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Institute of Bioengineering

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Prof Sir Mark Caulfield

Co-Director of the WHRI and Professor of Clinical Pharmacology

Department William Harvey Research Institute
 John Vane Science Centre, Charterhouse Square
Telephone +44 (0)20 7882 3403
Email m.j.caulfield@qmul.ac.uk
Homepage https://www.qmul.ac.uk/whri/people/academic-staff/items/caulfieldmark.html

IoB Highlights

Group members

Office of the William Harvey/NIHR Barts Biomedical Research Centre Co-Director’s
Claire Birch (Executive Assistant); Nina Ravic (Education Manager); Gerald McLaren (Institute Manager); Steve Coppen (Deputy Institute Manager); John Whiteley (Chief Operating Officer for the NIHR Barts Biomedical Research Centre).

Cardiovascular Genomics
Dr Helen Warren (Statistical Geneticist); Dr Claudia Cabrera (Bioinformatician); Dr Mike Barnes (Director of Bioinformatics); Dr Bori Mifsud (MRC Career Development Fellow from eMedLab). 

William Harvey Clinical Research Centre
Dr Vivienne Monk (Clinical Research Centre Manager); Dr David Collier (Co-Director); Dr Manish Saxena (Clinical Fellow); Dr Julian Shiel (Clinical Fellow), Anne Zak (Senior Nurse Manager); Mary Feely (Feasibility and startup); Marion Benford (Quality Assurance); Mike Taylor (Recruitment); Patrizia Ebano; Jo Hadley; Ania Michalska (Research Sisters).

Summary

Cardiovascular Genomics
Since 1996 he has been National Co-ordinator of the MRC British Genetics of Hypertension (BRIGHT) Study on behalf of 5 UK Universities. He led the hypertension study within the Wellcome Trust Case Control Consortium and has since formed and co-leads the Global BP gen consortium and International Consortium for Blood Pressure Genome-wide Studies which combined the talents of 354 scientists from 224 Institutions from 24 Countries. This work has now identified over 212 genes for blood pressure and 5 genes influencing statin response.

Cardiovascular Clinical Trials
He was on the Steering Group of the Anglo-Scandinavian Cardiac Outcome Trial recruiting 1157 hypertensives. This trial has changed international guidance on lipid lowering and blood pressure treatment. From this Barts and The London now have a major clinical trials programme and a partnership with Quintiles Transnational where we coordinate and enhance clinical research across UCLP Partners Academic Health Sciences Centre.

Research Keywords

Genomics England, Cardiovascular Genomics, hypertension, lipid lowering, statin responses

Research Interests

Professor Sir Mark Caulfield graduated in Medicine in 1984 from the London Hospital Medical College and trained in Clinical Pharmacology at St Bartholomew’s Hospital where he developed a research programme in molecular genetics of hypertension and translational clinical research.

In 2007, 2009 and 2011 his research has been independently rated amongst the top ten scientific discoveries in his field. In 2009 he won the Lily Prize of the British Pharmacology Society, in 2015 he won the Genome Valley Award at BioAsia and in 2016 the Bjorn Folkow Award of the European Society of Hypertension. Since 2008 he directs the NIHR Biomedical Research Centre at Barts. He was appointed Director of William Harvey Research Institute in 2002 and was elected to the Academy of Medical Sciences in 2008 and was President of the British Hypertension Society (2009-2011).

He is an NHS consultant in the Barts Blood Pressure Clinic within the Barts/William Harvey European Society of Hypertension Centre of Excellence. He raised £25m toward the William Harvey Heart Centre which created a translational clinical research centre and was the academic leader that created the Barts Heart Centre bringing 3 hospitals together in 2015 to create the UK’s largest heart centre (includes UCLH Heart Hospital, the London Chest Hospital and Barts). He served on the 2011 NICE Guideline Group for hypertension and leads the Joint UK Societies’ Working Group and Consensus on Renal Denervation. Since 2014 he has been one of the top 200 most highly cited researchers in the world in genomics according to Thomson Reuters. In 2013 he became an NIHR Senior Investigator.

In 2013 he was appointed Chief Scientist for Genomics England, charged with delivery of the 100,000 Genomes Project on whole genome sequencing in rare disease, cancer and infection. As chief scientist Mark leads on all scientific activities for Genomics England. He engages with NHS scientific teams and the general public to promote, explain and enthuse about the 100,000 Genomes Project. He also oversees a coalition of 2500 researchers which comprise the Genomics England Clinical Interpretation Partnership.

Key Publications

Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, Wiggins KL, Avery CL, Griffin P, Feng Q, Taylor KD, Li G, Evans DS, Smith AV, De Keyser CE, Johnson AD, De Craen AJM, Stott DJ, Buckley BM, Ford I, Westendorp RGJ and Slagbo (2014). Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nature Publishing Group  Nature Communications  vol. 5, 10.1038/ncomms6068

Rapsomaniki E, Timmis A, George J, Pujades-Rodriguez M, Shah AD, Denaxas S, White IR, Caulfield MJ, Deanfield JE, Smeeth L, Williams B, Hingorani A and Hemingway H (2014). Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1?25 million people. Lancet  vol. 383, (9932) 1899-1911. 10.1016/S0140-6736(14)60685-1

Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T, Holmes MV, Padmanabhan S, Karczewski KJ, Almoguera B, Barnard J, Baumert J, Chang Y-PC, Elbers CC, Farrall M, Fischer ME, Gaunt TR, Gho JMIH, Gieger C, Goel A, Gong Y, Isaacs A, Kleber ME and (2014). Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. Am J Hum Genet  vol. 94, (3) 349-360. 10.1016/j.ajhg.2013.12.016

Munroe PB, Barnes MR and Caulfield MJ (2013). Advances in blood pressure genomics. Circ Res  vol. 112, (10) 1365-1379. 10.1161/CIRCRESAHA.112.300387

Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M, Morris RW, Tzoulaki I, O'Brien ET, Poulter NR, Sever P, Shields DC, Thom S, Wannamethee SG, Whincup PH, Brown MJ, Connell JM, Dobson RJ, Howard PJ, Mein CA, Onipinla A, Shaw-Hawkins S, Zhang Y and Davey Smit (2011). Blood pressure loci identified with a gene-centric array. Am J Hum Genet  vol. 89, (6) 688-700. 10.1016/j.ajhg.2011.10.013

2020

Wei W, Pagnamenta AT, Gleadall N, Sanchis-Juan A, Stephens J, Broxholme J, Tuna S, Odhams CA, Ambrose JC, Baple EL, Bleda M, Boardman-Pretty F, Boissiere JM, Boustred CR, Caulfield MJ, Chan GC, Craig CEH, Daugherty LC, de Burca A, Devereau A, Elgar G, Foulger RE, Fowler T and Furi (2020). Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans. Nature Communications  vol. 11, (1) 10.1038/s41467-020-15336-3

Ntalla I, Weng L-C, Cartwright JH, Hall AW, Sveinbjornsson G, Tucker NR, Choi SH, Chaffin MD, Roselli C, Barnes MR, Mifsud B, Warren HR, Hayward C, Marten J, Cranley JJ, Concas MP, Gasparini P, Boutin T, Kolcic I, Polasek O, Rudan I, Araujo NM, Lima-Costa MF, Ribeiro ALP and Souza (2020). Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nat Commun  vol. 11, (1) 10.1038/s41467-020-15706-x

Pleguezuelos-Manzano C, Puschhof J, Rosendahl Huber A, van Hoeck A, Wood HM, Nomburg J, Gurjao C, Manders F, Dalmasso G, Stege PB, Paganelli FL, Geurts MH, Beumer J, Mizutani T, Miao Y, van der Linden R, van der Elst S, Ambrose JC, Arumugam P, Baple EL, Bleda M and Boardman-Pret (2020). Mutational signature in colorectal cancer caused by genotoxic pks + E. coli. Nature  vol. 580, (7802) 269-273. 10.1038/s41586-020-2080-8

Pu X, Chan K, Yang W, Xiao Q, Zhang L, Moore AD, Liu C, Webb TR, Caulfield MJ, Samani NJ, Zhu J and Ye S (2020). Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis. Atherosclerosis  vol. 296, 11-17. 10.1016/j.atherosclerosis.2020.01.015

Lloyd KCK, Adams DJ, Baynam G, Beaudet AL, Bosch F, Boycott KM, Braun RE, Caulfield M, Cohn R, Dickinson ME, Dobbie MS, Flenniken AM, Flicek P, Galande S, Gao X, Grobler A, Heaney JD, Herault Y, De Angelis MH, Lupski JR, Lyonnet S, Mallon AM, Mammano F, MacRae CA, McInnes R and McKe (2020). The Deep Genome Project. Genome Biology  vol. 21, (1) 10.1186/s13059-020-1931-9

Cacheiro P, Muñoz-Fuentes V, Murray SA, Dickinson ME, Bucan M, Nutter LMJ, Peterson KA, Haselimashhadi H, Flenniken AM, Morgan H, Westerberg H, Konopka T, Hsu CW, Christiansen A, Lanza DG, Beaudet AL, Heaney JD, Fuchs H, Gailus-Durner V, Sorg T, Prochazka J, Novosadova V and Lell (2020). Human and mouse essentiality screens as a resource for disease gene discovery. Nature Research (Part of Springer Nature)  Nature Communications  vol. 11, (1) 10.1038/s41467-020-14284-2

Siedlinski M, Jozefczuk E, Xu X, Teumer A, Evangelou E, Schnabel RB, Welsh P, Maffia P, Erdmann J, Tomaszewski M, Caulfield MJ, Sattar N, Holmes MV and Guzik TJ (2020). White Blood Cells and Blood Pressure: A Mendelian Randomization Study. Circulation  1307-1317. 10.1161/CIRCULATIONAHA.119.045102

Freeman TM, Wang D, Harris J, Ambrose JC, Arumugam P, Baple EL, Bleda M, Boardman-Pretty F, Boissiere JM, Boustred CR, Caulfield MJ, Chan GC, Craig CEH, Daugherty LC, de Burca A, Devereau A, Elgar G, Foulger RE, Fowler T, Furió-Tarí P, Hackett JM, Halai D, Hamblin A and Henderson (2020). Genomic loci susceptible to systematic sequencing bias in clinical whole genomes. Genome Research  vol. 30, (3) 415-426. 10.1101/gr.255349.119

2019

Marouli E, Del Greco MF, Astley CM, Yang J, Ahmad S, Berndt SI, Caulfield MJ, Evangelou E, McKnight B, Medina-Gomez C, van Vliet-Ostaptchouk JV, Warren HR, Zhu Z, Hirschhorn JN, Loos RJF, Kutalik Z and Deloukas P (2019). Mendelian randomisation analyses find pulmonary factors mediate the effect of height on coronary artery disease. Communications Biology  vol. 2, (1) 10.1038/s42003-019-0361-2

Cabrera CP, Ng F, Nicholls HL, Gupta A, Barnes MR, Munroe PB and Caulfield MJ (2019). Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated. Oxford University Press (Oup)  Human Molecular Genetics  vol. 28, (R2) R151-R161. 10.1093/hmg/ddz197

Martin AR, Williams E, Foulger RE, Leigh S, Daugherty LC, Niblock O, Leong IUS, Smith KR, Gerasimenko O, Haraldsdottir E, Thomas E, Scott RH, Baple E, Tucci A, Brittain H, de Burca A, Ibañez K, Kasperaviciute D, Smedley D, Caulfield M, Rendon A and McDonagh EM (2019). PanelApp crowdsources expert knowledge to establish consensus diagnostic gene panels. Nature Genetics  vol. 51, (11) 1560-1565. 10.1038/s41588-019-0528-2

Czesnikiewicz-Guzik M, Osmenda G, Siedlinski M, Nosalski R, Pelka P, Nowakowski D, Wilk G, Mikolajczyk TP, Schramm-Luc A, Furtak A, Matusik P, Koziol J, Drozdz M, Munoz-Aguilera E, Tomaszewski M, Evangelou E, Caulfield M, Grodzicki T, D'Aiuto F and Guzik TJ (2019). Causal association between periodontitis and hypertension: Evidence from Mendelian randomization and a randomized controlled trial of non-surgical periodontal therapy. European Heart Journal  vol. 40, (42) 3459-3470. 10.1093/eurheartj/ehz646

Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK, Lin K, Zhao JH, Deelen P, Rohde R, Schurmann C, Guo X, Giulianini F, Zhang W, Medina-Gomez C, Karlsson R, Bao Y, Bartz TM, Baumbach C, Biino G, Bixley MJ, Brumat M, Chai J-F, Corre T, Cousminer DL and (2019). Associations of autozygosity with a broad range of human phenotypes. Nature Research (Part of Springer Nature)  Nature Communications  vol. 10, (1) 4957-4957. 10.1038/s41467-019-12283-6

Scott RH, Fowler TA and Caulfield M (2019). Genomic medicine: time for health-care transformation. The Lancet  vol. 394, (10197) 454-456. 10.1016/S0140-6736(19)31796-9

Sung YJ, De Las Fuentes L, Winkler TW, Chasman DI, Bentley AR, Kraja AT, Ntalla I, Warren HR, Guo X, Schwander K, Manning AK, Brown MR, Aschard H, Feitosa MF, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Kilpeläinen TO, Richard MA, Aslibekyan S and Bartz (2019). A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Human Molecular Genetics  vol. 28, (15) 2615-2633. 10.1093/hmg/ddz070

