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Institute of Bioengineering

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Prof Hazel Screen

+44 (0)20 7882 6167

Professor of Biomedical Engineering

Department School of Engineering and Materials Science
 Mile End Campus
Email h.r.c.screen@qmul.ac.uk
Homepage http://www.sems.qmul.ac.uk/h.r.c.screen

Research Keywords

Connective tissue mechanics, Multiscale mechanics, in vitro models, organ-on-a-chip models, mechanical testing

Research Interests

Hazel Screen joined QMUL to do her PhD in 1999, and having begun a lectureship post in 2004, is now a Reader in Biomedical Engineering. She is also the Deputy Director for Taught Programmes, a role with a focus on ensuring our students have the best possible university experience. She is a member of the Institute of Bioengineering (www.bioengineering.qmul.ac.uk) and a member of the Biomedical Engineering and Materials research group within the School of Engineering and Materials Science.
Dr Screen is also a Chartered Engineer and an active member of the Institution of Mechanical Engineers, involved in the North West London IMechE committee. Alongside her research interest in tissue structure-function, she is very interested in supporting student learning, and is currently holding a Drapers Teaching Fellowship at QMUL (www.learninginstitute.qmul.ac.uk/lta/reward-and-recognition/drapers-teaching-fellows/).
In her spare time, Dr Screen enjoys sports (particularly running) and also scuba diving and hiking. She has been fortunate to visit and dive some great locations around the world with her family, including Hawaii, Borneo, Thailand and The Caribbean.

2019

Anssari-Benam A, Screen HRC and Bucchi A (2019). Insights into the micromechanics of stress-relaxation and creep behaviours in the aortic valve. Journal of The Mechanical Behavior of Biomedical Materials  vol. 93, 230-245. 10.1016/j.jmbbm.2019.02.011

Capilnasiu A, Hadjicharalambous M, Fovargue D, Patel D, Holub O, Bilston L, Screen H, Sinkus R and Nordsletten D (2019). Magnetic resonance elastography in nonlinear viscoelastic materials under load. Biomechanics and Modeling in Mechanobiology  vol. 18, (1) 111-135. 10.1007/s10237-018-1072-1

2018

Liu R, Becer CR and Screen HRC (2018). Guided Cell Attachment via Aligned Electrospinning of Glycopolymers. Macromolecular Bioscience  vol. 18, (12) 10.1002/mabi.201800293

Cook JL and Screen HR (2018). Tendon pathology: Have we missed the first step in the development of pathology? J Appl Physiol (1985)  10.1152/japplphysiol.00002.2018

PATEL D, Sharma S, SCREEN HRC and BRYANT S (2018). Effects of cell adhesion motif, fiber stiffness, and cyclic strain on tenocyte gene expression in a tendon mimetic fiber composite hydrogel. Elsevier  Biochemical and Biophysical Research Communications  10.1016/j.bbrc.2018.03.203

Spiesz EM, Thorpe CT, Thurner PJ and Screen HRC (2018). Structure and collagen crimp patterns of functionally distinct equine tendons, revealed by quantitative polarised light microscopy (qPLM). Acta Biomaterialia  vol. 70, 281-292. 10.1016/j.actbio.2018.01.034

2017

Shearer T, Thorpe CT and Screen HRC (2017). The relative compliance of energy-storing tendons may be due to the helical fibril arrangement of their fascicles. Journal of The Royal Society Interface  vol. 14, (133) 10.1098/rsif.2017.0261

Liu R, Patel D, Screen HRC and Becer CR (2017). A2B-Miktoarm Glycopolymer Fibers and Their Interactions with Tenocytes. Bioconjugate Chemistry  vol. 28, (7) 1955-1964. 10.1021/acs.bioconjchem.7b00279

Thorpe CT, Riley GP, Birch HL, Clegg PD and Screen HRC (2017). Fascicles and the interfascicular matrix show decreased fatigue life with ageing in energy storing tendons. Acta Biomaterialia  vol. 56, 58-64. 10.1016/j.actbio.2017.03.024

Patel D, Sharma S, Bryant SJ and Screen HRC (2017). Recapitulating the Micromechanical Behavior of Tension and Shear in a Biomimetic Hydrogel for Controlling Tenocyte Response. Advanced Healthcare Materials  vol. 6, (4) 10.1002/adhm.201601095

Anssari-Benam A, Bucchi A, SCREEN HRC and Evans SL (2017). A transverse isotropic viscoelastic constitutive model for aortic valve tissue. Royal Society, The: Open Access  Royal Society Open Science  10.1098/rsos.160585

2016

Thorpe CT, Riley GP, Birch HL, Clegg PD and Screen HRC (2016). Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons. Acta Biomaterialia  vol. 42, 308-315. 10.1016/j.actbio.2016.06.012

Handsfield GG, Slane LC and Screen HRC (2016). Nomenclature of the tendon hierarchy: An overview of inconsistent terminology and a proposed size-based naming scheme with terminology for multi-muscle tendons. J Biomech  vol. 49, (13) 3122-3124. 10.1016/j.jbiomech.2016.06.028

