4. Investigation of the role of TRPV1 in vascular reactivity: In 2004 we identified a major role for the TRPV1 channel and sensory C-fibres in mediating the constriction of resistance arteries that occurs in response to rises in intraluminal pressure; termed myogenic tone. We are currently investigating the molecular pathways involved in this response, in particular our observations have identified the arachidonate metabolite 20-hydroxyeicoasteraenois acid as an important TRPV1 activator.

Key Publications

Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, Pearl V, Benjamin N, Loukogeorgakis S, Macallister R, Hobbs AJ, Webb AJ and Ahluwalia A (2010). Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension  vol. 56, (2) 274-281. 10.1161/HYPERTENSIONAHA.110.153536

Duchene J, Cayla C, Vessillier S, Scotland R, Yamashiro K, Lecomte F, Syed I, Vo P, Marrelli A, Pitzalis C, Cipollone F, Schanstra J, Bascands J-L, Hobbs AJ, Perretti M and Ahluwalia A (2009). Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis. Arterioscler Thromb Vasc Biol  vol. 29, (11) 1757-1763. 10.1161/ATVBAHA.109.191775

Webb AJ, Milsom AB, Rathod KS, Chu WL, Qureshi S, Lovell MJ, Lecomte FMJ, Perrett D, Raimondo C, Khoshbin E, Ahmed Z, Uppal R, Benjamin N, Hobbs AJ and Ahluwalia A (2008). Mechanisms Underlying Erythrocyte and Endothelial Nitrite Reduction to Nitric Oxide in Hypoxia Role for Xanthine Oxidoreductase and Endothelial Nitric Oxide Synthase. Circ Res  vol. 103, (9) 957-U114. 10.1161/CIRCRESAHA.108.175810

Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ and Ahluwalia A (2008). Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension  vol. 51, (3) 784-790. 10.1161/HYPERTENSIONAHA.107.103523

2019

Guzik TJ and Ahluwalia A (2019). Plan S: in Service or Disservice to Society? Eur Heart J  vol. 40, (12) 949-952. 10.1093/eurheartj/ehz065

Guzik TJ and Ahluwalia A (2019). Plan S: In service or disservice to society? Br J Pharmacol  vol. 176, (6) 753-756. 10.1111/bph.14590

2018

Kapil V, Rathod KS, Khambata RS, Bahra M, Velmurugan S, Purba A, S Watson D, Barnes MR, Wade WG and Ahluwalia A (2018). Sex differences in the nitrate-nitrite-NO? pathway: Role of oral nitrate-reducing bacteria. Free Radic Biol Med  vol. 126, 113-121. 10.1016/j.freeradbiomed.2018.07.010

Jones DA, Rathod KS, Williamson A, Harrington D, Andiapen M, van Eijl S, Westwood M, Antoniou S, Schilling RJ, Ahluwalia A and Mathur A (2018). The effect of intracoronary sodium nitrite on the burden of ventricular arrhythmias following primary percutaneous coronary intervention for acute myocardial infarction. Int J Cardiol  vol. 266, 1-6. 10.1016/j.ijcard.2018.01.029

Curtis MJ, Ashton JC, Moon LDF and Ahluwalia A (2018). Clarification of the basis for the selection of requirements for publication in the British Journal of Pharmacology. Br J Pharmacol  vol. 175, (18) 3633-3635. 10.1111/bph.14443

AHLUWALIA A, JONES D and MATHUR A (2018). Sodium Nitrite-Mediated Cardioprotection in Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Cost-Effectiveness Analysis. Sage Publications  Journal of Cardiovascular Pharmacology and Therapeutics  10.1177/1074248418784940

Chen J, Hamers AJP, Finsterbusch M, Massimo G, Zafar M, Corder R, Colas RA, Dalli J, Thiemermann C and Ahluwalia A (2018). Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis. Faseb J  fj201701303-fj201701303. 10.1096/fj.201701303R

Ahluwalia A and Cirino G (2018). Launch of mini-reviews in hot topics. Br J Pharmacol  vol. 175, (13) 10.1111/bph.14342

Yellon DM, He Z, Khambata R, Ahluwalia A and Davidson SM (2018). The GTN patch: a simple and effective new approach to cardioprotection? Basic Res Cardiol  vol. 113, (3) 10.1007/s00395-018-0681-2

Curtis MJ, Alexander S, Cirino G, Docherty JR, George CH, Giembycz MA, Hoyer D, Insel PA, Izzo AA, Ji Y, MacEwan DJ, Sobey CG, Stanford SC, Teixeira MM, Wonnacott S and Ahluwalia A (2018). Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers. Br J Pharmacol  vol. 175, (7) 987-993. 10.1111/bph.14153

AHLUWALIA A (2018). Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology. Wiley  British Journal of Pharmacology  vol. 175, 407-411. 10.1111/bph.14112

2017

Campo G, Pavasini R, Morciano G, Lincoff AM, Gibson CM, Kitakaze M, Lonborg J, Ahluwalia A, Ishii H, Frenneaux M, Ovize M, Galvani M, Atar D, Ibanez B, Cerisano G, Biscaglia S, Neil BJ, Asakura M, Engstrom T, Jones DA, Dawson D, Ferrari R, Pinton P and Ottani F (2017). Clinical benefit of drugs targeting mitochondrial function as an adjunct to reperfusion in ST-segment elevation myocardial infarction: A meta-analysis of randomized clinical trials. Int J Cardiol  vol. 244, 59-66. 10.1016/j.ijcard.2017.06.040

Campo G, Pavasini R, Morciano G, Lincoff MA, C Gibson M, Kitakaze M, Lonborg J, Ahluwalia A, Ishii H, Frenneaux M, Ovize M, Galvani M, Atar D, Ibanez B, Cerisano G, Biscaglia S, Neil BJ, Asakura M, Engstrom T, Jones DA, Dawson D, Ferrari R, Pinton P and Ottani F (2017). Data on administration of cyclosporine, nicorandil, metoprolol on reperfusion related outcomes in ST-segment Elevation Myocardial Infarction treated with percutaneous coronary intervention. Data Brief  vol. 14, 197-205. 10.1016/j.dib.2017.07.033

