Prof Julia Shelton
Professor of Biomechanical Engineering
Wear properties of joint replacement, Total hip replacements, Surface coatings, Wear particle analysis, Orthopaedic systems
Prof Julia Shelton's field of research covers biomechanics, in particular, the development of measurement systems applied to the body. Aspects of my research include the evaluation of tissue engineered structures and developing accelerated wear testing, in vitro, for the evaluation of total hip joint replacements. I currently have two main areas of research interest namely orthopaedic systems and tissue engineering. Overall my research is concerned with all aspects of biomechanics. I was involved in research in the IRC in Biomedical Materials, co-ordinating 4 project areas namely orthopaedic alloys, fracture fixation, orthopaedic systems and ligament replacement. I have been leading research projects to investigate the mechanical stimulation of cells, in particular in tendon and ligaments. Cells experience strains physiologically and it is important to understand how these influence the biological response. The prediction of likely clinical success from short term laboratory tests is of increasing importance in the healthcare sector. My research is involved in developing such tests. I am interested in the wear of hip joints, and I am developing tests to improve the understanding of the development of high wear rates in a range of bearing material combinations.
Xu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM and Shelton JC (2018). Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages. Eur Cell Mater vol. 36, 142-155. 10.22203/eCM.v036a11
Rowson DT, Shelton JC, Screen HRC and Knight MM (2018). Mechanical loading induces primary cilia disassembly in tendon cells via TGF? and HDAC6. Sci Rep vol. 8, (1) 10.1038/s41598-018-29502-7
SHELTON JC (2018). Prediction of taper performance using quasi static FE models: The influence of loading and taper clearance and trunnion length. Journal of Biomedical Materials Research: Part B - Applied Biomaterials 10.1002/jbm.b.34104
SHELTON JC (2018). Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated downregulation of RhoA expression. Elsevier Acta Biomaterialia vol. 72, 434-446. 10.1016/j.actbio.2018.03.054
Xu J, Yang J, Nyga A, Ehteramyan M, Moraga A, Wu Y, Zeng L, Knight MM and Shelton JC (2018). Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression. Acta Biomater vol. 72, 434-446. 10.1016/j.actbio.2018.03.054
SHELTON JC (2017). Complex mechanical conditioning of cell-seeded agarose constructs can influence chondrocyte biosynthetic activity. Wiley Biotechnology and Bioengineering 10.1002/bit.26273
de Villiers D and Shelton JC (2016). Measurement outcomes from hip simulators. Proc Inst Mech Eng H vol. 230, (5) 398-405. 10.1177/0954411916628559
de Villiers D, Traynor A, Collins SN and Shelton JC (2015). The increase in cobalt release in metal-on-polyethylene hip bearings in tests with third body abrasives. Proc Inst Mech Eng H vol. 229, (9) 611-618. 10.1177/0954411915595433
de Villiers D, Traynor A, Collins SN, Banfield S, Housden J and Shelton JC (2015). Chromium nitride coating for large diameter metal-on-polyethylene hip bearings under extreme adverse hip simulator conditions. Wear vol. 328-329, 363-368. 10.1016/j.wear.2015.02.060
Di Federico E, Bader DL and Shelton JC (2014). Design and validation of an in vitro loading system for the combined application of cyclic compression and shear to 3D chondrocytes-seeded agarose constructs. Med Eng Phys vol. 36, (4) 534-540. 10.1016/j.medengphy.2013.11.007
Screen HRC, Toorani S and Shelton JC (2013). Microstructural stress relaxation mechanics in functionally different tendons. Medical Engineering and Physics vol. 35, (1) 96-102. 10.1016/j.medengphy.2012.04.004
Lu F, Royle M, Lali FV, Hart AJ, Collins S, Housden J and Shelton JC (2012). Simple isolation method for the bulk isolation of wear particles from metal on metal bearing surfaces generated in a hip simulator test. Journal of Materials Science: Materials in Medicine vol. 23, (4) 891-901. 10.1007/s10856-012-4573-y
Hothi HS, Busfield JJC and Shelton JC (2012). Deformation of uncemented metal acetabular cups following impaction: Experimental and finite element study. Computer Methods in Biomechanics and Biomedical Engineering 10.1080/10255842.2012.744397
Screen HRC, Toorani S and Shelton JC (2012). Microstructural stress relaxation mechanics in functionally different tendons. Medical Engineering and Physics 10.1016/j.medengphy.2012.04.004
Lu F, Royle M, Lali FV, Hart AJ, Collins S, Housden J and Shelton JC (2012). Simple isolation method for the bulk isolation of wear particles from metal on metal bearing surfaces generated in a hip simulator test. Journal of Materials Science: Materials in Medicine 1-11.
