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Institute of Bioengineering

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Prof Alvaro Mata

BSc, MSc, DEng

Professor of Biomedical Engineering & Biomaterials

Department School of Engineering and Materials Science
 Engineering E404, Mile End
Telephone +44 (0)20 7882 6279

Research Interests

We are a highly interdisciplinary group passionate about developing creative and innovative technologies to generate creative solutions for a variety of bioengineering applications. We use  interdisciplinary approaches that integrate engineering, materials science, chemistry, nanotechnology, biology, and medicine to develop materials and devices with hierarchical order, biomimetic character, spatio-temporal control, adaptability, tuneability, self-healing capacity, and functionality. Current research in our lab includes the development of in vitro biomimetic environments, dynamic and directed self-assembling systems, molecular patterning of 3D environments, and molecularly-designed bioactive implants. Applications range from tissue engineering and regenerative medicine to drug discovery.

Current Funded Research Projects


Redondo-Gómez C, Abdouni Y, Becer CR and Mata A (2019). Self-Assembling Hydrogels Based on a Complementary Host-Guest Peptide Amphiphile Pair. Biomacromolecules  vol. 20, (6) 2276-2285. 10.1021/acs.biomac.9b00224

BARRETT DW, John RK, Thrasivoulou C, MATA A, Deprest JA, Becker DL, David AL and CHOWDHURY TINA (2019). Targeting mechanotransduction mechanisms and tissue weakening signals in the human amniotic membrane. Nature Publishing Group  Scientific Reports  10.1038/s41598-019-42379-4


Elsharkawy S and Mata A (2018). Hierarchical Biomineralization: from Nature's Designs to Synthetic Materials for Regenerative Medicine and Dentistry. Adv Healthc Mater  vol. 7, (18) 10.1002/adhm.201800178

Elsharkawy S, Al-Jawad M, Pantano MF, Tejeda-Montes E, Mehta K, Jamal H, Agarwal S, Shuturminska K, Rice A, Tarakina NV, Wilson RM, Bushby AJ, Alonso M, Rodriguez-Cabello JC, Barbieri E, Del Río Hernández A, Stevens MM, Pugno NM, Anderson P and Mata A (2018). Protein disorder-order interplay to guide the growth of hierarchical mineralized structures. Nat Commun  vol. 9, (1) 10.1038/s41467-018-04319-0

Mata A (2018). Claim to FAME. Nat Chem  vol. 10, (5) 485-487. 10.1038/s41557-018-0049-0

MATA A (2018). Multicomponent self-assembly as a tool to harness new properties from peptides and proteins in materials design. Royal Society of Chemistry  Chemical Society Reviews  10.1039/C8CS00121A

Aguilar JP, Lipka M, Primo GA, Licon-Bernal EE, Fernández-Pradas JM, Yaroshchuk A, Albericio F and Mata A (2018). 3D Electrophoresis-Assisted Lithography (3DEAL): 3D Molecular Printing to Create Functional Patterns and Anisotropic Hydrogels. Advanced Functional Materials  vol. 28, (15) 10.1002/adfm.201703014

MATA A (2018). A fluidic device for the controlled formation and real-time monitoring of soft membranes self-assembled at liquid interfaces. Nature Publishing Group  Scientific Reports  10.1038/s41598-018-20998-7


Ribeiro S, Radvar E, Shi Y, Borges J, Pirraco RP, Leonor IB, Mano JF, Reis RL, Mata Á and Azevedo HS (2017). Nanostructured interfacial self-assembled peptide-polymer membranes for enhanced mineralization and cell adhesion. Nanoscale  vol. 9, (36) 13670-13682. 10.1039/c7nr03410e

Barrett DW, Kethees A, Thrasivoulou C, Mata A, Virasami A, Sebire NJ, Engels AC, Deprest JA, Becker DL, David AL and Chowdhury TT (2017). Trauma induces overexpression of Cx43 in human fetal membrane defects. Prenat Diagn  10.1002/pd.5104

Shuturminska K, Tarakina NV, Azevedo HS, Bushby AJ, Mata A, Anderson P and Al-Jawad M (2017). Elastin-Like Protein, with Statherin Derived Peptide, Controls Fluorapatite Formation and Morphology. Front Physiol  vol. 8, 368-368. 10.3389/fphys.2017.00368

Inostroza-Brito KE, Collin EC, Majkowska A, Elsharkawy S, Rice A, Del Río Hernández AE, Xiao X, Rodríguez-Cabello J and Mata A (2017). Cross-linking of a biopolymer-peptide co-assembling system. Acta Biomater  vol. 58, 80-89. 10.1016/j.actbio.2017.05.043