George CH, Stanford SC, Alexander S, Cirino G, Docherty JR, Giembycz MA, Hoyer D, Insel PA, Izzo AA, Ji Y, MacEwan DJ, Sobey CG, Wonnacott S and Ahluwalia A (2017). Updating the guidelines for data transparency in the British Journal of Pharmacology - data sharing and the use of scatter plots instead of bar charts. Wiley  British Journal of Pharmacology  vol. 174, (17) 2801-2804. 10.1111/bph.13925

Rathod KS, Hamshere S, Khambata RS, Andiapen M, Westwood M, Mathur A, Ahluwalia A and Jones DA (2017). Combined analysis of the safety of intra-coronary drug delivery during primary percutaneous coronary intervention for acute myocardial infarction: A study of three clinical trials. Sage Journals  Jrsm Cardiovasc Dis  vol. 6, 20480040177-20480040177. 10.1177/2048004017725988

Yuzugulen J, Douthwaite JA, Wood EG, Villar IC, Patel NSA, Jegard J, Gaertner H, Rossitto-Borlat I, Rose K, Hartley O, Cutillas PR, Ahluwalia A and Corder R (2017). Characterisation of preproendothelin-1 derived peptides identifies Endothelin-Like Domain Peptide as a modulator of Endothelin-1. Sci Rep  vol. 7, (1) 4956-4956. 10.1038/s41598-017-05365-2

AHLUWALIA A (2017). The anti-inflammatory actions of inorganic nitrate stabilise the atherosclerotic plaque. National Academy of Sciences  Proceedings of The National Academy of Sciences of Usa  10.1073/pnas.1613063114

Jones DA, Rathod KS and Ahluwalia A (2017). Update on Nitrite Reduction in Ischemic Disease: Mechanisms and Clinical Translation. Nitric Oxide: Biology and Pathobiology: Third Edition  10.1016/B978-0-12-804273-1.00015-6

2016

Rathod KS, Jones DA, Van-Eijl TJA, Tsang H, Warren H, Hamshere SM, Kapil V, Jain AK, Deaner A, Poulter N, Caulfield MJ, Mathur A and Ahluwalia A (2016). Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: protocol of the NITRATE-OCT study. Bmj Open  vol. 6, (12) 10.1136/bmjopen-2016-012728

AHLUWALIA A (2016). Accelerated resolution underlies sex differences in the inflammatory response in human. American Society For Clinical Investigation  Journal of Clinical Investigation  vol. 127, (1) 169-182. 10.1172/JCI89429.

Jones DA, Khambata RS, Andiapen M, Rathod KS, Mathur A and Ahluwalia A (2016). Intracoronary nitrite suppresses the inflammatory response following primary percutaneous coronary intervention. Bmj Publishing Group  Heart  10.1136/heartjnl-2016-309748

Ahluwalia A, Gladwin M, Coleman GD, Hord N, Howard G, Kim-Shapiro DB, Lajous M, Larsen FJ, Lefer DJ, McClure LA, Nolan BT, Pluta R, Schechter A, Wang C-Y, Ward MH and Harman JL (2016). Dietary Nitrate and the Epidemiology of Cardiovascular Disease: Report From a National Heart, Lung, and Blood Institute Workshop. J Am Heart Assoc  vol. 5, (7) 10.1161/JAHA.116.003402

Lara J, Ashor AW, Oggioni C, Ahluwalia A, Mathers JC and Siervo M (2016). Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysis. Eur J Nutr  vol. 55, (2) 451-459. 10.1007/s00394-015-0872-7

Gee LC and Ahluwalia A (2016). Dietary Nitrate Lowers Blood Pressure: Epidemiological, Pre-clinical Experimental and Clinical Trial Evidence. Curr Hypertens Rep  vol. 18, (2) 10.1007/s11906-015-0623-4

Rathod KS, Velmurugan S and Ahluwalia A (2016). A 'green' diet-based approach to cardiovascular health? Is inorganic nitrate the answer? Mol Nutr Food Res  vol. 60, (1) 185-202. 10.1002/mnfr.201500313

Velmurugan S, Gan JM, Rathod KS, Khambata RS, Ghosh SM, Hartley A, Van Eijl S, Sagi-Kiss V, Chowdhury TA, Curtis M, Kuhnle GGC, Wade WG and Ahluwalia A (2016). Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study. Am J Clin Nutr  vol. 103, (1) 25-38. 10.3945/ajcn.115.116244

2015

Khambata RS, Ghosh SM and Ahluwalia A (2015). Repurposing of Xanthine Oxidoreductase as a Nitrite Reductase: A New Paradigm for Therapeutic Targeting in Hypertension. Antioxid Redox Signal  vol. 23, (4) 340-353. 10.1089/ars.2015.6254

Velmurugan S, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ, Poole A and Ahluwalia A (2015). Erratum to Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex [Free Radic. Biol. Med. 65 (2013) 1521-1532]. Free Radic Biol Med  vol. 84, 10.1016/j.freeradbiomed.2015.03.015

Curtis MJ, Bond RA, Spina D, Ahluwalia A, Alexander SPA, Giembycz MA, Gilchrist A, Hoyer D, Insel PA, Izzo AA, Lawrence AJ, MacEwan DJ, Moon LDF, Wonnacott S, Weston AH and McGrath JC (2015). Experimental design and analysis and their reporting: new guidance for publication in BJP. Wiley  British Journal of Pharmacology  vol. 172, (14) 3461-3471. 10.1111/bph.12856

Velmurugan S, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ, Poole A and Ahluwalia A (2015). Erratum: Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex (Free Radical Biology and Medicine (2013) 65 (1521-1532)). Free Radical Biology and Medicine  vol. 84, 10.1016/j.freeradbiomed.2015.03.015

Kapil V, Khambata RS, Robertson A, Caulfield MJ and Ahluwalia A (2015). Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: A randomized, phase 2, double-blind, placebo-controlled study. Lippincott Williams and Wilkins  Hypertension  vol. 65, (2) 320-327. 10.1161/HYPERTENSIONAHA.114.04675

