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Institute of Bioengineering

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Prof Sir Mark Caulfield

Centre Lead for Clinical Pharmacology

Department William Harvey Research Institute
 John Vane Science Centre, Charterhouse Square
Telephone +44 (0)20 7882 3403
Email m.j.caulfield@qmul.ac.uk
Homepage http://www.qmul.ac.uk/whri/people/academic-staff/items/caulfieldmark-.html

IoB Highlights

Group members

Office of the William Harvey/NIHR Barts Biomedical Research Centre Co-Director’s
Claire Birch (Executive Assistant); Nina Ravic (Education Manager); Gerald McLaren (Institute Manager); Steve Coppen (Deputy Institute Manager); John Whiteley (Chief Operating Officer for the NIHR Barts Biomedical Research Centre).

Cardiovascular Genomics
Dr Helen Warren (Statistical Geneticist); Dr Claudia Cabrera (Bioinformatician); Dr Mike Barnes (Director of Bioinformatics); Dr Bori Mifsud (MRC Career Development Fellow from eMedLab). 

William Harvey Clinical Research Centre
Dr Vivienne Monk (Clinical Research Centre Manager); Dr David Collier (Co-Director); Dr Manish Saxena (Clinical Fellow); Dr Julian Shiel (Clinical Fellow), Anne Zak (Senior Nurse Manager); Mary Feely (Feasibility and startup); Marion Benford (Quality Assurance); Mike Taylor (Recruitment); Patrizia Ebano; Jo Hadley; Ania Michalska (Research Sisters).

Summary

Cardiovascular Genomics
Since 1996 he has been National Co-ordinator of the MRC British Genetics of Hypertension (BRIGHT) Study on behalf of 5 UK Universities. He led the hypertension study within the Wellcome Trust Case Control Consortium and has since formed and co-leads the Global BP gen consortium and International Consortium for Blood Pressure Genome-wide Studies which combined the talents of 354 scientists from 224 Institutions from 24 Countries. This work has now identified over 212 genes for blood pressure and 5 genes influencing statin response.

Cardiovascular Clinical Trials
He was on the Steering Group of the Anglo-Scandinavian Cardiac Outcome Trial recruiting 1157 hypertensives. This trial has changed international guidance on lipid lowering and blood pressure treatment. From this Barts and The London now have a major clinical trials programme and a partnership with Quintiles Transnational where we coordinate and enhance clinical research across UCLP Partners Academic Health Sciences Centre.

Research Keywords

Genomics England, Cardiovascular Genomics, hypertension, lipid lowering, statin responses

Research Interests

Professor Sir Mark Caulfield graduated in Medicine in 1984 from the London Hospital Medical College and trained in Clinical Pharmacology at St Bartholomew’s Hospital where he developed a research programme in molecular genetics of hypertension and translational clinical research.

In 2007, 2009 and 2011 his research has been independently rated amongst the top ten scientific discoveries in his field. In 2009 he won the Lily Prize of the British Pharmacology Society, in 2015 he won the Genome Valley Award at BioAsia and in 2016 the Bjorn Folkow Award of the European Society of Hypertension. Since 2008 he directs the NIHR Biomedical Research Centre at Barts. He was appointed Director of William Harvey Research Institute in 2002 and was elected to the Academy of Medical Sciences in 2008 and was President of the British Hypertension Society (2009-2011).

He is an NHS consultant in the Barts Blood Pressure Clinic within the Barts/William Harvey European Society of Hypertension Centre of Excellence. He raised £25m toward the William Harvey Heart Centre which created a translational clinical research centre and was the academic leader that created the Barts Heart Centre bringing 3 hospitals together in 2015 to create the UK’s largest heart centre (includes UCLH Heart Hospital, the London Chest Hospital and Barts). He served on the 2011 NICE Guideline Group for hypertension and leads the Joint UK Societies’ Working Group and Consensus on Renal Denervation. Since 2014 he has been one of the top 200 most highly cited researchers in the world in genomics according to Thomson Reuters. In 2013 he became an NIHR Senior Investigator.

In 2013 he was appointed Chief Scientist for Genomics England, charged with delivery of the 100,000 Genomes Project on whole genome sequencing in rare disease, cancer and infection. As chief scientist Mark leads on all scientific activities for Genomics England. He engages with NHS scientific teams and the general public to promote, explain and enthuse about the 100,000 Genomes Project. He also oversees a coalition of 2500 researchers which comprise the Genomics England Clinical Interpretation Partnership.

Key Publications

Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, Wiggins KL, Avery CL, Griffin P, Feng Q, Taylor KD, Li G, Evans DS, Smith AV, De Keyser CE, Johnson AD, De Craen AJM, Stott DJ, Buckley BM, Ford I, Westendorp RGJ and Slagbo (2014). Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nature Publishing Group  Nature Communications  vol. 5, 10.1038/ncomms6068

Rapsomaniki E, Timmis A, George J, Pujades-Rodriguez M, Shah AD, Denaxas S, White IR, Caulfield MJ, Deanfield JE, Smeeth L, Williams B, Hingorani A and Hemingway H (2014). Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1?25 million people. Lancet  vol. 383, (9932) 1899-1911. 10.1016/S0140-6736(14)60685-1

Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T, Holmes MV, Padmanabhan S, Karczewski KJ, Almoguera B, Barnard J, Baumert J, Chang Y-PC, Elbers CC, Farrall M, Fischer ME, Gaunt TR, Gho JMIH, Gieger C, Goel A, Gong Y, Isaacs A, Kleber ME and (2014). Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. Am J Hum Genet  vol. 94, (3) 349-360. 10.1016/j.ajhg.2013.12.016

Munroe PB, Barnes MR and Caulfield MJ (2013). Advances in blood pressure genomics. Circ Res  vol. 112, (10) 1365-1379. 10.1161/CIRCRESAHA.112.300387

Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M, Morris RW, Tzoulaki I, O'Brien ET, Poulter NR, Sever P, Shields DC, Thom S, Wannamethee SG, Whincup PH, Brown MJ, Connell JM, Dobson RJ, Howard PJ, Mein CA, Onipinla A, Shaw-Hawkins S, Zhang Y and Davey Smit (2011). Blood pressure loci identified with a gene-centric array. Am J Hum Genet  vol. 89, (6) 688-700. 10.1016/j.ajhg.2011.10.013

2019

Cabrera CP, Ng FL, Nicholls HL, Gupta A, Barnes MR, Munroe PB and Caulfield MJ (2019). Over 1,000 genetic loci influencing blood pressure with multiple systems and tissues implicated. Hum Mol Genet  10.1093/hmg/ddz197

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T, Feitosa MF, Masca NGD, Manning AK, Medina-Gomez C, Mudgal P and Ng (2019). Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet  vol. 51, (7) 1191-1192. 10.1038/s41588-019-0447-2

Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM, Biggs ML, Biino G, Catamo E, Concas MP, Ding J, Evans DS, Foco L, Grarup N, Lyytikäinen L-P, Mangino M, Mei H, van der Most PJ, Müller-Nurasyid M, Nelson CP, Qian Y, Repetto L, Said MA and (2019). Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals. J Am Coll Cardiol  vol. 73, (24) 3118-3131. 10.1016/j.jacc.2019.03.519

van Setten J, Verweij N, Mbarek H, Niemeijer MN, Trompet S, Arking DE, Brody JA, Gandin I, Grarup N, Hall LM, Hemerich D, Lyytikäinen L-P, Mei H, Müller-Nurasyid M, Prins BP, Robino A, Smith AV, Warren HR, Asselbergs FW, Boomsma DI, Caulfield MJ, Eijgelsheim M, Ford I and Hansen T (2019). Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits. Eur J Hum Genet  vol. 27, (6) 952-962. 10.1038/s41431-018-0295-z

Sung YJ, de Las Fuentes L, Winkler TW, Chasman DI, Bentley AR, Kraja AT, Ntalla I, Warren HR, Guo X, Schwander K, Manning AK, Brown MR, Aschard H, Feitosa MF, Franceschini N, Lu Y, Cheng C-Y, Sim X, Vojinovic D, Marten J, Musani SK, Kilpeläinen TO, Richard MA, Aslibekyan S and Bart (2019). A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Hum Mol Genet  10.1093/hmg/ddz070

Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL, Fine RS, Guo X, Schurmann C, Lempradl A, Marouli E, Mahajan A, Winkler TW, Locke AE, Medina-Gomez C, Esko T, Vedantam S, Giri A, Lo KS, Alfred T, Mudgal P, Ng MCY, Heard-Costa NL, Feitosa MF and Manning (2019). Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nat Genet  vol. 51, (3) 452-469. 10.1038/s41588-018-0334-2

Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, Datta G, Melbourne CA, Young R, Batini C, Surendran P, Jiang T, Adnan SD, Afaq S, Agrawal A, Altmaier E, Antoniou AC, Asselbergs FW, Baumbach C, Bierut L, Bertelsen S, Boehnke M, Bots ML, Brazel DM, Chambers JC, Chang-Claude J and Che (2019). Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. Mol Psychiatry  10.1038/s41380-018-0313-0

Giri A, Hellwege JN, Keaton JM, Park J, Qiu C, Warren HR, Torstenson ES, Kovesdy CP, Sun YV, Wilson OD, Robinson-Cohen C, Roumie CL, Chung CP, Birdwell KA, Damrauer SM, DuVall SL, Klarin D, Cho K, Wang Y, Evangelou E, Cabrera CP, Wain LV, Shrestha R, Mautz BS, Akwo EA and Sargurupre (2019). Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. Nat Genet  vol. 51, (1) 51-62. 10.1038/s41588-018-0303-9

Marouli E, Del Greco MF, Astley CM, Yang J, Ahmad S, Berndt SI, Caulfield MJ, Evangelou E, McKnight B, Medina-Gomez C, van Vliet-Ostaptchouk JV, Warren HR, Zhu Z, Hirschhorn JN, Loos RJF, Kutalik Z and Deloukas P (2019). Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease. Commun Biol  vol. 2, 10.1038/s42003-019-0361-2

2018

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L and (2018). Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet  vol. 50, (12) 1755-1755. 10.1038/s41588-018-0297-3

CRyPTIC Consortium and the 100 000 Genomes Project , Allix-Béguec C, Arandjelovic I, Bi L, Beckert P, Bonnet M, Bradley P, Cabibbe AM, Cancino-Muñoz I, Caulfield MJ, Chaiprasert A, Cirillo DM, Clifton DA, Comas I, Crook DW, De Filippo MR, de Neeling H, Diel R and Drobniewski (2018). Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing. N Engl J Med  vol. 379, (15) 1403-1415. 10.1056/NEJMoa1800474

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L and (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet  vol. 50, (10) 1412-1425. 10.1038/s41588-018-0205-x

Collier DJ, Juhasz A, Agabiti-Rosei E, Lloyd E, Hisada M, Zhao L, Kupfer S and Caulfield MJ (2018). Efficacy and safety of azilsartan medoxomil/chlortalidone fixed-dose combination in hypertensive patients uncontrolled on azilsartan medoxomil alone: A randomized trial. J Clin Hypertens (Greenwich)  vol. 20, (10) 1473-1484. 10.1111/jch.13376

Robbe P, Popitsch N, Knight SJL, Antoniou P, Becq J, He M, Kanapin A, Samsonova A, Vavoulis DV, Ross MT, Kingsbury Z, Cabes M, Ramos SDC, Page S, Dreau H, Ridout K, Jones LJ, Tuff-Lacey A, Henderson S, Mason J, Buffa FM, Verrill C, Maldonado-Perez D, Roxanis I, Collantes E and Brown (2018). Clinical whole-genome sequencing from routine formalin-fixed, paraffin-embedded specimens: pilot study for the 100,000 Genomes Project. Genet Med  vol. 20, (10) 1196-1205. 10.1038/gim.2017.241

