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Institute of Bioengineering

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Prof David Lee

Deputy Vice Principal for Research (Enterprise) in Science & Eng., Professor of Cell and Tissue Engineering

Department School of Engineering and Materials Science
Email d.a.lee@qmul.ac.uk
Homepage http://www.sems.qmul.ac.uk/d.a.lee

Research Interests

TBC

2019

Cortes E, Sarper M, Robinson B, Lachowski D, Chronopoulos A, Thorpe SD, Lee DA and Del Río Hernández AE (2019). GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment. Embo Rep  vol. 20, (1) 10.15252/embr.201846556

Cortes E, Lachowski D, Robinson B, Sarper M, Teppo JS, Thorpe SD, Lieberthal TJ, Iwamoto K, Lee DA, Okada-Hatakeyama M, Varjosalo MT and Del Río Hernández AE (2019). Tamoxifen mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival. Embo Rep  vol. 20, (1) 10.15252/embr.201846557

2018

Cortes E, Lachowski D, Rice A, THORPE SD, Robinson B, Yeldag G, LEE DA, Ghemtio L, Rombouts K and del Río Hernández AE (2018). Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor. Springer Nature [Academic Journals On Nature.Com]  Oncogene  10.1038/s41388-018-0631-3

THORPE SD, Cortes E, Lachowski D, Rice A, Chronopoulos A, Robinson B, LEE DA, Possamai LA, Wang H, Pinato DJ and del Rio Hernández AE (2018). RAR-? is downregulated in HCC & cirrhosis and its expression inhibits myosin-driven activation and durotaxis in hepatic stellate cells. Wiley  Hepatology  10.1002/hep.30193

2017

Heywood HK and Lee DA (2017). Bioenergetic reprogramming of articular chondrocytes by exposure to exogenous and endogenous reactive oxygen species and its role in the anabolic response to low oxygen. J Tissue Eng Regen Med  vol. 11, (8) 2286-2294. 10.1002/term.2126

THORPE SD and Lee DA (2017). Dynamic regulation of nuclear architecture and mechanics?a rheostatic role for the nucleus in tailoring cellular mechanosensitivity. Taylor & Francis  Nucleus  vol. 8, (3) 287-300. 10.1080/19491034.2017.1285988

Elyasigomari V, Lee DA, Screen HRC and SHAHEED MH (2017). Development of a two-stage gene selection method that incorporates a novel hybrid approach using the cuckoo optimization algorithm and harmony search for cancer classification. Journal of Biomedical Informatics  vol. 67, (2017) 11-20. 10.1016/j.jbi.2017.01.016

2016

Heo S-J, Driscoll TP, Thorpe SD, Nerurkar NL, Baker BM, Yang MT, Chen CS, Lee DA and Mauck RL (2016). Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity. Elife Sciences Publications Ltd  Elife  vol. 5, 10.7554/eLife.18207

Tilwani RK, Vessillier S, Pingguan-Murphy B, Lee DA, Bader DL and Chowdhury TT (2016). Oxygen tension modulates the effects of TNF? in compressed chondrocytes. Inflamm Res  10.1007/s00011-016-0991-5

Heo SJ, Han WM, Szczesny SE, Cosgrove BD, Elliott DM, Lee DA, Duncan RL and Mauck RL (2016). Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells. Biophysical Journal  vol. 111, (4) 864-874. 10.1016/j.bpj.2016.07.006

Sliogeryte K, Botto L, Lee DA and Knight MM (2016). Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion. Elsevier  Osteoarthritis and Cartilage  vol. 24, (5) 912-920. 10.1016/j.joca.2015.12.007

Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM and Connelly JT (2016). Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility. J Invest Dermatol  vol. 136, (1) 74-83. 10.1038/JID.2015.352

2015

Heo S-J, Thorpe SD, Driscoll TP, Duncan RL, Lee DA and Mauck RL (2015). Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells. Sci Rep  vol. 5, 10.1038/srep16895

Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM and Connelly JT (2015). Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility. J Invest Dermatol  10.1038/jid.2015.352

Chen J, Bader DL, Lee DA and Knight MM (2015). FINITE ELEMENT ANALYSIS of MECHANICAL DEFORMATION of CHONDROCYTE to 2D SUBSTRATE and 3D SCAFFOLD. Journal of Mechanics in Medicine and Biology  vol. 15, (5) 10.1142/S0219519415500773