Morris B, Zou L, Royle M, Simpson D and Shelton JC (2011). Quantifying the wear of acetabular cups using coordinate metrology. Wear vol. 271, (7-8) 1086-1092. 10.1016/j.wear.2011.05.014
Hothi HS, Busfield JJC and Shelton JC (2011). Explicit finite element modelling of the impaction of metal press-fit acetabular components. Proceedings of The Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine vol. 225, (3) 303-314. 10.1243/09544119JEIM864
McConlogue T, Mueller J and Shelton J (2010). Challenges of developing engineering students' writing through peer assessment. Engineering Education 2010: Inspiring The Next Generation of Engineers, Ee 2010
Maeda E, Fleischmann C, Mein CA, Shelton JC, Bader DL and Lee DA (2010). Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain. Connective Tissue Research vol. 51, (6) 434-444. 10.3109/03008201003597056
Maeda E, Shelton JC, Bader DL and Lee DA (2009). Effect of intermittent cyclic tensile strain on collagen synthesis by tenocytes in isolated fascicles. Journal of Biomechanical Science and Engineering vol. 4, (4) 510-517. 10.1299/jbse.4.510
Angadji A, Royle M, Collins SN and Shelton JC (2009). Influence of cup orientation on the wear performance of metal-on-metal hip replacements. Proceedings of The Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine vol. 223, (4) 449-457. 10.1243/09544119JEIM518
Maeda E, Shelton JC, Bader DL and Lee DA (2009). Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro. Journal of Applied Physiology vol. 106, (2) 506-512. 10.1152/japplphysiol.90981.2008
Berry CC, Shelton JC and Lee DA (2009). Cell-generated forces influence the viability, metabolism and mechanical properties of fibroblast-seeded collagen gel constructs. J Tissue Eng Regen Med vol. 3, (1) 43-53. 10.1002/term.133
Angadji A, Grossmann H, Royle M, Collins SN and Shelton JC (2008). Affect of cup positioning on the wear performance and wear particles from metal-on-metal hip replacements. 8th World Biomaterials Congress 2008 vol. 2,
Toorani S, Shelton JC and Screen HRC (2008). Characterizing structure-function relationships in tendon. 8th World Biomaterials Congress 2008 vol. 2,
Maeda E, Shelton JC, Bader DL and Lee DA (2008). Collagen synthesis by tenocytes in fascicles subjected to intermittent cyclic strain. European Cells and Materials vol. 16, (SUPPL. 3)
Schulz RM, Wüstneck N, Van Donkelaar CC, Shelton JC and Bader A (2008). Development and validation of a novel bioreactor system for load- and perfusion-controlled tissue engineering of chondrocyte-constructs. Biotechnology and Bioengineering vol. 101, (4) 714-728. 10.1002/bit.21955
Mootanah R, Jarrett P, Ingle P, Cheah K, Dowell JK and Shelton JC (2008). Configuration of anchorage holes affects cemented fixation of the acetabular component in total hip replacement: an in vitro study. Technol Health Care vol. 16, (1) 19-30.
Mootanah R, Dowell JK, Cheah K, Ingle P and Shelton JC (2007). Configuration of anchorage holes affects fixation of the acetabular component in cemented total hip replacement--a finite element study. Comput Methods Biomech Biomed Engin vol. 10, (6) 439-445. 10.1080/10255840701633943
Maeda E, Shelton JC, Bader DL and Lee DA (2007). Time dependence of cyclic tensile strain on collagen production in tendon fascicles. Biochem Biophys Res Commun vol. 362, (2) 399-404. 10.1016/j.bbrc.2007.08.029
Screen HRC, Chhaya VH, Greenwald SE, Bader DL, Lee DA and Shelton JC (2006). The influence of swelling and matrix degradation on the microstructural integrity of tendon. Acta Biomaterialia vol. 2, (5) 505-513. 10.1016/j.actbio.2006.05.008
Bowsher JG, Hussain A, Williams PA and Shelton JC (2006). Metal-on-metal hip simulator study of increased wear particle surface area due to 'severe' patient activity. Proc Inst Mech Eng H vol. 220, (2) 279-287. 10.1243/09544119JEIM93
Bowsher JG, Nevelos J, Williams PA and Shelton JC (2006). 'Severe' wear challenge to 'as-cast' and 'double heat-treated' large-diameter metal-on-metal hip bearings. P I Mech Eng H vol. 220, (H2) 135-143. 10.1243/09544119JEIM81
Screen HRC, Bader DL, Shelton JC and Lee DA (2005). Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen production. Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 193-194.