Ng FL, Warren HR and Caulfield MJ (2018). Hypertension genomics and cardiovascular prevention. Ann Transl Med  vol. 6, (15) 291-291. 10.21037/atm.2018.06.34

Whitworth J, Smith PS, Martin J-E, West H, Luchetti A, Rodger F, Clark G, Carss K, Stephens J, Stirrups K, Penkett C, Mapeta R, Ashford S, Megy K, Shakeel H, Ahmed M, Adlard J, Barwell J, Brewer C, Casey RT, Armstrong R, Cole T, Evans DG, Fostira F, Greenhalgh L, Hanson H and Henders (2018). Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes. Am J Hum Genet  vol. 103, (1) 3-18. 10.1016/j.ajhg.2018.04.013

Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N, Cheng C-Y, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Bentley AR, Brown MR, Schwander K, Richard MA, Noordam R, Aschard H, Bartz TM, Bielak LF, Dorajoo R, Fisher V, Hartwig FP and Horimoto AR (2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. Plos One  vol. 13, (6) e0198166-e0198166. 10.1371/journal.pone.0198166

Williams B, MacDonald TM, Morant SV, Webb DJ, Sever P, McInnes GT, Ford I, Cruickshank JK, Caulfield MJ, Padmanabhan S, Mackenzie IS, Salsbury J, Brown MJ and British Hypertension Society programme of Prevention And Treatment of Hypertension With Algorithm ba (2018). Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies. Lancet Diabetes Endocrinol  vol. 6, (6) 464-475. 10.1016/S2213-8587(18)30071-8

Turnbull C, Scott RH, Thomas E, Jones L, Murugaesu N, Pretty FB, Halai D, Baple E, Craig C, Hamblin A, Henderson S, Patch C, O'Neill A, Devereau A, Smith K, Martin AR, Sosinsky A, McDonagh EM, Sultana R, Mueller M, Smedley D, Toms A, Dinh L, Fowler T, Bale M, Hubbard T, Rendon A and H (2018). The 100 000 Genomes Project: bringing whole genome sequencing to the NHS. Bmj  vol. 361, 10.1136/bmj.k1687

Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng C-Y, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Feitosa MF, Kilpeläinen TO, Richard MA, Noordam R, Aslibekyan S, Aschard H, Bartz TM, Dorajoo R and Li (2018). A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet  vol. 102, (3) 375-400. 10.1016/j.ajhg.2018.01.015

Pazoki R, Dehghan A, Evangelou E, Warren H, Gao H, Caulfield M, Elliott P and Tzoulaki I (2018). Genetic Predisposition to High Blood Pressure and Lifestyle Factors: Associations With Midlife Blood Pressure Levels and Cardiovascular Events. Circulation  vol. 137, (7) 653-661. 10.1161/CIRCULATIONAHA.117.030898

McCarthy NS, Vangjeli C, Surendran P, Treumann A, Rooney C, Ho E, Sever P, Thom S, Hughes AD, Munroe PB, Howard P, Johnson T, Caulfield M, Shields DC, O'Brien E, Fitzgerald DJ and Stanton AV (2018). Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A2 formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). Atherosclerosis  vol. 269, 42-49. 10.1016/j.atherosclerosis.2017.12.013

Farmery JHR, Smith ML, NIHR BioResource - Rare Diseases and Lynch AG (2018). Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data. Sci Rep  vol. 8, (1) 10.1038/s41598-017-14403-y

Munroe PB, Jahangir SNS and Caulfield MJ (2018). Genetics and genomics of systemic hypertension. Cardiovascular Genetics and Genomics: Principles and Clinical Practice  10.1007/978-3-319-66114-8_25

Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R, Mifsud B, Munroe PB, Xiao Q, Townsend-Nicholson A, Hobbs AJ, Ye S and Caulfield MJ (2018). The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle. Hum Mol Genet  vol. 27, (1) 199-210. 10.1093/hmg/ddx375

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T, Feitosa MF, Masca NGD, Manning AK, Medina-Gomez C, Mudgal P and Ng (2018). Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet  vol. 50, (1) 26-41. 10.1038/s41588-017-0011-x

2017

Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, Baber U, Ballantyne CM, Bang LE, Benn M, Bis JC, Boehnke M, Boerwinkle E, Bork-Jensen J, Bottinger EP, Brandslund I and B (2017). Exome-wide association study of plasma lipids in >300,000 individuals. Nat Genet  vol. 49, (12) 1758-1766. 10.1038/ng.3977

Márquez-Luna C, Loh P-R, South Asian Type 2 Diabetes (SAT2D) Consortium , SIGMA Type 2 Diabetes Consortium and Price AL (2017). Multiethnic polygenic risk scores improve risk prediction in diverse populations. Genet Epidemiol  vol. 41, (8) 811-823. 10.1002/gepi.22083

MacDonald TM, Williams B, Webb DJ, Morant S, Caulfield M, Cruickshank JK, Ford I, Sever P, Mackenzie IS, Padmanabhan S, McCann GP, Salsbury J, McInnes G, Brown MJ and British Hypertension Society Programme of Prevention And Treatment of Hypertension With Algorithm¿ba (2017). Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double-Blind Randomized Controlled Trial. American Heart Association, Inc., by Wiley.  J Am Heart Assoc  vol. 6, (11) 10.1161/JAHA.117.006986

Kraja AT, Cook JP, Warren HR, Surendran P, Liu C, Evangelou E, Manning AK, Grarup N, Drenos F, Sim X, Smith AV, Amin N, Blakemore AIF, Bork-Jensen J, Brandslund I, Farmaki A-E, Fava C, Ferreira T, Herzig K-H, Giri A, Giulianini F, Grove ML, Guo X, Harris SE, Have CT and Havulinna AS (2017). New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals. Circ Cardiovasc Genet  vol. 10, (5) 10.1161/CIRCGENETICS.117.001778

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P, Liu C, Cook JP, Kraja AT, Drenos F, Loh M, Verweij N, Marten J, Karaman I, Segura Lepe MP, O'Reilly PF, Knight J, Snieder H, Kato N, He J, Tai ES, Said MA, Porteous D, Alver M, Poulter N, Farrall M and G (2017). Corrigendum: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet  vol. 49, (10) 1558-1558. 10.1038/ng1017-1558a

Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP, Warren HR, Rose LM, Verwoert GC, Hottenga J-J, Strawbridge RJ, Esko T, Arking DE, Hwang S-J, Guo X, Kutalik Z, Trompet S, Shrine N, Teumer A, Ried JS, Bis JC, Smith AV, Amin N and Nolt (2017). Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension  10.1161/HYPERTENSIONAHA.117.09438

Dale CE, Fatemifar G, Palmer TM, White J, Prieto-Merino D, Zabaneh D, Engmann JEL, Shah T, Wong A, Warren HR, McLachlan S, Trompet S, Moldovan M, Morris RW, Sofat R, Kumari M, Hyppönen E, Jefferis BJ, Gaunt TR, Ben-Shlomo Y, Zhou A, Gentry-Maharaj A, Ryan A, UCLEB Consortium and M (2017). Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis. Circulation  vol. 135, (24) 2373-2388. 10.1161/CIRCULATIONAHA.116.026560

Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD, Huang J, Sabater-Lleal M, Asselbergs FW, Tregouet D, Shin SY, Ding J, Baumert J, Oudot-Mellakh T, Folkersen L, Smith NL, Williams SM, Ikram MA, Kleber ME, Becker DM, Truong V, Mychaleckyj JC, Tang W, Yang Q, Sennblad B and Moo (2017). Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease. Journal of The American Heart Association  vol. 6, (6) 10.1161/JAHA.116.004918

Sabatine MS, Giugliano RP, Keech AC, Honarpour N, Wiviott SD, Murphy SA, Kuder JF, Wang H, Liu T, Wasserman SM, Sever PS, Pedersen TR and FOURIER Steering Committee and Investigators (2017). Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease. N Engl J Med  vol. 376, (18) 1713-1722. 10.1056/NEJMoa1615664

MUNROE PB, Caulfield M, Stirrups K, van den Berg M, Warren H and Cabrera CP (2017). Discovery of novel heart rate-associated loci using the exome chip. Oxford University Press (Oup)  Human Molecular Genetics  10.1093/hmg/ddx113

Taylor RL, Arno G, Poulter JA, Khan KN, Morarji J, Hull S, Pontikos N, Rueda Martin A, Smith KR, Ali M, Toomes C, McKibbin M, Clayton-Smith J, Grunewald S, Michaelides M, Moore AT, Hardcastle AJ, Inglehearn CF, Webster AR, Black GC and UK Inherited Retinal Disease Consortium an (2017). Association of Steroid 5?-Reductase Type 3 Congenital Disorder of Glycosylation With Early-Onset Retinal Dystrophy. Jama Ophthalmol  vol. 135, (4) 339-347. 10.1001/jamaophthalmol.2017.0046

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P, Liu C, Cook JP, Kraja AT, Drenos F, Loh M, Verweij N, Marten J, Karaman I, Lepe MPS, O'Reilly PF, Knight J, Snieder H, Kato N, He J, Tai ES, Said MA, Porteous D, Alver M, Poulter N, Farrall M and Gansevo (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet  vol. 49, (3) 403-415. 10.1038/ng.3768

Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y, Schurmann C, Highland HM, Rüeger S, Thorleifsson G, Justice AE, Lamparter D, Stirrups KE, Turcot V, Young KL, Winkler TW, Esko T, Karaderi T, Locke AE, Masca NGD, Ng MCY, Mudgal P, Rivas MA, Vedantam S and M (2017). Rare and low-frequency coding variants alter human adult height. Nature  vol. 542, (7640) 186-190. 10.1038/nature21039

Ng FL, Boedtkjer E, Witkowska K, Ren M, Zhang R, Tucker A, Aalkjær C, Caulfield MJ and Ye S (2017). Increased NBCn1 expression, Na+/HCO3- co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension. Hum Mol Genet  10.1093/hmg/ddx015

Carss KJ, Arno G, Erwood M, Stephens J, Sanchis-Juan A, Hull S, Megy K, Grozeva D, Dewhurst E, Malka S, Plagnol V, Penkett C, Stirrups K, Rizzo R, Wright G, Josifova D, Bitner-Glindzicz M, Scott RH, Clement E, Allen L, Armstrong R, Brady AF, Carmichael J, Chitre M and Henderson RHH (2017). Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease. Am J Hum Genet  vol. 100, (1) 75-90. 10.1016/j.ajhg.2016.12.003

Liang F and Caulfield MJ (2017). Status and future of genomics in blood pressure. European Heart Journal  vol. 38, (14) 1011-1013. 10.1093/eurheartj/ehx088

2016

Noordam R, Sitlani CM, Avery CL, Stewart JD, Gogarten SM, Wiggins KL, Trompet S, Warren HR, Sun F, Evans DS, Li X, Li J, Smith AV, Bis JC, Brody JA, Busch EL, Caulfield MJ, Chen Y-DI, Cummings SR, Cupples LA, Duan Q, Franco OH, Méndez-Giráldez R, Harris TB, Heckbert SR and van Heems (2016). A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. J Med Genet  10.1136/jmedgenet-2016-104112

Rathod KS, Jones DA, Van-Eijl TJA, Tsang H, Warren H, Hamshere SM, Kapil V, Jain AK, Deaner A, Poulter N, Caulfield MJ, Mathur A and Ahluwalia A (2016). Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: protocol of the NITRATE-OCT study. Bmj Open  vol. 6, (12) 10.1136/bmjopen-2016-012728

Evangelou E, Warren H, Cabrera C, Gao H, Tzoulaki I, Barnes M, Caulfield M, Elliott P, Grp UKB-CMCBPW, Pressure ICB, Consortium CHARGE, Consortium T-G, Consortium G, Consortium E and Consortium CHDE (2016). UK Biobank GWAS Identifies over 100 Novel Variants Associated with Blood Pressure. Genetic Epidemiology  vol. 40, (7) 613-613.

