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Institute of Bioengineering

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Prof Ken Suzuki

Professor of Translational Cardiovascular Therapeutics

Department William Harvey Research Institute
Email ken.suzuki@qmul.ac.uk
Homepage http://www.qmul.ac.uk/whri/people/academic-staff/items/suzukiken-.html

Research Interests

Suzuki’s research primarily aims to develop innovative therapies, including stem cell and regenerative therapy, to treat chronic heart failure, myocardial infarction as well as ischaemia-reperfusion injury. There are currently three major research lines in the group.

1. Adult stem cell therapy for myocardial repair: Adult stem/progenitor cells are able to improve cardiac performance and structure by repairing the damaged myocardium primarily through secretion of reparative factors (paracrine effects). Suzuki’s 18-year research suggested that allogeneic mesenchymal stromal cells are the most promising cell type for this approach to be a clinically successful. He has also clarified the issues associated with the current cell-delivery methods (i.e. intramyocardial and intracoronary injection), including poor donor cell engraftment and risks of complications such as arrhythmia occurrence and coronary embolism. To solve these limitations, he has developed a safer and more effective cell-delivery approach, “epicardial placement” by using biocompatible materials/tissue engineering. This project is funded by BHF Programme Grant and company co-development funds including Kaneka Corporation (Japan). Current projects include:

Translational and pre-clinical studies for development of biomaterial-aided epicardial placement of mesenchymal stromal cells. Suzuki aims to translate this innovative approach to the first-in-human clinical application in 2017/2018.
Pre-clinical characterisation for safety and effectiveness of human amnion-derived mesenchymal stromal cells as a donor for cell therapy.
Study of the potential of biomaterials to enhance cellular properties of stem cells.
Mechanistic investigations with focuses on the direct and indirect paracrine effects by mesenchymal stromal cell therapy.
Development of novel biocompatible materials for stem cell therapy (collaborative project with the Institute of Bioengineering in QMUL).

2. Alternatively activated macrophages for the treatment of heart failure and other diseases: Immunity and inflammation play an vital role in development of and recovery from heart failure. Suzuki’s group has investigated the role of high-mobility group protein 1

(HMGB-1), toll like receptors (TLRs) as well as cardiac alternatively-activated (M2) macrophages in heart failure. In addition to elucidating their basic molecular/cellular biological aspects, we challenge to apply these data for development of innovative therapies of heart failure and other diseases. These projects are funded by the Heart Research UK and Queen Mary Innovation. Current projects include:

Biological and functional characterisation of cardiac M2 macrophages in the intact and damaged heart.
Investigation of the role of M2 macrophages in non-cardiac diseases.
Development of new therapeutic approaches, including long-acting IL-4, for treating/preventing heart failure by modulating M2 macrophages.
Development of new therapeutic approaches for treating/preventing other cardiac and non-cardiac diseases by modulating M2 macrophages.
In vitro production and characterisation of M2 macrophages.
Improvement of bone marrow mononuclear cell transplantation therapy by regulating differentiation of the donor cells to a specific macrophage phenotype.

3. Pluripotent stem cell therapy for myocardial regeneration: Embryonic stem cells and induced pluripotent stem cells are more promising to achieve myocardial regeneration (generation of new cardiomyocytes), compared to adult stem cells. However, these pluripotent cells remain associated with critical issues to initiate clinical application, including mass production of high-quality cells and regulation of cardiomyogenic differentiation (i.e. avoidance of tumour formation). In addition, insufficient maturation and inappropriate integration of stem cell-derived cardiomyocytes as well as suboptimal cell-delivery method into the heart have to be overcome. With firm determination to progress this approach toward clinical application, we currently conduct basics/translational research of these cells (with fund from BHF Programme Grant and Japan Society for Promotion of Science Fellowship):

Development of an advanced method to deliver stem cells-derived cardiac progenitor cells or cardiomyocytes into the heart by applying above epicardial placement technique.
Investigation to understand and amplify intra-cardiac migration and integration of cardiomyocytes (or cardiac progenitors) derived from stem cells.