Screen HRC, Shelton JC, Chhaya VH, Kayser MV, Bader DL and Lee DA (2005). The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles. Annals of Biomedical Engineering vol. 33, (8) 1090-1099. 10.1007/s10439-005-5777-9
Screen HRC, Shelton JC, Bader DL and Lee DA (2005). Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles. Biochem Bioph Res Co vol. 336, (2) 424-429. 10.1016/j.bbro.2005.08.102
Mulholland JW, Shelton JC and Luo XY (2005). Blood flow and damage by the roller pumps during cardiopulmonary bypass. J Fluid Struct vol. 20, (1) 129-140. 10.1016/j.jfluidstructs.2004.10.008
Bowsher JG, Hussain A, Williams P, Nevelos J and Shelton JC (2004). Effect of ion implantation on the tribology of metal-on-metal hip prostheses. J Arthroplasty vol. 19, (8 Suppl 3) 107-111. 10.1016/j.arth.2004.09.021
Screen HRC, Bader DL, Lee DA and Shelton JC (2004). Local strain measurement within tendon. Strain vol. 40, (4) 157-163. 10.1111/j.1475-1305.2004.00164.x
Silwood CJL, Chikanza IC, Tanner KE, Shelton JC, Bowsher JG and Grootveld M (2004). Investigation of the molecular nature of low-molecular-mass cobalt(II) ions in isolated osteoarthritic knee-joint synovial fluid. Free Radical Res vol. 38, (6) 561-571. 10.1080/10715760410001684630
Sawae Y, Shelton JC, Bader DL and Knight MM (2004). Confocal analysis of local and cellular strains in chondrocyte-agarose constructs subjected to mechanical shear. Ann Biomed Eng vol. 32, (6) 860-870. 10.1023/B:ABME.0000030261.38396.c0
Screen HRC, Lee DA, Bader DL and Shelton JC (2004). An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties. Proceedings of The Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine vol. 218, (2) 109-119. 10.1243/095441104322984004
Fisher J, SHELTON JC and Nevelos J (2004). Metallurgical Considerations in the Wear of Metal-Metal Hip Bearings. Hip International vol. 14, 1-10. 10.5301/HIP.2008.5056
Mootanah R, Ingle P, Cheah K, Dowell JK and Shelton JC (2004). Total hip replacement: Results of a postal survey of current practice on the cement fixation of the acetubular cup in the UK. Hip International vol. 14, (3) 155-162. 10.5301/HIP.2008.3219
Chowdhury TT, Bader DL, Shelton JC and Lee DA (2003). Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression. Arch Biochem Biophys vol. 417, (1) 105-111. 10.1016/S0003-9861(03)00340-0
Berry CC, Shelton JC, Bader DL and Lee DA (2003). Influence of external uniaxial cyclic strain on oriented fibroblast-seeded collagen gels. Tissue Eng vol. 9, (4) 613-624. 10.1089/107632703768247313
Shelton JC, Bader DL and Lee DA (2003). Mechanical conditioning influences the metabolic response of cell-seeded constructs. Cells Tissues Organs vol. 175, (3) 140-150. 10.1159/000074630
Chowdhury TT, Shelton JC, Bader DL and LEE DA (2003). Control of mechanotrasduction processes in dynamically stimulated human and bovine chondrocytes cultured in agarose constructs. Internat. J. Artificial Organs vol. 26, (9) 858-858.
Chowdhury TT, LEE DA, Salter DM, Shelton JC and Bader DL (2003). alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta-stimulated human chondrocyte / agarose constructs and subjected to dynamic compression. Osteoarthritis Cartilage vol. 11, (Suppl 1) S2-S3.
