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Institute of Bioengineering

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Dr Stellios Arseniyadis

Reader in Organic Chemistry /
Institute of Bioengineering Director of Industrial Collaboration

Department School of Biological and Chemical Sciences
 Room G.08, Joseph Priestley Building
Telephone +44 (0)20 7882 8445
Email s.arseniyadis@qmul.ac.uk
Homepage https://www.qmul.ac.uk/sbcs/staff/stelliosarseniyadis.html
ResearcherID ResearcherID

Research Interests

Research Interests:

The group is principally interested in the development of new synthetic methods to attain high structural and functional complexity. These methods lie within the areas of organocatalysis, transition metal catalysis and, more recently, bio-hybrid catalysis. In addition to that, we are also interested in developing new drug-delivery devices by combining acoustics and microfluidics.

Find out more on our website

Key Publications

Duchemin N, Buccafusca R, Daumas M, Ferey V and Arseniyadis S (2019). A Unified Strategy for the Synthesis of Difluoromethyl- and Vinylfluoride-Containing Scaffolds. American Chemical Society (Acs)  Organic Letters  10.1021/acs.orglett.9b02887

ARSENIYADIS S, Smietana M, DUCHEMIN N, AUBERT S, Mansot J and Vasseur J-J (2019). A rational quest for selectivity through precise ligand-positioning in the tandem DNA-catalysed Friedel-Crafts alkylation/asymmetric protonation. Royal Society of Chemistry  Chemical Science  (10) 10.1039/C8SC05543B

ARSENIYADIS S, DUCHEMIN N, Skiredj A, Mansot J, Leblanc K, Vasseur J-J, Beniddir M, Evanno E, Poupon E and Smietana M (2018). DNA-Templated [2 2] Photocycloaddition: A Straightforward Entry into the Aplysinopsin Family of Natural Products. Wiley  Angewandte Chemie International Edition  10.1002/anie.201806357

Amirbekyan K, Duchemin N, Benedetti E, Joseph R, Colon A, Markarian SA, Bethge L, Vonhoff S, Klussmann S, Cossy J, Vasseur J-J, Arseniyadis S and Smietana M (2016). Design, Synthesis, and Binding Affinity Evaluation of Hoechst 33258 Derivatives for the Development of Sequence-Specific DNA-Based Asymmetric Catalysts. American Chemical Society  Acs Catalysis  3096-3105. 10.1021/acscatal.6b00495

Bezagu M, Errico C, Chaulot-Talmon V, Monti F, Tanter M, Tabeling P, Cossy J, Arseniyadis S and Couture O (2014). High Spatiotemporal Control of Spontaneous Reactions Using Ultrasound-Triggered Composite Droplets. American Chemical Society (Acs)  Journal of The American Chemical Society  vol. 136, (20) 7205-7208. 10.1021/ja5019354

2020

Mansot J, Lauberteaux J, Aurélien L, Marc M, Jean-Jacques V, Marcia de Figueiredo R, Arseniyadis S, Jean-Marc C and Smietana M (2020). DNA-Based Asymmetric Inverse Electron-Demand Hetero-Diels Alder. Wiley  Chemistry: a European Journal  10.1002/chem.202000516

2019

Katsina T, Sharma S, Buccafusca R, Quinn D, Moody T and Arseniyadis S (2019). A Sequential palladium-catalyzed allylic alkylation/retro-Dieckmann fragmentation strategy for the synthesis of ?-substituted acrylonitriles. American Chemical Society  Organic Letters  10.1021/acs.orglett.9b03522

Aubert S, Bezagu M, Spivey AC and Arseniyadis S (2019). Spatial and temporal control of chemical processes. Springer Science and Business Media Llc  Nature Reviews Chemistry  10.1038/s41570-019-0139-6

Duchemin N, Buccafusca R, Daumas M, Ferey V and Arseniyadis S (2019). A Unified Strategy for the Synthesis of Difluoromethyl- and Vinylfluoride-Containing Scaffolds. American Chemical Society (Acs)  Organic Letters  10.1021/acs.orglett.9b02887

Mansot J, Vasseur JJ, Arseniyadis S and Smietana M (2019). ?,?-Unsaturated 2-Acyl-Imidazoles in Asymmetric Biohybrid Catalysis. Wiley  Chemcatchem  10.1002/cctc.201900743