2014

Sliogeryte K, Thorpe SD, Lee DA, Botto L and Knight MM (2014). Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics. Sci Rep  vol. 4, 10.1038/srep07307

Irianto J, Lee DA and Knight MM (2014). Quantification of chromatin condensation level by image processing. Med Eng Phys  vol. 36, (3) 412-417. 10.1016/j.medengphy.2013.09.006

Heywood HK, Nalesso G, Lee DA and Dell'accio F (2014). Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture. Biores Open Access  vol. 3, (1) 9-18. 10.1089/biores.2013.0051

2013

Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE and Lee DA (2013). Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes. Biophys J  vol. 104, (4) 759-769. 10.1016/j.bpj.2013.01.006

Pattappa G, Thorpe SD, Jegard NC, Heywood HK, de Bruijn JD and Lee DA (2013). Continuous and Uninterrupted Oxygen Tension Influences the Colony Formation and Oxidative Metabolism of Human Mesenchymal Stem Cells. Tissue Engineering Part C: Methods  vol. 19, (1) 68-79. 10.1089/ten.tec.2011.0734

2012

Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL and Knight MM (2012). Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment. Biophys J  vol. 103, (6) 1188-1197. 10.1016/j.bpj.2012.07.054

Branford OA, Lee DA, Rolfe KJ and Grobbelaar AO (2012). The attachment of intrinsic and extrinsic, mobilized and immobilized adhesion cells to collagen and fibronectin. Journal of Hand Surgery: European Volume  vol. 37, (6) 564-572. 10.1177/1753193411428994

Branford OA, Lee DA, Bader DL and Grobbelaar AO (2012). The mechanics of flexor tendon adhesions. Journal of Hand Surgery: European Volume  vol. 37, (6) 555-563. 10.1177/1753193411432675

Bonzani IC, Campbell JJ, Knight MM, Williams A, Lee DA, Bader DL and Stevens MM (2012). Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: a case study. J Mech Behav Biomed Mater  vol. 11, 72-81. 10.1016/j.jmbbm.2011.06.015

Maeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA (2012). Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomechanics and Modeling in Mechanobiology  vol. 11, (3-4) 439-447. 10.1007/s10237-011-0323-1

Martins RP, Finan JD, Guilak F and Lee DA (2012). Mechanical regulation of nuclear structure and function. Annu Rev Biomed Eng  vol. 14, 431-455. 10.1146/annurev-bioeng-071910-124638

Hosny NA, Lee DA and Knight MM (2012). Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations. J Biomed Opt  vol. 17, (1) 10.1117/1.JBO.17.1.016007

2011

Pattappa G, Heywood HK, de Bruijn JD and Lee DA (2011). The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol  vol. 226, (10) 2562-2570. 10.1002/jcp.22605

Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC (2011). Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. Proc Inst Mech Eng H  vol. 225, (8) 821-830. 10.1177/0954411911406340

Maeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA (2011). Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading. Biomechanics and Modeling in Mechanobiology  1-9. 10.1007/s10237-011-0323-1

Martyn SV, Heywood HK, Rockett P, Paine MD, Wang MJ, Dobson PJ, Sheard SJ, Lee DA and Stark JPW (2011). Electrospray deposited fibronectin retains the ability to promote cell adhesion. Journal of Biomedical Materials Research - Part B Applied Biomaterials  vol. 96 B, (1) 110-118. 10.1002/jbm.b.31745

Lee DA, Knight MM, Campbell JJ and Bader DL (2011). Stem cell mechanobiology. J Cell Biochem  vol. 112, (1) 1-9. 10.1002/jcb.22758

Lee DA, Brand J, Salter D, Akanji O-O and Chowdhury TT (2011). Quantification of mRNA using real-time PCR and Western blot analysis of MAPK events in chondrocyte/agarose constructs. Methods Mol Biol  vol. 695, 77-97. 10.1007/978-1-60761-984-0_6

Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC (2011). Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. P I Mech Eng H  vol. 225, (H8) 821-830. 10.1177/0954411911406340

2010

Pattappa G, Heywood HK, de Bruijn JD and Lee DA (2010). The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol  10.1002/jcp.22605

Maeda E, Fleischmann C, Mein CA, Shelton JC, Bader DL and Lee DA (2010). Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain. Connective Tissue Research  vol. 51, (6) 434-444. 10.3109/03008201003597056