Noordam R, Young WJ, Salman R, Kanters JK, van den Berg ME, van Heemst D, Lin HJ, Barreto SM, Biggs ML, Biino G, Catamo E, Concas MP, Ding J, Evans DS, Foco L, Grarup N, Lyytikäinen LP, Mangino M, Mei H, van der Most PJ, Müller-Nurasyid M, Nelson CP, Qian Y, Repetto L, Said MA and S (2019). Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals. Journal of The American College of Cardiology  vol. 73, (24) 3118-3131. 10.1016/j.jacc.2019.03.519

van Setten J, Verweij N, Mbarek H, Niemeijer MN, Trompet S, Arking DE, Brody JA, Gandin I, Grarup N, Hall LM, Hemerich D, Lyytikäinen LP, Mei H, Müller-Nurasyid M, Prins BP, Robino A, Smith AV, Warren HR, Asselbergs FW, Boomsma DI, Caulfield MJ, Eijgelsheim M, Ford I, Hansen T and (2019). Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits. European Journal of Human Genetics  vol. 27, (6) 952-962. 10.1038/s41431-018-0295-z

Wei W, Tuna S, Keogh MJ, Smith KR, Aitman TJ, Beales PL, Bennett DL, Gale DP, Bitner-Glindzicz MAK, Black GC, Brennan P, Elliott P, Flinter FA, Floto RA, Houlden H, Irving M, Koziell A, Maher ER, Markus HS, Morrell NW, Newman WG, Roberts I, Sayer JA, Smith KGC, Taylor JC and Watkins (2019). Germline selection shapes human mitochondrial DNA diversity. Science (New York, N.Y.)  vol. 364, (6442) 10.1126/science.aau6520

Gorman KM, Meyer E, Grozeva D, Spinelli E, McTague A, Sanchis-Juan A, Carss KJ, Bryant E, Reich A, Schneider AL, Pressler RM, Simpson MA, Debelle GD, Wassmer E, Morton J, Sieciechowicz D, Jan-Kamsteeg E, Paciorkowski AR, King MD, Cross JH, Poduri A, Mefford HC, Scheffer IE and Haa (2019). Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia. American Journal of Human Genetics  vol. 104, (5) 948-956. 10.1016/j.ajhg.2019.03.005

Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL, Fine RS, Guo X, Schurmann C, Lempradl A, Marouli E, Mahajan A, Winkler TW, Locke AE, Medina-Gomez C, Esko T, Vedantam S, Giri A, Lo KS, Alfred T, Mudgal P, Ng MCY, Heard-Costa NL, Feitosa MF and Manning (2019). Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nature Genetics  vol. 51, (3) 452-469. 10.1038/s41588-018-0334-2

Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R and Austi (2019). Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. Lancet Respir Med  vol. 7, (3) 227-238. 10.1016/S2213-2600(18)30409-0

Giri A, Hellwege JN, Keaton JM, Park J, Qiu C, Warren HR, Torstenson ES, Kovesdy CP, Sun YV, Wilson OD, Robinson-Cohen C, Roumie CL, Chung CP, Birdwell KA, Damrauer SM, DuVall SL, Klarin D, Cho K, Wang Y, Evangelou E, Cabrera CP, Wain LV, Shrestha R, Mautz BS, Akwo EA and Sargurupre (2019). Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. Nature Genetics  vol. 51, (1) 51-62. 10.1038/s41588-018-0303-9

Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, Datta G, Melbourne CA, Young R, Batini C, Surendran P, Jiang T, Adnan SD, Afaq S, Agrawal A, Altmaier E, Antoniou AC, Asselbergs FW, Baumbach C, Bierut L, Bertelsen S, Boehnke M, Bots ML, Brazel DM, Chambers JC, Chang-Claude J and Che (2019). Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. Molecular Psychiatry  10.1038/s41380-018-0313-0

Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, Mahajan A, Marouli E, Sivapalaratnam S, Young KL, Alfred T, Feitosa MF, Masca NGD, Manning AK, Medina-Gomez C, Mudgal P and Ng (2019). Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (Nature Genetics, (2018), 50, 1, (26-41), 10.1038/s41588-017-0011-x). Nature Genetics  10.1038/s41588-019-0447-2

Wheway G, Mitchison HM, Ambrose JC, Baple EL, Bleda M, Boardman-Pretty F, Boissiere JM, Boustred CR, Caulfield MJ, Chan GC, Craig CEH, Daugherty LC, de Burca A, Devereau A, Elgar G, Foulger RE, Fowler T, Furió-Tarí P, Hackett JM, Halai D, Holman JE, Hubbard TJP, Jackson R and Kasp (2019). Corrigendum: Opportunities and challenges for molecular understanding of ciliopathies - The 100,000 Genomes Project (Frontiers in Genetics DOI: 10.3389/fgene.2019.00127). Frontiers in Genetics  vol. 10, (MAY) 10.3389/fgene.2019.00569

Marques P, Tufton N, Bhattacharya S, Caulfield M and Akker SA (2019). Hypertension due to a deoxycorticosterone-secreting adrenal tumour diagnosed during pregnancy. Endocrinology, Diabetes and Metabolism Case Reports  vol. 2019, (1) 10.1530/EDM-18-0164

Wheway G, Mitchison HM, Ambrose JC, Baple EL, Bleda M, Boardman-Pretty F, Boissiere JM, Boustred CR, Caulfield MJ, Chan GC, Craig CEH, Daugherty LC, de Burca A, Devereau A, Elgar G, Foulger RE, Fowler T, Furió-Tarí P, Hackett JM, Halai D, Holman JE, Hubbard TJP, Jackson R and Kasp (2019). Opportunities and challenges for molecular understanding of ciliopathies?the 100,000 genomes project. Frontiers in Genetics  vol. 10, (MAR) 10.3389/fgene.2019.00127

Hong Y, Nanthapisal S, Omoyinmi E, Olbrich P, Neth O, Speckmann C, Lucena JM, Gilmour K, Worth A, Genomics England Research Consortium , Klein N, Eleftheriou D and Brogan P (2019). Secondary C1q Deficiency in Activated PI3K? Syndrome Type 2. Front Immunol  vol. 10, 10.3389/fimmu.2019.02589

2018

Brazel DM, Jiang Y, Hughey JM, Turcot V, Zhan X, Gong J, Batini C, Weissenkampen JD, Liu MZ, Surendran P, Young R, Barnes DR, Nielsen SF, Rasheed A, Samuel M, Zhao W, Kontto J, Perola M, Caslake M, de Craen AJM, Trompet S, Uria-Nickelsen M, Malarstig A, Reily DF, Hoek M, Vogt T and J (2018). Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use. Biological Psychiatry  10.1016/j.biopsych.2018.11.024

Farmery JHR, Smith ML, Huissoon A, Furnell A, Mead A, Levine AP, Manzur A, Thrasher A, Greenhalgh A, Parker A, Sanchis-Juan A, Richter A, Gardham A, Lawrie A, Sohal A, Creaser-Myers A, Frary A, Greinacher A, Themistocleous A, Peacock AJ, Marshall A, Mumford A, Rice A and Webster A (2018). Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data. Scientific Reports  vol. 8, (1) 10.1038/s41598-017-14403-y

Farmery JHR, Smith ML, Huissoon A, Furnell A, Mead A, Levine AP, Manzur A, Thrasher A, Greenhalgh A, Parker A, Sanchis-Juan A, Richter A, Gardham A, Lawrie A, Sohal A, Creaser-Myers A, Frary A, Greinacher A, Themistocleous A, Peacock AJ, Marshall A, Mumford A, Rice A and Webster A (2018). Erratum to: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data (Scientific Reports, (2018), 8, 1, (1300), 10.1038/s41598-017-14403-y). Scientific Reports  vol. 8, (1) 10.1038/s41598-018-31524-0

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L and (2018). Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet  vol. 50, (12) 1755-1755. 10.1038/s41588-018-0297-3

CRyPTIC Consortium and the 100 000 Genomes Project , Allix-Béguec C, Arandjelovic I, Bi L, Beckert P, Bonnet M, Bradley P, Cabibbe AM, Cancino-Muñoz I, Caulfield MJ, Chaiprasert A, Cirillo DM, Clifton DA, Comas I, Crook DW, De Filippo MR, de Neeling H, Diel R and Drobniewski (2018). Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing. N Engl J Med  vol. 379, (15) 1403-1415. 10.1056/NEJMoa1800474

Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N, Cabrera CP, Karaman I, Ng FL, Evangelou M, Witkowska K, Tzanis E, Hellwege JN, Giri A, Velez Edwards DR, Sun YV, Cho K, Gaziano JM, Wilson PWF, Tsao PS, Kovesdy CP, Esko T, Mägi R, Milani L and (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics  vol. 50, (10) 1412-1425. 10.1038/s41588-018-0205-x

Collier DJ, Juhasz A, Agabiti-Rosei E, Lloyd E, Hisada M, Zhao L, Kupfer S and Caulfield MJ (2018). Efficacy and safety of azilsartan medoxomil/chlortalidone fixed-dose combination in hypertensive patients uncontrolled on azilsartan medoxomil alone: A randomized trial. Journal of Clinical Hypertension  vol. 20, (10) 1473-1484. 10.1111/jch.13376

Robbe P, Popitsch N, Knight SJL, Antoniou P, Becq J, He M, Kanapin A, Samsonova A, Vavoulis DV, Ross MT, Kingsbury Z, Cabes M, Ramos SDC, Page S, Dreau H, Ridout K, Jones LJ, Tuff-Lacey A, Henderson S, Mason J, Buffa FM, Verrill C, Maldonado-Perez D, Roxanis I, Collantes E and Brown (2018). Clinical whole-genome sequencing from routine formalin-fixed, paraffin-embedded specimens: pilot study for the 100,000 Genomes Project. Genetics in Medicine  vol. 20, (10) 1196-1205. 10.1038/gim.2017.241

Ng FL, Warren HR and Caulfield MJ (2018). Hypertension genomics and cardiovascular prevention. Ann Transl Med  vol. 6, (15) 291-291. 10.21037/atm.2018.06.34

Klintman J, Barmpouti K, Knight SJL, Robbe P, Dreau H, Clifford R, Ridout K, Burns A, Timbs A, Bruce D, Antoniou P, Sosinsky A, Becq J, Bentley D, Hillmen P, Taylor JC, Caulfield M and Schuh AH (2018). Clinical-grade validation of whole genome sequencing reveals robust detection of low-frequency variants and copy number alterations in CLL. British Journal of Haematology  vol. 182, (3) 412-417. 10.1111/bjh.15406

Whitworth J, Smith PS, Martin JE, West H, Luchetti A, Rodger F, Clark G, Carss K, Stephens J, Stirrups K, Penkett C, Mapeta R, Ashford S, Megy K, Shakeel H, Ahmed M, Adlard J, Barwell J, Brewer C, Casey RT, Armstrong R, Cole T, Evans DG, Fostira F, Greenhalgh L, Hanson H and Henderso (2018). Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes. American Journal of Human Genetics  vol. 103, (1) 3-18. 10.1016/j.ajhg.2018.04.013

Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N, Cheng C-Y, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Bentley AR, Brown MR, Schwander K, Richard MA, Noordam R, Aschard H, Bartz TM, Bielak LF, Dorajoo R, Fisher V, Hartwig FP and Horimoto AR (2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. Plos One  vol. 13, (6) e0198166-e0198166. 10.1371/journal.pone.0198166

BROWN MJ (2018). Investigation of the endocrine and haemodynamic changes in resistant hypertension, and its response to spironolactone or amiloride: the PATHWAY-2 mechanisms study. Elsevier  Lancet Diabetes and Endocrinology  vol. 6, (6) 464-475. 10.1016/S2213-8587(18)30071-8

Williams B, MacDonald TM, Morant SV, Webb DJ, Sever P, McInnes GT, Ford I, Cruickshank JK, Caulfield MJ, Padmanabhan S, Mackenzie IS, Salsbury J and Brown MJ (2018). Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies. The Lancet Diabetes and Endocrinology  vol. 6, (6) 464-475. 10.1016/S2213-8587(18)30071-8

Sung YJ, Winkler TW, de las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Feitosa MF, Kilpeläinen TO, Richard MA, Noordam R, Aslibekyan S, Aschard H, Bartz TM, Dorajoo R and Liu (2018). A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. American Journal of Human Genetics  vol. 102, (3) 375-400. 10.1016/j.ajhg.2018.01.015

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Dale CE, Fatemifar G, Palmer TM, White J, Prieto-Merino D, Zabaneh D, Engmann JEL, Shah T, Wong A, Warren HR, McLachlan S, Trompet S, Moldovan M, Morris RW, Sofat R, Kumari M, Hyppönen E, Jefferis BJ, Gaunt TR, Ben-Shlomo Y, Zhou A, Gentry-Maharaj A, Ryan A, Mutsert RD and Noordam (2017). Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis. Circulation  vol. 135, (24) 2373-2388. 10.1161/CIRCULATIONAHA.116.026560

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MUNROE PB, Caulfield M, Stirrups K, van den Berg M, Warren H and Cabrera CP (2017). Discovery of novel heart rate-associated loci using the exome chip. Oxford University Press (Oup)  Human Molecular Genetics  10.1093/hmg/ddx113

Taylor RL, Arno G, Poulter JA, Khan KN, Morarji J, Hull S, Pontikos N, Martin AR, Smith KR, Ali M, Toomes C, McKibbin M, Clayton-Smith J, Grunewald S, Michaelides M, Moore AT, Hardcastle AJ, Inglehearn CF, Webster AR, Black GC, Hall G, Ingram S, Ramsden S, Manson F and Sergouniotis (2017). Association of steroid 5?-reductase type 3 congenital disorder of glycosylation with early-onset retinal dystrophy. Jama Ophthalmology  vol. 135, (4) 339-347. 10.1001/jamaophthalmol.2017.0046