ARSENIYADIS S, Smietana M, DUCHEMIN N, AUBERT S, Mansot J and Vasseur J-J (2019). A rational quest for selectivity through precise ligand-positioning in the tandem DNA-catalysed Friedel-Crafts alkylation/asymmetric protonation. Royal Society of Chemistry  Chemical Science  (10) 10.1039/C8SC05543B

ARSENIYADIS S, AUBERT S and KATSINA S (2019). A Sequential Pd-AAA/Cross-Metathesis/Cope Rearrangement Strategy for the Stereoselective Synthesis of Chiral Butenolides. American Chemical Society  Organic Letters  10.1021/acs.orglett.9b00521

ARSENIYADIS S, Song T and Cossy J (2019). Asymmetric Synthesis of ?-Quaternary ?-Lactams through Palladium-Catalyzed Asymmetric Allylic Alkylation. American Chemical Society  Organic Letters  10.1021/acs.orglett.8b03613

2018

ARSENIYADIS S and Smietana M (2018). Challenges and Opportunities in DNA-based Asymmetric Catalysis. Schweizerische Chemische Gesellschaft  Chimia  10.2533/chimia.2018.630

ARSENIYADIS S, DUCHEMIN N, Skiredj A, Mansot J, Leblanc K, Vasseur J-J, Beniddir M, Evanno E, Poupon E and Smietana M (2018). DNA-Templated [2 2] Photocycloaddition: A Straightforward Entry into the Aplysinopsin Family of Natural Products. Wiley  Angewandte Chemie International Edition  10.1002/anie.201806357

ARSENIYADIS S, Song T and Cossy J (2018). Highly Enantioselective, Base-Free Synthesis of ?-Quaternary Succinimides through Catalytic Asymmetric Allylic Alkylation. Wiley  Chemistry - a European Journal  10.1002/chem.201800920

ARSENIYADIS S (2018). Palladium-catalyzed asymmetric allylic alkylation of 4-substituted isoxazolidin-5-ones: A straightforward access to b2,2-amino acids. Wiley  Chemistry - a European Journal  10.1002/chem.201800641

ARSENIYADIS S (2018). Dinucleating Schiff base ligand in Zn/4f coordination chemistry: synthetic challenges and catalytic activity evaluation. Royal Society of Chemistry  Dalton Transactions  10.1039/C8DT00538A

2017

Dolé Kerim M, Cattoen M, Fincias N, Dos Santos A, Arseniyadis S and El Kaim L (2017). Palladium-catalysed O-Allylation of ?-Hydroxyphosphonates: An Expedient entry into Phosphono-oxaheterocycles. Advanced Synthesis & Catalysis  10.1002/adsc.201701150

Duchemin N, Heath-Apostolopoulos I, Smietana M and Arseniyadis S (2017). A decade of DNA-hybrid catalysis: from innovation to comprehension. Org. Biomol. Chem.  vol. 15, (34) 7072-7087. 10.1039/C7OB00176B

Bezagu M, Clarhaut J, Renoux B, Monti F, Tanter M, Tabeling P, Cossy J, Couture O, Papot S and Arseniyadis S (2017). In situ targeted activation of an anticancer agent using ultrasound-triggered release of composite droplets. European Journal of Medicinal Chemistry  10.1016/j.ejmech.2017.03.057

Nascimento de Oliveira M, Fournier J, Arseniyadis S and Cossy J (2017). A Palladium-Catalyzed Asymmetric Allylic Alkylation Approach to ?-Quaternary ?-Butyrolactones. Organic Letters  vol. 19, (1) 14-17. 10.1021/acs.orglett.6b02971

2016

El Mamouni EH, Cattoen M, Cordier M, Cossy J, Arseniyadis S, Ilitki H and El Kaïm L (2016). Selective Tsuji?Trost type C-allylation of hydrazones: a straightforward entry into 4,5-dihydropyrazoles. Chem. Commun.  vol. 52, (100) 14490-14493. 10.1039/C6CC08171A

Kolleth A, Gebauer J, ElMarrouni A, Lebeuf R, Prévost C, Brohan E, Arseniyadis S and Cossy J (2016). Total Synthesis of Putative 11-epi-Lyngbouilloside Aglycon. Frontiers Media  Frontiers in Chemistry  vol. 4, 10.3389/fchem.2016.00034

ARSENIYADIS S, Bressy C, Smietana M and Benedetti E (2016). Acetate Biosynthetic Pathway - Polyketides. From Biosynthesis to Total Synthesis Strategies and Tactics For Natural Products  John Wiley & Sons 