Kapil V, Khambata RS, Robertson A, Caulfield MJ and Ahluwalia A (2015). Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension  vol. 65, (2) 320-327. 10.1161/HYPERTENSIONAHA.114.04675

Jones DA, Pellaton C, Velmurugan S, Rathod KS, Andiapen M, Antoniou S, van Eijl S, Webb AJ, Westwood MA, Parmar MK, Mathur A and Ahluwalia A (2015). Randomized phase 2 trial of intracoronary nitrite during acute myocardial infarction. Circ Res  vol. 116, (3) 437-447. 10.1161/CIRCRESAHA.116.305082

Jones DA, Pellaton C, Velmurugan S, Rathod KS, Andiapen M, Antoniou S, Van Eijl S, Webb AJ, Westwood MA, Parmar MK, Mathur A and Ahluwalia A (2015). Randomized phase 2 trial of intracoronary nitrite during acute myocardial infarction. Circulation Research  vol. 116, (3) 437-447. 10.1161/CIRCRESAHA.116.305082

2014

Velmurugan S, Ghosh S, Khambata R, Van Eijl S, Robertson A, Chowdhury T and Ahluwalia A (2014). Dietary nitrate improves endothelial function and vascular stiffness in hypercholesterolemia. Nitric Oxide  vol. 42C, 10.1016/j.niox.2014.09.141

Rathod K, Ghosh S, Khambata R and Ahluwalia A (2014). Xanthine oxidoreductase in atherosclerotic mice: Determination of expression and nitrite reductase activity. Nitric Oxide  vol. 42C, 10.1016/j.niox.2014.09.119

Jones DA, Pellaton C, Velmurugan S, Andiapen M, Antoniou S, Van Eiji S, Westwood MA, Webb AJ, Mathur A and Ahluwalia A (2014). The safety and efficacy of intra-coronary nitrite infusion during acute myocardial infarction (NITRITE-AMI): A single centre, randomised, double-blind controlled trial. Nitric Oxide-Biology and Chemistry  vol. 42, 127-128. 10.1016/j.niox.2014.09.087

Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ, Rebstock A-S, Worthington RJ, Simone MI, Mota F, Rivilla F, Vallejo S, Peiró C, Sánchez Ferrer CF, Djordjevic S, Caulfield MJ, MacAllister RJ, Selwood DL, Ahluwalia A and Hobbs AJ (2014). Endothelial C-type natriuretic peptide maintains vascular homeostasis. J Clin Invest  vol. 124, (9) 4039-4051. 10.1172/JCI74281

Kapil V, Weitzberg E, Lundberg JO and Ahluwalia A (2014). Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health. Nitric Oxide  vol. 38, 45-57. 10.1016/j.niox.2014.03.162

Kapil V, Weitzberg E, Lundberg JO and Ahluwalia A (2014). Clinical evidence demonstrating the utility of inorganic nitrate in cardiovascular health. Nitric Oxide - Biology and Chemistry  vol. 38, (1) 45-57. 10.1016/j.niox.2014.03.162

2013

Velmurugan S, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ, Poole A and Ahluwalia A (2013). Antiplatelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex. Free Radic Biol Med  vol. 65, 1521-1532. 10.1016/j.freeradbiomed.2013.06.031

Bubb KJ, Wen H, Panayiotou CM, Finsterbusch M, Khan FJ, Chan MV, Priestley JV, Baker MD and Ahluwalia A (2013). Activation of neuronal transient receptor potential vanilloid 1 channel underlies 20-hydroxyeicosatetraenoic acid-induced vasoactivity: role for protein kinase A. Hypertension  vol. 62, (2) 426-433. 10.1161/HYPERTENSIONAHA.111.00942

Ghosh SM, Kapil V, Fuentes-Calvo I, Bubb KJ, Pearl V, Milsom AB, Khambata R, Maleki-Toyserkani S, Yousuf M, Benjamin N, Webb AJ, Caulfield MJ, Hobbs AJ and Ahluwalia A (2013). Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential. Hypertension  vol. 61, (5) 1091-1102. 10.1161/HYPERTENSIONAHA.111.00933

Rousselle A, Qadri F, Leukel L, Yilmaz R, Fontaine J-F, Sihn G, Bader M, Ahluwalia A and Duchene J (2013). CXCL5 limits macrophage foam cell formation in atherosclerosis. Journal of Clinical Investigation  vol. 123, (3) 1343-1347. 10.1172/JCI66580

Kapil V, Haydar SMA, Pearl V, Lundberg JO, Weitzberg E and Ahluwalia A (2013). Physiological role for nitrate-reducing oral bacteria in blood pressure control. Free Radic Biol Med  vol. 55, 93-100. 10.1016/j.freeradbiomed.2012.11.013

Ahluwalia A and Hobbs AJ (2013). Letter by Ahluwalia and Hobbs Regarding Article, Nitrate-Nitrite-Nitric Oxide Pathway in Pulmonary Arterial Hypertension Therapeutics. Circulation  vol. 127, (2) E275-E275. 10.1161/CIRCULATIONAHA.112.118356

Jones DA, Andiapen M, Van-Eijl TJA, Webb AJ, Antoniou S, Schilling RJ, Ahluwalia A and Mathur A (2013). The safety and efficacy of intracoronary nitrite infusion during acute myocardial infarction (NITRITE-AMI): study protocol of a randomised controlled trial. Bmj Open  vol. 3, (4) 10.1136/bmjopen-2013-002813

Velmurugan S, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ, Poole A and Ahluwalia A (2013). Antiplatelet effects of dietary nitrate in healthy volunteers: Involvement of cGMP and influence of sex. Free Radical Biology and Medicine  vol. 65, 1521-1532. 10.1016/j.freeradbiomed.2013.06.031