Heywood HK, Knight MM and Lee DA (2010). Both superficial and deep zone articular chondrocyte subpopulations exhibit the crabtree effect but have different basal oxygen consumption rates. Journal of Cellular Physiology  vol. 223, (3) 630-639. 10.1002/jcp.22061

Heywood HK and Lee DA (2010). Low oxygen reduces the modulation to an oxidative phenotype in monolayer-expanded chondrocytes. J Cell Physiol  vol. 222, (1) 248-253. 10.1002/jcp.21946

2009

Maeda E, Shelton JC, Bader DL and Lee DA (2009). Effect of intermittent cyclic tensile strain on collagen synthesis by tenocytes in isolated fascicles. Journal of Biomechanical Science and Engineering  vol. 4, (4) 510-517. 10.1299/jbse.4.510

Pattappa G, Jegard NC, Lee DA and de Bruijn JD (2009). The effect of oxygen tension on the proliferation and differentiation of human mesenchymal stem cells. European Cells and Materials  vol. 18, (SUPPL. 1)

Pattappa G, Jegard NC, de Bruijn JD and Lee DA (2009). The influence of oxygen tension on the colony formation and proliferation of human mesenchymal stem cells. European Cells and Materials  vol. 18, (SUPPL. 2)

Campbell JJ, Maeda E, Ye SJ, Wang W and Lee DA (2009). Osteogenic differentiation of human mesenchymal stem cells within a perfused bioreactor system. European Cells and Materials  vol. 18, (SUPPL. 2)

Maeda E, Shelton JC, Bader DL and Lee DA (2009). Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro. Journal of Applied Physiology  vol. 106, (2) 506-512. 10.1152/japplphysiol.90981.2008

Berry CC, Shelton JC and Lee DA (2009). Cell-generated forces influence the viability, metabolism and mechanical properties of fibroblast-seeded collagen gel constructs. J Tissue Eng Regen Med  vol. 3, (1) 43-53. 10.1002/term.133

Eniwumide JO, Lee DA and Bader DL (2009). The development of a bioreactor to perfuse radially-confined hydrogel constructs: design and characterization of mass transport properties. Biorheology  vol. 46, (5) 417-437. 10.3233/BIR-2009-0552

2008

Heywood HK and Lee DA (2008). Monolayer expansion induces an oxidative metabolism and ROS in chondrocytes. Biochem Biophys Res Commun  vol. 373, (2) 224-229. 10.1016/j.bbrc.2008.06.011

Heywood HK and Lee DA (2008). The effect of oxygen supply on chondrocyte metabolic phenotype during monolayer culture. European Cells and Materials  vol. 16, (SUPPL. 3)

Chowdhury TT, Salter DM, Bader DL and Lee DA (2008). Signal transduction pathways involving p38 MAPK, JNK, NF kappa B and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1 beta and dynamic compression. Inflamm Res  vol. 57, (7) 306-313. 10.1007/s00011-007-7126-y

Maeda E, Shelton JC, Bader DL and Lee DA (2008). Collagen synthesis by tenocytes in fascicles subjected to intermittent cyclic strain. European Cells and Materials  vol. 16, (SUPPL. 3)

Chowdhury TT, Akanji OO, Salter DM, Bader DL and Lee DA (2008). Dynamic compression influences interleukin-1 beta-induced nitric oxide and prostaglandin E-2 release by articular chondrocytes via alterations in iNOS and COX-2 expression. Biorheology  vol. 45, (3-4) 257-274. 10.3233/BIR-2008-0474

Campbell JJ, Bader DL and Lee DA (2008). Mechanical loading modulates intracellular calcium signaling in human mesenchymal stem cells. J Appl Biomater Biom  vol. 6, (1) 9-15.

Chowdhury TT, Arghandawi S, Brand J, Akanji OO, Bader DL, Salter DM and Lee DA (2008). Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs. Arthritis Res Ther  vol. 10, (2) 10.1186/ar2389

2007

Maeda E, Shelton JC, Bader DL and Lee DA (2007). Time dependence of cyclic tensile strain on collagen production in tendon fascicles. Biochem Biophys Res Commun  vol. 362, (2) 399-404. 10.1016/j.bbrc.2007.08.029

2006

Screen HRC, Chhaya VH, Greenwald SE, Bader DL, Lee DA and Shelton JC (2006). The influence of swelling and matrix degradation on the microstructural integrity of tendon. Acta Biomaterialia  vol. 2, (5) 505-513. 10.1016/j.actbio.2006.05.008