Ken Suzuki is a Principal Investigator at the Centre for Microvascular Research

Key Publications

Fukushima S, Campbell NG, Coppen SR, Yamahara K, AHY Y, Smolenski RT, Yacoub MH and Suzuki K (2011). Quantitative assessment of initial retention of bone marrow mononuclear cells injected into the coronary arteries. Elsevier Inc  Journal of Heart and Lung Transplantation  vol. 30, (2) 227-233. 10.1016/j.healun.2010.09.002

Shintani Y, Fukushima S, Varela-Carver A, Lee J, Coppen SR, Takahashi K, Brouilette SW, Yashiro K, Terracciano CMN, Yacoub MH and Suzuki K (2009). Donor cell-type specific paracrine effects of cell transplantation for post-infarction heart failure. J Mol Cell Cardiol  vol. 47, (2) 288-295. 10.1016/j.yjmcc.2009.05.009

Coppen SR, Fukushima S, Shintani Y, Takahashi K, Varela-Carver A, Salem H, Yashiro K, Yacoub MH and Suzuki K (2008). A factor underlying late-phase arrhythmogenicity after cell therapy to the heart - Global downregulation of connexin43 in the host myocardium after skeletal myoblast transplantation. Circulation  vol. 118, (14) S138-S144. 10.1161/CIRCULATIONAHA.107.779629

Fukushima S, Coppen SR, Lee J, Yamahara K, Felkin LE, Terracciano CMN, Barton PJR, Yacoub MH and Suzuki K (2008). Choice of Cell-Delivery Route for Skeletal Myoblast Transplantation for Treating Post-Infarction Chronic Heart Failure in Rat. Plos One  vol. 3, (8) 10.1371/journal.pone.0003071

2018

Kobayashi K, Ichihara Y, Tano N, Fields L, Murugesu N, Ito T, Ikebe C, Lewis F, Yashiro K, Shintani Y, Uppal R and Suzuki K (2018). Fibrin Glue-aided, Instant Epicardial Placement Enhances the Efficacy of Mesenchymal Stromal Cell-Based Therapy for Heart Failure. Sci Rep  vol. 8, (1) 10.1038/s41598-018-27881-5

Sawhney V, Brouilette S, Campbell N, Coppen S, Baker V, Hunter R, Dhinoja M, Johnston A, Earley M, Sporton S, Suzuki K and Schilling R (2018). Association of genetic variation in telomere-related SNP and telomerase with ventricular arrhythmias in ischemic cardiomyopathy. Pacing Clin Electrophysiol  vol. 41, (3) 261-266. 10.1111/pace.13284

SUZUKI K (2018). Self-assembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure. Elsevier  Biomaterials  vol. 154, 12-23. 10.1016/j.biomaterials.2017.10.050

2017

SUZUKI K, Shintani Y, ITO T, FIELDS L, SHIRAISHI M, ICHIHARA Y, SATO N, PODARU M, KAINUMA S and TANAKA H (2017). IL-4 as a Repurposed Biological Drug for Myocardial Infarction through Augmentation of Reparative Cardiac Macrophages: Proof-of-Concept Data in Mice. Nature Publishing Group  Scientific Reports  10.1038/s41598-017-07328-z

2016

Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P, Miller D, Harmer S, Poliandri A, Kogaki S, Sakata Y, Dunkel L, Tinker A, Hadjantonakis A-K, Sawa Y, Sasaki H, Ozono K, Suzuki K and Yashiro K (2016). GFRA2 Identifies Cardiac Progenitors and Mediates Cardiomyocyte Differentiation in a RET-Independent Signaling Pathway. Cell Rep  vol. 16, (4) 1026-1038. 10.1016/j.celrep.2016.06.050

SUZUKI K, Campbell N and Mathur A (2016). Cell Size Critically Determines Initial Retention of Bone Marrow Mononuclear Cells in the Heart after Intracoronary Injection: Evidence from A Rat Model. Public Library of Science  Plos One  vol. 11, (7) 10.1371/journal.pone.0158232

Shiraishi M, Shintani Y, Shintani Y, Ishida H, Saba R, Yamaguchi A, Adachi H, Yashiro K and Suzuki K (2016). Alternatively activated macrophages determine repair of the infarcted adult murine heart. Journal of Clinical Investigation  10.1172/JCI85782

