Close

A note on cookies

We use cookies to improve your experience of our website. If you want to find out more see our Privacy Policy

Menu

Institute of Bioengineering

People menu

Professor Mangala Patel

Professor in Biomaterials in Relation to Dentistry

Department Institute of Dentistry
Email m.patel@qmul.ac.uk
Homepage http://www.dentistry.qmul.ac.uk/people/profiles/drmangalapatel.html

Research Interests

Professor Patel's research centres on the development of novel polymeric dental and related biomaterials, for the delivery of therapeutic (active) species, locally within the oral cavity and in the body, aimed at treating a range of pathological conditions, and based on the fundamental principles of polymer science. Four patents have been filed and two materials have been granted Medicines Control Agency approval for clinical trials.  Developing her understanding on the detailed kinetics of water sorption and release of active agents,  experimental and mathematical modelling, with specific reference to delivering proteins across the oral mucosa and dermal sites, has benefited from interdisciplinary,  international/national and industrial collaborations.

Examples of Professor Patel's research are: tissue repair material for growth of bone and cartilage, an intra-oral drug delivery system for the treatment of acute candidal infections, fluoride releasing systems, a monomer system for use in composite filling materials and a novel resin-modified glass ionomer cement.  An exciting innovative area includes iontophoretic drug delivery via the buccal mucosa.

Professor Patel is currently Principal Investigator on an EPSRC grant for producing a self-disinfecting (anti-viral) alginate dental impression material. On a Knowledge Transfer Partnership, developing a resin modified glass ionomer cement is in progress. As a Consultancy Team Specialist, she advises companies/industries with the development/testing of their materials.

Key Publications

Nallamuthu N, Braden M, Oxford J, Williams D and Patel M (2015). Modification of pH Conferring Virucidal Activity on Dental Alginates. Materials (Basel)  vol. 8, (4) 1966-1975. 10.3390/ma8041966

Patel MP, Churchman ST, Cruchley AT, Braden M and Williams DM (2013). Delivery of macromolecules across oral mucosa from polymeric hydrogels is enhanced by electrophoresis (iontophoresis). Dent Mater  vol. 29, (11) e299-e307. 10.1016/j.dental.2013.09.003

Patel MP, Churchman ST, Cruchley AT, Braden M and Williams DM (2013). Electrically induced transport of macromolecules through oral buccal mucosa. Dent Mater  vol. 29, (6) 674-681. 10.1016/j.dental.2013.03.016

Muzaffar D, Braden M, Parker S and Patel MP (2012). The effect of disinfecting solutions on the dimensional stability of dental alginate impression materials. Dent Mater  vol. 28, (7) 749-755. 10.1016/j.dental.2012.03.013

Nallamuthu NA, Braden M and Patel MP (2012). Some aspects of the formulation of alginate dental impression materials--setting characteristics and mechanical properties. Dent Mater  vol. 28, (7) 756-762. 10.1016/j.dental.2012.03.012

2018

Taha AA, Fleming PS, Hill RG and Patel MP (2018). Enamel Remineralization with Novel Bioactive Glass Air Abrasion. J Dent Res  22034518792-22034518792. 10.1177/0022034518792048

Taha AA, Hill RG, Fleming PS and Patel MP (2018). Development of a novel bioactive glass for air-abrasion to selectively remove orthodontic adhesives. Clin Oral Investig  vol. 22, (4) 1839-1849. 10.1007/s00784-017-2279-8

Ud Din S, Hassan M, Khalid S, Zafar MS, Ahmed B and Patel M (2018). Effect of surfactant?s molecular weight on the wettability of vinyl polysiloxane impression materials after immersion disinfection. Materials Express  vol. 8, (1) 85-92. 10.1166/mex.2018.1413

2017

Taha AA, Patel MP, Hill RG and Fleming PS (2017). The effect of bioactive glasses on enamel remineralization: A systematic review. J Dent  vol. 67, 9-17. 10.1016/j.jdent.2017.09.007

Agha A, Parker S and Patel MP (2017). The properties of experimental resin-modified glass-ionomer luting cements (RMGICs) containing novel monomers. Dent Mater  vol. 33, (12) 1331-1339. 10.1016/j.dental.2017.08.189

Ud Din S, Parker S, Braden M, Tomlins P and Patel M (2017). Experimental hydrophilic vinyl polysiloxane (VPS) impression materials incorporating a novel surfactant compared with commercial VPS. Dent Mater  10.1016/j.dental.2017.04.012

2016

Patel J, Granger C, Parker S and Patel M (2016). The effect of instrument lubricant on the diametral tensile strength and water uptake of posterior composite restorative material. J Dent  10.1016/j.jdent.2016.10.006

Agha A, Parker S and Patel MP (2016). Development of experimental resin modified glass ionomer cements (RMGICs) with reduced water uptake and dimensional change. Dent Mater  vol. 32, (6) 713-722. 10.1016/j.dental.2016.03.004

Abdulmohsen B, Parker S, Braden M and Patel MP (2016). A study to investigate and compare the physicomechanical properties of experimental and commercial temporary crown and bridge materials. Dent Mater  vol. 32, (2) 200-210. 10.1016/j.dental.2015.11.025

2015

Nallamuthu N, Braden M, Oxford J, Williams D and Patel M (2015). Modification of pH Conferring Virucidal Activity on Dental Alginates. Materials (Basel)  vol. 8, (4) 1966-1975. 10.3390/ma8041966