Akanji OO, Bader DL and Lee DA (2006). Direct current influences Ca 2+ signalling in chondrocytes. European Cells and Materials  vol. 11, (SUPPL.2)

Chowdhury TT, Appleby RN, Salter DM, Bader DA and Lee DA (2006). Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes. Biomech Model Mechanobiol  vol. 5, (2-3) 192-201. 10.1007/s10237-006-0032-3

Knight MM, Bomzon Z, Kimmel E, Sharma AM, Lee DA and Bader DL (2006). Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields. Biomech Model Mechan  vol. 5, (2-3) 180-191. 10.1007/s10237-006-0020-7

Enobakhare B, Bader DL and Lee DA (2006). Concentration and M/G ratio influence the physiochemical and mechanical properties of alginate constructs for tissue engineering. J Appl Biomater Biomech  vol. 4, (2) 87-96.

Heywood HK, Bader DL and Lee DA (2006). Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentration. Journal of Cellular Physiology  vol. 206, (2) 402-410. 10.1002/jcp.20491

Chowdhury TT, Bader DL and Lee DA (2006). Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes. Biochem Biophys Res Commun  vol. 339, (1) 241-247. 10.1016/j.bbrc.2005.11.016

Knight MM, Toyoda T, Lee DA and Bader DL (2006). Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose. J Biomech  vol. 39, (8) 1547-1551. 10.1016/j.jbiomech.2005.04.006

Chowdhury TT, Bader DL and Lee DA (2006). Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Biorheology  vol. 43, (3,4) 413-429.

2005

Wang MJ, Heywood HK, Bader DL, Paine MD, Stark JPW and Lee DA (2005). Identification and characterization of deposited fibronectin on biocompatible materials: Comparison of electrospray and wetting methods. Proceedings of The 2005 Summer Bioengineering Conference  vol. 2005, 439-440.

Chowdhury TT, Appleby RN, Salter DA, Bader DL and Lee DA (2005). Integrin mediated mechanotransduction in IL-1 stimulated bovine chondrocytes cultured in agarose constructs. Proceedings of The 2005 Summer Bioengineering Conference  vol. 2005, 545-546.

Chowdhury TT, Bader DL and Lee DA (2005). Dynamic compression counteracts IL-1-induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Proceedings of The 2005 Summer Bioengineering Conference  vol. 2005, 251-252.

Bader DL and Lee DA (2005). Mechanical conditioning of cell-seeded constructs for soft tissue repair - Are optimisation strategies possible? 10.1007/1-4020-3741-4_7

Screen HRC, Bader DL, Shelton JC and Lee DA (2005). Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen production. Proceedings of The 2005 Summer Bioengineering Conference  vol. 2005, 193-194.

Pingguan-Murphy B, Lee DA, Bader DL and Knight MM (2005). Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles. Arch Biochem Biophys  vol. 444, (1) 45-51. 10.1016/j.abb.2005.09.015

Screen HRC, Shelton JC, Chhaya VH, Kayser MV, Bader DL and Lee DA (2005). The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles. Annals of Biomedical Engineering  vol. 33, (8) 1090-1099. 10.1007/s10439-005-5777-9

Screen HRC, Shelton JC, Bader DL and Lee DA (2005). Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles. Biochem Bioph Res Co  vol. 336, (2) 424-429. 10.1016/j.bbro.2005.08.102

Sengers BG, Heywood HK, Lee DA, Oomens CWJ and Bader DL (2005). Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach. J Biomech Eng  vol. 127, (5) 758-766. 10.1115/1.1993664

Heywood HK, Bader DL and Lee DA (2005). Superficial and deep chondrocyte subpopulations both express the crabtree effect but exhibit differences in oxygen consumption rate. European Cells and Materials  vol. 10, (SUPPL.2)

Eniwumide JO, Lee DA and Bader DL (2005). Perfusion-Enhancement of molecular transport within 3D scaffolds. European Cells and Materials  vol. 10, (SUPPL.2)

Catuogno C, Chowdhury TT, Bader DL and Lee DA (2005). Dynamic compression influences the biochemical response of human mesenchymal stem cells cultured in agarose constructs. European Cells and Materials  vol. 10, (SUPPL.2)