Sawhney V, Campbell NG, Brouilette SW, Coppen SR, Harbo M, Baker V, Ikebe C, Shintani Y, Hunter RJ, Dhinoja M, Johnston A, Earley MJ, Sporton S, Bendix L, Suzuki K and Schilling RJ (2016). Telomere shortening and telomerase activity in ischaemic cardiomyopathy patients - Potential markers of ventricular arrhythmia. Int J Cardiol  vol. 207, 157-163. 10.1016/j.ijcard.2016.01.066

Tano N, Kaneko M, Ichihara Y, Ikebe C, Coppen SR, Shiraishi M, Shintani Y, Yashiro K, Warrens A and Suzuki K (2016). Allogeneic Mesenchymal Stromal Cells Transplanted Onto the Heart Surface Achieve Therapeutic Myocardial Repair Despite Immunologic Responses in Rats. J Am Heart Assoc  vol. 5, (2) 10.1161/JAHA.115.002815

Kokkinopoulos I, Ishida H, Saba R, Coppen S, Suzuki K and Yashiro K (2016). Cardiomyocyte differentiation from mouse embryonic stem cells using a simple and defined protocol. Dev Dyn  vol. 245, (2) 157-165. 10.1002/dvdy.24366

2015

Kokkinopoulos I, Ishida H, Saba R, Ruchaya P, Cabrera C, Struebig M, Barnes M, Terry A, Kaneko M, Shintani Y, Coppen S, Shiratori H, Ameen T, Mein C, Hamada H, Suzuki K and Yashiro K (2015). Single-Cell Expression Profiling Reveals a Dynamic State of Cardiac Precursor Cells in the Early Mouse Embryo. Plos One  vol. 10, (10) 10.1371/journal.pone.0140831

Narita T and Suzuki K (2015). Bone marrow-derived mesenchymal stem cells for the treatment of heart failure. Heart Fail Rev  vol. 20, (1) 53-68. 10.1007/s10741-014-9435-x

2014

Sawhney VS, Brouilette SW, Campbell NG, Coppen SR, Baker VB, Hunter RJ, Dhinoja MD, Earley MJ, Sporton SS, Suzuki KS and Schilling RJ (2014). 23Association of TERC related genetic variation and telomerase activity with ventricular arrhythmias in ischaemic cardiomyopathy. Europace  vol. 16 Suppl 3, 10.1093/europace/euu238.5

Tano N, Narita T, Kaneko M, Ikebe C, Coppen SR, Campbell NG, Shiraishi M, Shintani Y and Suzuki K (2014). Epicardial placement of mesenchymal stromal cell-sheets for the treatment of ischemic cardiomyopathy; in vivo proof-of-concept study. Mol Ther  vol. 22, (10) 1864-1871. 10.1038/mt.2014.110

Shintani Y, Drexler HCA, Kioka H, Terracciano CMN, Coppen SR, Imamura H, Akao M, Nakai J, Wheeler AP, Higo S, Nakayama H, Takashima S, Yashiro K and Suzuki K (2014). Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2. Embo Rep  vol. 15, (4) 438-445. 10.1002/embr.201337945

Ikebe C and Suzuki K (2014). Mesenchymal Stem Cells for Regenerative Therapy: Optimization of Cell Preparation Protocols. Biomed Research International  10.1155/2014/951512

2013

Narita T, Shintani Y, Ikebe C, Kaneko M, Harada N, Tshuma N, Takahashi K, Campbell NG, Coppen SR, Yashiro K, Sawa Y and Suzuki K (2013). The use of cell-sheet technique eliminates arrhythmogenicity of skeletal myoblast-based therapy to the heart with enhanced therapeutic effects. Int J Cardiol  vol. 168, (1) 261-269. 10.1016/j.ijcard.2012.09.081

Narita T, Shintani Y, Ikebe C, Kaneko M, Campbell NG, Coppen SR, Uppal R, Sawa Y, Yashiro K and Suzuki K (2013). The use of scaffold-free cell sheet technique to refine mesenchymal stromal cell-based therapy for heart failure. Mol Ther  vol. 21, (4) 860-867. 10.1038/mt.2013.9