Ng FL, Boedtkjer E, Ye S and Caulfield M (2016). Blood pressure-associated polymorphisms in SLC4A7 (sodium/bicarbonate co-transporter NBCn1) are linked to gene expression and intracellular pH (pHi) regulation. Journal of Human Hypertension  vol. 30, (10) 636-636.

MUNROE PB (2016). Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension. Nature Publishing Group  Nature Genetics  10.1038/ng.3654

Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S and Caulfield MJ (2016). [OP.7C.08] BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II. J Hypertens  vol. 34 Suppl 2, 10.1097/01.hjh.0000491573.57396.0f

Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC, Chasman DI, de Keyser CE, Deshmukh HA, Evans DS, Feng Q, Li X, Smit RA, Smith AV, Sun F, Taylor KD, Arnold AM, Barnes MR, Barratt BJ, Betteridge J, Boekholdt SM, Boerwinkle E, Buckley BM, Chen YI, de Craen AJ and Cummi (2016). Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. Bmj Publishing Group  Journal of Medical Genetics  10.1136/jmedgenet-2016-103966

Kanoni S, Masca NGD, Stirrups KE, Varga TV, Warren HR, Scott RA, Southam L, Zhang W, Yaghootkar H, Müller-Nurasyid M, Couto Alves A, Strawbridge RJ, Lataniotis L, Hashim NAN, Besse C, Boland A, Braund PS, Connell JM, Dominiczak A, Farmaki A-E, Franks S, Grallert H and Jansson J-H (2016). Analysis with the exome array identifies multiple new independent variants in lipid loci. Oxford University Press (Oup): Policy B - Oxford Open Option B  Human Molecular Genetics  vol. 25, (18) ddw227-ddw227. 10.1093/hmg/ddw227

Zhang R, Witkowska K, Afonso Guerra-Assunção J, Ren M, Ng FL, Mauro C, Tucker AT, Caulfield MJ and Ye S (2016). A blood pressure-associated variant of the SLC39A8 gene influences cellular cadmium accumulation and toxicity. Oxford University Press  Hum Mol Genet  vol. 25, (18) 4117-4126. 10.1093/hmg/ddw236

Yang W, Ng FL, Chan K, Pu X, Poston RN, Ren M, An W, Zhang R, Wu J, Yan S, Situ H, He X, Chen Y, Tan X, Xiao Q, Tucker AT, Caulfield MJ and Ye S (2016). Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction., Editors: Humphries SE. Public Library of Science  Plos Genetics  vol. 12, (7) e1006127-e1006127. 10.1371/journal.pgen.1006127

Sharp ASP, Davies JE, Lobo MD, Bent CL, Mark PB, Burchell AE, Thackray SD, Martin U, McKane WS, Gerber RT, Wilkinson JR, Antonios TF, Doulton TW, Patterson T, Clifford PC, Lindsay A, Houston GJ, Freedman J, Das N, Belli AM, Faris M, Cleveland TJ, Nightingale AK, Hameed A and Mahade (2016). Renal artery sympathetic denervation: observations from the UK experience. Clin Res Cardiol  vol. 105, (6) 544-552. 10.1007/s00392-015-0959-4

Burchell AE, Chan K, Ratcliffe LEK, Hart EC, Saxena M, Collier DJ, Jain AK, Mathur A, Knight CJ, Caulfield MJ, Paton JFR, Nightingale AK, Lobo MD and Baumbach A (2016). Controversies Surrounding Renal Denervation: Lessons Learned From Real-World Experience in Two United Kingdom Centers. J Clin Hypertens (Greenwich)  vol. 18, (6) 585-592. 10.1111/jch.12789

Lessard S, Manning AK, Low-Kam C, Auer PL, Giri A, Graff M, Schurmann C, Yaghootkar H, Luan J, Esko T, Karaderi T, NHLBI GO Exome Sequence Project , GOT2D , T2D-GENES , GIANT Consortium , Bottinger EP, Lu Y, Carlson C, Caulfield M, Dubé M-P, Jackson RD, Kooperberg C and McKnight (2016). Testing the role of predicted gene knockouts in human anthropometric trait variation. Hum Mol Genet  vol. 25, (10) 2082-2092. 10.1093/hmg/ddw055

Bodea CA, Neale BM, Ripke S, Daly MJ, Devlin B and Roeder K (2016). A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies. Elsevier (Cell Press): 6 Month Embargo  American Journal of Human Genetics  vol. 98, (5) 857-868. 10.1016/j.ajhg.2016.02.025

Diver LA, MacKenzie SM, Fraser R, McManus F, Freel EM, Alvarez-Madrazo S, McClure JD, Friel EC, Hanley NA, Dominiczak AF, Caulfield MJ, Munroe PB, Connell JM and Davies E (2016). Common Polymorphisms at the CYP17A1 Locus Associate With Steroid Phenotype: Support for Blood Pressure Genome-Wide Association Study Signals at This Locus. Hypertension  vol. 67, (4) 724-732. 10.1161/hypertensionaha.115.06925

Leusink M, Maitland-van der Zee AH, Ding B, Drenos F, van Iperen EP, Warren HR, Caulfield MJ, Cupples LA, Cushman M, Hingorani AD, Hoogeveen RC, Hovingh GK, Kumari M, Lange LA, Munroe PB, Nyberg F, Schreiner PJ, Sivapalaratnam S, de Bakker PI, de Boer A, Keating BJ and Asselberg (2016). A genetic risk score is associated with statin-induced low-density lipoprotein cholesterol lowering. Pharmacogenomics  vol. 17, (6) 583-591. 10.2217/pgs.16.8

Brown MJ, Williams B, Morant SV, Webb DJ, Caulfield MJ, Cruickshank JK, Ford I, McInnes G, Sever P, Salsbury J, Mackenzie IS, Padmanabhan S, MacDonald TM and British Hypertension Society's Prevention and Treatment of Hypertension with Algorithm-based Therapy (2016). Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial. Lancet Diabetes Endocrinol  vol. 4, (2) 136-147. 10.1016/S2213-8587(15)00377-0

Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, Taliun D, Olden M, Foster M, Yang Q, Chen M-H, Pers TH, Johnson AD, Ko Y-A, Fuchsberger C, Tayo B, Nalls M, Feitosa MF, Isaacs A, Dehghan A, d'Adamo P, Adeyemo A, Dieffenbach AK and Zonderman A (2016). Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat Commun  vol. 7, 10.1038/ncomms10023

2015

Williams B, MacDonald TM, Morant S, Webb DJ, Sever P, McInnes G, Ford I, Cruickshank JK, Caulfield MJ, Salsbury J, Mackenzie I, Padmanabhan S, Brown MJ and British Hypertension Society's PATHWAY Studies Group (2015). Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. Lancet  vol. 386, (10008) 2059-2068. 10.1016/S0140-6736(15)00257-3

Doyle JJ, Doyle AJ, Wilson NK, Habashi JP, Bedja D, Whitworth RE, Lindsay ME, Schoenhoff F, Myers L, Huso N, Bachir S, Squires O, Rusholme B, Ehsan H, Huso D, Thomas CJ, Caulfield MJ, Van Eyk JE, Judge DP, Dietz HC, GenTAC Registry Consortium and MIBAVA Leducq Consortium (2015). A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome. Elife  vol. 4, 10.7554/eLife.08648

Doyle JJ, Doyle AJ, Wilson NK, Habashi JP, Bedja D, Whitworth RE, Lindsay ME, Schoenhoff F, Myers L, Huso N, Bachir S, Squires O, Rusholme B, Ehsan H, Huso D, Thomas CJ, Caulfield MJ, Van Eyk JE, Judge DP, Dietz HC, Consortium GR and Consortium MIBAVAL (2015). A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome. Elife  vol. 4, 10.7554/eLife.08648

Warren H, Sever P, Poulter N, Stanton A, Caulfield M and Munroe P (2015). Pharmacogenetic GWAS meta-analysis of response to antihypertensive drugs. Journal of Human Hypertension  vol. 29, (10) 627-627.

Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S and Caulfield M (2015). Blood-pressure associated variants in NPR3 affect human vascular smooth muscle cells proliferation and calcium response to angiotensin II. Journal of Human Hypertension  vol. 29, (10) 624-624.

Zhang R, Witkowska K, Ng FL, Caulfield M and Ye S (2015). Hypertension related variant of SLC39A8 gene influences cadmium uptake and cell toxicity. Journal of Human Hypertension  vol. 29, (10) 645-645.

Wain LV, Shrine N, Miller S, Jackson VE, Ntalla I, Soler Artigas M, Billington CK, Kheirallah AK, Allen R, Cook JP, Probert K, Obeidat M, Bossé Y, Hao K, Postma DS, Paré PD, Ramasamy A, UK Brain Expression Consortium (UKBEC) , Mägi R, Mihailov E, Reinmaa E, Melén E and O'Connell (2015). Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. Lancet Respir Med  vol. 3, (10) 769-781. 10.1016/S2213-2600(15)00283-0

Poulter NR, Prabhakaran D and Caulfield M (2015). Hypertension. Lancet  vol. 386, (9995) 801-812. 10.1016/S0140-6736(14)61468-9

Treibel TA, Zemrak F, Sado DM, Banypersad SM, White SK, Maestrini V, Barison A, Patel V, Herrey AS, Davies C, Caulfield MJ, Petersen SE and Moon JC (2015). Extracellular volume quantification in isolated hypertension - changes at the detectable limits? J Cardiovasc Magn Reson  vol. 17, 10.1186/s12968-015-0176-3

MacDonald TM, Williams B, Caulfield M, Cruickshank JK, McInnes G, Sever P, Webb DJ, Mackenzie IS, Salsbury J, Morant S, Ford I and Brown MJ (2015). Monotherapy versus dual therapy for the initial treatment of hypertension (PATHWAY-1): a randomised double-blind controlled trial. Bmj Open  vol. 5, (8) 10.1136/bmjopen-2015-007645

Williams B, MacDonald TM, Caulfield M, Cruickshank JK, McInnes G, Sever P, Webb DJ, Salsbury J, Morant S, Ford I and Brown MJ (2015). Prevention And Treatment of Hypertension With Algorithm-based therapy (PATHWAY) number 2: protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension. Bmj Open  vol. 5, (8) 10.1136/bmjopen-2015-008951

Brown MJ, Williams B, MacDonald TM, Caulfield M, Cruickshank JK, McInnes G, Sever P, Webb DJ, Salsbury J, Morant S and Ford I (2015). Comparison of single and combination diuretics on glucose tolerance (PATHWAY-3): protocol for a randomised double-blind trial in patients with essential hypertension. Bmj Open  vol. 5, (8) 10.1136/bmjopen-2015-008086

Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C, Smith AV, Zhang W, Okada Y, Stan¿áková A, Faul JD, Zhao W, Bartz TM, Concas MP, Franceschini N, Enroth S, Vitart V, Trompet S, Guo X, Chasman DI, O'Connel JR, Corre T, Nongmaithem SS, Chen Y and Mang (2015). Directional dominance on stature and cognition in?diverse human populations. Nature  vol. 523, (7561) 459-462. 10.1038/nature14618

Mega JL, Stitziel NO, Smith JG, Chasman DI, Caulfield M, Devlin JJ, Nordio F, Hyde C, Cannon CP, Sacks F, Poulter N, Sever P, Ridker PM, Braunwald E, Melander O, Kathiresan S and Sabatine MS (2015). Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials. Lancet  vol. 385, (9984) 2264-2271. 10.1016/S0140-6736(14)61730-X

Zhang R, Witkowska K, Ng F, Caulfield MJ and Ye S (2015). LB03.08: HYPERTENSION RELATED VARIANT OF SOLUTE CARRIER FAMILY 39 MEMBER 8 GENE INFLUENCES CADMIUM UPTAKE AND CELL TOXICITY. J Hypertens  vol. 33 Suppl 1, 10.1097/01.hjh.0000467698.82617.d6