Chowdhury TT, Bader DL and Lee DA (2005). Dynamic compression counteracts IL-1? induced INOS and COX-2 activity by human chondrocytes cultured in agarose constructs. European Cells and Materials  vol. 10, (SUPPL.2)

Sudre L, Cheung F, Kevorkian L, Young DA, Darrah C, Donell ST, Shepstone L, Porter S, Brockbank S, Edwards DR, Parker AE, Clark IM, Boubriak OA, Urban JPG, Cui Z, Tew SR, Li Y, Tweats LM, Hawkins RE, Hardingham TE, Green D, Partridge KA, Leveque I, Mann S, Oreffo ROC, Ball SG and Kie (2005). British society for matrix biology autumn meeting. International Journal of Experimental Pathology  vol. 86, (3) 10.1111/j.0959-9673.2005.00426.x

Goldberg AJ, Lee DA, Bader DL and Bentley G (2005). Autologous chondrocyte implantation. Culture in a TGF-beta-containing medium enhances the re-expression of a chondrocytic phenotype in passaged human chondrocytes in pellet culture. J Bone Joint Surg Br  vol. 87, (1) 128-134. 10.1302/0301-620X.87B1.14154

Wang Y-N, Bouten CVC, Lee DA and Bader DL (2005). Compression-induced damage in a muscle cell model in vitro. Proc Inst Mech Eng H  vol. 219, (1) 1-12. 10.1243/095441105X9246

2004

Screen HRC, Bader DL, Lee DA and Shelton JC (2004). Local strain measurement within tendon. Strain  vol. 40, (4) 157-163. 10.1111/j.1475-1305.2004.00164.x

Bryant SJ, Anseth KS, Lee DA and Bader DL (2004). Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain. J Orthop Res  vol. 22, (5) 1143-1149. 10.1016/j.orthres.2004.02.001

Heywood HK, Sembi PK, Lee DA and Bader DL (2004). Cellular utilization determines viability and matrix distribution profiles in chondrocyte-seeded alginate constructs. Tissue Eng  vol. 10, (9-10) 1467-1479. 10.1089/ten.2004.10.1467

Chowdhury TT, Salter DM, Bader DL and Lee DA (2004). Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes. Biochem Biophys Res Commun  vol. 318, (4) 873-881. 10.1016/j.bbrc.2004.04.107

Bryant SJ, Chowdhury TT, Lee DA, Bader DL and Anseth KS (2004). Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels. Ann Biomed Eng  vol. 32, (3) 407-417. 10.1023/B:ABME.0000017535.00602.ca

Screen HRC, Lee DA, Bader DL and Shelton JC (2004). An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties. Proceedings of The Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine  vol. 218, (2) 109-119. 10.1243/095441104322984004

Wiseman M, Bader DL, Reisler T and Lee DA (2004). Passage in monolayer influences the response of chondrocytes to dynamic compression. Biorheology  vol. 41, (3-4) 283-298.

Bader DL, KNIGHT MM, Bentley G, Kayser M and Holloway I (2004). Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage. Osteoarthritis Cartilage  vol. 12, (1) 17-24. 10.1016/j.joca.2003.09.001

LEE DA, van Osch G, Verhaar JAN, Mandl EW, van der Linden JC, van der Breevaart Bravenboer J and Weinans H (2004). Extracellular matrix influences the response of chondrocytes to dynamic compression. Trans. Orthop.Rev. Soc  vol. 29, 839-839.

Lee DA and Knight MM (2004). Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain. Methods Mol Med  vol. 100, 307-324. 10.1385/1-59259-810-2:307

Holloway I, Kayser M, Lee DA, Bader DL, Bentley G and Knight MM (2004). Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage. Osteoarthritis Cartilage  vol. 12, (1) 17-24. 10.1016/j.joca.2003.09.001

2003

Chowdhury TT, Bader DL, Shelton JC and Lee DA (2003). Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression. Arch Biochem Biophys  vol. 417, (1) 105-111. 10.1016/S0003-9861(03)00340-0

Chowdhury TT, Bader DL and Lee DA (2003). Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs. Osteoarthritis Cartilage  vol. 11, (9) 688-696. 10.1016/S1063-4584(03)00149-3

Berry CC, Shelton JC, Bader DL and Lee DA (2003). Influence of external uniaxial cyclic strain on oriented fibroblast-seeded collagen gels. Tissue Eng  vol. 9, (4) 613-624. 10.1089/107632703768247313