Thorpe CT, Karunaseelan KJ, Hin JNC, Riley GP, Birch HL, Clegg PD and Screen HRC (2016). Distribution of proteins within different compartments of tendon varies according to tendon type. Journal of Anatomy  vol. 229, (3) 450-458. 10.1111/joa.12485

Thorpe CT, Peffers MJ, Simpson D, Halliwell E, Screen HRC and Clegg PD (2016). Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition. Scientific Reports  vol. 6, 10.1038/srep20455

Thorpe CT and Screen HRC (2016). Tendon Structure and Composition. Springer International Publishing  10.1007/978-3-319-33943-6_1

2015

Thorpe CT, Godinho MSC, Riley GP, Birch HL, Clegg PD and Screen HRC (2015). The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons. J Mech Behav Biomed Mater  vol. 52, 85-94. 10.1016/j.jmbbm.2015.04.009

Thorpe CT, Chaudhry S, Lei II, Varone A, Riley GP, Birch HL, Clegg PD and Screen HRC (2015). Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation. Wiley  Scandinavian Journal of Medicine & Science in Sports  vol. 25, (4) e381-e391. 10.1111/sms.12333

Spiesz EM, Thorpe CT, Chaudhry S, Riley GP, Birch HL, Clegg PD and Screen HRC (2015). Tendon Extracellular Matrix Damage, Degradation and Inflammation in Response to In Vitro Overload Exercise. Journal of Orthopaedic Research  vol. 33, (6) 889-897. 10.1002/jor.22879

Screen HRC, Berk DE, Kadler KE, Ramirez F and Young MF (2015). Tendon functional extracellular matrix. J Orthop Res  vol. 33, (6) 793-799. 10.1002/jor.22818

Thorpe CT, Birch HL, Clegg PD and Screen HRC (2015). Tendon Physiology and Mechanical Behavior. Tendon Regeneration  Elsevier  10.1016/b978-0-12-801590-2.00001-6

2014

Shepherd JH, Riley GP and Screen HRC (2014). Early stage fatigue damage occurs in bovine tendon fascicles in the absence of changes in mechanics at either the gross or micro-structural level. J Mech Behav Biomed Mater  vol. 38, 163-172. 10.1016/j.jmbbm.2014.06.005

Peffers MJ, Thorpe CT, Collins JA, Eong R, Wei TKJ, Screen HRC and Clegg PD (2014). Proteomic analysis reveals age-related changes in tendon matrix composition, with age- and injury-specific matrix fragmentation. J Biol Chem  vol. 289, (37) 25867-25878. 10.1074/jbc.M114.566554

Thorpe CT, Riley GP, Birch HL, Clegg PD and Screen HRC (2014). Effect of fatigue loading on structure and functional behaviour of fascicles from energy-storing tendons. Acta Biomater  vol. 10, (7) 3217-3224. 10.1016/j.actbio.2014.04.008

Thorpe CT, Riley GP, Birch HL, Clegg PD and Screen HRC (2014). Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading. Journal of The Royal Society Interface  vol. 11, (92) 10.1098/rsif.2013.1058

Shepherd JH, Legerlotz K, Demirci T, Klemt C, Riley GP and Screen HRC (2014). Functionally distinct tendon fascicles exhibit different creep and stress relaxation behaviour. Proc Inst Mech Eng H  vol. 228, (1) 49-59. 10.1177/0954411913509977

Smith R, McIlwraith W, Schweitzer R, Kadler K, Cook J, Caterson B, Dakin S, Heinegard D, Screen H, Stover S, Crevier-Denoix N, Clegg P, Collins M, Little C, Frisbie D, Kjaer M, van Weeren R, Werpy N, Denoix J-M, Carr A, Goldberg A, Bramlage L, Smith M and Nixon A (2014). Advances in the understanding of tendinopathies: A report on the Second Havemeyer Workshop on equine tendon disease. Equine Veterinary Journal  vol. 46, (1) 4-9. 10.1111/evj.12128

2013

Thorpe CT, Klemt C, Riley GP, Birch HL, Clegg PD and Screen HRC (2013). Helical sub-structures in energy-storing tendons provide a possible mechanism for efficient energy storage and return. Acta Biomater  vol. 9, (8) 7948-7956. 10.1016/j.actbio.2013.05.004

Thorpe CT, Birch HL, Clegg PD and Screen HRC (2013). The role of the non-collagenous matrix in tendon function. Int J Exp Pathol  vol. 94, (4) 248-259. 10.1111/iep.12027

Shepherd JH and Screen HRC (2013). Fatigue loading of tendon. Int J Exp Pathol  vol. 94, (4) 260-270. 10.1111/iep.12037