Shintani Y, Kapoor A, Kaneko M, Smolenski RT, D'Acquisto F, Coppen SR, Harada-Shoji N, Lee HJ, Thiemermann C, Takashima S, Yashiro K and Suzuki K (2013). TLR9 mediates cellular protection by modulating energy metabolism in cardiomyocytes and neurons. Proc Natl Acad Sci U S A  vol. 110, (13) 5109-5114. 10.1073/pnas.1219243110

Xiao Q, Zhang F, Lin L, Fang C, Wen G, Tsai T-N, Pu X, Sims D, Zhang Z, Yin X, Thomaszewski B, Schmidt B, Mayr M, Suzuki K, Xu Q and Ye S (2013). Functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions. Circ Res  vol. 112, (1) 35-47. 10.1161/CIRCRESAHA.112.274019

Kaneko M, Shintani Y, Narita T, Ikebe C, Tano N, Yamahara K, Fukushima S, Coppen SR and Suzuki K (2013). Extracellular high mobility group box 1 plays a role in the effect of bone marrow mononuclear cell transplantation for heart failure. Plos One  vol. 8, (10) 10.1371/journal.pone.0076908

2012

Xiao Q, Zhang F, Lin L, Fang C, Wen G, Tsai T-N, Pu X, Sims D, Zhang Z, Thomaszewski B, Schmidt B, Mayr M, Suzuki K, Xu Q and Ye S (2012). A Functional Role of Matrix Metalloproteinase-8 in Stem/progenitor Cell Migration and Their Recruitment Into Atherosclerotic Lesions. Circulation  vol. 126, (21)

Kaneko M, Shintani Y, Narita T, Ikebe C, Campbell N, Sawhney V, Tano N, Coppen S, Yashiro K and Suzuki K (2012). Bone Marrow Mononuclear Cell Transplantation Improves Cardiac Function in Ischemic Cardiomyopathy via High Mobility Group Box 1 Released from Dead Donor Cells. Circulation  vol. 126, (21)

Campbell NG and Suzuki K (2012). Cell Delivery Routes for Stem Cell Therapy to the Heart: Current and Future Approaches. Journal of Cardiovascular Translational Research  vol. 5, (5) 713-726. 10.1007/s12265-012-9378-3

Brouilette S, Kuersten S, Mein C, Bozek M, Terry A, Dias K-R, Bhaw-Rosun L, Shintani Y, Coppen S, Ikebe C, Sawhney V, Campbell N, Kaneko M, Tano N, Ishida H, Suzuki K and Yashiro K (2012). A simple and novel method for RNA-seq library preparation of single cell cDNA analysis by hyperactive Tn5 transposase. Dev Dyn  vol. 241, (10) 1584-1590. 10.1002/dvdy.23850

Nandra KK, Takahashi K, Collino M, Benetti E, Wong WSF, Goh FY, Suzuki K, Patel NSA and Thiemermann C (2012). Acute treatment with bone marrow-derived mononuclear cells attenuates the organ injury/dysfunction induced by hemorrhagic shock in the rat. Shock  vol. 37, (6) 592-598. 10.1097/SHK.0b013e31824e4c0d

2011

Narita T, Shintani Y, Ikebe C, Harada N, Kaneko M, Campbell NG, Sawhney V, Coppen SR, Yashiro K and Suzuki K (2011). Enhancing the Paracrine Effects of Mesenchymal Stem Cells to Recover Damaged Myocardium by the Use of Cell-Sheets. Circulation  vol. 124, (21)

Shintani Y, Kapoor A, Drexler H, Terracciano C, Smolenski R, Kaneko M, Harada N, Coppen S, Narita T, Campbell N, Ikebe C, Thiemermann C, Yashiro K and Suzuki K (2011). A Novel Toll-Like Receptor 9 Signaling in Cardiomyocytes. Circulation  vol. 124, (21)