Yousaf N, Low WY, Onipinla A, Mein C, Caulfield M, Munroe PB and Chernajovsky Y (2015). Differences between disease-associated endoplasmic reticulum aminopeptidase 1 (ERAP1) isoforms in cellular expression, interactions with tumour necrosis factor receptor 1 (TNF-R1) and regulation by cytokines. Clin Exp Immunol  vol. 180, (2) 289-304. 10.1111/cei.12575

Padmanabhan S, Caulfield M and Dominiczak AF (2015). Genetic and molecular aspects of hypertension. Circ Res  vol. 116, (6) 937-959. 10.1161/CIRCRESAHA.116.303647

Cabrera CP, Ng FL, Warren HR, Barnes MR, Munroe PB and Caulfield MJ (2015). Exploring hypertension genome-wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics. Wiley Interdiscip Rev Syst Biol Med  vol. 7, (2) 73-90. 10.1002/wsbm.1290

Huan T, Esko T, Peters MJ, Pilling LC, Schramm K, Schurmann C, Chen BH, Liu C, Joehanes R, Johnson AD, Yao C, Ying S-X, Courchesne P, Milani L, Raghavachari N, Wang R, Liu P, Reinmaa E, Dehghan A, Hofman A, Uitterlinden AG, Hernandez DG, Bandinelli S, Singleton A, Melzer D and Metsp (2015). A meta-analysis of gene expression signatures of blood pressure and hypertension. Plos Genet  vol. 11, (3) 10.1371/journal.pgen.1005035

Kapil V, Khambata RS, Robertson A, Caulfield MJ and Ahluwalia A (2015). Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: A randomized, phase 2, double-blind, placebo-controlled study. Lippincott Williams and Wilkins  Hypertension  vol. 65, (2) 320-327. 10.1161/HYPERTENSIONAHA.114.04675

Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T, Fall T, Ferreira T, Gustafsson S, Kutalik Z, Luan J, Mägi R, Randall JC, Winkler TW, Wood AR, Workalemahu T, Faul JD, Smith JA, Zhao JH, Zhao W and Chen (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature  vol. 518, (7538) 197-206. 10.1038/nature14177

Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH, Fischer K, Justice AE, Workalemahu T, Wu JMW, Buchkovich ML, Heard-Costa NL, Roman TS, Drong AW, Song C, Gustafsson S, Day FR, Esko T, Fall T, Kutalik Z, Luan J, Randall JC and Scherag (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature  vol. 518, (7538) 187-196. 10.1038/nature14132

Kapil V, Khambata RS, Robertson A, Caulfield MJ and Ahluwalia A (2015). Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension  vol. 65, (2) 320-327. 10.1161/HYPERTENSIONAHA.114.04675

Lobo MD, de Belder MA, Cleveland T, Collier D, Dasgupta I, Deanfield J, Kapil V, Knight C, Matson M, Moss J, Paton JFR, Poulter N, Simpson I, Williams B, Caulfield MJ, British Hypertension Society , British Cardiovascular Society and British Cardiovascular Intervention Soci (2015). Joint UK societies' 2014 consensus statement on renal denervation for resistant hypertension. Heart  vol. 101, (1) 10-16. 10.1136/heartjnl-2014-307029

Rautanen A, Mills TC, Gordon AC, Hutton P, Steffens M, Nuamah R, Chiche J-D, Parks T, Chapman SJ, Davenport EE, Elliott KS, Bion J, Lichtner P, Meitinger T, Wienker TF, Caulfield MJ, Mein C, Bloos F, Bobek I, Cotogni P, Sramek V, Sarapuu S, Kobilay M, Ranieri VM, Rello J and Sirgo G (2015). Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. Lancet Respir Med  vol. 3, (1) 53-60. 10.1016/S2213-2600(14)70290-5

Huffman JE, Albrecht E, Teumer A, Mangino M, Kapur K, Johnson T, Kutalik Z, Pirastu N, Pistis G, Lopez LM, Haller T, Salo P, Goel A, Li M, Tanaka T, Dehghan A, Ruggiero D, Malerba G, Smith AV, Nolte IM, Portas L, Phipps-Green A, Boteva L, Navarro P, Johansson A, Hicks AA and Polasek (2015). Modulation of genetic associations with serum urate levels by body-mass-index in humans. Plos One  vol. 10, (3) 10.1371/journal.pone.0119752

2014

Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, Amin N, Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y, Fall T, Fehrmann R, Ferreira T, Jackson AU, Karjalainen J, Lo KS, Locke AE, Mägi R, Mihailov E, Porcu E, Randall JC and Scherag (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics  vol. 46, (11) 1173-1186. 10.1038/ng.3097

Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, Amin N, Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y, Fall T, Fehrmann R, Ferreira T, Jackson AU, Karjalainen J, Lo KS, Locke AE, Mägi R, Mihailov E, Porcu E, Randall JC and Scherag (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet  vol. 46, (11) 1173-1186. 10.1038/ng.3097

Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ, Rebstock A-S, Worthington RJ, Simone MI, Mota F, Rivilla F, Vallejo S, Peiró C, Sánchez Ferrer CF, Djordjevic S, Caulfield MJ, MacAllister RJ, Selwood DL, Ahluwalia A and Hobbs AJ (2014). Endothelial C-type natriuretic peptide maintains vascular homeostasis. J Clin Invest  vol. 124, (9) 4039-4051. 10.1172/JCI74281

Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, Wiggins KL, Avery CL, Griffin P, Feng Q, Taylor KD, Li G, Evans DS, Smith AV, De Keyser CE, Johnson AD, De Craen AJM, Stott DJ, Buckley BM, Ford I, Westendorp RGJ and Slagbo (2014). Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nature Publishing Group  Nature Communications  vol. 5, 10.1038/ncomms6068

Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ, Morley M, Wang X, Johnson AD, Lundby A, Gudbjartsson DF, Noseworthy PA, Eijgelsheim M, Bradford Y, Tarasov KV, Dörr M, Müller-Nurasyid M, Lahtinen AM, Nolte IM, Smith AV, Bis JC and I (2014). Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nat Genet  vol. 46, (8) 826-836. 10.1038/ng.3014

Ganesh SK, Chasman DI, Larson MG, Guo X, Verwoert G, Bis JC, Gu X, Smith AV, Yang M-L, Zhang Y, Ehret G, Rose LM, Hwang S-J, Papanicolau GJ, Sijbrands EJ, Rice K, Eiriksdottir G, Pihur V, Ridker PM, Vasan RS, Newton-Cheh C, Global Blood Pressure Genetics Consortium and Raffel LJ (2014). Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. Am J Hum Genet  vol. 95, (1) 49-65. 10.1016/j.ajhg.2014.06.002

Ganesh SK, Chasman DI, Larson MG, Guo X, Verwoert G, Bis JC, Xiangjun GU, Smith AV, Yang ML, Zhang Y, Ehret G, Rose LM, Hwang SJ, Papanicolau GJ, Sijbrands EJ, Rice K, Eiriksdottir G, Pihur V, Ridker PM, Vasan RS, Newton-Cheh C, Raffel LJ, Amin N, Rotter JI, Liu K, Launer LJ and Ming (2014). Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. American Journal of Human Genetics  vol. 95, (1) 49-65. 10.1016/j.ajhg.2014.06.002

Hoggart CJ, Venturini G, Mangino M, Gomez F, Ascari G, Zhao JH, Teumer A, Winkler TW, Tšernikova N, Luan J, Mihailov E, Ehret GB, Zhang W, Lamparter D, Esko T, Macé A, Rüeger S, Bochud P-Y, Barcella M, Dauvilliers Y, Benyamin B, Evans DM, Hayward C, Lopez MF, Franke L, Russo A and He (2014). Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index. Plos Genet  vol. 10, (7) 10.1371/journal.pgen.1004508

Rapsomaniki E, Timmis A, George J, Pujades-Rodriguez M, Shah AD, Denaxas S, White IR, Caulfield MJ, Deanfield JE, Smeeth L, Williams B, Hingorani A and Hemingway H (2014). Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1?25 million people. Lancet  vol. 383, (9932) 1899-1911. 10.1016/S0140-6736(14)60685-1

Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T, Holmes MV, Padmanabhan S, Karczewski KJ, Almoguera B, Barnard J, Baumert J, Chang Y-PC, Elbers CC, Farrall M, Fischer ME, Gaunt TR, Gho JMIH, Gieger C, Goel A, Gong Y, Isaacs A, Kleber ME and (2014). Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. Am J Hum Genet  vol. 94, (3) 349-360. 10.1016/j.ajhg.2013.12.016

Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MCY, Prokopenko I, Saleheen D, Wang X, Zeggini E, Abecasis GR, Adair LS, Almgren P, Atalay M, Aung T, Baldassarre D, Balkau B, Bao Y, Barnett AH, Barroso I, Basit A, Been LF, Beilby J and Bell GI (2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics  vol. 46, (3) 234-+. 10.1038/ng.2897

Dobson RJB, Munroe PB, Caulfield MJ and Saqi MAS (2014). Protein interaction networks associated with cardiovascular disease and cancer: exploring the effect of bias on shared network properties. International Journal of Data Mining and Bioinformatics  vol. 9, (4) 339-357. 10.1504/IJDMB.2014.062150

Caulfield M (2014). Home Blood Pressure Monitoring: New Evidence for an Expanded Role. Plos Medicine  vol. 11, (1) 10.1371/journal.pmed.1001592

2013

Yadav S, Cotlarciuc I, Munroe PB, Khan MS, Nalls MA, Bevan S, Cheng Y-C, Chen W-M, Malik R, McCarthy NS, Holliday EG, Speed D, Hasan N, Pucek M, Rinne PE, Sever P, Stanton A, Shields DC, Maguire JM, McEvoy M, Scott RJ, Ferrucci L, Macleod MJ, Attia J, Markus HS, Sale MM and Worrall B (2013). Genome-wide analysis of blood pressure variability and ischemic stroke. Stroke  vol. 44, (10) 2703-2709. 10.1161/STROKEAHA.113.002186

Huang C, Ng F, Kapil V, Caulfield M and Lobo M (2013). Prognostic significance of short term blood pressure variability in a tertiary referral centre population. Journal of Human Hypertension  vol. 27, (10) 651-651.

Robinson PJ, Ng FL, Lobo MD, Akker S, Drake WM, Cavlan D and Caulfield MJ (2013). Phaeochromocytoma-paraganglioma syndrome presenting as a para-renal mass: A case report. Journal of Human Hypertension  vol. 27, (10) 654-655.

Thorgeirsson TE, Gudbjartsson DF, Sulem P, Besenbacher S, Styrkarsdottir U, Thorleifsson G, Walters GB, TAG Consortium , Oxford-GSK Consortium , ENGAGE consortium , Furberg H, Sullivan PF, Marchini J, McCarthy MI, Steinthorsdottir V, Thorsteinsdottir U and Stefansson K (2013). A common biological basis of obesity and nicotine addiction. Transl Psychiatry  vol. 3, 10.1038/tp.2013.81

Shah T, Engmann J, Dale C, Shah S, White J, Giambartolomei C, McLachlan S, Zabaneh D, Cavadino A, Finan C, Wong A, Amuzu A, Ong K, Gaunt T, Holmes MV, Warren H, Davies TL, Drenos F, Cooper J, Sofat R, Caulfield M, Ebrahim S, Lawlor DA, Talmud PJ, Humphries SE, Power C, Hypponen E and (2013). Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. Plos One  vol. 8, (8) 10.1371/journal.pone.0071345

Hu Y-J, Berndt SI, Gustafsson S, Ganna A, Genetic Investigation of ANthropometric Traits (GIANT) Consortium , Hirschhorn J, North KE, Ingelsson E and Lin D-Y (2013). Meta-analysis of gene-level associations for rare variants based on single-variant statistics. Am J Hum Genet  vol. 93, (2) 236-248. 10.1016/j.ajhg.2013.06.011

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McManus RJ, Caulfield M and Williams B (2012). NICE hypertension guideline 2011: evidence based evolution. Bmj-British Medical Journal  vol. 344, 10.1136/bmj.e181

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Williams B, Krause T, Lovibond K, Caulfield M and McCormack T (2011). Authors' reply to Harding and colleagues, Taylor, Cruickshank, and El Turabi and Payne. Bmj (Online)  vol. 343, (7827) 10.1136/bmj.d6506

Patel S, Ng FL, Uddin I, Caulfield MJ and Lobo MD (2011). Plasma renin activity in the South Asian population-an intermediate group. J Hum Hypertens  vol. 25, (10) 631-631.