2012

Yuzugulen J, Wood EG, Douthwaite JA, Villar IC, Patel NS, Jegard J, Montoya A, Cutillas P, Hartley O, Ahluwalia A and Corder R (2012). Characterization of Proendothelin-1 Derived Peptides Identifies a Co-secreted Modulator of ET-1 Vasoconstriction, and Provides Insights for Biomarker Measurements. Circulation  vol. 126, (21)

Velmurugan S, Pearl V, Ghosh SM, Davies S, Khambata RS, van Eijl S, Kapil V and Ahluwalia A (2012). Inorganic Nitrate Attenuates Platelet Reactivity in Healthy Males but not Females: Role of the Erythrocyte and Cyclic GMP. Circulation  vol. 126, (21)

Moyes AJ, Khambata RS, Ahluwalia A and Hobbs AJ (2012). Accelerated Atherogenesis and Diminished Vascular Integrity in Mice Lacking Endothelial C-Type Natriuretic Peptide. Circulation  vol. 126, (21)

Chan MV, Bubb KJ, Noyce A, Villar IC, Duchene J, Hobbs AJ, Scotland RS and Ahluwalia A (2012). Distinct endothelial pathways underlie sexual dimorphism in vascular auto-regulation. Br J Pharmacol  vol. 167, (4) 805-817. 10.1111/j.1476-5381.2012.02012.x

Bubb KJ, Khambata RS and Ahluwalia A (2012). Sexual dimorphism in rodent models of hypertension and atherosclerosis. Br J Pharmacol  vol. 167, (2) 298-312. 10.1111/j.1476-5381.2012.02036.x

Baliga RS, Milsom AB, Ghosh SM, Trinder SL, Macallister RJ, Ahluwalia A and Hobbs AJ (2012). Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase. Circulation  vol. 125, (23) 2922-2932. 10.1161/CIRCULATIONAHA.112.100586

Bahra M, Kapil V, Pearl V, Ghosh S and Ahluwalia A (2012). Inorganic nitrate ingestion improves vascular compliance but does not alter flow-mediated dilatation in healthy volunteers. Nitric Oxide  vol. 26, (4) 197-202. 10.1016/j.niox.2012.01.004

Wen H, Östman J, Bubb KJ, Panayiotou C, Priestley JV, Baker MD and Ahluwalia A (2012). 20-Hydroxyeicosatetraenoic acid (20-HETE) is a novel activator of transient receptor potential vanilloid 1 (TRPV1) channel. J Biol Chem  vol. 287, (17) 13868-13876. 10.1074/jbc.M111.334896

Colom B, Poitelon Y, Huang W, Woodfin A, Averill S, Del Carro U, Zambroni D, Brain SD, Perretti M, Ahluwalia A, Priestley JV, Chavakis T, Imhof BA, Feltri ML and Nourshargh S (2012). Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves. Faseb J  vol. 26, (3) 1064-1076. 10.1096/fj.11-196220

2011

Duchene J and Ahluwalia A (2011). Kallikrein-kinin system in inflammation. 10.1515/9783110252354

Villar IC, Scotland RS, Khambata RS, Chan M, Duchene J, Sampaio AL, Perretti M, Hobbs AJ and Ahluwalia A (2011). Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin. Arterioscler Thromb Vasc Biol  vol. 31, (5) 1075-1083. 10.1161/ATVBAHA.111.223545

Kapil V, Benjamin N, Hobbs A and Ahluwalia A (2011). Response to Inorganic Nitrate for Blood Pressure Lowering? Hypertension  vol. 57, (2) E3-E3. 10.1161/HYPERTENSIONAHA.110.164814

2010

Kapil V, Webb AJ and Ahluwalia A (2010). Inorganic nitrate and the cardiovascular system. Heart  vol. 96, (21) 1703-1709. 10.1136/hrt.2009.180372

Yamashiro K, Milsom AB, Duchene J, Panayiotou C, Urabe T, Hattori N and Ahluwalia A (2010). Alterations in nitric oxide and endothelin-1 bioactivity underlie cerebrovascular dysfunction in ApoE-deficient mice. J Cereb Blood Flow Metab  vol. 30, (8) 1494-1503. 10.1038/jcbfm.2010.34

Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, Pearl V, Benjamin N, Loukogeorgakis S, Macallister R, Hobbs AJ, Webb AJ and Ahluwalia A (2010). Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension  vol. 56, (2) 274-281. 10.1161/HYPERTENSIONAHA.110.153536

Milsom AB, Patel NSA, Mazzon E, Tripatara P, Storey A, Mota-Filipe H, Sepodes B, Webb AJ, Cuzzocrea S, Hobbs AJ, Thiemermann C and Ahluwalia A (2010). Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia-reperfusion injury in mice. Nitric Oxide-Biol Ch  vol. 22, (2) 141-148. 10.1016/j.niox.2009.10.010

Laxton RC, Hu Y, Duchene J, Zhang F, Zhang Z, Leung K-Y, Xiao Q, Scotland RS, Hodgkinson CP, Smith K, Willeit J, Lopez-Otin C, Simpson IA, Kiechl S, Ahluwalia A, Xu Q and Ye S (2010). A Role of Matrix Metalloproteinase-8 in Atherosclerosis (vol 105, pg 921, 2009). Circulation Research  vol. 106, (1) E1-E1. 10.1161/RES.0b013e3181cdee32

WEBB A, Webb A and Ahluwalia A (2010). Mechanisms of Nitrite Reduction in Ischemia in the Cardiovascular System. Nitric Oxide Biology and Pathobiology , Editors: Ignarro LJ. Academic Press  10.1016/B978-0-12-373866-0.00017-4

Webb AJ and Ahluwalia A (2010). Mechanisms of nitrite reduction in ischemia in the cardiovascular system. Nitric Oxide: Biology and Pathobiology , Editors: Ignarro L. Elsevier 

2009

Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, Cabrales P, Fago A, Feelisch M, Ford PC, Freeman BA, Frenneaux M, Friedman J, Kelm M, Kevil CG, Kim-Shapiro DB, Kozlov AV, Lancaster JR, Lefer DJ, McColl K, McCurry K, Patel RP, Petersson J, Rassaf T and Reutov V (2009). Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol  vol. 5, (12) 865-869. 10.1038/nchembio.260