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P, Liu C, Cook JP, Kraja AT, Drenos F, Loh M, Verweij N, Marten J, Karaman I, Lepe MPS, O'Reilly PF, Knight J, Snieder H, Kato N, He J, Tai ES, Said MA, Porteous D, Alver M, Poulter N, Farrall M and Gansevo (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet  vol. 49, (3) 403-415. 10.1038/ng.3768

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Ng FL, Boedtkjer E, Witkowska K, Ren M, Zhang R, Tucker A, Aalkjær C, Caulfield MJ and Ye S (2017). Increased NBCn1 expression, Na+/HCO3- co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension. Hum Mol Genet  10.1093/hmg/ddx015

Carss KJ, Arno G, Erwood M, Stephens J, Sanchis-Juan A, Hull S, Megy K, Grozeva D, Dewhurst E, Malka S, Plagnol V, Penkett C, Stirrups K, Rizzo R, Wright G, Josifova D, Bitner-Glindzicz M, Scott RH, Clement E, Allen L, Armstrong R, Brady AF, Carmichael J, Chitre M and Henderson RHH (2017). Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease. American Journal of Human Genetics  vol. 100, (1) 75-90. 10.1016/j.ajhg.2016.12.003

Liang F and Caulfield MJ (2017). Status and future of genomics in blood pressure. European Heart Journal  vol. 38, (14) 1011-1013. 10.1093/eurheartj/ehx088

2016

Noordam R, Sitlani CM, Avery CL, Stewart JD, Gogarten SM, Wiggins KL, Trompet S, Warren HR, Sun F, Evans DS, Li X, Li J, Smith AV, Bis JC, Brody JA, Busch EL, Caulfield MJ, Chen Y-DI, Cummings SR, Cupples LA, Duan Q, Franco OH, Méndez-Giráldez R, Harris TB, Heckbert SR and van Heems (2016). A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. J Med Genet  10.1136/jmedgenet-2016-104112

Rathod KS, Jones DA, Van-Eijl TJA, Tsang H, Warren H, Hamshere SM, Kapil V, Jain AK, Deaner A, Poulter N, Caulfield MJ, Mathur A and Ahluwalia A (2016). Randomised, double-blind, placebo-controlled study investigating the effects of inorganic nitrate on vascular function, platelet reactivity and restenosis in stable angina: Protocol of the NITRATE-OCT study. Bmj Open  vol. 6, (12) 10.1136/bmjopen-2016-012728

Evangelou E, Warren H, Cabrera C, Gao H, Tzoulaki I, Barnes M, Caulfield M, Elliott P, Grp UKB-CMCBPW, Pressure ICB, Consortium CHARGE, Consortium T-G, Consortium G, Consortium E and Consortium CHDE (2016). UK Biobank GWAS Identifies over 100 Novel Variants Associated with Blood Pressure. Genetic Epidemiology  vol. 40, (7) 613-613.

Ng FL, Boedtkjer E, Ye S and Caulfield M (2016). Blood pressure-associated polymorphisms in SLC4A7 (sodium/bicarbonate co-transporter NBCn1) are linked to gene expression and intracellular pH (pHi) regulation. Journal of Human Hypertension  vol. 30, (10) 636-636.

MUNROE PB (2016). Trans-ancestry meta-analyses identify novel rare and common variants associated with blood pressure and hypertension. Nature Publishing Group  Nature Genetics  10.1038/ng.3654

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2015

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Rautanen A, Mills TC, Gordon AC, Hutton P, Steffens M, Nuamah R, Chiche JD, Parks T, Chapman SJ, Davenport EE, Elliott KS, Bion J, Lichtner P, Meitinger T, Wienker TF, Caulfield MJ, Mein C, Bloos F, Bobek I, Cotogni P, Sramek V, Sarapuu S, Kobilay M, Ranieri VM, Rello J, Sirgo G and (2015). Genome-wide association study of survival from sepsis due to pneumonia: An observational cohort study. The Lancet Respiratory Medicine  vol. 3, (1) 53-60. 10.1016/S2213-2600(14)70290-5

Padmanabhan S, Caulfield M and Dominiczak AF (2015). Genetic and Molecular Aspects of Hypertension. Circulation Research  vol. 116, (6) 937-959. 10.1161/CIRCRESAHA.116.303647

Mega JL, Stitziel NO, Smith JG, Chasman DI, Caulfield MJ, Devlin JJ, Nordio F, Hyde CL, Cannon CP, Sacks FM, Poulter NR, Sever PS, Ridker PM, Braunwald E, Melander O, Kathiresan S and Sabatine MS (2015). Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: An analysis of primary and secondary prevention trials. The Lancet  vol. 385, (9984) 2264-2271. 10.1016/S0140-6736(14)61730-X

MacDonald TM, Williams B, Caulfield M, Kennedy Cruickshank J, McInnes G, Sever P, Webb DJ, MacKenzie IS, Salsbury J, Morant S, Ford I and Brown MJ (2015). Monotherapy versus dual therapy for the initial treatment of hypertension (PATHWAY-1): A randomised doubleblind controlled trial. Bmj Open  vol. 5, (8) 10.1136/bmjopen-2015-007645

Williams B, MacDonald TM, Caulfield M, Kennedy Cruickshank J, McInnes G, Sever P, Webb DJ, Salsbury J, Morant S, Ford I and Brown MJ (2015). Prevention And Treatment of HypertensionWith Algorithm-based therapy (PATHWAY) number 2: Protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension. Bmj Open  vol. 5, (8) 10.1136/bmjopen-2015-008951

Brown MJ, Williams B, MacDonald TM, Caulfield M, Kennedy Cruickshank J, McInnes G, Sever P, Webb DJ, Salsbury J, Morant S and Ford I (2015). Comparison of single and combination diuretics on glucose tolerance (PATHWAY-3): Protocol for a randomised double-blind trial in patients with essential hypertension. Bmj Open  vol. 5, (8) 10.1136/bmjopen-2015-008086

Poulter NR, Prabhakaran D and Caulfield M (2015). Hypertension. The Lancet  vol. 386, (9995) 801-812. 10.1016/S0140-6736(14)61468-9

Williams B, Macdonald TM, Morant S, Webb DJ, Sever P, McInnes G, Ford I, Cruickshank JK, Caulfield MJ, Salsbury J, Mackenzie I, Padmanabhan S and Brown MJ (2015). Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): A randomised, double-blind, crossover trial. The Lancet  vol. 386, (10008) 2059-2068. 10.1016/S0140-6736(15)00257-3

Witkowska K, Ren M and Caulfield M (2015). Genetic Markers in Prediction of Cardiovascular Disease. Early Vascular Aging (Eva): New Directions in Cardiovascular Protection  10.1016/B978-0-12-801387-8.000247

2014

Kapil V, Khambata RS, Robertson A, Caulfield MJ and Ahluwalia A (2014). Dietary Nitrate Provides Sustained Blood Pressure Lowering in Hypertensive Patients: A Randomized, Phase 2, Double-Blind, Placebo-Controlled Study. Lippincott Williams and Wilkins  Hypertension  10.1161/HYPERTENSIONAHA.114.04675

Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, Amin N, Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y, Fall T, Fehrmann R, Ferreira T, Jackson AU, Karjalainen J, Lo KS, Locke AE, Mägi R, Mihailov E, Porcu E, Randall JC and Scherag (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics  vol. 46, (11) 1173-1186. 10.1038/ng.3097

Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ, Rebstock A-S, Worthington RJ, Simone MI, Mota F, Rivilla F, Vallejo S, Peiró C, Sánchez Ferrer CF, Djordjevic S, Caulfield MJ, MacAllister RJ, Selwood DL, Ahluwalia A and Hobbs AJ (2014). Endothelial C-type natriuretic peptide maintains vascular homeostasis. J Clin Invest  vol. 124, (9) 4039-4051. 10.1172/JCI74281

Postmus I, Trompet S, Deshmukh HA, Barnes MR, Li X, Warren HR, Chasman DI, Zhou K, Arsenault BJ, Donnelly LA, Wiggins KL, Avery CL, Griffin P, Feng Q, Taylor KD, Li G, Evans DS, Smith AV, De Keyser CE, Johnson AD, De Craen AJM, Stott DJ, Buckley BM, Ford I, Westendorp RGJ and Slagbo (2014). Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nature Publishing Group  Nature Communications  vol. 5, 10.1038/ncomms6068

Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ, Morley M, Wang X, Johnson AD, Lundby A, Gudbjartsson DF, Noseworthy PA, Eijgelsheim M, Bradford Y, Tarasov KV, Dörr M, Müller-Nurasyid M, Lahtinen AM, Nolte IM, Smith AV, Bis JC and I (2014). Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nat Genet  vol. 46, (8) 826-836. 10.1038/ng.3014

Ganesh SK, Chasman DI, Larson MG, Guo X, Verwoert G, Bis JC, Gu X, Smith AV, Yang M-L, Zhang Y, Ehret G, Rose LM, Hwang S-J, Papanicolau GJ, Sijbrands EJ, Rice K, Eiriksdottir G, Pihur V, Ridker PM, Vasan RS, Newton-Cheh C, Global Blood Pressure Genetics Consortium and Raffel LJ (2014). Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. Am J Hum Genet  vol. 95, (1) 49-65. 10.1016/j.ajhg.2014.06.002

Ganesh SK, Chasman DI, Larson MG, Guo X, Verwoert G, Bis JC, Xiangjun GU, Smith AV, Yang ML, Zhang Y, Ehret G, Rose LM, Hwang SJ, Papanicolau GJ, Sijbrands EJ, Rice K, Eiriksdottir G, Pihur V, Ridker PM, Vasan RS, Newton-Cheh C, Raffel LJ, Amin N, Rotter JI, Liu K, Launer LJ and Ming (2014). Effects of long-term averaging of quantitative blood pressure traits on the detection of genetic associations. American Journal of Human Genetics  vol. 95, (1) 49-65. 10.1016/j.ajhg.2014.06.002

Rapsomaniki E, Timmis A, George J, Pujades-Rodriguez M, Shah AD, Denaxas S, White IR, Caulfield MJ, Deanfield JE, Smeeth L, Williams B, Hingorani A and Hemingway H (2014). Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1?25 million people. Lancet  vol. 383, (9932) 1899-1911. 10.1016/S0140-6736(14)60685-1

Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T, Holmes MV, Padmanabhan S, Karczewski KJ, Almoguera B, Barnard J, Baumert J, Chang Y-PC, Elbers CC, Farrall M, Fischer ME, Gaunt TR, Gho JMIH, Gieger C, Goel A, Gong Y, Isaacs A, Kleber ME and (2014). Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. Am J Hum Genet  vol. 94, (3) 349-360. 10.1016/j.ajhg.2013.12.016

Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MCY, Prokopenko I, Saleheen D, Wang X, Zeggini E, Abecasis GR, Adair LS, Almgren P, Atalay M, Aung T, Baldassarre D, Balkau B, Bao Y, Barnett AH, Barroso I, Basit A, Been LF, Beilby J and Bell GI (2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics  vol. 46, (3) 234-+. 10.1038/ng.2897

Dobson RJB, Munroe PB, Caulfield MJ and Saqi MAS (2014). Protein interaction networks associated with cardiovascular disease and cancer: exploring the effect of bias on shared network properties. International Journal of Data Mining and Bioinformatics  vol. 9, (4) 339-357. 10.1504/IJDMB.2014.062150

Caulfield M (2014). Home Blood Pressure Monitoring: New Evidence for an Expanded Role. Plos Medicine  vol. 11, (1) 10.1371/journal.pmed.1001592

Hoggart CJ, Venturini G, Mangino M, Gomez F, Ascari G, Zhao JH, Teumer A, Winkler TW, Tšernikova N, Luan J, Mihailov E, Ehret GB, Zhang W, Lamparter D, Esko T, Macé A, Rüeger S, Bochud PY, Barcella M, Dauvilliers Y, Benyamin B, Evans DM, Hayward C, Lopez MF, Franke L, Russo A and Hei (2014). Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index. Plos Genetics  vol. 10, (7) 1-12. 10.1371/journal.pgen.1004508

Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, Amin N, Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y, Fall T, Fehrmann R, Ferreira T, Jackson AU, Karjalainen J, Lo KS, Locke AE, MäGi R, Mihailov E, Porcu E, Randall JC and Scherag (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics  10.1038/ng.3097

2013

Yadav S, Cotlarciuc I, Munroe PB, Khan MS, Nalls MA, Bevan S, Cheng Y-C, Chen W-M, Malik R, McCarthy NS, Holliday EG, Speed D, Hasan N, Pucek M, Rinne PE, Sever P, Stanton A, Shields DC, Maguire JM, McEvoy M, Scott RJ, Ferrucci L, Macleod MJ, Attia J, Markus HS, Sale MM and Worrall B (2013). Genome-wide analysis of blood pressure variability and ischemic stroke. Stroke  vol. 44, (10) 2703-2709. 10.1161/STROKEAHA.113.002186

Huang C, Ng F, Kapil V, Caulfield M and Lobo M (2013). Prognostic significance of short term blood pressure variability in a tertiary referral centre population. Journal of Human Hypertension  vol. 27, (10) 651-651.

Robinson PJ, Ng FL, Lobo MD, Akker S, Drake WM, Cavlan D and Caulfield MJ (2013). Phaeochromocytoma-paraganglioma syndrome presenting as a para-renal mass: A case report. Journal of Human Hypertension  vol. 27, (10) 654-655.