Screen HRC, Lee DA, Bader DL and Shelton JC (2003). Development of a technique to determine strains in tendons using the cell nuclei. Biorheology vol. 40, (1-3) 361-368.
Berry CC, Cacou C, Lee DA, Bader DL and Shelton JC (2003). Dermal fibroblasts respond to mechanical conditioning in a strain profile dependent manner. Biorheology vol. 40, (1-3) 337-345.
Bader DL, SHELTON JC, Knight MM and Sawae Y (2003). Confocal Analysis of Local and Cellular Strains in Chondrocyte - Agarose Constructs Subjected to Shear. J Biochemical Engineering Asme 10.1023/B:ABME.0000030261.38396.c0
Kakunai S, Sakamoto T, Sakurai D, Aota Y and Shelton J (2002). Profile measurement of worn acetabular cup by holographic contouring. Jsme Int J C-Mech Sy vol. 45, (4) 1028-1032. 10.1299/jsmec.45.1028
Berry CC, Shelton JC, Bader DL and Lee DA (2002). The influence of uniaxial cyclic strain on orientated fibroblast seeded collagen gels. Third Smith and Nephew International Symposium - Translating Tissue Engineering Into Products
Screen HRC, Bader DL, Shelton JC and Lee DA (2002). Non-collagenous matrix components influence the micro-mechanical environment of tenocytes within tendon fascicles subjected to tensile strain. European Cells and Materials vol. 4, (SUPPL. 1) 41-42.
Saadalla ME, Ahad N, Gibson IR and Shelton JC (2002). Comparison between commercial calcium phosphate bone cements., Editors: Brown S, Clarke I and Williams P. Bioceramics 14 vol. 218-2, 331-334. 10.4028/www.scientific.net/KEM.218-220.331
Mushipe MT, Revell PA and Shelton JC (2002). Cancellous bone repair using bovine trabecular bone matrix particulates. Biomaterials vol. 23, (2) 365-370. 10.1016/S0142-9612(01)00114-4
SHELTON JC, Revell PA and Mushipe MT (2002). Comparison of influence of cortical bone repair using autologous and Endobon particulates. J Mats Sci: Materials in Medicine vol. 13, 99-105.
BADER DL, Shelton JC, Lee DA and Screen HRC (2002). Development of a technique to determine strains in tendons using the cell nuclei. Biorheology vol. 40, 361-368.
Mushipe MT, Revell PA and Shelton JC (2002). The effects of bovine trabecular bone matrix particulates on cortical bone repair. J Mater Sci Mater Med vol. 13, (1) 99-105. 10.1023/A:1013607207410
SHELTON JC, Revell PA and Mushipe MT (2002). Enhancement of cancellous bone repair using particulates. Biomaterials vol. 23, 365-370.
Ind TEJ, Shelton JC and Shepherd JH (2001). Influence of training on reliability of surgical knots. Brit J Obstet Gynaec vol. 108, (10) 1013-1016. 10.1016/S0306-5456(01)00251-0
SHELTON JC and Bowsher JG (2001). A hip simulator study of the influence of patient activity level on the wear of crosslinked polyethylene under smooth and roughened femoral conditions. Wear vol. 250, (1-2) 167-179. 10.1016/S0043-1648(01)00619-6
Zou L, Samarawickrama DYD, Jovanovski V and Shelton JC (2001). Measurements of sequential impressions of acetabula cups from a total hip joint replacement using a non-contact measurement system. International Journal of Machine Tools & Manufacture vol. 41, (13-14) 2023-2030. 10.1016/S0890-6955(01)00067-0
Berry CC, Cacou C, Shelton JC, Bader DL and Lee DA (2000). Biological response of cyclic strain on developed cell seeded collagen gel model. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell
Mulholland JW, Massey W and Shelton JC (2000). Investigation and quantification of the blood trauma caused by the combined dynamic forces experienced during cardiopulmonary bypass. Perfusion vol. 15, (6) 485-494. 10.1177/026765910001500603
Cacou C, Palmer D, Lee DA, Bader DL and Shelton JC (2000). A system for monitoring the response of uniaxial strain on cell seeded collagen gels. Med Eng Phys vol. 22, (5) 327-333. 10.1016/S1350-4533(00)00040-0
Mootanah R, Ingle P, Dowell J, Cheah K and Shelton JC (2000). Fixation of the acetabular cup in cemented total hip replacement: improving the anchorage hole profile using finite element method. Technol Health Care vol. 8, (6) 343-355.