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Patel S, Ng FL, Uddin I, Caulfield MJ and Lobo MD (2011). Salt intake in hypertensive patients with at or above-target blood pressures. J Hum Hypertens  vol. 25, (10) 632-632.

Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Munroe PB, Psaty BM, Caulfield MJ, Rao DC, Tobin MD, Elliott P and van Duijn CM (2011). A large genome-wide association study of pulse pressure and mean arterial pressure reveals seven novel blood pressure LOCI. J Hum Hypertens  vol. 25, (10) 647-647.

McCarthy N, Vangjeli C, Surendran P, Treumann A, Rooney C, Ho E, Sever P, Thom S, Hughes A, Munroe P, Howard P, Johnson T, Caulfield MJ, Shields D, O'Brien E, Fitzgerald D and Stanton A (2011). PPARGC1 beta is a genetic determinant of the cardiovascular risk factor, Thromboxane A2-an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) sub-study. J Hum Hypertens  vol. 25, (10) 625-625.

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Johnson AD, Newton-Cheh C, Chasman DI, Ehret GB, Johnson T, Rose L, Rice K, Verwoert GC, Launer LJ, Gudnason V, Larson MG, Chakravarti A, Psaty BM, Caulfield M, van Duijn CM, Ridker PM, Munroe PB, Levy D and Cohorts for Heart and Aging Research in Genomic Epidemiology Consort (2011). Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals. Hypertension  vol. 57, (5) 903-910. 10.1161/HYPERTENSIONAHA.110.158667

Michell AR, Bodey AR and Caulfield M (2011). Evolution, essential hypertension and the high arterial pressures in certain athletic breeds of dogs. Vet J  vol. 188, (2) 125-127. 10.1016/j.tvjl.2011.03.011

Peden JF, Hopewell JC, Saleheen D, Chambers JC, Hager J, Soranzo N, Collins R, Danesh J, Elliott P, Farrall M, Stirrups K, Zhang WH, Hamsten A, Parish S, Lathrop M, Watkins H, Clarke R, Deloukas P, Kooner JS, Goel A, Ongen H, Strawbridge RJ, Heath S, Malarstig A, Helgadottir A and O (2011). A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat Genet  vol. 43, (4) 339-U89. 10.1038/ng.782

Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, Nalls MA, Clark JM, Mitchell BD, Shuldiner AR, Butler JL, Tomas M, Hoffmann U, Hwang S-J, Massaro JM, O'Donnell CJ, Sahani DV, Salomaa V, Schadt EE and Schwartz (2011). Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. Plos Genet  vol. 7, (3) 10.1371/journal.pgen.1001324

Collier DJ, Poulter NR, Dahlöf B, Sever PS, Wedel H, Buch J, Caulfield MJ and ASCOT Investigators (2011). Impact of amlodipine-based therapy among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA). J Hypertens  vol. 29, (3) 583-591. 10.1097/HJH.0b013e328342c845

Collier DJ, Poulter NR, Dahlöf B, Sever PS, Wedel H, Buch J, Caulfield MJ and ASCOT Investigators (2011). Impact of atorvastatin among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial Lipid-Lowering Arm. J Hypertens  vol. 29, (3) 592-599. 10.1097/HJH.0b013e328342c8f7

Lanktree MB, Guo YR, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen HQ, Nelson CP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, Maloney CM, Lobmeyer MT, Stanton A and Zafarma (2011). Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet  vol. 88, (1) 6-18. 10.1016/j.ajhg.2010.11.007

Chapman N, Chang CL, Caulfield M, Dahlof B, Feder G, Sever PS and Poulter NR (2011). ETHNIC VARIATIONS IN LIPID-LOWERING IN RESPONSE TO A STATIN (EVIREST): A SUBSTUDY OF THE ANGLO-SCANDINAVIAN CARDIAC OUTCOMES TRIAL (ASCOT). Ethnic Dis  vol. 21, (2) 150-157.

2010

Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Boehm M, Mahfoud F, Sievert H, Wunderlich N, Rump LC, Vonend O, Uder M, Lobo M, Caulfield M, Erglis A, Azizi M, Sapoval M, Thambar S, Persu A, Renkin J, Schunkert H, Weil J, Hoppe UC, Walton T, Scheinert D, Binder T and Janusze (2010). Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet  vol. 376, (9756) 1903-1909. 10.1016/S0140-6736(10)62039-9

Sotoodehnia N, Isaacs A, de Bakker PIW, Dorr M, Newton-Cheh C, Nolte IM, van der Harst P, Muller M, Eijgelsheim M, Alonso A, Hicks AA, Padmanabhan S, Hayward C, Smith AV, Polasek O, Giovannone S, Fu JY, Magnani JW, Marciante KD, Pfeufer A, Gharib SA, Teumer A, Li M, Bis JC and Riva (2010). Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet  vol. 42, (12) 1068-U62. 10.1038/ng.716

Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, Ohkubo T, Hiura Y, Tajima A, Morisaki T, Miyata T, Nakayama T, Takashima N, Nakura J, Kawamoto R, Takahashi N, Hata A, Soma M, Imai Y, Kokubo Y, Okamura T, Tomoike H, Iwai N, Ogihara T, Inoue I, Tokunaga K, Johnson T, Caulfield M and Mu (2010). Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project. Hypertension  vol. 56, (5) 973-980. 10.1161/HYPERTENSIONAHA.110.153429

Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Mägi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, Ingelsson E, Willer CJ, Weedon MN, Luan J, Vedantam S, Esko T, Kilpeläinen TO, Kutalik Z and Li (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet  vol. 42, (11) 949-960. 10.1038/ng.685

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM, Luan J, Mägi R, Randall JC, Vedantam S, Winkler TW, Qi L, Workalemahu T, Heid IM, Steinthorsdottir V, Stringham HM, Weedon MN, Wheeler E, Wood AR, Ferreira T, Weyant RJ and Segrè (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet  vol. 42, (11) 937-948. 10.1038/ng.686

Padmanabhan S, Melander O, Johnson T, Di Blasio AM, Lee WK, Gentilini D, Hastie CE, Menni C, Monti MC, Delles C, Laing S, Corso B, Navis G, Kwakernaak AJ, van der Harst P, Bochud M, Maillard M, Burnier M, Hedner T, Kjeldsen S, Wahlstrand B, Sjögren M, Fava C, Montagnana M and Danes (2010). Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. Plos Genet  vol. 6, (10) 10.1371/journal.pgen.1001177

Allen HL, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, Ferreira T, Wood AR, Weyant RJ, Segre AV, Speliotes EK, Wheeler E, Soranzo N, Park JH, Yang J, Gudbjartsson D, Heard-Costa NL, Randall JC, Qi L, Smith AV and Magi (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature  vol. 467, (7317) 832-838. 10.1038/nature09410

Hastie CE, Padmanabhan S, Melander O, Johnson T, Di Blasio AM, Munroe PB, Caulfield M, Zanchetti A, Dominiczak AF and Extreme BP GWAS Collaborations (2010). Genome wide association study of blood pressure extremes identifies variant in uromodulin gene associated with hypertension. J Hum Hypertens  vol. 24, (10) 687-687.

Johnson T, Shaw-Hawkins S, Howard P, Lathrop M, Stanton A, Shields D, Poulter N, Sever P, Munroe PB and Caulfield M (2010). A novel gene locus for blood pressure variability identified by genomewide association scanning in the Anglo-Scandinavian Cardiac Outcome Trial. J Hum Hypertens  vol. 24, (10) 694-694.

Collier DJ, Robson J, Scott R, Will CM, Eldridge SE, Griffiths CJ, Badrick E, Saxena M, Richards S and Caulfield MJ (2010). HiLo: a health services intervention study: methods and interim results on the first 2000 patients at 1 year. J Hum Hypertens  vol. 24, (10) 708-709.

Gupta AK, Poulter NR, Dobson J, Eldridge S, Cappuccio FP, Caulfield M, Collier D, Cruickshank JK, Sever PS, Feder G and ASCOT Investigators (2010). Ethnic Differences in Blood Pressure Response to First and Second-Line Antihypertensive Therapies in Patients Randomized in the ASCOT Trial. Am J Hypertens  vol. 23, (9) 1023-1030. 10.1038/ajh.2010.105

Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, Johansen CT, Fouchier SW, Isaacs A, Peloso GM, Barbalic M, Ricketts SL, Bis JC, Aulchenko YS, Thorleifsson G, Feitosa MF, Chambers J, Orho-Melander M and Me (2010). Biological, clinical and population relevance of 95 loci for blood lipids. Nature  vol. 466, (7307) 707-713. 10.1038/nature09270

Mancia G, Laurent S, Agabiti-Rosei E, Ambrosioni E, Burnier M, Caulfield MJ, Cifkova R, Clément D, Coca A, Dominiczak A, Erdine S, Fagard R, Farsang C, Grassi G, Haller H, Heagerty A, Kjeldsen SE, Kiowski W, Mallion JM, Manolis A, Narkiewicz K, Nilsson P, Olsen MH, Rahn KH and Redo (2010). European guidelines on the management of hypertension: The European Society of Hypertension position statement (2009). Nadcisnienie Tetnicze  vol. 14, (1) 1-47.

Chambers JC, Zhang WH, Lord GM, van der Harst P, Lawlor DA, Sehmi JS, Gale DP, Wass MN, Ahmadi KR, Bakker SJL, Beckmann J, Bilo HJG, Bochud M, Brown MJ, Caulfield MJ, Connell JMC, Cook HT, Cotlarciuc I, Smith GD, de Silva R, Deng GH, Devuyst O, Dikkeschei LD, Dimkovic N and Dockrel (2010). Genetic loci influencing kidney function and chronic kidney disease. Nat Genet  vol. 42, (5) 373-375. 10.1038/ng.566

Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, Middleton L, Berrettini W, Knouff CW, Yuan X, Waeber G, Vollenweider P, Preisig M, Wareham NJ, Zhao JH, Loos RJF, Barroso I, Khaw KT, Grundy S, Barter P, Mahley R, Kesaniemi A, McPherson R, Vincent JB, Strauss J, Kennedy JL and Fa (2010). Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet  vol. 42, (5) 436-U75. 10.1038/ng.572

Craddock N, Hurles ME, Cardin N, Pearson RD, Plagnol V, Robson S, Vukcevic D, Barnes C, Conrad DF, Giannoulatou E, Holmes C, Marchini JL, Stirrups K, Tobin MD, Wain LV, Yau C, Aerts J, Ahmad T, Andrews TD, Arbury H, Attwood A, Auton A, Ball SG, Balmforth AJ, Barrett JC and Barroso I (2010). Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature  vol. 464, (7289) 713-U86. 10.1038/nature08979

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM, Jackson AU, Lim N, Scheet P, Soranzo N, Amin N, Aulchenko YS, Chambers JC, Drong A, Luan JA, Lyon HN, Rivadeneira F, Sanna S, Timpson NJ, Zillikens MC and Zhao (2010). Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution. Plos Genet  vol. 6, (4) 10.1371/journal.pgen.1000508

van der Harst P, Bakker SJL, de Boer RA, Wolffenbuttel BHR, Johnson T, Caulfield MJ and Navis G (2010). Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms. Hum Mol Genet  vol. 19, (2) 387-395. 10.1093/hmg/ddp489

2009

Munroe PB, Johnson T and Caulfield MJ (2009). The genetic architecture of blood pressure variation. Current Cardiovascular Risk Reports  vol. 3, (6) 418-425. 10.1007/s12170-009-0062-3

Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C and E (2009). Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip. Am J Hum Genet  vol. 85, (5) 628-642. 10.1016/j.ajhg.2009.10.014

Mancia G, Laurent S, Agabiti-Rosei E, Ambrosioni E, Burnier M, Caulfield MJ, Cifkova R, Clement D, Coca A, Dominiczak A, Erdine S, Fagard R, Farsang C, Grassi G, Haller H, Heagerty A, Kjeldsen SE, Kiowski W, Mallion JM, Manolis A, Narkiewicz K, Nilsson P, Olsen MH, Rahn KH and Redo (2009). Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. J Hypertens  vol. 27, (11) 2121-2158. 10.1097/HJH.0b013e328333146d

Vidyarthi M, Balakumar Y, Perry I, Berney D, Bhattacharya S, Lobo M, Rull G, Drake WM, Caulfield MJ and Akker SA (2009). Hypokalaemic hypertension due to a rare cause. J Hum Hypertens  vol. 23, (10) 698-698.