Shah T, Engmann J, Dale C, Shah S, White J, Giambartolomei C, McLachlan S, Zabaneh D, Cavadino A, Finan C, Wong A, Amuzu A, Ong K, Gaunt T, Holmes MV, Warren H, Davies TL, Drenos F, Cooper J, Sofat R, Caulfield M, Ebrahim S, Lawlor DA, Talmud PJ, Humphries SE, Power C, Hypponen E and (2013). Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium. Plos One  vol. 8, (8) 10.1371/journal.pone.0071345

Hu YJ, Berndt SI, Gustafsson S, Ganna A, Hirschhorn J, North KE, Ingelsson E, Lin DY, Mägi R, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW and Wood A (2013). Meta-analysis of gene-level associations for rare variants based on single-variant statistics. American Journal of Human Genetics  vol. 93, (2) 236-248. 10.1016/j.ajhg.2013.06.011

Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA, Barnard J, Baumert J, Chang YPC, Elbers CC, Farrall M, Fischer ME, Gaunt NF, Johannes JMI, Gieger C, Gong Y, Isaacs A, Kleber ME, Leach IM, McDonough CW, Meijs MFL, Mellander O, Molony CM and Nolte I (2013). Loci influencing blood pressure identified using a cardiovascular gene-centric array. Human Molecular Genetics  vol. 22, (16) 3394-3395. 10.1093/hmg/ddt177

Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, Christiaens T, Cifkova R, De Backer G, Dominiczak A, Galderisi M, Grobbee DE, Jaarsma T, Kirchhof P, Kjeldsen SE, Laurent S, Manolis AJ, Nilsson PM, Ruilope LM, Schmieder RE, Sirnes PA, Sleight P, Viigimaa M and Waebe (2013). 2013 ESH/ESC guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). European Heart Journal  vol. 34, (28) 2159-2219. 10.1093/eurheartj/eht151

Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, Workalemahu T, Feitosa MF, Croteau-Chonka DC, Day FR, Fall T, Ferreira T, Gustafsson S, Locke AE, Mathieson I, Scherag A, Vedantam S, Wood AR, Liang L, Steinthorsdottir V and T (2013). Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. Plos Genetics  vol. 9, (6) 10.1371/journal.pgen.1003500

Munroe PB, Barnes MR and Caulfield MJ (2013). Advances in blood pressure genomics. Circ Res  vol. 112, (10) 1365-1379. 10.1161/CIRCRESAHA.112.300387

Ghosh SM, Kapil V, Fuentes-Calvo I, Bubb KJ, Pearl V, Milsom AB, Khambata R, Maleki-Toyserkani S, Yousuf M, Benjamin N, Webb AJ, Caulfield MJ, Hobbs AJ and Ahluwalia A (2013). Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential. Hypertension  vol. 61, (5) 1091-1102. 10.1161/HYPERTENSIONAHA.111.00933

Berndt SI, Gustafsson S, Maegi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW, Wood AR, Workalemahu T, Hu Y-J, Lee SH, Liang L, Lin D-Y and (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics  vol. 45, (5) 501-U69. 10.1038/ng.2606

Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA, Barnard J, Baumert J, Chang Y-PC, Elbers CC, Farrall M, Fischer ME, Franceschini N, Gaunt TR, Gho JMIH, Gieger C, Gong Y, Isaacs A, Kleber ME, Leach IM, McDonough CW, Meijs MFL, Mellander O and Molon (2013). Loci influencing blood pressure identified using a cardiovascular gene-centric array. Human Molecular Genetics  vol. 22, (8) 1663-1678. 10.1093/hmg/dds555

Huertas-Vazquez A, Nelson CP, Guo X, Reinier K, Uy-Evanado A, Teodorescu C, Ayala J, Jerger K, Chugh H, Braund PS, Deloukas P, Hall AS, Balmforth AJ, Jones M, Taylor KD, Pulit SL, Newton-Cheh C, Gunson K, Jui J, Rotter JI, Albert CM, Samani NJ, Chugh SS, Aerts J, Ahmad T and Arbury (2013). Novel Loci Associated with Increased Risk of Sudden Cardiac Death in the Context of Coronary Artery Disease. Plos One  vol. 8, (4) 10.1371/journal.pone.0059905

Ehret GB and Caulfield MJ (2013). Genes for blood pressure: an opportunity to understand hypertension. European Heart Journal  vol. 34, (13) 951-961. 10.1093/eurheartj/ehs455

Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, Poston RN, Fang C, Patel A, Senver EC, Shaw-Hawkins S, Willeit J, Liu C, Zhu J, Tucker AT, Xu Q, Caulfield MJ and Ye S (2013). ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant. Am J Hum Genet  vol. 92, (3) 366-374. 10.1016/j.ajhg.2013.01.012

Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, Poston RN, Fang C, Patel A, Senver EC, Shaw-Hawkins S, Willeit J, Liu C, Zhu J, Tucker AT, Xu Q, Caulfield MJ and Ye S (2013). ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant. American Journal of Human Genetics  vol. 92, (3) 366-374. 10.1016/j.ajhg.2013.01.012

Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, Wood AR, Michaëlsson K, Vandenput L, Zgaga L, Yerges-Armstrong LM, McCarthy MI, Dupuis J, Kaakinen M, Kleber ME, Jameson K, Arden N, Raitakari O, Viikari J, Lohman KK and Ferrucc (2013). Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts. Plos Medicine  vol. 10, (2) 10.1371/journal.pmed.1001383

Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D, O'Seaghdha CM, Haller T, Yang Q, Tanaka T, Johnson AD, Kutalik Z, Smith AV, Shi J, Struchalin M, Middelberg RPS, Brown MJ, Gaffo AL, Pirastu N, Li G, Hayward C, Zemunik T, Huffman J and Yengo (2013). Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature Genetics  vol. 45, (2) 145-154. 10.1038/ng.2500

Alvarez-Madrazo S, MacKenzie SM, Davies E, Fraser R, Lee W-K, Brown M, Caulfield MJ, Dominiczak AF, Farrall M, Lathrop M, Hedner T, Melander O, Munroe PB, Samani N, Stewart PM, Wahlstrand B, Webster J, Palmer CNA, Padmanabhan S and Connell JM (2013). Common Polymorphisms in the CYP11B1 and CYP11B2 Genes: Evidence for a Digenic Influence on Hypertension. Hypertension  vol. 61, (1) 232-+. 10.1161/HYPERTENSIONAHA.112.200741

Guo Y, Lanktree MB, Taylor KC, Hakonarson H, Lange LA, Keating BJ, Guo Y, Lanktree MB, Taylor KC, Fairfax BP, Elbers CC, Barnard J, Farrall M, Padmanabhan S, Baumert J, Castillo BA, Gaunt TR, Gong Y, Rajagopalan R, Romaine SPR, Kumari M, Rafelt S, Smith EN, Li YR and Sivapalaratnam (2013). Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Human Molecular Genetics  vol. 22, (1) 184-201. 10.1093/hmg/dds396

Thorgeirsson TE, Gudbjartsson DF, Sulem P, Besenbacher S, Styrkarsdottir U, Thorleifsson G, Walters GB, Furberg H, Sullivan PF, Marchini J, McCarthy MI, Steinthorsdottir V, Thorsteinsdottir U, Stefansson K, Surakka I, Vink JM, Amin N, Geller F, Rafnar T, Esko T, Walter S and Gie (2013). A common biological basis of obesity and nicotine addiction. Translational Psychiatry  vol. 3, 1-7. 10.1038/tp.2013.81

2012

Maller JB, McVean G, Byrnes J, Vukcevic D, Palin K, Su Z, Howson JMM, Auton A, Myers S, Morris A, Pirinen M, Brown MA, Burton PR, Caulfield MJ, Compston A, Farrall M, Hall AS, Hattersley AT, Hill AVS, Mathew CG, Pembrey M, Satsangi J, Stratton MR, Worthington J, Craddock N and Hurle (2012). Bayesian refinement of association signals for 14 loci in 3 common diseases. Nature Genetics  vol. 44, (12) 1294-1301. 10.1038/ng.2435

Eyre S, Bowes J, Diogo D, Lee A, Barton A, Martin P, Zhernakova A, Stahl E, Viatte S, McAllister K, Amos CI, Padyukov L, Toes REM, Huizinga TWJ, Wijmenga C, Trynka G, Franke L, Westra HJ, Alfredsson L, Hu X, Sandor C, De Bakker PIW, Davila S, Khor CC, Heng KK, Andrews R, Edkins S and (2012). High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nature Genetics  vol. 44, (12) 1336-1340. 10.1038/ng.2462

Cooper JD, Simmonds MJ, Walker NM, Burren O, Brand OJ, Guo H, Wallace C, Stevens H, Coleman G, Franklyn JA, Todd JA, Gough SCL, Aerts J, Ahmad T, Arbury H, Attwood A, Auton A, Ball SG, Balmforth AJ, Barnes C, Barrett JC, Barroso I, Barton A, Bennett AJ, Bhaskar S, Blaszczyk K and Bow (2012). Seven newly identified loci for autoimmune thyroid disease. Human Molecular Genetics  vol. 21, (23) 5202-5208. 10.1093/hmg/dds357

Asselbergs FW, Guo Y, van Iperen EPA, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B, Appelman YE, Barnard J, Baumert J, Beitelshees AL, Bhangale TR, Chen Y-DI, Gaunt TR, Gong Y, Hopewell JC, Johnson T, Kleber ME, Langaee TY, Li M, Li YR, Liu K, McDonough CW and M (2012). Large-Scale Gene-Centric Meta-analysis across 32 Studies Identifies Multiple Lipid Loci. American Journal of Human Genetics  vol. 91, (5) 823-838. 10.1016/j.ajhg.2012.08.032

Doyle AJ, Doyle JJ, Bessling SL, Maragh S, Lindsay ME, Schepers D, Gillis E, Mortier G, Homfray T, Sauls K, Norris RA, Huso ND, Leahy D, Mohr DW, Caulfield MJ, Scott AF, Destree A, Hennekam RC, Arn PH, Curry CJ, Van Laer L, McCallion AS, Loeys BL and Dietz HC (2012). Mutations in the TGF-beta repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm. Nature Genetics  vol. 44, (11) 1249-1254. 10.1038/ng.2421

Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Philip Schumm L, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN and Anderse (2012). Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature  vol. 491, (7422) 119-124. 10.1038/nature11582

Chan K, Ng FL, Saxena M, Collier D, Matson M, Jain A, Caulfield M and Lobo M (2012). Renal denervation in resistant hypertension-a prospective case series. Journal of Human Hypertension  vol. 26, (10) 631-631.

Surendran P, Vangjeli C, McCarthy N, Thom S, Sever P, O'Brien E, Poulter N, Mayet J, Hughes A, Caulfield M, Munroe P, Johnson T, Shields D and Stanton A (2012). Genome-wide association analysis identifies the MTHFR-CLCN6-NPPA-NPPB gene cluster as an important influence on BNP levels-implications for the use of BNP levels in the diagnosis and therapeutic monitoring of heart failure-an ASCOT sub study. Journal of Human Hypertension  vol. 26, (10) 620-620.

Saxena M, Collier D, Caulfield M and Lobo M (2012). Patients with resistant hypertension warrant a trial of salt restriction before and after renal denervation (RD). Journal of Human Hypertension  vol. 26, (10) 619-619.

Motterle A, Pu X, Wood H, Xiao Q, Gor S, Ng FL, Chan K, Cross F, Shohreh B, Poston RN, Tucker AT, Caulfield MJ and Ye S (2012). Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells. Hum Mol Genet  vol. 21, (18) 4021-4029. 10.1093/hmg/dds224

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, MäGi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik LJ, Yengo L, Lecoeur C, Shungin D, Sanna S, Sidore C, Johnson PCD, Jukema JW, Johnson T, Mahajan A, Verweij N, Thorleifsson G, Hottenga JJ and (2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics  vol. 44, (9) 991-1005. 10.1038/ng.2385

Islam M, Jafar TH, Wood AR, De Silva NMG, Caulfield M, Chaturvedi N and Frayling TM (2012). Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis. Diabetologia  vol. 55, (8) 2193-2204. 10.1007/s00125-012-2560-y

Okada Y, Sim X, Go MJ, Wu JY, Gu D, Takeuchi F, Takahashi A, Maeda S, Tsunoda T, Chen P, Lim SC, Wong TY, Liu J, Young TL, Aung T, Seielstad M, Teo YY, Kim YJ, Lee JY, Han BG, Kang D, Chen CH, Tsai FJ, Chang LC, Fann SJ, Mei H, Rao DC, Hixson JE, Chen S and Katsuya T (2012). Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nature Genetics  vol. 44, (8) 904-909. 10.1038/ng.2352

Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, Maloney CM, Lobmeyer MT, Stanton A and Zafarmand (2012). Erratum: Meta-analysis of dense genecentric association studies reveals common and uncommon variants associated with height ((The American Journal of Human Genetics (2010) 88 (6-18)). American Journal of Human Genetics  vol. 90, (6) 1116-1117. 10.1016/j.ajhg.2012.05.017

Deshmukh HA, Colhoun HM, Johnson T, McKeigue PM, Betteridge DJ, Durrington PN, Fuller JH, Livingstone S, Charlton-Menys V, Neil A, Poulter N, Sever P, Shields DC, Stanton AV, Chatterjee A, Hyde C, Calle RA, DeMicco DA, Trompet S, Postmus I, Ford I, Jukema JW, Caulfield M and Hitma (2012). Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a). Journal of Lipid Research  vol. 53, (5) 1000-1011. 10.1194/jlr.P021113