Felkin LE, Narita T, Germack R, Shintani Y, Takahashi K, Sarathchandra P, Lopez-Olaneta MM, Gomez-Salinero JM, Suzuki K, Barton PJR, Rosenthal N and Lara-Pezzi E (2011). Calcineurin Splicing Variant Calcineurin A beta 1 Improves Cardiac Function After Myocardial Infarction Without Inducing Hypertrophy. Circulation  vol. 123, (24) 2838-2847. 10.1161/CIRCULATIONAHA.110.012211

Fukushima S, Campbell NG, Coppen SR, Yamahara K, AHY Y, Smolenski RT, Yacoub MH and Suzuki K (2011). Quantitative assessment of initial retention of bone marrow mononuclear cells injected into the coronary arteries. Elsevier Inc  Journal of Heart and Lung Transplantation  vol. 30, (2) 227-233. 10.1016/j.healun.2010.09.002

Nandra K, Takahashi K, Collino M, Benetti E, Wong WSF, Goh FY, Salem H, Suzuki K, Patel NSA and Thiemermann C (2011). BONE-MARROW DERIVED MONONUCLEAR CELLS PROTECT AGAINST MULTIPLE ORGAN FAILURE IN HEMORRHAGIC SHOCK THROUGH AN AKT DEPENDANT PATHWAY. Shock  vol. 36, 26-26.

2010

Kapoor A, Shintani Y, Collino M, Osuchowski MF, Busch D, Patel NSA, Sepodes B, Castiglia S, Fantozzi R, Bishop-Bailey D, Mota-Filipe H, Yaqoob MM, Suzuki K, Bahrami S, Desvergne B, Mitchell JA and Thiemermann C (2010). Protective role of peroxisome proliferator-activated receptor-?/? in septic shock. Am J Respir Crit Care Med  vol. 182, (12) 1506-1515. 10.1164/rccm.201002-0240OC

Lovell MJ, Yasin M, Lee KL, Cheung KK, Shintani Y, Collino M, Sivarajah A, Leung K-Y, Takahashi K, Kapoor A, Yaqoob MM, Suzuki K, Lythgoe MF, Martin J, Munroe PB, Thiemermann C and Mathur A (2010). Bone marrow mononuclear cells reduce myocardial reperfusion injury by activating the PI3K/Akt survival pathway. Atherosclerosis  vol. 213, (1) 67-76. 10.1016/j.atherosclerosis.2010.07.045

Kratsios P, Huth M, Temmerman L, Salimova E, Al Banchaabouchi M, Sgoifo A, Manghi M, Suzuki K, Rosenthal N and Mourkioti F (2010). Antioxidant Amelioration of Dilated Cardiomyopathy Caused by Conditional Deletion of NEMO/IKK gamma in Cardiomyocytes. Circ Res  vol. 106, (1) 133-144. 10.1161/CIRCRESAHA.109.202200

2009

Shintani Y, Fukushima S, Varela-Carver A, Lee J, Coppen SR, Takahashi K, Brouilette SW, Yashiro K, Terracciano CMN, Yacoub MH and Suzuki K (2009). Donor cell-type specific paracrine effects of cell transplantation for post-infarction heart failure. J Mol Cell Cardiol  vol. 47, (2) 288-295. 10.1016/j.yjmcc.2009.05.009

Lee J, Stagg MA, Fukushima S, Soppa GKR, Siedlecka U, Youssef SJ, Suzuki K, Yacoub MH and Terracciano CMN (2009). Adult progenitor cell transplantation influences contractile performance and calcium handling of recipient cardiomyocytes. Am J Physiol-Heart C  vol. 296, (4) H927-H936. 10.1152/ajpheart.00931.2008

2008

Coppen SR, Fukushima S, Shintani Y, Takahashi K, Varela-Carver A, Salem H, Yashiro K, Yacoub MH and Suzuki K (2008). A factor underlying late-phase arrhythmogenicity after cell therapy to the heart - Global downregulation of connexin43 in the host myocardium after skeletal myoblast transplantation. Circulation  vol. 118, (14) S138-S144. 10.1161/CIRCULATIONAHA.107.779629

