Dr Karin Hing
Reader in Biomedical Materials
Bioresponsive Materials in Healthcare
Key strengths, technologies, know-how
- Rigorous materials and tissue characterisation Static and dynamic acellular ‘physiological’ environmental testing, including customised protein labelling for competitive binding analysis
- Analysis of cell response in both traditional 2D static tissue culture and bespoke 3D dynamic perfusion rig
- Supported by basic research into the phenomena behind normal physiological behaviour, biocompatibility, and the smart stimulation of tissue regeneration
- In vivo evaluation of material safety, efficacy and device functionality, study design for regulatory and basic science investigations
Selective research achievements
- Proven, internationally leading expertise in the discovery, innovation and translation of pioneering healthcare materials and therapies
- ApaTech: Internationally leading orthobiologics company, spun out in 2000 and sold for £220M in 2010
- 2012: ApaTech synthetic bone graft substitutes have 10% of global market with ActiFuse bone graft substitutes treating an estimated 125,000 patients annually in over 30 countries globally including the UK and USA
- 2013: Further research leads to launch of InductiGraft an osteoinductive bone graft substitute in the UK
Research InterestsKarin Hing is a senior lecturer in Biomaterials within the School of Engineering and Materials at Queen Mary University of London, prior to this she was an EPSRC Advanced Research Fellow within the IRC in Biomedical Materials. She was awarded the Fellowship in 1999, having worked as a post doc after completing her PhD studying the biological response to Bovine derived bone graft substitutes in 1996. As a Post-doc she invented a novel processing route for the manufacture of porous ceramics with a hierarchical porous structure (reflecting the structure of natural trabecular bone). She used this technology to achieve the objective of her advanced research fellowship, which was to develop a fully synthetic ceramic (apatite based) bone graft substitute material (Actifuse) with a pore structure and chemistry optimised to facilitate good quality, rapid bone repair in applications such as spinal fusion, total hip revision and skeletal reconstruction following trauma or disease.
This work formed the underpinning science behind ApaTech Ltd. a QMUL spin-out company that she co-founded with colleagues from the IRC in 2001. Apatech was aquired by Baxter in 2010 for $330m in recongition of its position as a global leader in the provision of their Actifuse based bone graft substitute technologies.
Karin's research group is now engaged in the development of next generation bone graft substitution technologies through physico-chemical and hierarchical 3-D structural characterisation of bone grafts, the study of protein interactions, cell response and chemotaxis, to probe the underlying mechanisms behind chemical and structural control of osteoconductive and osteoinductive behaviour in bone graft substitutes.
Mafina MK, Sullivan AC and Hing KA (2017). Use of a fluorescent probe to monitor the enhanced affinity of rh-BMP-2 to silicated-calcium phosphate synthetic bone graft substitutes under competitive conditions. Materials Science and Engineering C vol. 80, 207-212. 10.1016/j.msec.2017.05.142
Sriranganathan D, Chen X, Hing KA, Kanwal N and Hill RG (2016). The effect of the incorporation of fluoride into strontium containing bioactive glasses. Journal of Non-Crystalline Solids vol. 457, 25-30. 10.1016/j.jnoncrysol.2016.11.018
Campion C and Hing KA (2016). Porous Bone Graft Substitutes: When Less is More. Mechanobiology: Exploitation For Medical Benefit 10.1002/9781118966174.ch21
Sriranganathan D, Kanwal N, Hing KA and Hill RG (2016). Strontium substituted bioactive glasses for tissue engineered scaffolds: the importance of octacalcium phosphate. J Mater Sci Mater Med vol. 27, (2) 10.1007/s10856-015-5653-6
Coathup MJ, Blunn GW, Campion C, Ho C-Y and Hing KA (2016). The effect of increased microporosity on bone formation within silicate-substituted scaffolds in an ovine posterolateral spinal fusion model. J Biomed Mater Res B Appl Biomater vol. 105, (4) 805-814. 10.1002/jbm.b.33614
Hutchens SA, Campion C, Assad M, Chagnon M and Hing KA (2015). Efficacy of silicate-substituted calcium phosphate with enhanced strut porosity as a standalone bone graft substitute and autograft extender in an ovine distal femoral critical defect model. J Mater Sci Mater Med vol. 27, (1) 20-20. 10.1007/s10856-015-5559-3