Duchene J, Cayla C, Vessillier S, Scotland R, Yamashiro K, Lecomte F, Syed I, Vo P, Marrelli A, Pitzalis C, Cipollone F, Schanstra J, Bascands J-L, Hobbs AJ, Perretti M and Ahluwalia A (2009). Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis. Arterioscler Thromb Vasc Biol  vol. 29, (11) 1757-1763. 10.1161/ATVBAHA.109.191775

Laxton RC, Hu Y, Duchene J, Zhang F, Zhang Z, Leung K-Y, Xiao Q, Scotland RS, Hodgkinson CP, Smith K, Willeit J, López-Otín C, Simpson IA, Kiechl S, Ahluwalia A, Xu Q and Ye S (2009). A role of matrix metalloproteinase-8 in atherosclerosis. Circ Res  vol. 105, (9) 921-929. 10.1161/CIRCRESAHA.109.200279

Kapil V, Rehman F, Arghandawi S, Milsom A, Benjamin N, Hobbs A, MacAllister R, Webb A and Ahluwalia A (2009). BLOOD PRESSURE LOWERING EFFECTS OF ORAL INORGANIC NITRATE VIA BIOCONVERSION TO NITRITE. Basic Clin Pharmacol  vol. 105, 31-31.

Okorie M, Akram F, Loukogeorgakis S, Webb A, Deanfield J, Benjamin N, Hobbs A, MacAllister R and Ahluwalia A (2009). ORAL INORGANIC NITRATE PROTECTS AGAINST ENDOTHELIAL ISCHAEMIA-REPERFUSION INJURY IN HUMANS. Basic Clin Pharmacol  vol. 105, 26-26.

Hobbs AJ, Gane P, Lumsden N, Nobles M, Rebstock A-S, Simone M, Villar I, Worthington R, Xiao F, Ahluwalia A and Selwood D (2009). Design and development of novel non-peptide agonists at natriuretic peptide receptor-C. Faseb Journal  vol. 23,

Duchene J and Ahluwalia A (2009). The kinin B(1) receptor and inflammation: new therapeutic target for cardiovascular disease. Curr Opin Pharmacol  vol. 9, (2) 125-131. 10.1016/j.coph.2008.11.011

Klein J, Gonzalez J, Duchene J, Esposito L, Pradere JP, Neau E, Delage C, Calise D, Ahluwalia A, Carayon P, Pesquero JB, Bader M, Schanstra JP and Bascands JL (2009). Delayed blockade of the kinin B1 receptor reduces renal inflammation and fibrosis in obstructive nephropathy. Faseb J  vol. 23, (1) 134-142. 10.1096/fj.08-115600

2008

Webb AJ, Milsom AB, Rathod KS, Chu WL, Qureshi S, Lovell MJ, Lecomte FMJ, Perrett D, Raimondo C, Khoshbin E, Ahmed Z, Uppal R, Benjamin N, Hobbs AJ and Ahluwalia A (2008). Mechanisms Underlying Erythrocyte and Endothelial Nitrite Reduction to Nitric Oxide in Hypoxia Role for Xanthine Oxidoreductase and Endothelial Nitric Oxide Synthase. Circ Res  vol. 103, (9) 957-U114. 10.1161/CIRCRESAHA.108.175810

Villar IC, Hobbs AJ and Ahluwalia A (2008). Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factor. J Endocrinol  vol. 197, (3) 447-462. 10.1677/JOE-08-0070

Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ and Ahluwalia A (2008). Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension  vol. 51, (3) 784-790. 10.1161/HYPERTENSIONAHA.107.103523

Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ and Ahluwalia A (2008). Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. American Heart Association  Hypertension  vol. 51, 784-790. 10.1161/HYPERTENSIONAHA.107.103523

2007

Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M and Ahluwalia A (2007). A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5. J Immunol  vol. 179, (7) 4849-4856. 10.4049/jimmunol.179.7.4849

Sexton A, McDonald M, Cayla C, Thiemermann C and Ahluwalia A (2007). 12-Lipoxygenase-derived eicosanoids protect against myocardial ischemia/reperfusion injury via activation of neuronal TRPV1. Faseb J  vol. 21, (11) 2695-2703. 10.1096/fj.06-7828com

Villar IC, Panayiotou CM, Sheraz A, Madhani M, Scotland RS, Nobles M, Kemp-Harper B, Ahluwalia A and Hobbs AJ (2007). Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor. Cardiovasc Res  vol. 74, (3) 515-525. 10.1016/j.cardiores.2007.02.032

Tripatara P, Patel NSA, Webb A, Rathod K, Lecomte FMJ, Mazzon E, Cuzzocrea S, Yaqoob MM, Ahluwalia A and Thiemermann C (2007). Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase. J Am Soc Nephrol  vol. 18, (2) 570-580. 10.1681/ASN.2006050450

2006

Villar IC, Ahluwalia A and Hobbs AJ (2006). Distinct pathways regulate endothelium derived hyperpolarising factor-mediated responses in rat mesenteric arteries. Acta Pharmacol Sin  vol. 27, (9) 1276-1276.

Villar IC, Francis S, Webb A, Hobbs AJ and Ahluwalia A (2006). Novel aspects of endothelium-dependent regulation of vascular tone. Kidney Int  vol. 70, (5) 840-853. 10.1038/sj.ki.5001680

2005

Scotland RS, Cohen M, Foster P, Lovell M, Mathur A, Ahluwalia A and Hobbs AJ (2005). C-type natriuretic peptide inhibits leukocyte recruitment and platelet-leukocyte interactions via suppression of P-selectin expression. Proc Natl Acad Sci U S A  vol. 102, (40) 14452-14457. 10.1073/pnas.0504961102

Webb A, Qureshi S, Benjamin N, Perrett D and Ahluwalia A (2005). Xanthine oxidase activity provides an alternative source of no during ischaemia from inorganic nitrite in rat blood vessels. Brit J Clin Pharmaco  vol. 59, (5) 631-632.