Kobayashi E, Doi H, Yoneyama T, Hamanaka H, Gibson IR, Best SM, Shelton JC and Bonfield W (1998). Influence of aging heat treatment on mechanical properties of biomedical Ti-Zr based ternary alloys containing niobium. J Mater Sci Mater Med vol. 9, (11) 625-630. 10.1023/A:1008927407556
Mo N and Shelton JC (1998). Laser speckle photography to measure surface displacements on cortical bone--verification of an automated analysis system. Med Eng Phys vol. 20, (8) 594-601. 10.1016/S1350-4533(98)00062-9
Katz DM, Blatcher S and Shelton JC (1998). Quantification of holographic fringe data: comparison of intact and implanted femurs. Med Eng Phys vol. 20, (2) 114-123. 10.1016/S1350-4533(98)00003-4
Kobayashi E, Doi H, Yoneyama T, Hamanaka H, Best SM, Shelton JC and Bonfield W (1996). Alloy-design of titanium-zirconium based alloys containing niobium as biomedical materials. Transactions of The Annual Meeting of The Society For Biomaterials in Conjunction With The International Biomaterials Symposium vol. 2,
McDougall I, Gregson PJ and Shelton JC (1996). Multiaxial fatigue testing of medical grade titanium alloy. Transactions of The Annual Meeting of The Society For Biomaterials in Conjunction With The International Biomaterials Symposium vol. 1,
Forrest DJ, Shelton JC and Gregson PJ (1996). Fatigue failure in a plasma sprayed hydroxyapatite coated titanium alloy. Transactions of The Annual Meeting of The Society For Biomaterials in Conjunction With The International Biomaterials Symposium vol. 1,
Gong F, Swain P, Kadirkamanathan S, Hepworth C, Laufer J, Shelton J and Mills T (1996). Cutting thread at flexible endoscopy. Gastrointest Endosc vol. 44, (6) 667-674. 10.1016/S0016-5107(96)70049-4
Horgan LF, Shelton JC, O'Riordan DC, Moore DP, Winslet MC and Davidson BR (1996). Strengths and weaknesses of laparoscopic and open mesh inguinal hernia repair: a randomized controlled experimental study. Br J Surg vol. 83, (10) 1463-1467. 10.1002/bjs.1800831044
Shelton JC and Loukota RA (1996). Pull-out strength of screws from cortical bone in the maxillo-facial region. J Mater Sci-Mater M vol. 7, (4) 231-235. 10.1007/BF00119736
Kadirkamanathan SS, Shelton JC, Hepworth CC, Laufer JG and Swain CP (1996). A comparison of the strength of knots tied by hand and at laparoscopy. J Am Coll Surg vol. 182, (1) 46-54.
Loukota RA and Shelton JC (1995). Mechanical analysis of maxillofacial miniplates. Br J Oral Maxillofac Surg vol. 33, (3) 174-179. 10.1016/0266-4356(95)90293-7
KADIRKAMANATHAN SS, LAUFER JG, HEPWORTH CC, SHELTON JC and SWAIN CP (1995). ARE KNOTS TIED AT LAPAROSCOPY AS SECURE AS HAND TIED KNOTS. Gastrointest Endosc vol. 41, (4) 432-432. 10.1016/S0016-5107(05)80581-4
Netti PA, Shelton JC, Revell PA, Pirie C, Smith S, Ambrosio L, Nicolais L and Bonfield W (1993). Hydrogels as an interface between bone and an implant. Biomaterials vol. 14, (14) 1098-1104. 10.1016/0142-9612(93)90211-J
Shelton JC and Katz DM (1991). Laser interferometric techniques in orthopaedics. J Med Eng Technol vol. 15, (6) 209-221. 10.3109/03091909109005419
SHELTON JC, GORMAN D and BONFIELD W (1990). THE APPLICATION OF HOLOGRAPHY TO EXAMINE PLATED FRACTURE FIXATION SYSTEMS. J Mater Sci-Mater M vol. 1, (3) 146-153. 10.1007/BF00700874
Shelton JC, Gorman D and Bonfield W (1989). Double exposure holographic interferometric evaluation of plated fracture systems. Journal of Biomechanics vol. 22, (10) 10.1016/0021-9290(89)90459-4