Shah FA, Brauer DS, Hill RG and Hing KA (2015). Apatite formation of bioactive glasses is enhanced by low additions of fluoride but delayed in the presence of serum proteins. Materials Letters vol. 153, 143-147. 10.1016/j.matlet.2015.04.013
Shah FA, Brauer DS, Desai N, Hill RG and Hing KA (2014). Fluoride-containing bioactive glasses and Bioglass? 45S5 form apatite in low pH cell culture medium. Materials Letters vol. 119, 96-99. 10.1016/j.matlet.2013.12.102
Shah FA, Brauer DS, Wilson RM, Hill RG and Hing KA (2014). Influence of cell culture medium composition on in vitro dissolution behavior of a fluoride-containing bioactive glass. J Biomed Mater Res A vol. 102, (3) 647-654. 10.1002/jbm.a.34724
Castagna V, Olivares-Navarrete R, Schwartz Z, Boyan BD and Hing KA (2013). HMSC proliferation and differentiation are dependent on chemistry and surface roughness of calcium phosphate bone substitutes. European Cells and Materials vol. 26, (SUPPL. 3)
Mafina M-K, Hing KA and Sullivan AC (2013). Development of novel fluorescent probes for the analysis of protein interactions under physiological conditions with medical devices. Langmuir vol. 29, (5) 1420-1426. 10.1021/la304244s
Hing KA (2013). Biomimetic bone regeneration. 10.1533/9780857098887.2.207
Ghani Y, Coathup MJ, Hing KA and Blunn GW (2013). Antibacterial effect of incorporating silver ions in electrochemically deposited hydroxyapatite coating: An experimental study. Jrsm Short Rep vol. 4, (9) 10.1177/2042533313481212
Ghani Y, Coathup MJ, Hing KA and Blunn GW (2012). Development of a hydroxyapatite coating containing silver for the prevention of peri-prosthetic infection. J Orthop Res vol. 30, (3) 356-363. 10.1002/jor.21543
Campion CR, Ball SL, Clarke DL and Hing KA (2012). Microstructure and chemistry affects apatite nucleation on calcium phosphate bone graft substitutes. Journal of Materials Science: Materials in Medicine 1-14. 10.1007/s10856-012-4833-x
Chan O, Coathup MJ, Nesbitt A, Ho C-Y, Hing KA, Buckland T, Campion C and Blunn GW (2012). The effects of microporosity on osteoinduction of calcium phosphate bone graft substitute biomaterials. Acta Biomaterialia 10.1016/j.actbio.2012.03.038
Coathup MJ, Hing KA, Samizadeh S, Chan O, Fang YS, Campion C, Buckland T and Blunn GW (2012). Effect of increased strut porosity of calcium phosphate bone graft substitute biomaterials on osteoinduction. Journal of Biomedical Materials Research - Part A 10.1002/jbm.a.34094
Coathup MJ, Samizadeh S, Fang YS, Buckland T, Hing KA and Blunn GW (2011). The osteoinductivity of silicate-substituted calcium phosphate. J Bone Joint Surg Am vol. 93, (23) 2219-2226. 10.2106/JBJS.I.01623
Castagna V, Sullivan A and Hing K (2011). Fibronectin adsorption to stoichiometric and silicate substituted hydroxyapatite sensitive to FN concentration and presence of serum proteins. 24th European Conference On Biomaterials - Annual Conference of The European Society For Biomaterials
Parish A, Davis G and Hing K (2011). The quantitative and qualitative analysis bone ingrowth network quality of hydroxyapatite implants over time to investigate the process of internal bone growth via novel automated 3D image processing. 24th European Conference On Biomaterials - Annual Conference of The European Society For Biomaterials
Guth K, Campion C, Buckland T and Hing KA (2011). Effects of serum protein on ionic exchange between culture medium and microporous hydroxyapatite and silicate-substituted hydroxyapatite. Journal of Materials Science: Materials in Medicine vol. 22, (10) 2155-2164. 10.1007/s10856-011-4409-1
Campion CR, Chander C, Buckland T and Hing K (2011). Increasing strut porosity in silicate-substituted calcium-phosphate bone graft substitutes enhances osteogenesis. Journal of Biomedical Materials Research - Part B Applied Biomaterials vol. 97 B, (2) 245-254. 10.1002/jbm.b.31807
Mafina MK, Sullivan AC and Hing KA (2011). Recording and evaluating the effect of silicon-substitution on protein adsorption/desorption to hydroxyapatite. European Cells and Materials vol. 22, (SUPPL.2)
Castagna V, Sullivan A and Hing KA (2011). Behaviour of fibronectin on interaction with stoichiometric and silicate substituted hydroxyapatite bone graft substitiutes. European Cells and Materials vol. 22, (SUPPL.2)
Parish AJB, Davis GR and Hing KA (2011). Automated computation of 3D histomorphometry within implanted hydroxyapatite porous scaffolds. European Cells and Materials vol. 22, (SUPPL.2)
Hing K (2010). Tissue engineering. Mater World vol. 18, (9) 28-30.