Wiseman M, Henson F, Lee DA and Bader DL (2003). Dynamic compressive strain inhibits nitric oxide synthesis by equine chondrocytes isolated from different areas of the cartilage surface. Equine Vet J  vol. 35, (5) 451-456. 10.2746/042516403775600532

Knight MM, Roberts SR, Lee DA and Bader DL (2003). Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death. Am J Physiol Cell Physiol  vol. 284, (4) C1083-C1089. 10.1152/ajpcell.00276.2002

Lee DA, Reisler T and Bader DL (2003). Expansion of chondrocytes for tissue engineering in alginate beads enhances chondrocytic phenotype compared to conventional monolayer techniques. Acta Orthop Scand  vol. 74, (1) 6-15. 10.1080/00016470310013581

Hernandez D, Addou S, Lee D, Orengo C, Shephard EA and Phillips IR (2003). Trimethylaminuria and a human FMO3 mutation database. Hum Mutat  vol. 22, (3) 209-213. 10.1002/humu.10252

Chowdhury TT, LEE DA, Salter DM, Shelton JC and Bader DL (2003). alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta-stimulated human chondrocyte / agarose constructs and subjected to dynamic compression. Osteoarthritis Cartilage  vol. 11, (Suppl 1) S2-S3.

Screen HRC, Lee DA, Bader DL and Shelton JC (2003). Development of a technique to determine strains in tendons using the cell nuclei. Biorheology  vol. 40, (1-3) 361-368.

Shelton JC, Bader DL and Lee DA (2003). Mechanical conditioning influences the metabolic response of cell-seeded constructs. Cells Tissues Organs  vol. 175, (3) 140-150. 10.1159/000074630

Berry CC, Cacou C, Lee DA, Bader DL and Shelton JC (2003). Dermal fibroblasts respond to mechanical conditioning in a strain profile dependent manner. Biorheology  vol. 40, (1-3) 337-345.

LEE DA, Heywood HK, Baaijens FPT, Oomens CWJ and Sengers BG (2003). Experimental and theoretical analysis of glucose dependent oxygen utilization by bovine articular chondrocytes. Internat. J. Artificial Organs  vol. 26, 875-875.

Chowdhury TT, Shelton JC, Bader DL and LEE DA (2003). Control of mechanotrasduction processes in dynamically stimulated human and bovine chondrocytes cultured in agarose constructs. Internat. J. Artificial Organs  vol. 26, (9) 858-858.

2002

Lee DA (2002). The design of bioreactor systems for cartilage tissue engineering. Third Smith and Nephew International Symposium - Translating Tissue Engineering Into Products 

Berry CC, Shelton JC, Bader DL and Lee DA (2002). The influence of uniaxial cyclic strain on orientated fibroblast seeded collagen gels. Third Smith and Nephew International Symposium - Translating Tissue Engineering Into Products 

Screen HRC, Bader DL, Shelton JC and Lee DA (2002). Non-collagenous matrix components influence the micro-mechanical environment of tenocytes within tendon fascicles subjected to tensile strain. European Cells and Materials  vol. 4, (SUPPL. 1) 41-42.

Knight MM, van de Breevaart Bravenboer J, Lee DA, van Osch GJVM, Weinans H and Bader DL (2002). Cell and nucleus deformation in compressed chondrocyte-alginate constructs: temporal changes and calculation of cell modulus. Biochim Biophys Acta  vol. 1570, (1) 1-8. 10.1016/S0304-4165(02)00144-7

BADER DL, Shelton JC, Lee DA and Screen HRC (2002). Development of a technique to determine strains in tendons using the cell nuclei. Biorheology  vol. 40, 361-368.

2001

Chowdhury TT, Bader DL and Lee DA (2001). Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs. Biochem Biophys Res Commun  vol. 285, (5) 1168-1174. 10.1006/bbrc.2001.5311

Knight MM, Ross JM, Sherwin AF, Lee DA, Bader DL and Poole CA (2001). Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose. Biochim Biophys Acta  vol. 1526, (2) 141-146. 10.1016/S0304-4165(01)00118-0

Knight MM, Idowu BD, Lee DA and Bader DL (2001). Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique. Med Biol Eng Comput  vol. 39, (3) 397-404. 10.1007/BF02345297

Roberts SR, Knight MM, Lee DA and Bader DL (2001). Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs. J Appl Physiol (1985)  vol. 90, (4) 1385-1391. 10.1152/jappl.2001.90.4.1385