Dobson RJB, Munroe PB, Caulfield MJ and Saqi MAS (2009). Global sequence properties for superfamily prediction: a machine learning approach. J Integr Bioinform  vol. 6, (1) 10.2390/biecoll-jib-2009-109

Caulfield M (2009). PREDICTION OF ANTIHYPERTENSIVE RESPONSE - GENOTYPE. Basic Clin Pharmacol  vol. 105, 11-11.

Caulfield M (2009). Atheromatous vascular disease and ischaemic stroke in the UK. J Dent  vol. 37, (8) S579-S581. 10.1016/j.jdent.2009.05.018

Nolte IM, Wallace C, Newhouse SJ, Waggott D, Fu J, Soranzo N, Gwilliam R, Deloukas P, Savelieva I, Zheng D, Dalageorgou C, Farrall M, Samani NJ, Connell J, Brown M, Dominiczak A, Lathrop M, Zeggini E, Wain LV, Wellcome Trust Case Control Consortium and DCCT/EDIC Research Group (2009). Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. Plos One  vol. 4, (7) 10.1371/journal.pone.0006138

Sõber S, Org E, Kepp K, Juhanson P, Eyheramendy S, Gieger C, Lichtner P, Klopp N, Veldre G, Viigimaa M, Döring A, Kooperative Gesundheitsforschung in der Region Augsburg Study , Putku M, Kelgo P, HYPertension in ESTonia Study , Shaw-Hawkins S, Howard P, Onipinla A and Dobson (2009). Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array. Plos One  vol. 4, (6) 10.1371/journal.pone.0006034

Org E, Eyheramendy S, Juhanson P, Gieger C, Lichtner P, Klopp N, Veldre G, Doring A, Viigimaa M, Sober S, Tomberg K, Eckstein G, Kelgo P, Rebane T, Shaw-Hawkins S, Howard P, Onipinla A, Dobson RJ, Newhouse SJ, Brown M, Dominiczak A, Connell J, Samani N, Farrall M, Caulfield MJ and M (2009). Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. Hum Mol Genet  vol. 18, (12) 2288-2296. 10.1093/hmg/ddp135

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM, Jackson AU, Lim N, Scheet P, Soranzo N, Amin N, Aulchenko YS, Chambers JC, Drong A, Luan JA, Lyon HN, Rivadeneira F, Sanna S, Timpson NJ, Zillikens MC and Zhao (2009). Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution. Plos Genet  vol. 5, (6) 10.1371/journal.pgen.1000508

Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S, Papadakis K, Voight BF, Scott LJ, Zhang F, Farrall M, Tanaka T, Wallace C, Chambers JC, Khaw KT, Nilsson P, van der Harst P, Polidoro S, Grobbee DE, Onland-Moret NC and Bots (2009). Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet  vol. 41, (6) 666-676. 10.1038/ng.361

Kolz M, Johnson T, Sanna S, Teumer A, Vitart V, Perola M, Mangino M, Albrecht E, Wallace C, Farrall M, Johansson A, Nyholt DR, Aulchenko Y, Beckmann JS, Bergmann S, Bochud M, Brown M, Campbell H, Connell J, Dominiczak A, Homuth G, Lamina C, McCarthy MI, Meitinger T, Mooser V and Mun (2009). Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations. Plos Genet  vol. 5, (6) 10.1371/journal.pgen.1000504

Newhouse S, Farrall M, Wallace C, Hoti M, Burke B, Howard P, Onipinla A, Lee K, Shaw-Hawkins S, Dobson R, Brown M, Samani NJ, Dominiczak AF, Connell JM, Lathrop GM, Kooner J, Chambers J, Elliott P, Clarke R, Collins R, Laan M, Org E, Juhanson P, Veldre G, Viigimaa M and Eyheramendy (2009). Polymorphisms in the WNK1 Gene Are Associated with Blood Pressure Variation and Urinary Potassium Excretion. Plos One  vol. 4, (4) 10.1371/journal.pone.0005003

Dolan E, Stanton AV, Thom S, Caulfield M, Atkins N, McInnes G, Collier D, Dicker P, O'Brien E and ASCOT Investigators (2009). Ambulatory blood pressure monitoring predicts cardiovascular events in treated hypertensive patients - an Anglo-Scandinavian cardiac outcomes trial substudy. J Hypertens  vol. 27, (4) 876-885. 10.1097/HJH.0b013e328322cd62

Willer CJ, Speliotes EK, Loos RJF, Li SX, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N and (2009). Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet  vol. 41, (1) 25-34. 10.1038/ng.287

Mancia G, Laurent S, Agabiti-Rosei E, Ambrosioni E, Burnier M, Caulfield MJ, Cifkova R, Clement D, Coca A, Dominiczak A, Erdine S, Fagard R, Farsang C, Grassi G, Haller H, Heagerty A, Kjeldsen SE, Kiowski W, Mallion JM, Manolis A, Narkiewicz K, Nilsson P, Olsen MH, Rahn KH and Redo (2009). Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. Blood Pressure  vol. 18, (6) 308-347. 10.3109/08037050903450468

2008

Ostergren J, Poulter NR, Sever PS, Dahlof B, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E and Ascot Invest (2008). The Anglo-Scandinavian Cardiac Outcomes Trial: blood pressure-lowering limb: effects in patients with type II diabetes. J Hypertens  vol. 26, (11) 2103-2111. 10.1097/HJH.0b013e328310e0d9

Samani NJ, Braund PS, Erdmann J, Gotz A, Tomaszewski M, Linsel-Nitschke P, Hajat C, Mangino M, Hengstenberg C, Stark K, Ziegler A, Caulfield M, Burton PR, Schunkert H and Tobin MD (2008). The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol. J Mol Med-Jmm  vol. 86, (11) 1233-1241. 10.1007/s00109-008-0387-2

Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, Galver L, Barrett JC, Grant SFA, Farlow DN, Chandrupatla HR, Hansen M, Ajmal S, Papanicolaou GJ, Guo YR, Li MY, DerOhannessian S, de Bakker PIW, Bailey SD, Montpetit A, Edmondson AC, Taylor K, Gai XW and Wang (2008). Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies. Plos One  vol. 3, (10) 10.1371/journal.pone.0003583

Gupta AK, Poulter NR, Eldridge S, Cappuccio FP, Caulfield MJ, Dobson J, Cruickshank JK, Griffiths CJ, Hemingway H, Sever PS and Feder G (2008). Ethnic differences in blood pressure response to atenolol and amlodipine monotherapy and to add on diuretic and ACE inhibitor dual therapy in hypertensive patients from UK in ASCOT-BPLA. J Hum Hypertens  vol. 22, (10) 726-727.

Caulfield MJ, Munroe PB, O'Neill D, Witkowska K, Charchar FJ, Doblado M, Evans S, Eyheramendy S, Onipinla A, Howard P, Shaw-Hawkins S, Dobson RJ, Wallace C, Newhouse SJ, Brown M, Connell JM, Dominiczak A, Farrall M, Lathrop GM, Samani NJ, Kumari M, Marmot M, Brunner E and Chambers (2008). SLC2A9 Is a High-Capacity Urate Transporter in Humans. Plos Med  vol. 5, (10) 1509-1523. 10.1371/journal.pmed.0050197

Delles C, Padmanabhan S, Lee WK, Miller WH, McBride MW, McClure JD, Brain NJ, Wallace C, Marcano ACB, Schmieder RE, Brown MJ, Caulfield MJ, Munroe PB, Farrall M, Webster J, Connell JM and Dominiczak AF (2008). Glutathione S-transferase variants and hypertension. J Hypertens  vol. 26, (7) 1343-1352. 10.1097/HJH.0b013e3282fe1d67

Tobin MD, Tomaszewski M, Braund PS, Hajat C, Raleigh SM, Palmer TM, Caulfield M, Burton PR and Samani NJ (2008). Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population. Hypertension  vol. 51, (6) 1658-1664. 10.1161/HYPERTENSIONAHA.108.112664

Loos RJF, Lindgren CM, Li SX, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney ASF, Elliott KS and El (2008). Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet  vol. 40, (6) 768-775. 10.1038/ng.140

Weedon MN, Lango H, Lindgren CM, Wallace C, Evans DM, Mangino M, Freathy RM, Perry JRB, Stevens S, Hall AS, Samani NJ, Shields B, Prokopenko I, Farrall M, Dominiczak A, Johnson T, Bergmann S, Beckmann JS, Vollenweider P, Waterworth DM, Mooser V, Palmer CNA, Morris AD and Ouwehand (2008). Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet  vol. 40, (5) 575-583. 10.1038/ng.121

Sever PS, Poulter NR, Dahlof B, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes G, Mehlsen J, Nieminen MS, O'Brien ET, Ostergren J and ASCOT Investigators (2008). The Anglo-Scandinavian Cardiac Outcomes Trial lipid lowering arm: extended observations 2 years after trial closure. Eur Heart J  vol. 29, (4) 499-508. 10.1093/eurheartj/ehm583

Wallace C, Newhouse SJ, Braund P, Zhang F, Tobin M, Falchi M, Ahmadi K, Dobson RJ, Maracano ACB, Hajat C, Burton P, Deloukas P, Brown M, Connell JM, Dominiczak A, Lathrop GM, Webster J, Farrall M, Spector T, Samani NJ, Caulfield MJ, Munroe PB and Wellcome Trust Case Control (2008). Genome-wide association study identifies genes for biomarkers of cardiovascular disease: Serum urate and dyslipiclemia. Am J Hum Genet  vol. 82, (1) 139-149. 10.1016/j.ajhg.2007.11.001

Johnston L, Ester W, Koelega AH, Ranke M, Caliebe J, Caulfield M, Tauber M, Molinas C, Wollmann H, Parodi L, Savage M, van Duijn C and Clark A (2008). Analysis of GDF5-UQCC polymorphism with height in NESTEGG SGA and ISS subjects. Horm Res  vol. 70, 90-90.