Louis-Dit-Picard H, Barc J, Trujillano D, Miserey-Lenkei S, Bouatia-Naji N, Pylypenko O, Beaurain G, Bonnefond A, Sand O, Simian C, Vidal-Petiot E, Soukaseum C, Mandet C, Broux F, Chabre O, Delahousse M, Esnault V, Fiquet B, Houillier P, Bagnis CI, Koenig J, Konrad M and Landais (2012). Erratum: KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron (Nature Genetics (2012) 44 (458-462)). Nature Genetics  vol. 44, (5) 10.1038/ng0512-609

Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A, Castillo BA, Li YR, Johnson T, Bruinenberg M, Gilbert-Diamond D, Rajagopalan R, Voight BF, Balasubramanyam A, Barnard J, Bauer F, Baumert J, Bhangale T, Böhm BO, Braund PS, Burton PR, Chandrupatla HR and C (2012). Erratum: Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci (American Journal of Human Genetics (2012) 90 (410-425)). American Journal of Human Genetics  vol. 90, (4) 10.1016/j.ajhg.2012.03.001

Louis-Dit-Picard H, Barc J, Trujillano D, Miserey-Lenkei S, Bouatia-Naji N, Pylypenko O, Beaurain G, Bonnefond A, Sand O, Simian C, Vidal-Petiot E, Soukaseum C, Mandet C, Broux F, Chabre O, Delahousse M, Esnault V, Fiquet B, Houillier P, Bagnis CI, Koenig J, Konrad M and Landais (2012). KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron. Nature Genetics  vol. 44, (4) 456-+. 10.1038/ng.2218

Dastani Z, Hivert MF, Timpson N, Perry JRB, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, Beekman M, Coassin S, Lohman K, Qi L, Kanoni S, Pankow JS, Uh HW, Wu Y, Bidulescu A, Rasmussen-Torvik LJ and Greenwood (2012). Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals. Plos Genetics  vol. 8, (3) 10.1371/journal.pgen.1002607

Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A, Almoguera Castillo B, Li YR, Johnson T, Bruinenberg M, Gilbert-Diamond D, Rajagopalan R, Voight BF, Balasubramanyam A, Barnard J, Bauer F, Baumert J, Bhangale T, Boehm BO, Braund PS, Burton PR and Chandru (2012). Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci. American Journal of Human Genetics  vol. 90, (3) 410-425. 10.1016/j.ajhg.2011.12.022

Angelakopoulou A, Shah T, Sofat R, Shah S, Berry DJ, Cooper J, Palmen J, Tzoulaki I, Wong A, Jefferis BJ, Maniatis N, Drenos F, Gigante B, Hardy R, Laxton RC, Leander K, Motterle A, Simpson IA, Smeeth L, Thomson A, Verzilli C, Kuh D, Ireland H, Deanfield J, Caulfield M and Wallace C (2012). Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration. Eur Heart J  vol. 33, (3) 393-407. 10.1093/eurheartj/ehr225

Motterle A, Xiao Q, Kiechl S, Pender SLF, Morris GE, Willeit J, Caulfield MJ and Ye S (2012). Influence of matrix metalloproteinase-12 on fibrinogen level. Atherosclerosis  vol. 220, (2) 351-354. 10.1016/j.atherosclerosis.2011.11.003

Salvi E, Kutalik Z, Glorioso N, Benaglio P, Frau F, Kuznetsova T, Arima H, Hoggart C, Tichet J, Nikitin YP, Conti C, Seidlerova J, Tikhonoff V, Stolarz-Skrzypek K, Johnson T, Devos N, Zagato L, Guarrera S, Zaninello R, Calabria A, Stancanelli B, Troffa C, Thijs L, Rizzi F and Simon (2012). Genomewide association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase. Hypertension  vol. 59, (2) 248-255. 10.1161/HYPERTENSIONAHA.111.181990

McManus RJ, Caulfield M and Williams B (2012). NICE hypertension guideline 2011: evidence based evolution. Bmj-British Medical Journal  vol. 344, 10.1136/bmj.e181

Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik LJ, Yengo L, Lecoeur C, Shungin D, Sanna S, Sidore C, Johnson PCD, Jukema JW, Johnson T, Mahajan A, Verweij N, Thorleifsson G and Hottenga J-J (2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics  10.1038/ng.2385

2011

Johnson T, Gaunt TR, Newhouse SJ, Padmanabhan S, Tomaszewski M, Kumari M, Morris RW, Tzoulaki I, O'Brien ET, Poulter NR, Sever P, Shields DC, Thom S, Wannamethee SG, Whincup PH, Brown MJ, Connell JM, Dobson RJ, Howard PJ, Mein CA, Onipinla A, Shaw-Hawkins S, Zhang Y and Davey Smit (2011). Blood pressure loci identified with a gene-centric array. Am J Hum Genet  vol. 89, (6) 688-700. 10.1016/j.ajhg.2011.10.013

Bown MJ, Jones GT, Harrison SC, Wright BJ, Bumpstead S, Baas AF, Gretarsdottir S, Badger SA, Bradley DT, Burnand K, Child AH, Clough RE, Cockerill G, Hafez H, Scott DJA, Futers S, Johnson A, Sohrabi S, Smith A, Thompson MM, van Bockxmeer FM, Waltham M, Matthiasson SE and Thorleifs (2011). Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1. American Journal of Human Genetics  vol. 89, (5) 619-627. 10.1016/j.ajhg.2011.10.002

Chambers JC, Zhang WH, Sehmi J, Li XZ, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng GH, Gieger C, Heard-Costa NL, Hottenga JJ, Kuhnel B, Kumar V, Lagou V, Liang LM, Luan JA, Vidal PM, Leach IM, O'Reilly PF, Peden JF, Rahmioglu N, Soininen P and S (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet  vol. 43, (11) 1131-U129. 10.1038/ng.970

Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Mägi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, Ingelsson E, Willer CJ, Weedon MN, Luan J, Vedantam S, Esko T, Kilpeläinen TO, Kutalik Z and Li (2011). Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution (Nature Genetics (2010) 42 (949-960)). Nature Genetics  vol. 43, (11) 10.1038/ng1111-1164a

Williams B, Krause T, Lovibond K, Caulfield M and McCormack T (2011). Authors' reply to Harding and colleagues, Taylor, Cruickshank, and El Turabi and Payne. Bmj (Online)  vol. 343, (7827) 10.1136/bmj.d6506

Patel S, Ng FL, Uddin I, Caulfield MJ and Lobo MD (2011). Plasma renin activity in the South Asian population-an intermediate group. J Hum Hypertens  vol. 25, (10) 631-631.

Ehret G, Munroe PB, Rice K, Bochud M, Johnson A, Chasman D, Vernon-Smith A, Psaty B, Abecasis G, Charavarti A, Elliott P, van Diujn C, Cheh CN, Levy D, Caulfield M and Johnson T (2011). Sixteen novel loci influence blood pressure and cardiovascular risk. J Hum Hypertens  vol. 25, (10) 635-636.

Patel S, Ng FL, Uddin I, Caulfield MJ and Lobo MD (2011). Salt intake in hypertensive patients with at or above-target blood pressures. J Hum Hypertens  vol. 25, (10) 632-632.

Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Munroe PB, Psaty BM, Caulfield MJ, Rao DC, Tobin MD, Elliott P and van Duijn CM (2011). A large genome-wide association study of pulse pressure and mean arterial pressure reveals seven novel blood pressure LOCI. J Hum Hypertens  vol. 25, (10) 647-647.

McCarthy N, Vangjeli C, Surendran P, Treumann A, Rooney C, Ho E, Sever P, Thom S, Hughes A, Munroe P, Howard P, Johnson T, Caulfield MJ, Shields D, O'Brien E, Fitzgerald D and Stanton A (2011). PPARGC1 beta is a genetic determinant of the cardiovascular risk factor, Thromboxane A2-an Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) sub-study. J Hum Hypertens  vol. 25, (10) 625-625.

Kooner JS, Saleheen D, Sim X, Sehmi J, Zhang WH, Frossard P, Been LF, Chia KS, Dimas AS, Hassanali N, Jafar T, Jowett JBM, Li XZ, Radha V, Rees SD, Takeuchi F, Young R, Aung T, Basit A, Chidambaram M, Das D, Grundberg E, Hedman AK, Hydrie ZI, Islam M, Khor CC, Kowlessur S and Kristens (2011). Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet  vol. 43, (10) 984-U94. 10.1038/ng.921

Wain LV, Verwoert GC, O'Reilly PF, Shi G, Johnson T, Johnson AD, Bochud M, Rice KM, Henneman P, Smith AV, Ehret GB, Amin N, Larson MG, Mooser V, Hadley D, Dorr M, Bis JC, Aspelund T, Esko T, Janssens ACJW, Zhao JH, Heath S, Laan M, Fu JY, Pistis G, Luan JA, Arora P, Lucas G and Pirastu (2011). Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet  vol. 43, (10) 1005-U122. 10.1038/ng.922

Lovibond K, Jowett S, Barton P, Caulfield M, Heneghan C, Hobbs FDR, Hodgkinson J, Mant J, Martin U, Williams B, Wonderling D and McManus RJ (2011). Cost-effectiveness of options for the diagnosis of high blood pressure in primary care: a modelling study. Lancet  vol. 378, (9798) 1219-1230. 10.1016/S0140-6736(11)61184-7

Michell AR, Bodey AR and Caulfield M (2011). Evolution, essential hypertension and the high arterial pressures in certain athletic breeds of dogs (vol 188, pg 125, 2011). Vet J  vol. 190, (1) 184-184. 10.1016/j.tvjl.2011.08.015

International Consortium for Blood Pressure Genome-Wide Association Studies , Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, Hwang S-J, Pihur V, Vollenweider P, O'Reilly PF, Amin N, Bragg-Gresham JL, Teumer A, Glazer NL and La (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature  vol. 478, (7367) 103-109. 10.1038/nature10405

Krause T, Lovibond K, Caulfield M, McCormack T, Williams B and Guideline Dev Grp (2011). GUIDELINES Management of hypertension: summary of NICE guidance. Brit Med J  vol. 343, 10.1136/bmj.d4891

Putku M, Kepp K, Org E, Sõber S, Comas D, Viigimaa M, Veldre G, Juhanson P, Hallast P, Tõnisson N, HYPertension in ESTonia (HYPEST) , Shaw-Hawkins S, Caulfield MJ, BRItish Genetics of HyperTension (BRIGHT) , Khusnutdinova E, Kožich V, Munroe PB and Laan M (2011). Novel polymorphic AluYb8 insertion in the WNK1 gene is associated with blood pressure variation in Europeans. Hum Mutat  vol. 32, (7) 806-814. 10.1002/humu.21508

Fox ER, Young JH, Li YL, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC, Ganesh S, Kutlar A, Ramachandran VS, Polak JF, Fabsitz RR, Dries DL, Farlow DN, Redline S, Adeyemo A, Hirschorn JN, Sun YV, Wyatt SB, Penman AD, Palmas W, Rotter JI, Townsend RR, Doumatey AP and Tayo B (2011). Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet  vol. 20, (11) 2273-2284. 10.1093/hmg/ddr092

Fox ER, Young JH, Li Y, Dreisbach AW, Keating BJ, Musani SK, Liu K, Morrison AC, Ganesh S, Kutlar A, Ramachandran VS, Polak JF, Fabsitz RR, Dries DL, Farlow DN, Redline S, Adeyemo A, Hirschorn JN, Sun YV, Wyatt SB, Penman AD, Palmas W, Rotter JI, Townsend RR, Doumatey AP and Tayo BO (2011). Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet  vol. 20, (11) 2273-2284. 10.1093/hmg/ddr092

Johnson AD, Newton-Cheh C, Chasman DI, Ehret GB, Johnson T, Rose L, Rice K, Verwoert GC, Launer LJ, Gudnason V, Larson MG, Chakravarti A, Psaty BM, Caulfield M, van Duijn CM, Ridker PM, Munroe PB, Levy D and Cohorts for Heart and Aging Research in Genomic Epidemiology Consort (2011). Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals. Hypertension  vol. 57, (5) 903-910. 10.1161/HYPERTENSIONAHA.110.158667

Michell AR, Bodey AR and Caulfield M (2011). Evolution, essential hypertension and the high arterial pressures in certain athletic breeds of dogs. Vet J  vol. 188, (2) 125-127. 10.1016/j.tvjl.2011.03.011

Peden JF, Hopewell JC, Saleheen D, Chambers JC, Hager J, Soranzo N, Collins R, Danesh J, Elliott P, Farrall M, Stirrups K, Zhang WH, Hamsten A, Parish S, Lathrop M, Watkins H, Clarke R, Deloukas P, Kooner JS, Goel A, Ongen H, Strawbridge RJ, Heath S, Malarstig A, Helgadottir A and O (2011). A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat Genet  vol. 43, (4) 339-U89. 10.1038/ng.782

Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G, Garcia ME, Launer LJ, Nalls MA, Clark JM, Mitchell BD, Shuldiner AR, Butler JL, Tomas M, Hoffmann U, Hwang SJ, Massaro JM, O'Donnell CJ, Sahani DV, Salomaa V, Schadt EE and Schwartz (2011). Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. Plos Genetics  vol. 7, (3) 10.1371/journal.pgen.1001324

Collier DJ, Poulter NR, Dahlöf B, Sever PS, Wedel H, Buch J, Caulfield MJ and ASCOT Investigators (2011). Impact of amlodipine-based therapy among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA). J Hypertens  vol. 29, (3) 583-591. 10.1097/HJH.0b013e328342c845

Collier DJ, Poulter NR, Dahlöf B, Sever PS, Wedel H, Buch J, Caulfield MJ and ASCOT Investigators (2011). Impact of atorvastatin among older and younger patients in the Anglo-Scandinavian Cardiac Outcomes Trial Lipid-Lowering Arm. J Hypertens  vol. 29, (3) 592-599. 10.1097/HJH.0b013e328342c8f7

Lanktree MB, Guo YR, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen HQ, Nelson CP, Klopp N, Baumert J, Padmanabhan S, Pankratz N, Pankow JS, Shah S, Taylor K, Barnard J, Peters BJ, Maloney CM, Lobmeyer MT, Stanton A and Zafarma (2011). Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet  vol. 88, (1) 6-18. 10.1016/j.ajhg.2010.11.007

Chapman N, Chang CL, Caulfield M, Dahlof B, Feder G, Sever PS and Poulter NR (2011). ETHNIC VARIATIONS IN LIPID-LOWERING IN RESPONSE TO A STATIN (EVIREST): A SUBSTUDY OF THE ANGLO-SCANDINAVIAN CARDIAC OUTCOMES TRIAL (ASCOT). Ethnic Dis  vol. 21, (2) 150-157.