Guth K, Campion C, Buckland T and Hing KA (2010). Surface physiochemistry affects protein adsorption to stoichiometric and silicate-substituted microporous hydroxyapatites. Advanced Engineering Materials vol. 12, (4) 10.1002/adem.200980026
Guth K, Campion C, Buckland T and Hing KA (2010). Effect of silicate-substitution on attachment and early development of human osteoblast-like cells seeded on microporous hydroxyapatite discs. Advanced Engineering Materials vol. 12, (1-2) 10.1002/adem.200980003
Mafina MK, Sullivan AC and Hing KA (2009). Monitoring the effect of silicate substitution on protein adsorption/desorption to hydroxyapatite. European Cells and Materials vol. 18, (SUPPL. 2)
Samizadeh S, Amogbokpa J, Fang SC, Coathup MJ, Hing KA, Buckland T and Blunn GW (2008). Osseoinduction by calcium phosphate bone substitutes is a function of chemical composition and structure. 8th World Biomaterials Congress 2008 vol. 2,
Hing KA (2008). Biomaterials - Where biology, physics, chemistry, engineering and medicine meet. Journal of Physics: Conference Series vol. 105, (1) 10.1088/1742-6596/105/1/012010
Rashid N, Harding I, Buckland T and HING KA (2008). Nano-scale manipulation of silicate-substituted apatite chemistry impacts surface charge, hydrophilicity, protein adsorption and cell attachment., Editors: Meenan BJ and Boyd AR. International Journal of Nano and Biomaterials vol. 1, (3) 299-319. 10.1504/IJNBM.2008.016877
Hing KA, Wilson LF and Buckland T (2007). Comparative performance of three ceramic bone graft substitutes. Spine J vol. 7, (4) 475-490. 10.1016/j.spinee.2006.07.017
Hing KA, Revell PA, Smith N and Buckland T (2006). Effect of silicon level on rate, quality and progression of bone healing within silicate-substituted porous hydroxyapatite scaffolds. Biomaterials vol. 27, (29) 5014-5026. 10.1016/j.biomaterials.2006.05.039
De Carlos A, Lusquinos F, Pou J, Leon B, Perez-Amor M, Driessens FCM, HING KA, Best S and Bonfield W (2006). In vitro testing of Nd : YAG laser processed calcium phosphate coatings. Journal of Materials Science Materials in Medicine vol. 17, (11) 1153-1160.
Harding IS, Rashid N and Hing KA (2005). Surface charge and the effect of excess calcium ions on the hydroxyapatite surface. Biomaterials vol. 26, (34) 6818-6826. 10.1016/j.biomaterials.2005.04.060
Mehta JS, Futter CE, Sandeman SR, Faragher RGAF, Hing KA, Tanner KE and Allan BDS (2005). Hydroxyapatite promotes superior keratocyte adhesion and proliferation in comparison with current keratoprosthesis skirt materials. Brit J Ophthalmol vol. 89, (10) 1356-1362. 10.1136/bjo.2004.064147
HING KA, Annaz B, Saeed S, Revell PA and Buckland T (2005). Microporosity enhances bioactivity of synthetic bone graft substitutes. Journal of Materials Science Materials in Medicine vol. 16, (5) 467-475.