2007

Nejentsev S, Howson JMM, Walker NM, Szeszko J, Field SF, Stevens HE, Reynolds P, Hardy M, King E, Masters J, Hulme J, Maier LM, Smyth D, Bailey R, Cooper JD, Ribas G, Campbell RD, Clayton DG, Todd JA and Wellcome Trust Case Control Consortium (2007). Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature  vol. 450, (7171) 887-892. 10.1038/nature06406

Thomson W, Barton A, Ke X, Eyre S, Hinks A, Bowes J, Donn R, Symmons D, Hider S, Bruce IN, Wellcome Trust Case Control Consortium , Wilson AG, Marinou I, Morgan A, Emery P, YEAR Consortium , Carter A, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Strachan D and Worthingto (2007). Rheumatoid arthritis association at 6q23. Nat Genet  vol. 39, (12) 1431-1433. 10.1038/ng.2007.32

Burke B, Gungadoo J, Marçano ACB, Newhouse SJ, Shiel J, Caulfield MJ and Munroe PB (2007). Monogenic Forms of Human Hypertension. Comprehensive Hypertension  10.1016/B978-0-323-03961-1.50039-8

Freel EM, Ingram M, Friel EC, Fraser R, Brown M, Samani NJ, Caulfield M, Munroe P, Farrall M, Webster J, Clayton D, Dominiczak AF, Davies E and Connell JMC (2007). Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study. Clin Endocrinol  vol. 67, (6) 832-838. 10.1111/j.1365-2265.2007.02971.x

Barter PJ, Caulfield M, Eriksson M, Grundy SM, Kastelein JJP, Komajda M, Lopez-Sendon J, Mosca L, Tardif J, Waters DD, Shear CL, Revkin JH, Buhr KA, Fisher MR, Tall AR, Brewer B and ILLUMINATE Investigators (2007). Effects of torcetrapib in patients at high risk for coronary events. New Engl J Med  vol. 357, (21) 2109-2122. 10.1056/NEJMoa0706628

Wallace C, Dobson RJ, Munroe PB and Caulfield MJ (2007). Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates. Genome Res  vol. 17, (11) 1596-1602. 10.1101/gr.5996407

Newport M, Sirugo G, Lyons E, Vannberg F, Hill AVS, Bradbury LA, Farrar C, Pointon JJ, Wordsworth P, Brown MA, Franklyn JA, Heward JM, Simmonds MJ, Gough SC, Seal S, Stratton MR, Rahman N, Ban M, Goris A, Sawcer SJ, Compston A, Conway D, Jallow M, Newport M, Sirugo G, Rockett KA and (2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet  vol. 39, (11) 1329-1337. 10.1038/ng.2007.17

HITMAN GA, Todd JA, Samani NJ, Ouwehand WH, Kwiatkowski DP, Deloukas P, Craddock N, Cardon LR, Donnelly P, Barrett JC, Davison D, Easton D, Evans DM, Leung HT, Duncanson A, McCarthy MI, Burton PR and Clayton DG (2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet  vol. 39, 129-1337. 10.1038/ng.2007.17

Padmanabhan S, Davies E, MacKenzie SM, Lim W, Barr M, Friel EC, Munroe PB, Brown MJ, Samani NJ, Farrall M, Dobson R, Webster J, Lathrop M, Caulfield MJ, Dominiczak AF and Connell JMC (2007). Association of the CYP11B1 and CYP11B2 gene polymorphisms with hypertension in the British Genetics of Hypertension case-control study. J Hum Hypertens  vol. 21, (10) 837-837.

Collier DJ, Davies LC, Bernardi L, Sleight P, Misra S, Shiel J, David CM, Scott B and Caulfield MJ (2007). Baroreceptor function changes with differing blood pressure treatment during the anglo-scandinavian cardiac outcomes trial: principal results from the cardiac autonomic reflex assessment trial (CARAT). J Hum Hypertens  vol. 21, (10) 846-847.

Marcano ACB, Burke B, Gungadoo J, Wallace C, Kaisaki PJ, Woon PY, Farrall M, Clayton D, Brown M, Dominiczak A, Connell JM, Webster J, Lathrop M, Caulfield M, Samani N, Gauguier D and Munroe PB (2007). Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension. J Med Genet  vol. 44, (9) 10.1136/jmg.2007.049718

Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ, Todd JA, Donnelly P, Barrett JC, Davison D, Easton D, Evans D, Leung HT, Marchini JL, Morris AP, Spencer CCA, Tobin MD, Attwood AP, Boorman JP, Cant B and Eve (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature  vol. 447, (7145) 661-678. 10.1038/nature05911

Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JRB, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney ASF and Wellcome Tr (2007). Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science  vol. 316, (5829) 1336-1341. 10.1126/science.1142364

Brown M, Boon N, Brooks N, Camm J, Corris P, Caulfield M, Chilvers E, Ewan P, Gibson J, Griffin G, Grossman A, Hall A, Hart G, Heagerty T, Hodgson H, Home P, Hughes R, Khaw K-T, Lazarus J, Leaper D, Monson J, O'Rahilly S, Rowlands B, Scolding N, Sutton R, Taylor R, Watkins H and Wrigh (2007). Medical training in the UK: sleepwalking to disaster. Lancet  vol. 369, (9574) 1673-1675. 10.1016/S0140-6736(07)60754-5

Genetics of Pre-eclampsia (GOPEC) consortium (2007). Babies, pre-eclamptic mothers and grandparents: a three-generation phenotyping study. J Hypertens  vol. 25, (4) 849-854. 10.1097/HJH.0b013e32803fb634

Brown M, Boon N, Brooks N, Brown E, Camm J, Caulfield M, Chilvers E, Gibson J, Griffin G, Grossman A, Hall A, Hart G, Heagerty T, Home P, Hodgson H, Horton R, Hughes R, Khaw KT, Lazarus J, Leaper D, McCollum P, Monson J, O'Rahilly S, Rowlands B, Scott J, Sutton R, Taylor R and Watkins (2007). Modernising Medical Careers, Medical Training Application Service, and the Postgraduate Medical Education and Training Board: time for the emperors to don their clothes. Lancet  vol. 369, (9566) 967-968. 10.1016/S0140-6736(07)60459-0

Sever P, Dahlöf B, Poulter N, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen S, Kristinsson A, McInnes G, Mehlsen J, Nieminem M, O'Brien E and Ostergren J (2007). Erratum: Potential synergy between lipid-lowering and blood-pressure- lowering in the Anglo-Scandinavian Cardiac Outcomes Trial (European Heart Journal (2006) 27 (2982-2988)). European Heart Journal  vol. 28, (1) 10.1093/eurheartj/ehl453

Barr M, MacKenzie SM, Friel EC, Holloway CD, Wilkinson DM, Brain NJR, Ingram MC, Fraser R, Brown M, Samani NJ, Caulfield M, Munroe PB, Farrall M, Webster J, Clayton D, Dominiczak AF, Connell JMC and Davies E (2007). Polymorphic variation in the 11 beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency. Hypertension  vol. 49, (1) 113-119. 10.1161/01.HYP.0000249904.93940.7a

2006

Sever P, Dahlöf B, Poulter N, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen S, Kristinsson A, McInnes G, Mehlsen J, Nieminem M, O'Brien E, Ostergren J and ASCOT Steering Committee Members (2006). Potential synergy between lipid-lowering and blood-pressure-lowering in the Anglo-Scandinavian Cardiac Outcomes Trial. Eur Heart J  vol. 27, (24) 2982-2988. 10.1093/eurheartj/ehl403

Wallace C, Xue M-Z, Newhouse SJ, Marcano ACB, Onipinla AK, Burke B, Gungadoo J, Dobson RJ, Brown M, Connell JM, Dominiczak A, Lathrop GM, Webster J, Farrall M, Mein C, Samani NJ, Caulfield MJ, Clayton DG and Munroe PB (2006). Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension. Am J Hum Genet  vol. 79, (2) 323-331. 10.1086/506370

Munroe PB, Wallace C, Xue M-Z, Marçano ACB, Dobson RJ, Onipinla AK, Burke B, Gungadoo J, Newhouse SJ, Pembroke J, Brown M, Dominiczak AF, Samani NJ, Lathrop M, Connell J, Webster J, Clayton D, Farrall M, Mein CA, Caulfield M and Medical Research Council British Genetics of Hype (2006). Increased support for linkage of a novel locus on chromosome 5q13 for essential hypertension in the British Genetics of Hypertension Study. Hypertension  vol. 48, (1) 105-111. 10.1161/01.HYP.0000228324.74255.f1

Dobson RJ, Munroe PB, Caulfield MJ and Saqi MA (2006). Predicting deleterious nsSNPs: an analysis of sequence and structural attributes. Bmc Bioinformatics  vol. 7, 10.1186/1471-2105-7-217

Bell JT, Wallace C, Dobson R, Wiltshire S, Mein C, Pembroke J, Brown M, Clayton D, Samani N, Dominiczak A, Webster J, Lathrop GM, Connell J, Munroe P, Caulfield M and Farrall M (2006). Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension. Hum Mol Genet  vol. 15, (8) 1365-1374. 10.1093/hmg/ddl058

Binder A, Garcia E, Wallace C, Kazeem G, Ben-Shlomo Y, Yarnell J, Brown P, Caulfield M, Skrabal F, Kotanko P and Munroe P (2006). Haplotypes of the beta-2 adrenergic receptor associate with high diastolic blood pressure in the Caerphilly prospective study. J Hypertens  vol. 24, (3) 471-477. 10.1097/01.hjh.0000209983.28735.33

2005

Tobin MD, Raleigh SM, Newhouse S, Braund P, Bodycote C, Ogleby J, Cross D, Gracey J, Hayes S, Smith T, Ridge C, Caulfield M, Sheehan NA, Munroe PB, Burton PR and Samani NJ (2005). Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population. Circulation  vol. 112, (22) 3423-3429. 10.1161/CIRCULATIONHA.105.555474

Dahlof B, Sever PS, Poulter NR, Wedel H, Beevers DG, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J and ASCOT Investigators (2005). Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-B. Lancet  vol. 366, (9489) 895-906. 10.1016/S0140-6736(05)67185-1

Poulter NR, Wedel H, Dahlof B, Sever PS, Beevers DG, Caulfield M, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J, Pocock S and ASCOT Investigators (2005). Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA). Lancet  vol. 366, (9489) 907-913. 10.1016/S0140-6736(05)67186-3

GOPEC Consortium (2005). Disentangling fetal and maternal susceptibility for pre-eclampsia: a British multicenter candidate-gene study. Am J Hum Genet  vol. 77, (1) 127-131. 10.1086/431245

Newhouse SJ, Wallace C, Dobson R, Mein C, Pembroke J, Farrall M, Clayton D, Brown M, Samani N, Dominiczak A, Connell JM, Webster J, Lathrop GM, Caulfield M and Munroe PB (2005). Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study. Hum Mol Genet  vol. 14, (13) 1805-1814. 10.1093/hmg/ddi187

Marcano ACB, Onipinla AK, Caulfield MJ and Munroe PB (2005). Recent advances in the identification of genes for human hypertension. Expert Rev Cardiovasc Ther  vol. 3, (4) 733-741. 10.1586/14779072.3.4.733

Sever PS, Poulter NR, Dahlof B, Wedel H, Collins R, Beevers G, Caulfield M, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J and ASCOT Invest (2005). Reduction in cardiovascular events with atorvastatin in 2,532 patients with type 2 diabetes: Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA). Diabetes Care  vol. 28, (5) 1151-1157. 10.2337/diacare.28.5.1151

Newhouse SJ, Huq SM, Arunachalam G, Caulfield MJ and Munroe PB (2005). Genetics of hypertension. Hypertension: Principles and Practice 

Mein CA, Caulfield MJ and Munroe PB (2005). Selection of candidate genes in hypertension.