Donnelly H, Smith CA, Sweeten PE, Gadegaard N, Meek D, D'Este MD, MATA A, Eglin D and Dalby MJ (2017). Bone and cartilage differentiation of a single stem cell population driven by material interface. Sage Publications  Journal of Tissue Engineering  vol. 8, 10.1177/2041731417705615

MATA A, Azevedo HS, Botto L, Gavara N and Su L (2017). New Bioengineering Breakthroughs and Enabling Tools in Regenerative Medicine. Current Stem Cell Reports  10.1007/s40778-017-0081-9


Elsharkawy S, Tejeda-Montes E, Al-Jawad M and MATA A (2016). Preferential nucleation and crystal growth on micro fabricated topography. Materials Today  10.1016/j.mattod.2016.08.002

Barrett DW, David AL, Thrasivoulou C, Mata A, Becker DL, Engels AC, Deprest JA and CHOWDHURY TT (2016). Connexin 43 is overexpressed in human fetal membrane defects after fetoscopic surgery. Prental Diagnosis  10.1002/pd.4917


Sánchez-Ferrero A, Mata Á, Mateos-Timoneda MA, Rodríguez-Cabello JC, Alonso M, Planell J and Engel E (2015). Development of tailored and self-mineralizing citric acid-crosslinked hydrogels for in situ bone regeneration. Biomaterials  vol. 68, 42-53. 10.1016/j.biomaterials.2015.07.062

Inostroza-Brito KE, Collin E, Siton-Mendelson O, Smith KH, Monge-Marcet A, Ferreira DS, Rodríguez RP, Alonso M, Rodríguez-Cabello JC, Reis RL, Sagués F, Botto L, Bitton R, Azevedo HS and Mata A (2015). Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein-peptide system. Nat Chem  vol. 7, (11) 897-904. 10.1038/nchem.2349

Seelbach RJ, Fransen P, Pulido D, D'Este M, Duttenhoefer F, Sauerbier S, Freiman TM, Niemeyer P, Albericio F, Alini M, Royo M, Mata A and Eglin D (2015). Injectable Hyaluronan Hydrogels with Peptide-Binding Dendrimers Modulate the Controlled Release of BMP-2 and TGF-?1. Macromol Biosci  vol. 15, (8) 1035-1044. 10.1002/mabi.201500082

Rey-Rico A, Venkatesan JK, Frisch J, Schmitt G, Monge-Marcet A, Lopez-Chicon P, Mata A, Semino C, Madry H and Cucchiarini M (2015). Effective and durable genetic modification of human mesenchymal stem cells via controlled release of rAAV vectors from self-assembling peptide hydrogels with a maintained differentiation potency. Acta Biomater  vol. 18, 118-127. 10.1016/j.actbio.2015.02.013

Fernández-Muiños T, Recha-Sancho L, López-Chicón P, Castells-Sala C, Mata A and Semino CE (2015). Bimolecular based heparin and self-assembling hydrogel for tissue engineering applications. Acta Biomater  vol. 16, 35-48. 10.1016/j.actbio.2015.01.008

Seelbach RJ, D'Este M, Alini M, Mata A and Eglin D (2015). Copper catalyst efficiency for the CuAAC synthesis of a poly(N-isopropylacrylamide) conjugated hyaluronan. Clin Hemorheol Microcirc  vol. 60, (1) 25-37. 10.3233/CH-151933


Seelbach RJ, Fransen P, Peroglio M, Pulido D, Lopez-Chicon P, Duttenhoefer F, Sauerbier S, Freiman T, Niemeyer P, Semino C, Albericio F, Alini M, Royo M, Mata A and Eglin D (2014). Multivalent dendrimers presenting spatially controlled clusters of binding epitopes in thermoresponsive hyaluronan hydrogels. Acta Biomater  vol. 10, (10) 4340-4350. 10.1016/j.actbio.2014.06.028

Tejeda-Montes E, Klymov A, Nejadnik MR, Alonso M, Rodriguez-Cabello JC, Walboomers XF and Mata A (2014). Mineralization and bone regeneration using a bioactive elastin-like recombinamer membrane. Biomaterials  vol. 35, (29) 8339-8347. 10.1016/j.biomaterials.2014.05.095

Aguilar Aleman JP, Licon Bernal EE, Fernandez Pradas JM, Yaroshchuk A, Albericio F and Mata A (2014). 3D electrophoresis-assisted lithography (3DEAL) for patterning hydrogel environments. Journal of Tissue Engineering and Regenerative Medicine  vol. 8, 375-375.

Seelbach R, Peroglio M, Fransen P, Royo M, Albericio F, Alini M, Eglin D and Mata A (2014). Binding epitope decorated dendrimers in thermoreponsive hyaluronic acid hydrogels influence stem cells. Journal of Tissue Engineering and Regenerative Medicine  vol. 8, 215-216.