Fukushima S, Coppen SR, Lee J, Yamahara K, Felkin LE, Terracciano CMN, Barton PJR, Yacoub MH and Suzuki K (2008). Choice of Cell-Delivery Route for Skeletal Myoblast Transplantation for Treating Post-Infarction Chronic Heart Failure in Rat. Plos One  vol. 3, (8) 10.1371/journal.pone.0003071

Yamahara K, Fukushima S, Coppen SR, Felkin LE, Varela-Carver A, Barton PJR, Yacoub MH and Suzuki K (2008). Heterogeneic nature of adult cardiac side population cells. Biochem Bioph Res Co  vol. 371, (4) 615-620. 10.1016/j.bbrc.2008.04.021

2007

Lara-Pezzi E, Winn N, Paul A, McCullagh K, Slominsky E, Santini MP, Mourkioti F, Sarathchandra P, Fukushima S, Suzuki K and Rosenthal N (2007). A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration. J Cell Biol  vol. 179, (6) 1205-1218. 10.1083/jcb.200704179

Suzuki K, Fukushima S, Varela-Carver A, Coppen SR, Yamahara K, Felkin LE, Lee J, Barton PJR, Terracciano CMN and Yacoub MH (2007). Response to letter regarding article, Direct Intramyocardial but Not Intracoronary Injection of Bone Marrow Cells Induces Ventricular Arrhythmias in a Rat Chronic Ischemic Heart Failure Model. Circulation  vol. 116, (23) E555-E555. 10.1161/CIRCULATIONAHA.107.725937

Santini MP, Tsao L, Monassier L, Theodoropoulos C, Carter J, Lara-Pezzi E, Slonimsky E, Salimova E, Delafontaine P, Song YH, Bergmann M, Freund C, Suzuki K and Rosenthal N (2007). Enhancing repair of the mammalian heart. Circ Res  vol. 100, (12) 1732-1740. 10.1161/CIRCRESAHA.107.148791

Fukushima S, Varela-Carver A, Coppen SR, Yamahara K, Felkin LE, Lee J, Barton PJR, Terracciano CMN, Yacoub MH and Suzuki K (2007). Direct intramyocardial but not intracoronary injection of bone marrow cells induces ventricular arrhythmias in a rat chronic ischemic heart failure model. Circulation  vol. 115, (17) 2254-2261. 10.1161/CIRCULATIONAHA.106.662577

Smolenski RT, Forni M, Maccherini M, Bacci ML, Slominska EM, Wang HJ, Fornasari P, Giovannoni R, Simeone F, Zannoni A, Frati G, Suzuki K, Yacoub MH and Lavitrano M (2007). Reduction of hyperacute rejection and protection of metabolism and function in hearts of human decay accelerating factor (hDAF)-expressing pigs. Cardiovasc Res  vol. 73, (1) 143-152. 10.1016/j.cardiores.2006.10.027

2006

Fukushima S, Coppen SR, Varela-Carver A, Brindley G, Yamahara K, Sarathchandra P, Yacoub MH and Suzuki K (2006). Enhanced efficiency of superoxide dismutase-induced cardioprotection by retrograde intracoronary administration. Cardiovasc Res  vol. 69, (2) 459-465. 10.1016/j.cardiores.2005.10.008

Lee J, Fukushima S, Stagg MA, Soppa GK, Youssef SJ, Yacoub MH, Suzuki K and Terracciano CM (2006). Paracrine effects of transplanted bone marrow cells and skeletal myoblasts on recipient cardiomyocyte function in a rat model of heart failure. J Heart Lung Transpl  vol. 25, (2) S152-S152. 10.1016/j.healun.2005.11.324

Stagg MA, Coppen SR, Suzuki K, Varela-Carver A, Lee J, Brand NJ, Fukushima S, Yacoub MH and Terracciano CMN (2006). Evaluation of frequency, type, and function of gap junctions between skeletal myoblasts overexpressing connexin43 and cardiomyocytes: relevance to cell transplantation. Faseb J  vol. 20, (1) 744-+. 10.1096/fj.05-5088fje