2004

Lee YW, Oh VMS, Garcia E, Taylor EA, Wu HM, Yap EPH, Kazeem GR, Caulfield MJ and Munroe PB (2004). Haplotypes of the beta 2-adrenegic receptor gene are associated with essential hypertension in a Singaporean Chinese population. J Hypertens  vol. 22, (11) 2111-2116. 10.1097/00004872-200411000-00012

Mein CA, Caulfield MJ, Dobson RJ and Munroe PB (2004). Genetics of essential hypertension. Hum Mol Genet  vol. 13 Spec No 1, R169-R175. 10.1093/hmg/ddh078

Mein CA, Caulfield MJ, Dobson RJ and Munroe PB (2004). Genetics of essential hypertension. Human Molecular Genetics  vol. 13, (REV. ISS. 1)

2003

Kübler W, Ssever P, Dahlöf B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen S, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brian E and Östergren J (2003). Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesteroal concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial - Lipid Lowering Arm (ASCOL-LLA): A multicentre random. Zeitschrift Fur Kardiologie  vol. 92, (7) 10.1007/s00392-003-0967-7

Wilson S, Johnston A, Robson J, Poulter N, Collier D, Feder G and Caulfield MJ (2003). Comparison of methods to identify individuals at increased risk of coronary disease from the general population. Bmj  vol. 326, (7404) 10.1136/bmj.326.7404.1436

Caulfield M, Munroe P, Pembroke J, Samani N, Dominiczak A, Brown M, Benjamin N, Webster J, Ratcliffe P, O'Shea S, Papp J, Taylor E, Dobson R, Knight J, Newhouse S, Hooper J, Lee W, Brain N, Clayton D, Lathrop GM, Farrall M, Connell J and MRC British Genetics of Hypertension Study (2003). Genome-wide mapping of human loci for essential hypertension. Lancet  vol. 361, (9375) 2118-2123. 10.1016/S0140-6736(03)13722-1

Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J and ASCOT Investigators (2003). Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomise. Lancet  vol. 361, (9364) 1149-1158. 10.1016/S0140-6736(03)12948-0

Wilson S, Johnston A, Robson J, Poulter NR, Collier DJ, Feder GS and Caulfield MJ (2003). Predicting coronary risk in the general population--is it necessary to measure high-density lipoprotein cholesterol? J Cardiovasc Risk  vol. 10, (2) 137-141. 10.1097/01.hjr.0000060844.48106.ff

Knight J, Munroe PB, Pembroke JC and Caulfield MJ (2003). Human chromosome 17 in essential hypertension. Ann Hum Genet  vol. 67, (Pt 2) 193-206. 10.1046/j.1469-1809.2003.t01-1-00002.x

Garcia EA, Newhouse S, Caulfield MJ and Munroe PB (2003). Genes and hypertension. Curr Pharm Des  vol. 9, (21) 1679-1689. 10.2174/1381612033454513

2001

Chapman JN, Kirby P, Caulfield MC and Poulter NR (2001). Cardiovascular risk factors in a cohort of 30 000 high-risk men and women in the UK: Cross-sectional, retrospective and prospective studies of screenees for the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). Journal of Human Hypertension  vol. 15, (SUPPL. 1) 10.1038/sj.jhh.1001078

Metherell LA, Akker SA, Munroe PB, Rose SJ, Caulfield M, Savage MO, Chew SL and Clark AJ (2001). Pseudoexon activation as a novel mechanism for disease resulting in atypical growth-hormone insensitivity. Am J Hum Genet  vol. 69, (3) 641-646. 10.1086/323266

Poulter NR, Caulfield M and Feder G (2001). Ethnic variations in response to a statin (EVIREST). J Hum Hypertens  vol. 15, S87-S89. 10.1038/sj.jhh.1001213

Kirby PL, Caulfield MC, Collier DJ, Eldridge S, Griffiths CG, Hemingway H, Poulter NR, Feder GS and Anglo-Scandinavian Cardiac Outcomes Trial (2001). Differential response to amlodipine and atenolol mono-therapy for hypertension by ethnic group. J Hum Hypertens  vol. 15 Suppl 1, S61-S64. 10.1038/sj.jhh.1001080

Chapman JN, Kirby P, Caulfield MC and Poulter NR (2001). Cardiovascular risk factors in a cohort of 30,000 high-risk men and women in the UK: cross-sectional, retrospective and prospective studies of screenees for the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). J Hum Hypertens  vol. 15, S23-S26. 10.1038/sj.jhh.1001078

Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J and ASCOT Steering Comm (2001). Anglo-Scandinavian Cardiac Outcomes Trial: a brief history, rationale and outline protocol. J Hum Hypertens  vol. 15, S11-S12. 10.1038/sj.jhh.1001212

Wilson S, Collier D, Johnston A, Poulter N, Feder G, Robson J, Caulfield M and Anglo-Scandinavian Cardiac Outcomes Trial (2001). Evaluation of cardiovascular risk equations using the ASCOT cohort. J Hum Hypertens  vol. 15 Suppl 1, S31-S33. 10.1038/sj.jhh.1001084

O'Brien E, McInnes GT, Stanton A, Thom S, Caulfield M, Atkins N and Nichol FM (2001). Ambulatory blood pressure monitoring and 24-h blood pressure control as predictors of outcome in treated hypertensive patients. J Hum Hypertens  vol. 15, S47-S51. 10.1038/sj.jhh.1001076

Collier DJ, Bernardi L, Angell-James JE, Caulfield MJ, Sleight P and Anglo-Scandinavian Cardiac Outcomes Trial (2001). Baroreflex sensitivity and heart rate variability as predictors of cardiovascular outcome in hypertensive patients with multiple risk factors for coronary disease. J Hum Hypertens  vol. 15 Suppl 1, S57-S60. 10.1038/sj.jhh.1001077

White PC, Agarwal AK, Li AR, Nikkila H, Pratt JH, Caulfield M, Clark A, McTernan C and Stewart PM (2001). Possible association but no linkage of the HSD11B2 gene encoding the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase to hypertension in Black people. Clin Endocrinol  vol. 55, (2) 249-252. 10.1046/j.1365-2265.2001.01314.x

Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J and ASCOT Investigators (2001). Rationale, design, methods and baseline demography of participants of the Anglo-Scandinavian cardiac outcomes trial. J Hypertens  vol. 19, (6) 1139-1147. 10.1097/00004872-200106000-00020

Sever PS, Dahlöf B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, McInnes GT, Mehlsen J, Nieminen M, O'Brien E and Ostergren J (2001). Anglo-Scandinavian cardiac outcomes trial: A brief history, rationale and outline protocol. Journal of Human Hypertension  vol. 15, (SUPPL. 1) 10.1038/sj.jhh.1001212

Caulfield MJ (2001). Genes for common diseases. Brit J Clin Pharmaco  vol. 51, (1) 1-3. 10.1046/j.1365-2125.2001.01343.x

2000

Munroe PB and Caulfield MJ (2000). Genetics of hypertension. Curr Opin Genet Dev  vol. 10, (3) 325-329. 10.1016/S0959-437X(00)00081-2

Munroe PB, Knight J and Caulfield MJ (2000). 1990-2000: progress in determining high blood pressure genes. Ann Acad Med Singapore  vol. 29, (3) 357-363.

Munroe P, Sandhu M, Jadhav D, Knight J, Clark A and Caulfield M (2000). No association of the epithelial sodium channel beta-subunit T594M variant with essential hypertension in an African Caribbean population. J Hypertens  vol. 18, S178-S178.

1998

O'Byrne S and Caulfield M (1998). Genetics of hypertension. Therapeutic implications. Drugs  vol. 56, (2) 203-214. 10.2165/00003495-199856020-00004

Munroe PB, Strautnieks SS, Farrall M, Daniel HI, Lawson M, DeFreitas P, Fogarty P, Gardiner RM and Caulfield M (1998). Absence of linkage of the epithelial sodium channel to hypertension in black Caribbeans. Am J Hypertens  vol. 11, (8 Pt 1) 942-945. 10.1016/s0895-7061(98)00092-2

Caulfield M and Cafferkey M (1998). Gene therapy: The possibilities and the problems. International Journal of Pharmaceutical Medicine  vol. 12, (1) 5-7.

Brand E, Chatelain N, Keavney B, Caulfield M, Citterio L, Connell J, Grobbee D, Schmidt S, Schunkert H, Schuster H, Sharma AM and Soubrier F (1998). Evaluation of the angiotensinogen locus in human essential hypertension: a European study. Hypertension  vol. 31, (3) 725-729. 10.1161/01.hyp.31.3.725

1997

Kotanko P, Binder A, Tasker J, DeFreitas P, Kamdar S, Clark AJ, Skrabal F and Caulfield M (1997). Essential hypertension in African Caribbeans associates with a variant of the beta2-adrenoceptor. Hypertension  vol. 30, (4) 773-776. 10.1161/01.hyp.30.4.773

Daniel HI, Munroe PB, Kamdar SM, Lawson M, Lavender P, Forgaty P and Caulfield MJ (1997). The atrial natriuretic peptide gene and essential hypertension in African-Caribbeans from St Vincent and the Grenadines. J Hum Hypertens  vol. 11, (2) 113-117. 10.1038/sj.jhh.1000389

1995

Caulfield M and Newell-Price J (1995). The angiotensin converting enzyme gene in cardiovascular disease. Br Heart J  vol. 74, (3) 207-208. 10.1136/hrt.74.3.207

Caulfield M, Lavender P, Newell-Price J, Farrall M, Kamdar S, Daniel H, Lawson M, De Freitas P, Fogarty P and Clark AJ (1995). Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans. J Clin Invest  vol. 96, (2) 687-692. 10.1172/JCI118111

Mattu RK, Needham EW, Galton DJ, Frangos E, Clark AJ and Caulfield M (1995). A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study. Circulation  vol. 91, (2) 270-274. 10.1161/01.cir.91.2.270

1994

Brown MJ and Clayton D (1994). Linkage of the angiotensinogen gene to essential hypertension. N Engl J Med  vol. 331, (16) 1096-1097. 10.1056/NEJM199410203311615

Caulfield M, Lavender P, Farrall M, Munroe P, Lawson M, Turner P and Clark AJ (1994). Linkage of the angiotensinogen gene to essential hypertension. N Engl J Med  vol. 330, (23) 1629-1633. 10.1056/NEJM199406093302301

1992

Raveendran R, Heybroek W, Caulfield M, Lawson M, Abrams SM, Wrigley PF, Slevin M and Turner P (1992). Indomethacin and protein binding of methotrexate. Hum Exp Toxicol  vol. 11, (4) 291-293. 10.1177/096032719201100411

Raveendran R, Heybroek WM, Caulfield M, Abrams SM, Wrigley PF, Slevin M and Turner P (1992). Protein binding of indomethacin, methotrexate and morphine in patients with cancer. Int J Clin Pharmacol Res  vol. 12, (3) 117-122.

1990

Caulfield MJ, Dilkes MG, Iles RK, Handel BT and Oliver RT (1990). Rapid diagnosis of testicular choriocarcinoma by urinary pregnancy tests. Lancet  vol. 335, (8699) 10.1016/0140-6736(90)92761-6

Heybroek WM, Caulfield M, Johnston A and Turner P (1990). Automatic on-line extraction coupled with electrochemical detection as an improved method for the HPLC co-analysis of codeine and morphine in plasma and gastric juice. J Pharm Biomed Anal  vol. 8, (8-12) 1021-1027. 10.1016/0731-7085(90)80163-j

1988

Jenkins BJ, Caulfield MJ, Fowler CG, Badenoch DF, Tiptaft RC, Paris AM, Hope-Stone HF, Oliver RT and Blandy JP (1988). Reappraisal of the role of radical radiotherapy and salvage cystectomy in the treatment of invasive (T2/T3) bladder cancer. Br J Urol  vol. 62, (4) 343-346. 10.1111/j.1464-410x.1988.tb04362.x

Blandy JP, Jenkins BJ, Fowler CG, Caulfield M, Badenoch DF, England HR, Hope-Stone HF, Mair GM, Mantell BS and Oliver RT (1988). Radical radiotherapy and salvage cystectomy for T2/3 cancer of the bladder. Prog Clin Biol Res  vol. 260, 447-451.

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