Ahluwalia A and Hobbs AJ (2005). Endothelium-derived C-type natriuretic peptide: more than just a hyperpolarizing factor. Trends Pharmacol Sci  vol. 26, (3) 162-167. 10.1016/j.tips.2005.01.005

Vo PA, Lad B, Tomlinson JAP, Francis S and Ahluwalia A (2005). autoregulatory role of endothelium-derived nitric oxide (NO) on Lipopolysaccharide-induced vascular inducible NO synthase expression and function. J Biol Chem  vol. 280, (8) 7236-7243. 10.1074/jbc.M411317200

Scotland RS, Madhani M, Chauhan S, Moncada S, Andresen J, Nilsson H, Hobbs AJ and Ahluwalia A (2005). Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice - Key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo. Circulation  vol. 111, (6) 796-803. 10.1161/01.CIR.0000155238.70797.4E

Scotland RS, Ahluwalia A and Hobbs AJ (2005). C-type natniuretic peptide in vascular physiology and disease. Pharmacol Therapeut  vol. 105, (2) 85-93. 10.1016/j.pharmthera.2004.08.011

Ahluwalia A, SCOTLAND RS, Andersen J, Chauhan S, Moncada S, Nilsson H, Hobbs AJ and Madhani M (2005). Investigation of Vascular Responses in Endothelial Nitric Oxide Synthase/Cyclooxygenase-1 Double-Knockout Mice: Key Role for Endothelium-Derived Hyperpolarizing Factor in the Regulation of Blood Pressure in Vivo. Circulation  vol. 111, (6) 796-803. 10.1161/01.CIR.0000155238.70797.4E

AHLUWALIA A, Scotland RS, Hobbs AJ, Moncada S, Chauhan S, Andresen J, Nilsson H and Madhani M (2005). Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo. Circulation  vol. 111, (6) 796-803.

AHLUWALIA A, Francis S, Tomlinson JA, Lad B and Vo PA (2005). role of endothelium-derived nitric oxide (NO) on Lipopolysaccharide-induced vascular inducible NO synthase expression and function. J Biol Chem  vol. 25280, (8) 7236-7243.

AHLUWALIA A, Mathur A, Lovell M, Hobbs AJ, Cohen M and Scotland RS (2005). C-type natriuretic peptide inhibits leukocyte recruitment and platelet aggregation. Pnas  vol. 102, (40) 14452-14457.

2004

Scotland RS, Chauhan S, Davis C, De Felipe C, Hunt S, Kabir J, Kotsonis P, Oh U and Ahluwalia A (2004). Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction. Circ Res  vol. 95, (10) 1027-1034. 10.1161/01.RES.0000148633.93110.24

AHLUWALIA A, Oh U, Kabir J, De Felipe C, Chauhan S, Scotland RS, Davis C, Hunt S and Kotsonis P (2004). Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction. Circ Res  vol. 95, (10) 1027-1034. 10.1161/01.RES.0000148633.93110.24

Chauhan SD, Hobbs AJ and Ahluwalia A (2004). C-type natriuretic peptide: new candidate for endothelium-derived hyperpolarising factor. Int J Biochem Cell B  vol. 36, (10) 1878-1881. 10.1016/j.biocel.2003.09.009

Webb A, Bond R, McLean P, Uppal R, Benjamin N and Ahluwalia A (2004). Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. P Natl Acad Sci Usa  vol. 101, (37) 13683-13688. 10.1073/pnas.0402927101

Hobbs A, Foster P, Prescott C, Scotland R and Ahluwalia A (2004). Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury - Novel cardioprotective role for endothelium-derived C-type natriuretic peptide. Circulation  vol. 110, (10) 1231-1235. 10.1161/01.CIR.0000141802.29945.34

Ahluwalia A, MacAllister RJ and Hobbs AJ (2004). Vascular actions of natriuretic peptides - Cyclic GMP-dependent and -independent mechanisms. Basic Res Cardiol  vol. 99, (2) 83-89. 10.1007/s00395-004-0459-6

Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A, Perretti M, Moncada S and Hobbs AJ (2004). Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. Proc Natl Acad Sci U S A  vol. 101, (5) 1386-1391. 10.1073/pnas.0304264101

AHLUWALIA A, Sarkar D, Aston D and McLean P (2004). Protease-activated receptor (PAR)-2 causes endothelium-dependant, NO-independant coronary vasodilatation: involvement of C-fibres and EDHF. Circ. Res  vol. 90, 465-472.

AHLUWALIA A, Hobbs A, Prescott C, Scotland R and Foster P (2004). Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide. Circulation  vol. 110, (10) 1231-1235. 10.1161/01.CIR.0000141802.29945.34

Ahluwalia A, PERRETTI M, Mathur A, Moncada S, McLean PG, Hobbs AJ, Scotland RS and Foster P (2004). Inhibition of leukocyte-endothelial cell interactions by nitric oxide via a cGMP-mediated down-regulation of P-selectin expression. Proceedings of The National Academy of Sciences Usa  vol. 101, 1386-1391.

2003

Ahluwalia A (2003). To b'EET or not to b'EET? That is the question! Clin Sci (Lond)  vol. 105, (4) 399-401. 10.1042/CS20030232

Chauhan SD, Seggara G, Vo PA, Macallister RJ, Hobbs AJ and Ahluwalia A (2003). Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice. Faseb J  vol. 17, (6) 773-775. 10.1096/fj.02-0668fje

Chauhan SD, Nilsson H, Ahluwalia A and Hobbs AJ (2003). Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor. P Natl Acad Sci Usa  vol. 100, (3) 1426-1431. 10.1073/pnas.0336365100

Chauhan S, Rahman A, Nilsson H, Clapp L, MacAllister R and Ahluwalia A (2003). NO contributes to EDHF-like responses in rat small arteries: a role for NO stores. Cardiovasc Res  vol. 57, (1) 207-216. 10.1016/s0008-6363(02)00611-9

2002

Chauhan SD, MacAllister RJ, Hobbs AJ and Ahluwalia A (2002). Mechanisms underlying the vasorelaxant activity of C-type natriuretic peptide (CNP) in rat mesenteric resistance arteries. Faseb J  vol. 16, (4) A572-A572.