2005

Yuen AHY, Boscoe M, Lango R, Suzuki K, Slominska EM, Yacoub MH and Smolenski RT (2005). Prevention of adriamycin induced heart failure by an increase in endogenous adenosine production. Nucleos Nucleot Nucl  vol. 24, (4) 267-270. 10.1081/NCN-200059705

2004

Suzuki K, Murtuza B, Fukushima S, Smolenski RT, Varela-Carver A, Coppen SR and Yacoub MH (2004). Targeted cell delivery into infarcted rat hearts by retrograde intracoronary infusion: Distribution, dynamics, and influence on cardiac function. Circulation  vol. 110, (11) II225-II230. 10.1161/01.CIR.0000138191.11580.e3

Suzuki K, Murtuza B, Beauchamp JR, Brand NJ, Barton PJR, Varela-Carver A, Fukushima S, Coppen SR, Partridge TA and Yacoub MH (2004). Role of interleukin-1 beta in acute inflammation and graft death after cell transplantation to the heart. Circulation  vol. 110, (11) II219-II224. 10.1161/01.CIR.0000138388.55416.06

Yacoub MH, Yuen AHY, Kalsi KAK, Birks EJ, Taegtmeyer A, Barton PJ, Johnson PH, Suzuki K and Smolenski RT (2004). C34T AMP deaminase 1 gene mutation protects cardiac function in donors. Transplantation  vol. 77, (10) 1621-1623. 10.1097/01.TP.0000122413.46512.05

Suzuki K, Murtuza B, Beauchamp JR, Smolenski RT, Varela-Carver A, Fukushima S, Coppen SR, Partridge TA and Yacoub MH (2004). Dynamics and mediators of acute graft attrition after myoblast transplantation to the heart. Faseb J  vol. 18, (7) 1153-+. 10.1096/fj.03-1308fje

Suzuki K, Murtuza B, Brand NJ, Varela-Carver A, Fukushima S and Yacoub MH (2004). Enhanced effect of myocardial gene transfection by VP22-mediated intercellular protein transport. J Mol Cell Cardiol  vol. 36, (4) 603-606. 10.1016/j.yjmcc.2004.01.007

Murtuza B, Suzuki K, Bou-Gharios G, Beauchamp JR, Smolenski RT, Partridge TA and Yacoub MH (2004). Transplantation of skeletal myoblasts secreting an IL-1 inhibitor modulates adverse remodeling in infarcted murine myocardium. P Natl Acad Sci Usa  vol. 101, (12) 4216-4221. 10.1073/pnas.0306205101

Suzuki K, Murtuza B, Smolenski RT and Yacoub MH (2004). Selective cell dissemination into the heart by retrograde intracoronary infusion in the rat. Transplantation  vol. 77, (5) 757-759. 10.1097/01.TP.0000114482.21064.8F

2003

Murtuza B, Suzuki K and Yacoub MH (2003). Single fiber skeletal muscle transplantation or purified myoblast engraftment? Reply. J Thorac Cardiov Sur  vol. 125, (5) 1182-1182. 10.1067/mtc.2003.289

2002

Suzuki K, Murtuza B, Suzuki N, Khan M, Kaneda Y and Yacoub MH (2002). Human cytomegalovirus immediate-early protein IE2-86, but not IE1-72, causes graft coronary arteriopathy in the transplanted rat heart. Circulation  vol. 106, (13) I158-I162. 10.1161/01.cir.0000032881.55218.db

Suzuki K, Murtuza B, Sammut IA, Latif N, Jayakumar J, Smolenski RT, Kaneda Y, Sawa Y, Matsuda H and Yacoub MH (2002). Heat shock protein 72 enhances manganese superoxide dismutase activity during myocardial ischemia-reperfusion injury, associated with myocardial protection and apoptosis reduction. Circulation  vol. 106, (13) I270-I276. 10.1161/01.cir.0000032880.55215.92

Suzuki K, Murtuza B, Smolenski RT, Suzuki N and Yacoub MH (2002). Development of an in vivo ischemia-reperfusion model in heterotopically transplanted rat hearts. Transplantation  vol. 73, (9) 1398-1402. 10.1097/00007890-200205150-00007

Suzuki K, Murtuza B, Heslop L, Morgan JE, Smolenski RT, Suzuki N, Partridge TA and Yacoub MH (2002). Single fibers of skeletal muscle as a novel graft for cell transplantation to the heart. J Thorac Cardiov Sur  vol. 123, (5) 984-992. 10.1067/mtc.2002.121507

2001

Suzuki K, Latif N, Sammut IA, Jayakumar J, Murtuza B, Ono T and Ono N (2001). Heat shock protein 70-induced cardioprotection involves preservation of manganese superoxide dismutase activity, associated with mitochondrial protection and apoptosis reduction. Circulation  vol. 104, (17) 472-472.