2010

Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Boehm M, Mahfoud F, Sievert H, Wunderlich N, Rump LC, Vonend O, Uder M, Lobo M, Caulfield M, Erglis A, Azizi M, Sapoval M, Thambar S, Persu A, Renkin J, Schunkert H, Weil J, Hoppe UC, Walton T, Scheinert D, Binder T and Janusze (2010). Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet  vol. 376, (9756) 1903-1909. 10.1016/S0140-6736(10)62039-9

Sotoodehnia N, Isaacs A, de Bakker PIW, Dorr M, Newton-Cheh C, Nolte IM, van der Harst P, Muller M, Eijgelsheim M, Alonso A, Hicks AA, Padmanabhan S, Hayward C, Smith AV, Polasek O, Giovannone S, Fu JY, Magnani JW, Marciante KD, Pfeufer A, Gharib SA, Teumer A, Li M, Bis JC and Riva (2010). Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet  vol. 42, (12) 1068-U62. 10.1038/ng.716

Tabara Y, Kohara K, Kita Y, Hirawa N, Katsuya T, Ohkubo T, Hiura Y, Tajima A, Morisaki T, Miyata T, Nakayama T, Takashima N, Nakura J, Kawamoto R, Takahashi N, Hata A, Soma M, Imai Y, Kokubo Y, Okamura T, Tomoike H, Iwai N, Ogihara T, Inoue I, Tokunaga K, Johnson T, Caulfield M and Mu (2010). Common variants in the ATP2B1 gene are associated with susceptibility to hypertension: the Japanese Millennium Genome Project. Hypertension  vol. 56, (5) 973-980. 10.1161/HYPERTENSIONAHA.110.153429

Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Mägi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, Ingelsson E, Willer CJ, Weedon MN, Luan J, Vedantam S, Esko T, Kilpeläinen TO, Kutalik Z and Li (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet  vol. 42, (11) 949-960. 10.1038/ng.685

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM, Luan J, Mägi R, Randall JC, Vedantam S, Winkler TW, Qi L, Workalemahu T, Heid IM, Steinthorsdottir V, Stringham HM, Weedon MN, Wheeler E, Wood AR, Ferreira T, Weyant RJ and Segrè (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet  vol. 42, (11) 937-948. 10.1038/ng.686

Padmanabhan S, Melander O, Johnson T, Di Blasio AM, Lee WK, Gentilini D, Hastie CE, Menni C, Monti MC, Delles C, Laing S, Corso B, Navis G, Kwakernaak AJ, van der Harst P, Bochud M, Maillard M, Burnier M, Hedner T, Kjeldsen S, Wahlstrand B, Sjögren M, Fava C, Montagnana M and Danes (2010). Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. Plos Genet  vol. 6, (10) 10.1371/journal.pgen.1001177

Allen HL, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, Ferreira T, Wood AR, Weyant RJ, Segre AV, Speliotes EK, Wheeler E, Soranzo N, Park JH, Yang J, Gudbjartsson D, Heard-Costa NL, Randall JC, Qi L, Smith AV and Magi (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature  vol. 467, (7317) 832-838. 10.1038/nature09410

Hastie CE, Padmanabhan S, Melander O, Johnson T, Di Blasio AM, Munroe PB, Caulfield M, Zanchetti A, Dominiczak AF and Extreme BP GWAS Collaborations (2010). Genome wide association study of blood pressure extremes identifies variant in uromodulin gene associated with hypertension. J Hum Hypertens  vol. 24, (10) 687-687.

Johnson T, Shaw-Hawkins S, Howard P, Lathrop M, Stanton A, Shields D, Poulter N, Sever P, Munroe PB and Caulfield M (2010). A novel gene locus for blood pressure variability identified by genomewide association scanning in the Anglo-Scandinavian Cardiac Outcome Trial. J Hum Hypertens  vol. 24, (10) 694-694.

Collier DJ, Robson J, Scott R, Will CM, Eldridge SE, Griffiths CJ, Badrick E, Saxena M, Richards S and Caulfield MJ (2010). HiLo: a health services intervention study: methods and interim results on the first 2000 patients at 1 year. J Hum Hypertens  vol. 24, (10) 708-709.

Gupta AK, Poulter NR, Dobson J, Eldridge S, Cappuccio FP, Caulfield M, Collier D, Cruickshank JK, Sever PS, Feder G and ASCOT Investigators (2010). Ethnic Differences in Blood Pressure Response to First and Second-Line Antihypertensive Therapies in Patients Randomized in the ASCOT Trial. Am J Hypertens  vol. 23, (9) 1023-1030. 10.1038/ajh.2010.105

Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, Johansen CT, Fouchier SW, Isaacs A, Peloso GM, Barbalic M, Ricketts SL, Bis JC, Aulchenko YS, Thorleifsson G, Feitosa MF, Chambers J, Orho-Melander M and Me (2010). Biological, clinical and population relevance of 95 loci for blood lipids. Nature  vol. 466, (7307) 707-713. 10.1038/nature09270

Mancia G, Laurent S, Agabiti-Rosei E, Ambrosioni E, Burnier M, Caulfield MJ, Cifkova R, Clément D, Coca A, Dominiczak A, Erdine S, Fagard R, Farsang C, Grassi G, Haller H, Heagerty A, Kjeldsen SE, Kiowski W, Mallion JM, Manolis A, Narkiewicz K, Nilsson P, Olsen MH, Rahn KH and Redo (2010). European guidelines on the management of hypertension: The European Society of Hypertension position statement (2009). Nadcisnienie Tetnicze  vol. 14, (1) 1-47.

Chambers JC, Zhang WH, Lord GM, van der Harst P, Lawlor DA, Sehmi JS, Gale DP, Wass MN, Ahmadi KR, Bakker SJL, Beckmann J, Bilo HJG, Bochud M, Brown MJ, Caulfield MJ, Connell JMC, Cook HT, Cotlarciuc I, Smith GD, de Silva R, Deng GH, Devuyst O, Dikkeschei LD, Dimkovic N and Dockrel (2010). Genetic loci influencing kidney function and chronic kidney disease. Nat Genet  vol. 42, (5) 373-375. 10.1038/ng.566

Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, Middleton L, Berrettini W, Knouff CW, Yuan X, Waeber G, Vollenweider P, Preisig M, Wareham NJ, Zhao JH, Loos RJF, Barroso I, Khaw KT, Grundy S, Barter P, Mahley R, Kesaniemi A, McPherson R, Vincent JB, Strauss J, Kennedy JL and Fa (2010). Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet  vol. 42, (5) 436-U75. 10.1038/ng.572

Craddock N, Hurles ME, Cardin N, Pearson RD, Plagnol V, Robson S, Vukcevic D, Barnes C, Conrad DF, Giannoulatou E, Holmes C, Marchini JL, Stirrups K, Tobin MD, Wain LV, Yau C, Aerts J, Ahmad T, Andrews TD, Arbury H, Attwood A, Auton A, Ball SG, Balmforth AJ, Barrett JC and Barroso I (2010). Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature  vol. 464, (7289) 713-U86. 10.1038/nature08979

Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM, Jackson AU, Lim N, Scheet P, Soranzo N, Amin N, Aulchenko YS, Chambers JC, Drong A, Luan JA, Lyon HN, Rivadeneira F, Sanna S, Timpson NJ, Zillikens MC and Zhao (2010). Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution. Plos Genet  vol. 6, (4) 10.1371/journal.pgen.1000508

van der Harst P, Bakker SJL, de Boer RA, Wolffenbuttel BHR, Johnson T, Caulfield MJ and Navis G (2010). Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms. Hum Mol Genet  vol. 19, (2) 387-395. 10.1093/hmg/ddp489

2009

Munroe PB, Johnson T and Caulfield MJ (2009). The genetic architecture of blood pressure variation. Current Cardiovascular Risk Reports  vol. 3, (6) 418-425. 10.1007/s12170-009-0062-3

Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C and E (2009). Gene-centric Association Signals for Lipids and Apolipoproteins Identified via the HumanCVD BeadChip. Am J Hum Genet  vol. 85, (5) 628-642. 10.1016/j.ajhg.2009.10.014

Mancia G, Laurent S, Agabiti-Rosei E, Ambrosioni E, Burnier M, Caulfield MJ, Cifkova R, Clement D, Coca A, Dominiczak A, Erdine S, Fagard R, Farsang C, Grassi G, Haller H, Heagerty A, Kjeldsen SE, Kiowski W, Mallion JM, Manolis A, Narkiewicz K, Nilsson P, Olsen MH, Rahn KH and Redo (2009). Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. J Hypertens  vol. 27, (11) 2121-2158. 10.1097/HJH.0b013e328333146d

Vidyarthi M, Balakumar Y, Perry I, Berney D, Bhattacharya S, Lobo M, Rull G, Drake WM, Caulfield MJ and Akker SA (2009). Hypokalaemic hypertension due to a rare cause. J Hum Hypertens  vol. 23, (10) 698-698.

Caulfield M (2009). PREDICTION OF ANTIHYPERTENSIVE RESPONSE - GENOTYPE. Basic Clin Pharmacol  vol. 105, 11-11.

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Dolan E, Stanton AV, Thom S, Caulfield M, Atkins N, McInnes G, Collier D, Dicker P, O'Brien E and ASCOT Investigators (2009). Ambulatory blood pressure monitoring predicts cardiovascular events in treated hypertensive patients - an Anglo-Scandinavian cardiac outcomes trial substudy. J Hypertens  vol. 27, (4) 876-885. 10.1097/HJH.0b013e328322cd62

Dobson RJB, Munroe PB, Caulfield MJ and Saqi MAS (2009). Global sequence properties for superfamily prediction: a machine learning approach. Journal of Integrative Bioinformatics  vol. 6, (1) 10.2390/biecoll-jib-2009-109

Willer CJ, Speliotes EK, Loos RJF, Li SX, Lindgren CM, Heid IM, Berndt SI, Elliott AL, Jackson AU, Lamina C, Lettre G, Lim N, Lyon HN, McCarroll SA, Papadakis K, Qi L, Randall JC, Roccasecca RM, Sanna S, Scheet P, Weedon MN, Wheeler E, Zhao JH, Jacobs LC, Prokopenko I, Soranzo N and (2009). Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet  vol. 41, (1) 25-34. 10.1038/ng.287

Mancia G, Laurent S, Agabiti-Rosei E, Ambrosioni E, Burnier M, Caulfield MJ, Cifkova R, Clement D, Coca A, Dominiczak A, Erdine S, Fagard R, Farsang C, Grassi G, Haller H, Heagerty A, Kjeldsen SE, Kiowski W, Mallion JM, Manolis A, Narkiewicz K, Nilsson P, Olsen MH, Rahn KH and Redo (2009). Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. Blood Pressure  vol. 18, (6) 308-347. 10.3109/08037050903450468

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Ostergren J, Poulter NR, Sever PS, Dahlof B, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E and Ascot Invest (2008). The Anglo-Scandinavian Cardiac Outcomes Trial: blood pressure-lowering limb: effects in patients with type II diabetes. J Hypertens  vol. 26, (11) 2103-2111. 10.1097/HJH.0b013e328310e0d9

Samani NJ, Braund PS, Erdmann J, Gotz A, Tomaszewski M, Linsel-Nitschke P, Hajat C, Mangino M, Hengstenberg C, Stark K, Ziegler A, Caulfield M, Burton PR, Schunkert H and Tobin MD (2008). The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol. J Mol Med-Jmm  vol. 86, (11) 1233-1241. 10.1007/s00109-008-0387-2

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Gupta AK, Poulter NR, Eldridge S, Cappuccio FP, Caulfield MJ, Dobson J, Cruickshank JK, Griffiths CJ, Hemingway H, Sever PS and Feder G (2008). Ethnic differences in blood pressure response to atenolol and amlodipine monotherapy and to add on diuretic and ACE inhibitor dual therapy in hypertensive patients from UK in ASCOT-BPLA. J Hum Hypertens  vol. 22, (10) 726-727.