Bouten CV, Knight MM, Lee DA and Bade DL (2001). Compressive deformation and damage of muscle cell subpopulations in a model system. Ann Biomed Eng  vol. 29, (2) 153-163. 10.1114/1.1349698

Bader DL, KNIGHT MM, Lee DA and Bouten CV (2001). Compressive deformation and damage of muscle cell subpopulaltions in a model system. Ann. Biomed. Eng.  vol. 29, (2) 153-163. 10.1114/1.1349698

Lee DA (2001). Embryonic stem cells: scientific possibilities, ethical considerations, and regulation in the UK. Interdiscipl Sci Rev  vol. 26, (2) 112-124. 10.1179/isr.2001.26.2.112

2000

Chowdhury TT, Bader DL and Lee DA (2000). Dynamic compression inhibits the synthesis of nitric oxide by IL-1? stimulated chondrocytes cultured in agarose constructs. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell 

Enobakhare BO, Bader DL and Lee DA (2000). Physiochemical, biochemical and mechanical characterisation of chondrocyte-alginate constructs. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell 

Berry CC, Cacou C, Shelton JC, Bader DL and Lee DA (2000). Biological response of cyclic strain on developed cell seeded collagen gel model. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell 

Cacou C, Palmer D, Lee DA, Bader DL and Shelton JC (2000). A system for monitoring the response of uniaxial strain on cell seeded collagen gels. Med Eng Phys  vol. 22, (5) 327-333. 10.1016/S1350-4533(00)00040-0

Idowu BD, Knight MM, Bader DL and Lee DA (2000). Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose. Histochem J  vol. 32, (3) 165-174. 10.1023/A:1004095207330

Lee DA, Knight MM, Bolton JF, Idowu BD, Kayser MV and Bader DL (2000). Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels. J Biomech  vol. 33, (1) 81-95. 10.1016/S0021-9290(99)00160-8

Lee DA, Noguchi T, Frean SP, Lees P and Bader DL (2000). The influence of mechanical loading on isolated chondrocytes seeded in agarose constructs. Biorheology  vol. 37, (1-2) 149-161.

1999

White AET, Bentley G, Stephens MD, Bader DL, Giddins GEB and Lee DA (1999). The effects of storage temperature on the composition, metabolism acid biomechanical properties of human articular cartilage. Knee  vol. 6, (3) 197-205. 10.1016/S0968-0160(99)00007-1

1998

Lee DA, Noguchi T, Knight MM, O'Donnell L, Bentley G and Bader DL (1998). Response of chondrocyte subpopulations cultured within unloaded and loaded agarose. J Orthop Res  vol. 16, (6) 726-733. 10.1002/jor.1100160615

Knight MM, Ghori SA, Lee DA and Bader DL (1998). Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression. Med Eng Phys  vol. 20, (9) 684-688. 10.1016/S1350-4533(98)00080-0

Knight MM, Lee DA and Bader DL (1998). The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose. Biochim Biophys Acta  vol. 1405, (1-3) 67-77. 10.1016/S0167-4889(98)00102-5

Lee DA, Frean SP, Lees P and Bader DL (1998). Dynamic mechanical compression influences nitric oxide production by articular chondrocytes seeded in agarose. Biochem Bioph Res Co  vol. 251, (2) 580-585. 10.1006/bbrc.1998.9520

Lee DA, Assoku E and Doyle V (1998). A specific quantitative assay for collagen synthesis by cells seeded in collagen-based biomaterials using sirius red F3B precipitation. J Mater Sci-Mater M  vol. 9, (1) 47-51. 10.1023/A:1008882628142

1997

Lee DA and Bader DL (1997). Compressive strains at physiological frequencies influence the metabolism of chondrocytes seeded in agarose. J Orthop Res  vol. 15, (2) 181-188. 10.1002/jor.1100150205

1996

Enobakhare BO, Bader DL and Lee DA (1996). Quantification of sulfated glycosaminoglycans in chondrocyte/alginate cultures, by use of 1,9-dimethylmethylene blue. Anal Biochem  vol. 243, (1) 189-191. 10.1006/abio.1996.0502

1995

Lee DA and Bader DL (1995). The development and characterization of an in vitro system to study strain-induced cell deformation in isolated chondrocytes. In Vitro Cell Dev-An  vol. 31, (11) 828-835. 10.1007/BF02634565

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