McLean P and Ahluwalia A (2002). Protease-activated receptor (PAR)-2 activation causes EDHF-like coronary vasodilation: selective preservation in ischemia-reperfusion injury, involvement of lipoxygenase products, VR1 receptors and C-fibers. Faseb J  vol. 16, (4) A569-A569.

McLean PG, Aston D, Sarkar D and Ahluwalia A (2002). Protease-activated receptor-2 activation causes EDHF-like coronary vasodilation - Selective preservation in ischemia/reperfusion injury: Involvement of lipoxygenase products, VR1 receptors, and C-fibers. Circ Res  vol. 90, (4) 465-472. 10.1161/hh0402.105372

2001

Scotland RS, Chauhan S, Vallance PJ and Ahluwalia A (2001). An endothelium-derived hyperpolarizing factor-like factor moderates myogenic constriction of mesenteric resistance arteries in the absence of endothelial nitric oxide synthase-derived nitric oxide. Hypertension  vol. 38, (4) 833-839. 10.1161/hy1001.092651

Ahluwalia A (2001). Nepadutant Menarini Richerche. Curr Opin Investig Drugs  vol. 2, (7) 919-922.

2000

McLean PG, Perretti M and Ahluwalia A (2000). Kinin B(1) receptors and the cardiovascular system: regulation of expression and function. Cardiovasc Res  vol. 48, (2) 194-210. 10.1016/s0008-6363(00)00184-x

McLean PG, Ahluwalia A and Perretti M (2000). Association between kinin B(1) receptor expression and leukocyte trafficking across mouse mesenteric postcapillary venules. J Exp Med  vol. 192, (3) 367-380. 10.1084/jem.192.3.367

Scotland RS, Vallance PJ and Ahluwalia A (2000). Endogenous factors involved in regulation of tone of arterial vasa vasorum: implications for conduit vessel physiology. Cardiovasc Res  vol. 46, (3) 403-411. 10.1016/s0008-6363(00)00023-7

Perretti M and Ahluwalia A (2000). The microcirculation and inflammation: site of action for glucocorticoids. Microcirculation  vol. 7, (3) 147-161. 10.1111/j.1549-8719.2000.tb00117.x

Bogle RG, McLean PG, Ahluwalia A and Vallance P (2000). Impaired vascular sensitivity to nitric oxide in the coronary microvasculature after endotoxaemia. Br J Pharmacol  vol. 130, (1) 118-124. 10.1038/sj.bjp.0703267

McLean PG, Perretti M and Ahluwalia A (2000). Kinin B1 receptors as novel anti-inflammatory targets. Expert Opinion On Therapeutic Targets  vol. 4, (2) 127-141. 10.1517/14728222.4.2.127

Ahluwalia A and Scotland R (2000). Activation of sensory C-fibres partially mediates the vascular myogenic response. Faseb Journal  vol. 14, (4) A143-A143.

Chauhan SD, MacAllister RJ, Clapp LH and Ahluwalia A (2000). Evidence that no may contribute to EDHF-like responses in rat mesenteric and hepatic small arteries. British Journal of Pharmacology  vol. 129,

1999

Scotland R, Vallance P and Ahluwalia A (1999). Endothelin alters the reactivity of vasa vasorum: mechanisms and implications for conduit vessel physiology and pathophysiology. Br J Pharmacol  vol. 128, (6) 1229-1234. 10.1038/sj.bjp.0702930

McLean PG, Perretti M and Ahluwalia A (1999). Inducible expression of the kinin B1 receptor in the endotoxemic heart: mechanisms of des-Arg9bradykinin-induced coronary vasodilation. Br J Pharmacol  vol. 128, (2) 275-282. 10.1038/sj.bjp.0702743

McLean PG, Perretti M and Ahluwalia A (1999). The involvement of kinin B1 receptors in the hypotensive response to endotoxin in rats. British Journal of Pharmacology  vol. 127, U62-U62.

Varsani M, MacAllister R, Ahluwalia A and Marshall I (1999). Investigation of the alpha(1) adrenoceptor subtype(s) mediating contraction in the human internal mammary artery. British Journal of Pharmacology  vol. 127,

Ahluwalia A and Perretti M (1999). B1 receptors as a new inflammatory target. Could this B the 1? Trends Pharmacol Sci  vol. 20, (3) 100-104. 10.1016/S0165-6147(99)01321-8

Scotland R, Vallance P and Ahluwalia A (1999). On the regulation of tone in vasa vasorum. Cardiovasc Res  vol. 41, (1) 237-245. 10.1016/s0008-6363(98)00223-5

1998

Ahluwalia A, De Felipe C, O'Brien J, Hunt SP and Perretti M (1998). Impaired IL-1beta-induced neutrophil accumulation in tachykinin NK1 receptor knockout mice. Br J Pharmacol  vol. 124, (6) 1013-1015. 10.1038/sj.bjp.0701978

Ahluwalia A (1998). Topical glucocorticoids and the skin--mechanisms of action: an update. Mediators Inflamm  vol. 7, (3) 183-193. 10.1080/09629359891126

McLean PG, Perretti M and Ahluwalia A (1998). Investigation of endotoxin-inducible B-1 and constitutive B-2 kinin receptors mediating coronary vasodilation in the rat isolated heart. Naunyn-Schmiedebergs Archives of Pharmacology  vol. 358, (1) R335-R335.

Kakuyama M, Vallance P and Ahluwalia A (1998). Endothelium-dependent sensory NANC vasodilatation: involvement of ATP, CGRP and a possible NO store. Br J Pharmacol  vol. 123, (2) 310-316. 10.1038/sj.bjp.0701610

1997

Ahluwalia A, Giuliani S and Maggi CA (1997). Allergic inflammation in the rat urinary bladder: Involvement of mast cells and C-fibres. British Journal of Pharmacology  vol. 122,

Scotland RS, Vallance PJ and Ahluwalia A (1997). Comparison of vascular reactivity of porcine aorta and its vasa vasorum. Circulation  vol. 96, (8) 908-908.