Tejeda-Montes E, Smith KH, Rebollo E, Gómez R, Alonso M, Rodriguez-Cabello JC, Engel E and Mata A (2014). Bioactive membranes for bone regeneration applications: effect of physical and biomolecular signals on mesenchymal stem cell behavior. Acta Biomater  vol. 10, (1) 134-141. 10.1016/j.actbio.2013.09.001


López-Bosque MJ, Tejeda-Montes E, Cazorla M, Linacero J, Atienza Y, Smith KH, Lladó A, Colombelli J, Engel E and Mata A (2013). Fabrication of hierarchical micro-nanotopographies for cell attachment studies. Nanotechnology  vol. 24, (25) 10.1088/0957-4484/24/25/255305

Mendes AC, Smith KH, Tejeda-Montes E, Engel E, Reis RL, Azevedo HS and Mata A (2013). Co-assembled and microfabricated bioactive membranes. Advanced Functional Materials  vol. 23, (4) 430-438. 10.1002/adfm.201201065

Johnstone B, Alini M, Cucchiarini M, Dodge GR, Eglin D, Guilak F, Madry H, Mata A, Mauck RL, Semino CE and Stoddart MJ (2013). TISSUE ENGINEERING FOR ARTICULAR CARTILAGE REPAIR - THE STATE OF THE ART. European Cells & Materials  vol. 25, 248-267. 10.22203/eCM.v025a18


Tejeda-Montes E, Smith KH, Rebollo E, Gomez R, Alonso M, Engel E and Mata A (2012). A top-down/bottom-up strategy to develop a bioactive periostium graft. Journal of Tissue Engineering and Regenerative Medicine  vol. 6, 19-19.

Smith KH, Inostroza KE, Alonso M, Reis RL, Azevedo HS and Mata A (2012). Spontaneous co-assembly of molecularly designed building blocks into hierarchically ordered, dynamic, hybrid macrotubes. Journal of Tissue Engineering and Regenerative Medicine  vol. 6, 224-225.

Fransen P, Pulido D, Seelbach R, Mata A, Eglin D, Royo M and Albericio F (2012). Biofunctionalization of biopolymers with peptide conjugated dendrons. Journal of Peptide Science  vol. 18, S25-S25.

Tejeda-Montes E, Smith KH, Poch M, López-Bosque MJ, Martín L, Alonso M, Engel E and Mata A (2012). Engineering membrane scaffolds with both physical and biomolecular signaling. Acta Biomaterialia  vol. 8, (3) 998-1009. 10.1016/j.actbio.2011.09.005

Mata A, Palmer L, Tejeda-Montes E and Stupp SI (2012). Design of biomolecules for nanoengineered biomaterials for regenerative medicine. Methods in Molecular Biology  vol. 811, 39-49. 10.1007/978-1-61779-388-2_3


Sánchez-Ferrero A, Mata A, Alonso M, Rodríguez-Cabello JC, Planell J and Engel E (2011). Preparation and characterization of glutaraldehyde-cross-linked RGD-containing elastin-like polymer matrices. 24th European Conference On Biomaterials - Annual Conference of The European Society For Biomaterials 

Seelbach R, Peroglio M, Fransen P, Royo M, Mata A, Alini M and Eglin D (2011). Designing a multifunctional, thermoreversible hyaluronan-based hydrogel scaffold for tissue regeneration. 24th European Conference On Biomaterials - Annual Conference of The European Society For Biomaterials 

Smith KH, Tejeda-Montes E, Poch M and Mata A (2011). Integrating top-down and self-assembly in the fabrication of peptide and protein-based biomedical materials. Chemical Society Reviews  vol. 40, (9) 4563-4577. 10.1039/c1cs15064b

Mata A (2011). Micro and nanotechnologies for bioengineering regenerative medicine scaffolds. International Journal of Biomedical Engineering and Technology  vol. 5, (2-3) 266-291. 10.1504/IJBET.2011.039202

Seelbach R, Peroglio M, Fransen P, Royo M, Mata A, Alini M and Eglin D (2011). Toward multifaceted biomaterials that guide stem cell behaviour: Injectable, bioactive hyaluronan-based hydrogel scaffolds. European Cells and Materials  vol. 22, (SUPPL.4)


Mata A, Geng Y, Henrikson KJ, Aparicio C, Stock SR, Satcher RL and Stupp SI (2010). Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix. Biomaterials  vol. 31, (23) 6004-6012. 10.1016/j.biomaterials.2010.04.013

Zhang S, Greenfield MA, Mata A, Palmer LC, Bitton R, Mantei JR, Aparicio C, De La Cruz MO and Stupp SI (2010). A self-assembly pathway to aligned monodomain gels. Nature Materials  vol. 9, (7) 594-601. 10.1038/nmat2778