Caulfield MJ, Munroe PB, O'Neill D, Witkowska K, Charchar FJ, Doblado M, Evans S, Eyheramendy S, Onipinla A, Howard P, Shaw-Hawkins S, Dobson RJ, Wallace C, Newhouse SJ, Brown M, Connell JM, Dominiczak A, Farrall M, Lathrop GM, Samani NJ, Kumari M, Marmot M, Brunner E and Chambers (2008). SLC2A9 Is a High-Capacity Urate Transporter in Humans. Plos Med  vol. 5, (10) 1509-1523. 10.1371/journal.pmed.0050197

Delles C, Padmanabhan S, Lee WK, Miller WH, McBride MW, McClure JD, Brain NJ, Wallace C, Marcano ACB, Schmieder RE, Brown MJ, Caulfield MJ, Munroe PB, Farrall M, Webster J, Connell JM and Dominiczak AF (2008). Glutathione S-transferase variants and hypertension. J Hypertens  vol. 26, (7) 1343-1352. 10.1097/HJH.0b013e3282fe1d67

Tobin MD, Tomaszewski M, Braund PS, Hajat C, Raleigh SM, Palmer TM, Caulfield M, Burton PR and Samani NJ (2008). Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population. Hypertension  vol. 51, (6) 1658-1664. 10.1161/HYPERTENSIONAHA.108.112664

Loos RJF, Lindgren CM, Li SX, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney ASF, Elliott KS and El (2008). Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet  vol. 40, (6) 768-775. 10.1038/ng.140

Weedon MN, Lango H, Lindgren CM, Wallace C, Evans DM, Mangino M, Freathy RM, Perry JRB, Stevens S, Hall AS, Samani NJ, Shields B, Prokopenko I, Farrall M, Dominiczak A, Johnson T, Bergmann S, Beckmann JS, Vollenweider P, Waterworth DM, Mooser V, Palmer CNA, Morris AD and Ouwehand (2008). Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet  vol. 40, (5) 575-583. 10.1038/ng.121

Sever PS, Poulter NR, Dahlof B, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes G, Mehlsen J, Nieminen MS, O'Brien ET, Ostergren J and ASCOT Investigators (2008). The Anglo-Scandinavian Cardiac Outcomes Trial lipid lowering arm: extended observations 2 years after trial closure. Eur Heart J  vol. 29, (4) 499-508. 10.1093/eurheartj/ehm583

Wallace C, Newhouse SJ, Braund P, Zhang F, Tobin M, Falchi M, Ahmadi K, Dobson RJ, Maracano ACB, Hajat C, Burton P, Deloukas P, Brown M, Connell JM, Dominiczak A, Lathrop GM, Webster J, Farrall M, Spector T, Samani NJ, Caulfield MJ, Munroe PB and Wellcome Trust Case Control (2008). Genome-wide association study identifies genes for biomarkers of cardiovascular disease: Serum urate and dyslipiclemia. Am J Hum Genet  vol. 82, (1) 139-149. 10.1016/j.ajhg.2007.11.001

Johnston L, Ester W, Koelega AH, Ranke M, Caliebe J, Caulfield M, Tauber M, Molinas C, Wollmann H, Parodi L, Savage M, van Duijn C and Clark A (2008). Analysis of GDF5-UQCC polymorphism with height in NESTEGG SGA and ISS subjects. Horm Res  vol. 70, 90-90.

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Nejentsev S, Howson JMM, Walker NM, Szeszko J, Field SF, Stevens HE, Reynolds P, Hardy M, King E, Masters J, Hulme J, Maier LM, Smyth D, Bailey R, Cooper JD, Ribas G, Campbell RD, Clayton DG, Todd JA, Burton PR, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP and McCa (2007). Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature  vol. 450, (7171) 887-892. 10.1038/nature06406

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Burke B, Gungadoo J, Marçano ACB, Newhouse SJ, Shiel J, Caulfield MJ and Munroe PB (2007). Monogenic Forms of Human Hypertension. Comprehensive Hypertension  10.1016/B978-0-323-03961-1.50039-8

Freel EM, Ingram M, Friel EC, Fraser R, Brown M, Samani NJ, Caulfield M, Munroe P, Farrall M, Webster J, Clayton D, Dominiczak AF, Davies E and Connell JMC (2007). Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study. Clin Endocrinol  vol. 67, (6) 832-838. 10.1111/j.1365-2265.2007.02971.x

Barter PJ, Caulfield M, Eriksson M, Grundy SM, Kastelein JJP, Komajda M, Lopez-Sendon J, Mosca L, Tardif J, Waters DD, Shear CL, Revkin JH, Buhr KA, Fisher MR, Tall AR, Brewer B and ILLUMINATE Investigators (2007). Effects of torcetrapib in patients at high risk for coronary events. New Engl J Med  vol. 357, (21) 2109-2122. 10.1056/NEJMoa0706628

Wallace C, Dobson RJ, Munroe PB and Caulfield MJ (2007). Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates. Genome Res  vol. 17, (11) 1596-1602. 10.1101/gr.5996407

Newport M, Sirugo G, Lyons E, Vannberg F, Hill AVS, Bradbury LA, Farrar C, Pointon JJ, Wordsworth P, Brown MA, Franklyn JA, Heward JM, Simmonds MJ, Gough SC, Seal S, Stratton MR, Rahman N, Ban M, Goris A, Sawcer SJ, Compston A, Conway D, Jallow M, Newport M, Sirugo G, Rockett KA and (2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet  vol. 39, (11) 1329-1337. 10.1038/ng.2007.17

HITMAN GA, Todd JA, Samani NJ, Ouwehand WH, Kwiatkowski DP, Deloukas P, Craddock N, Cardon LR, Donnelly P, Barrett JC, Davison D, Easton D, Evans DM, Leung HT, Duncanson A, McCarthy MI, Burton PR and Clayton DG (2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet  vol. 39, 129-1337. 10.1038/ng.2007.17

Padmanabhan S, Davies E, MacKenzie SM, Lim W, Barr M, Friel EC, Munroe PB, Brown MJ, Samani NJ, Farrall M, Dobson R, Webster J, Lathrop M, Caulfield MJ, Dominiczak AF and Connell JMC (2007). Association of the CYP11B1 and CYP11B2 gene polymorphisms with hypertension in the British Genetics of Hypertension case-control study. J Hum Hypertens  vol. 21, (10) 837-837.

Collier DJ, Davies LC, Bernardi L, Sleight P, Misra S, Shiel J, David CM, Scott B and Caulfield MJ (2007). Baroreceptor function changes with differing blood pressure treatment during the anglo-scandinavian cardiac outcomes trial: principal results from the cardiac autonomic reflex assessment trial (CARAT). J Hum Hypertens  vol. 21, (10) 846-847.

Marcano ACB, Burke B, Gungadoo J, Wallace C, Kaisaki PJ, Woon PY, Farrall M, Clayton D, Brown M, Dominiczak A, Connell JM, Webster J, Lathrop M, Caulfield M, Samani N, Gauguier D and Munroe PB (2007). Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension. J Med Genet  vol. 44, (9) 10.1136/jmg.2007.049718

Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ, Todd JA, Donnelly P, Barrett JC, Davison D, Easton D, Evans D, Leung HT, Marchini JL, Morris AP, Spencer CCA, Tobin MD, Attwood AP, Boorman JP, Cant B and Eve (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature  vol. 447, (7145) 661-678. 10.1038/nature05911

Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JRB, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney ASF and Wellcome Tr (2007). Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science  vol. 316, (5829) 1336-1341. 10.1126/science.1142364

Brown M, Boon N, Brooks N, Camm J, Corris P, Caulfield M, Chilvers E, Ewan P, Gibson J, Griffin G, Grossman A, Hall A, Hart G, Heagerty T, Hodgson H, Home P, Hughes R, Khaw KT, Lazarus J, Leaper D, Monson J, O'Rahilly S, Rowlands B, Scolding N, Sutton R, Taylor R, Watkins H and Wright (2007). Medical training in the UK: sleepwalking to disaster. Lancet  vol. 369, (9574) 1673-1675. 10.1016/S0140-6736(07)60754-5

Broughton Pipkin F, Broughton Pipkin F, Kalsheker N, Morgan L, O'Malley S, Henfrey M, Arulkumaran S, Symonds I, Cameron A, Dominiczak A, McDade M, Kwong Lee W, McCulloch J, Caulfield M, Farrall M, Kilby M, Davies L, O'Brien PMS, Habiba M, Dodd C, Baker PN, Macphail S and O'Shaugh (2007). Babies, pre-eclamptic mothers and grandparents: A three-generation phenotyping study. Journal of Hypertension  vol. 25, (4) 849-854. 10.1097/HJH.0b013e32803fb634

Brown M, Boon N, Brooks N, Brown E, Camm J, Caulfield M, Chilvers E, Gibson J, Griffin G, Grossman A, Hall A, Hart G, Heagerty T, Home P, Hodgson H, Horton R, Hughes R, Khaw KT, Lazarus J, Leaper D, McCollum P, Monson J, O'Rahilly S, Rowlands B, Scott J, Sutton R, Taylor R and Watkins (2007). Modernising Medical Careers, Medical Training Application Service, and the Postgraduate Medical Education and Training Board: time for the emperors to don their clothes. Lancet  vol. 369, (9566) 967-968. 10.1016/S0140-6736(07)60459-0

Sever P, Dahlöf B, Poulter N, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen S, Kristinsson A, McInnes G, Mehlsen J, Nieminem M, O'Brien E and Ostergren J (2007). Erratum: Potential synergy between lipid-lowering and blood-pressure- lowering in the Anglo-Scandinavian Cardiac Outcomes Trial (European Heart Journal (2006) 27 (2982-2988)). European Heart Journal  vol. 28, (1) 10.1093/eurheartj/ehl453

Barr M, MacKenzie SM, Friel EC, Holloway CD, Wilkinson DM, Brain NJR, Ingram MC, Fraser R, Brown M, Samani NJ, Caulfield M, Munroe PB, Farrall M, Webster J, Clayton D, Dominiczak AF, Connell JMC and Davies E (2007). Polymorphic variation in the 11 beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency. Hypertension  vol. 49, (1) 113-119. 10.1161/01.HYP.0000249904.93940.7a

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Sever P, Dahlöf B, Poulter N, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen S, Kristinsson A, McInnes G, Mehlsen J, Nieminem M, O'Brien E and Östergren J (2006). Potential synergy between lipid-lowering and blood-pressure-lowering in the Anglo-Scandinavian Cardiac Outcomes Trial. European Heart Journal  vol. 27, (24) 2982-2988. 10.1093/eurheartj/ehl403

Wallace C, Xue M-Z, Newhouse SJ, Marcano ACB, Onipinla AK, Burke B, Gungadoo J, Dobson RJ, Brown M, Connell JM, Dominiczak A, Lathrop GM, Webster J, Farrall M, Mein C, Samani NJ, Caulfield MJ, Clayton DG and Munroe PB (2006). Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension. Am J Hum Genet  vol. 79, (2) 323-331. 10.1086/506370

Munroe PB, Wallace C, Xue M-Z, Marçano ACB, Dobson RJ, Onipinla AK, Burke B, Gungadoo J, Newhouse SJ, Pembroke J, Brown M, Dominiczak AF, Samani NJ, Lathrop M, Connell J, Webster J, Clayton D, Farrall M, Mein CA, Caulfield M and Medical Research Council British Genetics of Hype (2006). Increased support for linkage of a novel locus on chromosome 5q13 for essential hypertension in the British Genetics of Hypertension Study. Hypertension  vol. 48, (1) 105-111. 10.1161/01.HYP.0000228324.74255.f1

Dobson RJ, Munroe PB, Caulfield MJ and Saqi MA (2006). Predicting deleterious nsSNPs: an analysis of sequence and structural attributes. Bmc Bioinformatics  vol. 7, 10.1186/1471-2105-7-217

Bell JT, Wallace C, Dobson R, Wiltshire S, Mein C, Pembroke J, Brown M, Clayton D, Samani N, Dominiczak A, Webster J, Lathrop GM, Connell J, Munroe P, Caulfield M and Farrall M (2006). Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension. Hum Mol Genet  vol. 15, (8) 1365-1374. 10.1093/hmg/ddl058

Binder A, Garcia E, Wallace C, Kazeem G, Ben-Shlomo Y, Yarnell J, Brown P, Caulfield M, Skrabal F, Kotanko P and Munroe P (2006). Haplotypes of the beta-2 adrenergic receptor associate with high diastolic blood pressure in the Caerphilly prospective study. J Hypertens  vol. 24, (3) 471-477. 10.1097/01.hjh.0000209983.28735.33

2005

Tobin MD, Raleigh SM, Newhouse S, Braund P, Bodycote C, Ogleby J, Cross D, Gracey J, Hayes S, Smith T, Ridge C, Caulfield M, Sheehan NA, Munroe PB, Burton PR and Samani NJ (2005). Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population. Circulation  vol. 112, (22) 3423-3429. 10.1161/CIRCULATIONHA.105.555474

Dahlof B, Sever PS, Poulter NR, Wedel H, Beevers DG, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J and ASCOT Investigators (2005). Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-B. Lancet  vol. 366, (9489) 895-906. 10.1016/S0140-6736(05)67185-1

Poulter NR, Wedel H, Dahlof B, Sever PS, Beevers DG, Caulfield M, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J, Pocock S and ASCOT Investigators (2005). Role of blood pressure and other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA). Lancet  vol. 366, (9489) 907-913. 10.1016/S0140-6736(05)67186-3

Newhouse SJ, Wallace C, Dobson R, Mein C, Pembroke J, Farrall M, Clayton D, Brown M, Samani N, Dominiczak A, Connell JM, Webster J, Lathrop GM, Caulfield M and Munroe PB (2005). Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study. Hum Mol Genet  vol. 14, (13) 1805-1814. 10.1093/hmg/ddi187

Marcano ACB, Onipinla AK, Caulfield MJ and Munroe PB (2005). Recent advances in the identification of genes for human hypertension. Expert Rev Cardiovasc Ther  vol. 3, (4) 733-741. 10.1586/14779072.3.4.733

Sever PS, Poulter NR, Dahlof B, Wedel H, Collins R, Beevers G, Caulfield M, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J and ASCOT Invest (2005). Reduction in cardiovascular events with atorvastatin in 2,532 patients with type 2 diabetes: Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA). Diabetes Care  vol. 28, (5) 1151-1157. 10.2337/diacare.28.5.1151