Hing KA (2005). Bioceramic bone graft substitutes: Influence of porosity and chemistry. Int J Appl Ceram Tec vol. 2, (3) 184-199. 10.1111/j.1744-7402.2005.02020.x
Hing KA (2004). Bone repair in the twenty-first century: biology, chemistry or engineering? Philos Trans a Math Phys Eng Sci vol. 362, (1825) 2821-2850. 10.1098/rsta.2004.1466
Annaz B, Hing KA, Kayser M, Buckland T and Di Silvio L (2004). The role of microporosity in synthetic porous ceramics. Transactions - 7th World Biomaterials Congress
Saeed S, Hing K and Revell PA (2004). HA activates T cells and causes inflammation in liver and spleen from rabbits following intraosseous implantation. Transactions - 7th World Biomaterials Congress
Hing KA, Saeed S, Annaz B, Buckland T and Revell PA (2004). Microporosity enhances bioactivity of synthetic bone graft substitutes. Transactions - 7th World Biomaterials Congress
Hing KA, Saeed S, Annaz B, Buckland T and Revell PA (2004). Bone development is sensitive to silicon level in substituted apatites. Transactions - 7th World Biomaterials Congress
Rashid N, Harding I and Hing KA (2004). Effect of silicate substitution on the surface charge of hydroxyapatite. Transactions - 7th World Biomaterials Congress
Annaz B, Hing KA, Kayser M, Buckland T and Di Silvio L (2004). An ultrastructural study of cellular response to variation in porosity in phase-pure hydroxyapatite. J Microsc vol. 216, (Pt 2) 97-109. 10.1111/j.0022-2720.2004.01403.x
Annaz B, Hing KA, Kayser M, Buckland T and Di Silvio L (2004). Porosity variation in hydroxyapatite and osteoblast morphology: a scanning electron microscopy study. J Microsc vol. 215, (Pt 1) 100-110. 10.1111/j.0022-2720.2004.01354.x
Hing KA, Best SM, Tanner KE, Bonfield W and Revell PA (2004). Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutes. J Biomed Mater Res A vol. 68, (1) 187-200. 10.1002/jbm.a.10050
HING KA, Revell PA, McInness T and Damien E (2004). Novel Bioceramic Foams For Bone Grafting. Journal of Bone & Joint Surgery - British Volume vol. 86-B Suppl I:II,
HING KA, Tanner KE, Best SM, Bonfield W and Revell PA (2004). Mediation of bone ingrowth in porous hydroxyaptite bone graft substitutes. Journal of Biomedical Materials Research vol. 68A, 187-200. 10.1002/jbm.a.10050
Damien E, Hing K, Saeed S and Revell PA (2003). A preliminary study on the enhancement of the osteointegration of a novel synthetic hydroxyapatite scaffold in vivo. J Biomed Mater Res A vol. 66, (2) 241-246. 10.1002/jbm.a.10564
Lusquiños F, De Carlos A, Pou J, Arias JL, Boutinguiza M, León B, Pérez-Amor M, Driessens FCM, Hing K, Gibson I, Best S and Bonfield W (2003). Calcium phosphate coatings obtained by Nd:YAG laser cladding: physicochemical and biologic properties. J Biomed Mater Res A vol. 64, (4) 630-637. 10.1002/jbm.a.10440
Patel N, Best SM, Bonfield W, Gibson IR, Hing KA, Damien E and Revell PA (2002). A comparative study on the in vivo behavior of hydroxyapatite and silicon substituted hydroxyapatite granules. J Mater Sci Mater Med vol. 13, (12) 1199-1206. 10.1023/A:1021114710076
Damien E, MacInnes T, Hing K and Revell PA (2001). Insulin like growth factor (IGF-I) increases the bioactivity of porous hydroxyapatite (PHA) in vivo in rabbits. J Pathol vol. 193, 6A-6A.
Hing KA, Best SM, Tanner KE, Bonfield W and Revell PA (1999). Quantification of bone ingrowth within bone-derived porous hydroxyapatite implants of varying density. J Mater Sci Mater Med vol. 10, (10/11) 663-670. 10.1023/A:1008900127475
Hing KA, Best SM and Bonfield W (1999). Characterization of porous hydroxyapatite. J Mater Sci Mater Med vol. 10, (3) 135-145. 10.1023/A:1008929305897
Di Silvio L, Hing K and Bonfield W (1999). Macroporous hydroxyapatites: Potential drug delivery systems. Proceedings of The Controlled Release Society (26) 1152-1153.
Hing K and Knight M (1998). Prize-winning peeks at the microscopic world.
Hing KA, Best SM, Tanner KE, Revell PA and Bonfield W (1998). Histomorphological and biomechanical characterization of calcium phosphates in the osseous environment. Proc Inst Mech Eng H vol. 212, (6) 437-451. 10.1243/0954411981534204
Hing KA, Best SM, Tanner KE, Bonfield W and Revell PA (1997). Biomechanical assessment of bone ingrowth in porous hydroxyapatite. J Mater Sci Mater Med vol. 8, (12) 731-736. 10.1023/A:1018500309969
Hing KA, Best SM, Revell PA, Tanner KE and Bonfield W (1996). Histomorphometric and biomechanical assessment of bone ingrowth in porous hydroxyapatite. Transactions of The Annual Meeting of The Society For Biomaterials in Conjunction With The International Biomaterials Symposium vol. 2,
HING KA (1996). Assessment of porous hydroxyapatite for bone replacement., Editors: Best SM and Bonfield W.
HING KA and Bonfield W (2009). foamed ceramics. US8613876 B2.