Legerlotz K, Riley GP and Screen HRC (2013). GAG depletion increases the stress-relaxation response of tendon fascicles, but does not influence recovery. Acta Biomater  vol. 9, (6) 6860-6866. 10.1016/j.actbio.2013.02.028

Anssari-Benam A, Legerlotz K, Bader DL and Screen HRC (2013). Response to letter to the editor: End effects in mechanical testing of biomaterials. Journal of Biomechanics  vol. 46, (5) 10.1016/j.jbiomech.2012.12.020

Legerlotz K, Jones GC, Screen HRC and Riley GP (2013). Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin-6 expression by tenocytes. Scandinavian Journal of Medicine and Science in Sports  vol. 23, (1) 31-37. 10.1111/j.1600-0838.2011.01410.x

Thorpe CT, Udeze CP, Birch HL, Clegg PD and Screen HR (2013). Capacity for sliding between tendon fascicles decreases with ageing in injury prone equine tendons: a possible mechanism for age-related tendinopathy? Eur Cell Mater  vol. 25, 48-60. 10.22203/eCM.v025a04

Anssari-Benam A, Legerlotz K, Bader DL and Screen HRC (2013). Response to letter to the editor: End effects in mechanical testing of biomaterials. Journal of Biomechanics  10.1016/j.jbiomech.2012.12.020

Thorpe CT, Klemt C, Riley GP, Birch HL, Clegg PD and Screen HRC (2013). Helical sub-structures in energy-storing tendons provide a possible mechanism for efficient energy storage and return. Acta Biomaterialia  vol. 9, (8) 7948-7956. 10.1016/j.actbio.2013.05.004

2012

Thorpe CT, Udeze CP, Birch HL, Clegg PD and Screen HRC (2012). Specialization of tendon mechanical properties results from interfascicular differences. Journal of The Royal Society Interface  vol. 9, (76) 3108-3117. 10.1098/rsif.2012.0362

Anssari-Benam A, Legerlotz K, Bader DL and Screen HRC (2012). On the specimen length dependency of tensile mechanical properties in soft tissues: gripping effects and the characteristic decay length. J Biomech  vol. 45, (14) 2481-2482. 10.1016/j.jbiomech.2012.07.016

Legerlotz K, Jones ER, Screen HRC and Riley GP (2012). Increased expression of IL-6 family members in tendon pathology. Rheumatology  vol. 51, (7) 1161-1165. 10.1093/rheumatology/kes002

2011

Simms C, Screen H and Evans S (2011). Nonlinearities in soft tissue strain. J Mech Behav Biomed Mater  vol. 4, (8) 10.1016/j.jmbbm.2011.10.004

Anssari-Benam A, Bader DL and Screen HRC (2011). Anisotropic time-dependant behaviour of the aortic valve. Journal of The Mechanical Behavior of Biomedical Materials  vol. 4, (8) 1603-1610. 10.1016/j.jmbbm.2011.02.010

Anssari-Benam A, Bader DL and Screen HRC (2011). A combined experimental and modelling approach to aortic valve viscoelasticity in tensile deformation. J Mater Sci-Mater M  vol. 22, (2) 253-262. 10.1007/s10856-010-4210-6

2010

Legerlotz K, Riley GP and Screen HRC (2010). Specimen dimensions influence the measurement of material properties in tendon fascicles. Journal of Biomechanics  vol. 43, (12) 2274-2280. 10.1016/j.jbiomech.2010.04.040

Screen HRC, Byers S, Lynn AD, Nguyen V, Patel D and Bryant SJ (2010). Characterization of a novel fiber composite material for mechanotransduction research of fibrous connective tissues. Advanced Functional Materials  vol. 20, (5) 738-747. 10.1002/adfm.200901711

2009

Screen HRC and Evans SL (2009). Measuring strain distributions in the tendon using confocal microscopy and finite elements. J Strain Anal Eng  vol. 44, (5) 327-335. 10.1243/03093247JSA491

SCREEN H (2009). Hierarchical approaches to understanding tendon mechanics. Japan Society of Mechanical Engineers  Journal of Biomechanical Science and Engineering  vol. 4, (4) 481-499. 10.1299/jbse.4.481

2008

Screen HRC (2008). Investigating load relaxation mechanics in tendon. Journal of The Mechanical Behavior of Biomedical Materials  vol. 1, (1) 51-58. 10.1016/j.jmbbm.2007.03.002

2007

Cheng VWT and Screen HRC (2007). The micro-structural strain response of tendon. J Mater Sci  vol. 42, (21) 8957-8965. 10.1007/s10853-007-1653-3

SCREEN HRC and Cheng VWT (2007). Strain mechanisms in tendon fascicles. J.Mat.Sci.  vol. 21, 8957-8965. 10.1007/s10853-007-1653-3

2002

Bader DL, Shelton JC, LEE DA and Screen HRC (2002). Non-collagenous matrix components influence the micro-mechanical environment of tenocytes within tendon fasciles subjected to tensile strain. Eur. Cells Materials  vol. 4 suppl 1, 41-42.

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