Morgan L, Farrall M, Baker PN, Pipkin FB, Kalsheker N, O¿Malley S, Henfrey M, Arulkumaran S, Symonds I, Cameron A, Dominiczak A, McDade M, Lee WK, McCulloch J, Caulfield M, Habiba M, Dodd C, Kilby M, Davies L, Macphail S, O¿Brien PMS, O¿Shaughnessy K, Newcombe B, De La Salle P and (2005). Disentangling fetal and maternal susceptibility for pre-eclampsia: A British multicenter candidate-gene study. American Journal of Human Genetics  vol. 77, (1) 127-131. 10.1086/431245

Newhouse SJ, Huq SM, Arunachalam G, Caulfield MJ and Munroe PB (2005). Genetics of hypertension. Hypertension: Principles and Practice 

Mein CA, Caulfield MJ and Munroe PB (2005). Selection of candidate genes in hypertension. 10.1385/1-59259-850-1:107

2004

Lee YW, Oh VMS, Garcia E, Taylor EA, Wu HM, Yap EPH, Kazeem GR, Caulfield MJ and Munroe PB (2004). Haplotypes of the beta 2-adrenegic receptor gene are associated with essential hypertension in a Singaporean Chinese population. J Hypertens  vol. 22, (11) 2111-2116. 10.1097/00004872-200411000-00012

Mein CA, Caulfield MJ, Dobson RJ and Munroe PB (2004). Genetics of essential hypertension. Hum Mol Genet  vol. 13 Spec No 1, R169-R175. 10.1093/hmg/ddh078

Mein CA, Caulfield MJ, Dobson RJ and Munroe PB (2004). Genetics of essential hypertension. Human Molecular Genetics  vol. 13, (REV. ISS. 1)

2003

Kübler W, Ssever P, Dahlöf B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen S, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brian E and Östergren J (2003). Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesteroal concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial - Lipid Lowering Arm (ASCOL-LLA): A multicentre random. Zeitschrift Fur Kardiologie  vol. 92, (7) 10.1007/s00392-003-0967-7

Wilson S, Johnston A, Robson J, Poulter N, Collier D, Feder G and Caulfield MJ (2003). Comparison of methods to identify individuals at increased risk of coronary disease from the general population. Bmj  vol. 326, (7404) 10.1136/bmj.326.7404.1436

Caulfield M, Munroe P, Pembroke J, Samani N, Dominiczak A, Brown M, Benjamin N, Webster J, Ratcliffe P, O'Shea S, Papp J, Taylor E, Dobson R, Knight J, Newhouse S, Hooper J, Lee W, Brain N, Clayton D, Lathrop GM, Farrall M, Connell J and MRC British Genetics of Hypertension Study (2003). Genome-wide mapping of human loci for essential hypertension. Lancet  vol. 361, (9375) 2118-2123. 10.1016/S0140-6736(03)13722-1

Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, Kristinsson A, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J and ASCOT Investigators (2003). Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomise. Lancet  vol. 361, (9364) 1149-1158. 10.1016/S0140-6736(03)12948-0

Wilson S, Johnston A, Robson J, Poulter NR, Collier DJ, Feder GS and Caulfield MJ (2003). Predicting coronary risk in the general population--is it necessary to measure high-density lipoprotein cholesterol? J Cardiovasc Risk  vol. 10, (2) 137-141. 10.1097/01.hjr.0000060844.48106.ff

Knight J, Munroe PB, Pembroke JC and Caulfield MJ (2003). Human chromosome 17 in essential hypertension. Ann Hum Genet  vol. 67, (Pt 2) 193-206. 10.1046/j.1469-1809.2003.t01-1-00002.x

Garcia EA, Newhouse S, Caulfield MJ and Munroe PB (2003). Genes and hypertension. Curr Pharm Des  vol. 9, (21) 1679-1689. 10.2174/1381612033454513

2001

Chapman JN, Kirby P, Caulfield MC and Poulter NR (2001). Cardiovascular risk factors in a cohort of 30 000 high-risk men and women in the UK: Cross-sectional, retrospective and prospective studies of screenees for the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). Journal of Human Hypertension  vol. 15, (SUPPL. 1) 10.1038/sj.jhh.1001078

Metherell LA, Akker SA, Munroe PB, Rose SJ, Caulfield M, Savage MO, Chew SL and Clark AJ (2001). Pseudoexon activation as a novel mechanism for disease resulting in atypical growth-hormone insensitivity. Am J Hum Genet  vol. 69, (3) 641-646. 10.1086/323266

Poulter NR, Caulfield M and Feder G (2001). Ethnic variations in response to a statin (EVIREST). J Hum Hypertens  vol. 15, S87-S89. 10.1038/sj.jhh.1001213

Kirby PL, Caulfield MC, Collier DJ, Eldridge S, Griffiths CG, Hemingway H, Poulter NR, Feder GS and Anglo-Scandinavian Cardiac Outcomes Trial (2001). Differential response to amlodipine and atenolol mono-therapy for hypertension by ethnic group. J Hum Hypertens  vol. 15 Suppl 1, S61-S64. 10.1038/sj.jhh.1001080

Chapman JN, Kirby P, Caulfield MC and Poulter NR (2001). Cardiovascular risk factors in a cohort of 30,000 high-risk men and women in the UK: cross-sectional, retrospective and prospective studies of screenees for the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT). J Hum Hypertens  vol. 15, S23-S26. 10.1038/sj.jhh.1001078

Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J and ASCOT Steering Comm (2001). Anglo-Scandinavian Cardiac Outcomes Trial: a brief history, rationale and outline protocol. J Hum Hypertens  vol. 15, S11-S12. 10.1038/sj.jhh.1001212

Wilson S, Collier D, Johnston A, Poulter N, Feder G, Robson J, Caulfield M and Anglo-Scandinavian Cardiac Outcomes Trial (2001). Evaluation of cardiovascular risk equations using the ASCOT cohort. J Hum Hypertens  vol. 15 Suppl 1, S31-S33. 10.1038/sj.jhh.1001084

O'Brien E, McInnes GT, Stanton A, Thom S, Caulfield M, Atkins N and Nichol FM (2001). Ambulatory blood pressure monitoring and 24-h blood pressure control as predictors of outcome in treated hypertensive patients. J Hum Hypertens  vol. 15, S47-S51. 10.1038/sj.jhh.1001076

Collier DJ, Bernardi L, Angell-James JE, Caulfield MJ, Sleight P and Anglo-Scandinavian Cardiac Outcomes Trial (2001). Baroreflex sensitivity and heart rate variability as predictors of cardiovascular outcome in hypertensive patients with multiple risk factors for coronary disease. J Hum Hypertens  vol. 15 Suppl 1, S57-S60. 10.1038/sj.jhh.1001077

White PC, Agarwal AK, Li AR, Nikkila H, Pratt JH, Caulfield M, Clark A, McTernan C and Stewart PM (2001). Possible association but no linkage of the HSD11B2 gene encoding the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase to hypertension in Black people. Clin Endocrinol  vol. 55, (2) 249-252. 10.1046/j.1365-2265.2001.01314.x

Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, McInnes GT, Mehlsen J, Nieminen M, O'Brien E, Ostergren J and ASCOT Investigators (2001). Rationale, design, methods and baseline demography of participants of the Anglo-Scandinavian cardiac outcomes trial. J Hypertens  vol. 19, (6) 1139-1147. 10.1097/00004872-200106000-00020

Sever PS, Dahlöf B, Poulter NR, Wedel H, Beevers G, Caulfield M, Collins R, Kjeldsen SE, McInnes GT, Mehlsen J, Nieminen M, O'Brien E and Ostergren J (2001). Anglo-Scandinavian cardiac outcomes trial: A brief history, rationale and outline protocol. Journal of Human Hypertension  vol. 15, (SUPPL. 1) 10.1038/sj.jhh.1001212

Caulfield MJ (2001). Genes for common diseases. Brit J Clin Pharmaco  vol. 51, (1) 1-3. 10.1046/j.1365-2125.2001.01343.x

2000

Munroe PB, Knight J and Caulfield MJ (2000). 1990-2000: Progress in determining high blood pressure genes. Annals of The Academy of Medicine Singapore  vol. 29, (3) 357-363.

Munroe PB and Caulfield MJ (2000). Genetics of hypertension. Current Opinion in Genetics and Development  vol. 10, (3) 325-329. 10.1016/S0959-437X(00)00081-2

Munroe P, Sandhu M, Jadhav D, Knight J, Clark A and Caulfield M (2000). No association of the epithelial sodium channel beta-subunit T594M variant with essential hypertension in an African Caribbean population. J Hypertens  vol. 18, S178-S178.

1998

Munroe PB, Strautnieks SS, Farrall M, Daniel HI, Lawson M, DeFreitas P, Fogarty P, Gardiner RM and Caulfield M (1998). Absence of linkage of the epithelial sodium channel to hypertension in black Caribbeans. American Journal of Hypertension  vol. 11, (8 I) 942-945. 10.1016/S0895-7061(98)00092-2

Caulfield M and Cafferkey M (1998). Gene therapy: The possibilities and the problems. International Journal of Pharmaceutical Medicine  vol. 12, (1) 5-7.

O'Byrne S and Caulfield M (1998). Genetics of hypertension. Therapeutic implications. Drugs  vol. 56, (2) 203-214. 10.2165/00003495-199856020-00004

Brand E, Chatelain N, Keavney B, Caulfield M, Citterio L, Connell J, Grobbee D, Schmidt S, Schunkert H, Schuster H, Sharma AM and Soubrier F (1998). Evaluation of the angiotensinogen locus in human essential hypertension: A European study. Hypertension  vol. 31, (3) 725-729. 10.1161/01.HYP.31.3.725

1997

Daniel HI, Munroe PB, Kamdar SM, Lawson M, Lavender P, Forgaty P and Caulfield MJ (1997). The atrial natriuretic peptide gene and essential hypertension in African-Caribbeans from St Vincent and the Grenadines. Journal of Human Hypertension  vol. 11, (2) 113-117. 10.1038/sj.jhh.1000389

Kotanko P, Binder A, Tasker J, DeFreitas P, Kamdar S, Clark AJL, Skrabal F and Caulfield M (1997). Essential hypertension in African Caribbeans associates with a variant of the ?2-adrenoceptor. Hypertension  vol. 30, (4) 773-776. 10.1161/01.HYP.30.4.773

1995

Caulfield M and Newell-Price J (1995). The angiotensin converting enzyme gene in cardiovascular Disease. Heart  vol. 74, (3) 207-208. 10.1136/hrt.74.3.207

Mattu RK, Needham EWA, Galton DJ, Frangos E, Clark AJL and Caulfield M (1995). A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly Heart Study. Circulation  vol. 91, (2) 270-274. 10.1161/01.cir.91.2.270

Caulfield M, Lavender P, Newell-Price J, Farrall M, Kamdar S, Daniel H, Lawson M, De Freitas P, Fogarty P and Clark AJL (1995). Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans. Journal of Clinical Investigation  vol. 96, (2) 687-692. 10.1172/JCI118111

1994

Brown MJ, Clayton D, Caulfield M, Farrall M and Clark AJL (1994). Linkage of the angiotensinogen gene to essential hypertension. New England Journal of Medicine  vol. 331, (16) 1096-1097. 10.1056/NEJM199410203311615

Caulfield M, Lavender P, Farrall M, Munroe P, Lawson M, Turner P and Clark AJL (1994). Linkage of the angiotensinogen gene to essential hypertension. New England Journal of Medicine  vol. 330, (23) 1629-1633. 10.1056/NEJM199406093302301

1992

Raveendran R, Heybroek WM, Caulfield M, Abrams SML, Wrigley PFM, Slevin M and Turner P (1992). Protein binding of indomethacin, methotrexate and morphine in patients with cancer. International Journal of Clinical Pharmacology Research  vol. 12, (3) 117-122.

Raveendran R, Heybroek W, Caulfield M, Lawson M, Abrams SML, Wrigley PFM, Slevin M and Turner P (1992). Indomethacin and Protein Binding of Methotrexate. Human and Experimental Toxicology  vol. 11, (4) 291-293. 10.1177/096032719201100411

1990

Caulfield MJ, Dilkes MG, Iles RK, Handel BT and Oliver RTD (1990). Rapid diagnosis of testicular choriocarcinoma by urinary pregnancy tests. The Lancet  vol. 335, (8699) 10.1016/0140-6736(90)92761-6

Heybroek WM, Caulfield M, Johnston A and Turner P (1990). Automatic on-line extraction coupled with electrochemical detection as an improved method for the HPLC co-analysis of codeine and morphine in plasma and gastric juice. Journal of Pharmaceutical and Biomedical Analysis  vol. 8, (8-12) 1021-1027. 10.1016/0731-7085(90)80163-J

1988

Blandy JP, Jenkins BJ, Fowler CG, Caulfield M, Badenoch DF, England HR, Hope-Stone HF, Mair GM, Mantell BS and Oliver RT (1988). Radical radiotherapy and salvage cystectomy for T2/3 cancer of the bladder. Progress in Clinical and Biological Research  vol. 260, 447-451.

JENKINS BJ, CAULFIELD MJ, FOWLER CG, BADENOCH DF, TIPTAFT RC, PARIS AMI, HOPE¿STONE HF, OLIVER RTD and BLANDY JP (1988). Reappraisal of the Role of Radical Radiotherapy and Salvage Cystectomy in the Treatment of Invasive (T2/T3) Bladder Cancer. British Journal of Urology  vol. 62, (4) 343-346. 10.1111/j.1464-410X.1988.tb04362.x

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