Ahluwalia A and Vallance P (1997). Evidence for functional responses to sensory nerve stimulation of rat small mesenteric veins. J Pharmacol Exp Ther  vol. 281, (1) 9-14.

Ahluwalia A and Cellek S (1997). Regulation of the cardiovascular system by non-adrenergic non-cholinergic nerves. Curr Opin Nephrol Hypertens  vol. 6, (1) 74-79. 10.1097/00041552-199701000-00014

1996

Ahluwalia A and Vallance PJ (1996). Reactivity of the vasa vasorum. Circulation  vol. 94, (8) 3443-3443.

Perretti M, Ahluwalia A, Harris JG, Harris HJ, Wheller SK and Flower RJ (1996). Acute inflammatory response in the mouse: exacerbation by immunoneutralization of lipocortin 1. Br J Pharmacol  vol. 117, (6) 1145-1154. 10.1111/j.1476-5381.1996.tb16709.x

Ahluwalia A and Perretti M (1996). Involvement of bradykinin B1 receptors in the polymorphonuclear leukocyte accumulation induced by IL-1 beta in vivo in the mouse. J Immunol  vol. 156, (1) 269-274.

Halpern SM, Ahluwalia A, Makunura CN and Jordan S (1996). Investigation of notalgia paraesthetica using laser Doppler velocimetry and immunohistochemistry before and after treatment with topical capsaicin. Journal of The European Academy of Dermatology and Venereology  vol. 7, (3) 228-234. 10.1016/S0926-9959(94)00070-0

1995

Ahluwalia A, Giuliani S and Maggi CA (1995). Demonstration of a 'septide-sensitive' inflammatory response in rat skin. Br J Pharmacol  vol. 116, (4) 2170-2174. 10.1111/j.1476-5381.1995.tb15050.x

Ahluwalia A, Newbold P, Brain SD and Flower RJ (1995). Topical glucocorticoids inhibit neurogenic inflammation: involvement of lipocortin 1. Eur J Pharmacol  vol. 283, (1-3) 193-198. 10.1016/0014-2999(95)00350-t

AHLUWALIA A, NEWBOLD P and FLOWER RJ (1995). TOPICAL GLUCOCORTICOIDS INHIBIT NEUROGENIC INFLAMMATION - INVOLVEMENT OF LIPOCORTIN-1. British Journal of Pharmacology  vol. 114, P61-P61.

AHLUWALIA A, GIULIANI S and MAGGI CA (1995). DEMONSTRATION OF A SEPTIDE-SENSITIVE INFLAMMATORY RESPONSE IN RAT SKIN. British Journal of Pharmacology  vol. 114, P41-P41.

1994

Ahluwalia A and Perretti M (1994). Calcitonin gene-related peptides modulate the acute inflammatory response induced by interleukin-1 in the mouse. Eur J Pharmacol  vol. 264, (3) 407-415. 10.1016/0014-2999(94)00503-6

Ahluwalia A, Mohamed RW and Flower RJ (1994). Induction of lipocortin 1 by topical steroid in rat skin. Biochem Pharmacol  vol. 48, (8) 1647-1654. 10.1016/0006-2952(94)90210-0

AHLUWALIA A and FLOWER RJ (1994). CHARACTERIZATION OF CAPSAICIN-INDUCED VASODILATION OF THE PERFUSED RABBIT EAR AND ITS MODULATION BY DEXAMETHASONE. British Journal of Pharmacology  vol. 112, U104-U104.

Ahluwalia A, Maggi CA, Santicioli P, Lecci A and Giuliani S (1994). Characterization of the capsaicin-sensitive component of cyclophosphamide-induced inflammation in the rat urinary bladder. Br J Pharmacol  vol. 111, (4) 1017-1022. 10.1111/j.1476-5381.1994.tb14845.x

Ahluwalia A and Perretti M (1994). Anti-inflammatory effect of prostanoids in mouse and rat skin: evidence for a role of EP3-receptors. J Pharmacol Exp Ther  vol. 268, (3) 1526-1531.

1993

Perretti M, Ahluwalia A, Harris JG, Goulding NJ and Flower RJ (1993). Lipocortin-1 fragments inhibit neutrophil accumulation and neutrophil-dependent edema in the mouse. A qualitative comparison with an anti-CD11b monoclonal antibody. J Immunol  vol. 151, (8) 4306-4314.

Perretti M, Ahluwalia A, Flower RJ and Manzini S (1993). Endogenous tachykinins play a role in IL-1-induced neutrophil accumulation: involvement of NK-1 receptors. Immunology  vol. 80, (1) 73-77.

AHLUWALIA A, FLOWER RJ and PERRETTI M (1993). DUAL-ACTION OF PROSTAGLANDINS (PGS) IN THE MOUSE SKIN EDEMA TEST. British Journal of Pharmacology  vol. 109, P5-P5.

Ahluwalia A and Flower RJ (1993). Investigations into the mechanism of vasoconstrictor action of the topical steroid betamethasone-17-valerate in the rat. Br J Pharmacol  vol. 108, (2) 544-548. 10.1111/j.1476-5381.1993.tb12838.x

Ahluwalia A and Flower RJ (1993). Topical betamethasone-17-valerate inhibits heat-induced vasodilatation in man. Br J Dermatol  vol. 128, (1) 45-48. 10.1111/j.1365-2133.1993.tb00146.x

1992

AHLUWALIA A and FLOWER RJ (1992). TOPICAL STEROIDS AND ACE INHIBITORS - A COMMON LINK. British Journal of Pharmacology  vol. 106, P5-P5.

Ahluwalia A, Peers SH and Flower RJ (1992). Steroid inhibition of oedema formation in the rat skin. Br J Pharmacol  vol. 106, (3) 628-631. 10.1111/j.1476-5381.1992.tb14386.x

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