2014

PATEL MP, Mustaza TA and Braden M (2014). Comparison of various properties of a Silorane based dental composite with two methacrylate based dental composites DOI 10.7603/s40782-014-0012-y. Gstf International Journal of Advances in Medical Research (Jamr)  vol. 1, (1) 78-83. 10.7603/s40782-014-0012-y

2013

Patel MP, Churchman ST, Cruchley AT, Braden M and Williams DM (2013). Delivery of macromolecules across oral mucosa from polymeric hydrogels is enhanced by electrophoresis (iontophoresis). Dent Mater  vol. 29, (11) e299-e307. 10.1016/j.dental.2013.09.003

Patel MP, Churchman ST, Cruchley AT, Braden M and Williams DM (2013). Electrically induced transport of macromolecules through oral buccal mucosa. Dent Mater  vol. 29, (6) 674-681. 10.1016/j.dental.2013.03.016

2012

Muzaffar D, Braden M, Parker S and Patel MP (2012). The effect of disinfecting solutions on the dimensional stability of dental alginate impression materials. Dent Mater  vol. 28, (7) 749-755. 10.1016/j.dental.2012.03.013

Nallamuthu NA, Braden M and Patel MP (2012). Some aspects of the formulation of alginate dental impression materials--setting characteristics and mechanical properties. Dent Mater  vol. 28, (7) 756-762. 10.1016/j.dental.2012.03.012

PATEL MP, Nallamuthu NA and Braden M (2012). Some aspects of the formulation of alginate dental impression materials - Setting characteristics and mechanical properties. Dental Materials  vol. 28, (7) 756-762. 10.1016/j.dental.2012.03.012

2010

Siddiqui A, Braden M, Patel MP and Parker S (2010). An experimental and theoretical study of the effect of sample thickness on the Shore hardness of elastomers. Dent Mater  vol. 26, (6) 560-564. 10.1016/j.dental.2010.02.004

2009

Meththananda IM, Parker S, Patel MP and Braden M (2009). The relationship between Shore hardness of elastomeric dental materials and Young's modulus. Dent Mater  vol. 25, (8) 956-959. 10.1016/j.dental.2009.02.001

2007

Gong K, Braden M, Patel MP, Rehman IU, Zhang Z and Darr JA (2007). Controlled release of chlorhexidine diacetate from a porous methacrylate system: supercritical fluid assisted foaming and impregnation. J Pharm Sci  vol. 96, (8) 2048-2056. 10.1002/jps.20850

2006

Nallamuthu N, Braden M and Patel MP (2006). Dimensional changes of alginate dental impression materials. J Mater Sci Mater Med  vol. 17, (12) 1205-1210. 10.1007/s10856-006-0593-9

Anderson P, Ahmed Y, Patel MP, Davis GR and Braden M (2006). X-ray microtomographic studies of novel radio-opaque polymeric materials for dental applications. Materials Science and Technology  vol. 22, (9) 1094-1097. 10.1179/174328406X114180

2005

Braden M, Latham D and Patel MP (2005). Observations on the swelling of cross-linked poly(dimethylsiloxane) networks by solvents. Eur Polym J  vol. 41, (12) 3069-3071. 10.1016/j.eurpolymj.2005.06.001

2004

Chowdhury MA, Hill DJT, Whittaker AK, Braden M and Patel MP (2004). NMR imaging of the diffusion of water at 310 K into semi-IPNs of PEM and Poly(HEMA-co-THFMA). Biomacromolecules  vol. 5, (4) 1405-1411. 10.1021/bm040003u

PATEL MP, Braden M, Hill DJT, Whittaker AK and Chowdhury MA (2004). NMR imaging of water diffusion into PEM/P9HEMA-co_THFMA) semi_IPN Matrices. Polymer Preprints  vol. 45,

2003

Scott G, Patel M and Braden M (2003). Use of prepolymerized cement spacers to augment the femoral component in revision total knee arthroplasty - A clinical outcome report and laboratory experiment. J Arthroplasty  vol. 18, (6) 769-774. 10.1054/S0883-5403(03)00109-8

2001

Patel MP, Cruchley AT, Coleman DC, Swai H, Braden M and Williams DM (2001). A polymeric system for the intra-oral delivery of an anti-fungal agent. Biomaterials  vol. 22, (17) 2319-2324. 10.1016/s0142-9612(00)00367-7

Nazhat SN, Parker S, Patel MP and Braden M (2001). Isoprene-styrene copolymer elastomer and tetrahydrofurfuryl methacrylate mixtures for soft prosthetic applications. Biomaterials  vol. 22, (17) 2411-2416. 10.1016/s0142-9612(00)00428-2

Patel MP, Pavlovic P, Hughes FJ, King GN, Cruchley A and Braden M (2001). Release of recombinant human bone morphogenetic protein-2 from heterocyclic methacrylate polymer systems. Biomaterials  vol. 22, (15) 2081-2086. 10.1016/s0142-9612(00)00396-3

Riggs PD, Kinchesh P, Braden M and Patel MP (2001). Nuclear magnetic imaging of an osmotic water uptake and delivery process. Biomaterials  vol. 22, (5) 419-427. 10.1016/s0142-9612(00)00093-4

Patel MP, Johnstone MB, Hughes FJ and Braden M (2001). The effect of two hydrophilic monomers on the water uptake of a heterocyclic methacrylate system. Biomaterials  vol. 22, (1) 81-86. 10.1016/s0142-9612(00)00171-x

^ Back to Top