Suzuki K, Khan M, Murtuza B, Ono T, Ono N and Suzuki N (2001). Human cytomegalovirus immediate-early protein IE2, but not IE1, causes graft coronary arteriopathy in the transplanted rat heart. Circulation  vol. 104, (17) 758-758.

Suzuki K, Brand NJ, Allen S, Khan MA, Farrell AO, Murtuza B, El Oakley R and Yacoub MH (2001). Overexpression of connexin 43 in skeletal myoblasts: Relevance to cell transplantation to the heart. J Thorac Cardiov Sur  vol. 122, (4) 759-766. 10.1067/mtc.2001.116210

Suzuki K, Murtuza B, Smolenski RT, Sammut IA, Suzuki N, Kaneda Y and Yacoub MH (2001). Cell transplantation for the treatment of acute myocardial infarction using vascular endothelial growth factor-expressing skeletal myoblasts. Circulation  vol. 104, (12) I207-I212.

Suzuki K, Murtuza B, Suzuki N, Smolenski RT and Yacoub MH (2001). Intracoronary infusion of skeletal myoblasts improves cardiac function in doxorubicin-induced heart failure. Circulation  vol. 104, (12) I213-I217.

Jayakumar J, Suzuki K, Sammut IA, Smolenski RT, Khan M, Latif N, Abunasra H, Murtuza B, Amrani M and Yacoub MH (2001). Heat shock protein 70 gene transfection protects mitochondrial and ventricular function against ischemia-reperfusion injury. Circulation  vol. 104, (12) I303-I307.

Smolenski RT, Raisky O, Slominska EM, Abunasra H, Kalsi KK, Jayakumar J, Suzuki K and Yacoub MH (2001). Protection from reperfusion injury after cardiac transplantation by inhibition of adenosine metabolism and nucleotide precursor supply. Circulation  vol. 104, (12) I246-I252.

Suzuki K, Murtuza B, Smolenski RT, Sammut IA, Suzuki N, Kaneda Y and Yacoub MH (2001). Overexpression of interleukin-1 receptor antagonist provides cardioprotection against ischemia-reperfusion injury associated with reduction in apoptosis. Circulation  vol. 104, (12) I308-I313.

2000

Suzuki K, Murtuza B, Abunasra H and Suzuki N (2000). Infra-coronary infusion of skeletal myoblasts improves cardiac function of doxorubicin-induced heart failure. Circulation  vol. 102, (18) 651-651.

Suzuki K, Murtuza B, Sammut IA, Suzuki N and Smolenski RT (2000). Refinement of cell transplantation to the heart by using VEGF-overexpressing skeletal myoblasts. Circulation  vol. 102, (18) 651-651.

Jayakumar J, Suzuki K, Sammut IA, Smolenski RT, Khan MA, Morrison K, Latif N, Murtuza B, Abunasra H, Amrani M and Amrani M (2000). Hsp70 gene therapy protects both mitochondrial and ventricular function after ischemia-reperfusion injury. Circulation  vol. 102, (18) 464-464.

Suzuki K, Murtuza B, Jayakumar J and Suzuki N (2000). Feasibility of single fiber of skeletal muscle as a novel graft for cell transplantation to the heart. Circulation  vol. 102, (18) 650-650.

Suzuki K, Murtuza B, Sammut IA, Latif N and Suzuki N (2000). Overexpression of IL-1 receptor antagonist provides cardioprotection against ischemia-reperfusion injury associated with reduction in apoptotis. Circulation  vol. 102, (18) 580-580.

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