Kim EJ, Boehm CA, Mata A, Fleischman AJ, Muschler GF and Roy S (2010). Post microtextures accelerate cell proliferation and osteogenesis. Acta Biomaterialia  vol. 6, (1) 160-169. 10.1016/j.actbio.2009.06.016


Mata A, Kim EJ, Boehm CA, Fleischman AJ, Muschler GF and Roy S (2009). A three-dimensional scaffold with precise micro-architecture and surface micro-textures. Biomaterials  vol. 30, (27) 4610-4617. 10.1016/j.biomaterials.2009.05.023

Mata A, Hsu L, Capito R, Aparicio C, Henrikson K and Stupp SI (2009). Micropatterning of bioactive self-assembling gels. Soft Matter  vol. 5, (6) 1228-1236. 10.1039/b819002j


Capito RM, Azevedo HS, Velichko Y, Mata A and Stupp SI (2008). Self-assembly of biomaterials at an interface: Formation of sacs, membranes, and strings. 8th World Biomaterials Congress 2008  vol. 1,

Mata A, Hsu L, Capito R, Aparicio C and Stupp SI (2008). Peptide amphiphile microtextures for in vitro osteoblastic differentiation. 8th World Biomaterials Congress 2008  vol. 3,

Mata A, Geng Y, Henrikson K, Sergeant T, Aparicio C, Satcher RL and Stupp SI (2008). Peptide amphiphiles for bone regeneration. 8th World Biomaterials Congress 2008  vol. 3,

Huang Z, Sargeant TD, Hulvat JF, Mata A, Bringas P, Koh CY, Stupp SI and Snead ML (2008). Bioactive nanofibers instruct cells to proliferate and differentiate during enamel regeneration. Journal of Bone and Mineral Research  vol. 23, (12) 1995-2006. 10.1359/jbmr.080705

Capito RM, Azevedo HS, Velichko YS, Mata A and Stupp SI (2008). Self-assembly of large and small molecules into hierarchically ordered sacs and membranes. Science  vol. 319, (5871) 1812-1816. 10.1126/science.1154586

Sargeant TD, Guler MO, Oppenheimer SM, Mata A, Satcher RL, Dunand DC and Stupp SI (2008). Hybrid bone implants: Self-assembly of peptide amphiphile nanofibers within porous titanium. Biomaterials  vol. 29, (2) 161-171. 10.1016/j.biomaterials.2007.09.012


Mata A, Boehm C, Fleischman AJ, Muschler GF and Roy S (2007). Connective tissue progenitor cell growth characteristics on textured substrates. Int J Nanomedicine  vol. 2, (3) 389-406.


Mata A, Fleischman AJ and Roy S (2006). Fabrication of multi-layer SU-8 microstructures. Journal of Micromechanics and Microengineering  vol. 16, (2) 276-284. 10.1088/0960-1317/16/2/012


Mata A, Fleischman AJ and Roy S (2005). Characterization of polydimethylsiloxane (PDMS) properties for biomedical micro/nanosystems. Biomedical Microdevices  vol. 7, (4) 281-293. 10.1007/s10544-005-6070-2

Mata A, Fleischman AJ and Roy S (2005). Fabrication of 3D micro-textured scaffolds for tissue engineering. Proceedings - Aspe Spring Topical Meeting On Precision Micro/Nano Scale Polymer Based Component and Device Fabrication, Aspe 200  15-19.

Stupp SI, Donners JJJM, Li L-S and Mata A (2005). Expanding Frontiers in Biomaterials. Cambridge University Press (Cup)  Mrs Bulletin  vol. 30, (11) 864-873. 10.1557/mrs2005.276

Mata A, Fleischman AJ and Roy S (2005). Microfabricated 3D scaffolds for tissue engineering applications. Materials Research Society Symposium Proceedings  vol. 845, 97-103.


Mata A, Su X, Fleischman AJ, Roy S, Banks BA, Miller SK and Midura RJ (2003). Osteoblast attachment to a textured surface in the absence of exogenous adhesion proteins. Ieee Trans Nanobioscience  vol. 2, (4) 287-294. 10.1109/TNB.2003.820268


Mata A, Boehm C, Fleischman AJ, Muschler G and Roy S (2002). Growth of connective tissue progenitor cells on microtextured polydimethylsiloxane surfaces. Journal of Biomedical Materials Research  vol. 62, (4) 499-506. 10.1002/jbm.10353

Mata A, Boehm C, Fleischman AJ, Muschler G and Roy S (2002). Analysis of connective tissue progenitor cell behavior on polydimethylsiloxane smooth and channel micro-textures. Biomedical Microdevices  vol. 4, (4) 267-275. 10.1023/A:1020950022074

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