Amirbekyan K, Duchemin N, Benedetti E, Joseph R, Colon A, Markarian SA, Bethge L, Vonhoff S, Klussmann S, Cossy J, Vasseur J-J, Arseniyadis S and Smietana M (2016). Design, Synthesis, and Binding Affinity Evaluation of Hoechst 33258 Derivatives for the Development of Sequence-Specific DNA-Based Asymmetric Catalysts. American Chemical Society  Acs Catalysis  3096-3105. 10.1021/acscatal.6b00495

2014

Barbeyron R, Benedetti E, Cossy J, Vasseur J-J, Arseniyadis S and Smietana M (2014). Recent developments in alkyne borylations. Elsevier Bv  Tetrahedron  vol. 70, (45) 8431-8452. 10.1016/j.tet.2014.06.026

Bezagu M, Errico C, Chaulot-Talmon V, Monti F, Tanter M, Tabeling P, Cossy J, Arseniyadis S and Couture O (2014). High Spatiotemporal Control of Spontaneous Reactions Using Ultrasound-Triggered Composite Droplets. American Chemical Society (Acs)  Journal of The American Chemical Society  vol. 136, (20) 7205-7208. 10.1021/ja5019354

2013

ARSENIYADIS S and Spivey AC (2013). Regio- and Position Selective Reactions and Desymmetrizations. Comprehensive Enantioselective Organocatalysis Catalysts, Reactions, and Applications, 3 Volume Set  Wiley-Vch 

El Marrouni A, Kolleth A, Lebeuf R, Gebauer J, Prevost S, Heras M, Arseniyadis S and Cossy J (2013). ChemInform Abstract: Lyngbouilloside and Related Macrolides from Marine Cyanobacteria. Wiley  Cheminform  vol. 44, (49) no-no. 10.1002/chin.201349234

Wang J, Benedetti E, Bethge L, Vonhoff S, Klussmann S, Vasseur J-J, Cossy J, Smietana M and Arseniyadis S (2013). DNA vs. Mirror-Image DNA: A Universal Approach to Tune the Absolute Configuration in DNA-Based Asymmetric Catalysis. Wiley  Angewandte Chemie International Edition  vol. 52, (44) 11546-11549. 10.1002/anie.201306232

Kolleth A, Cattoen M, Arseniyadis S and Cossy J (2013). Non-enzymatic acylative kinetic resolution of primary allylic amines. Chemical Communications  vol. 49, (81) 9338-9340. 10.1039/c3cc45453c

Smietana M, Vasseur J-J, Cossy J and Arseniyadis S (2013). ChemInform Abstract: DNA as a Tool for Molecular Discovery. Wiley  Cheminform  vol. 44, (30) no-no. 10.1002/chin.201330243

Fournier J, Lozano O, Menozzi C, Arseniyadis S and Cossy J (2013). Palladium-Catalyzed Asymmetric Allylic Alkylation of Cyclic Dienol Carbonates: Efficient Route to Enantioenriched ?-Butenolides Bearing an All-Carbon ?-Quaternary Stereogenic Center. Wiley  Angewandte Chemie  vol. 125, (4) 1295-1299. 10.1002/ange.201206368

2012

ARSENIYADIS S, Cossy J, Smietana M and Vasseur J-J (2012). DNA as a Tool for Molecular Discovery. Modern Tools For The Synthesis of Complex Bioactive Molecules  John Wiley & Sons 

Cossy J and Arseniyadis S (2012). Modern Tools for the Synthesis of Complex Bioactive Molecules. John Wiley & Sons 

Fournier J, Arseniyadis S and Cossy J (2012). A Modular and Scalable One-Pot Synthesis of Polysubstituted Furans. Wiley  Angewandte Chemie International Edition  vol. 51, (30) 7562-7566. 10.1002/anie.201202486

ElMarrouni A, Lebeuf R, Gebauer J, Heras M, Arseniyadis S and Cossy J (2012). Total Synthesis of Nominal Lyngbouilloside Aglycon. American Chemical Society (Acs)  Organic Letters  vol. 14, (1) 314-317. 10.1021/ol203064r

Kolleth A, Christoph S, Arseniyadis S and Cossy J (2012). Kinetic resolution of propargylamines via a highly enantioselective non-enzymatic N-acylation process. Royal Society of Chemistry (Rsc)  Chemical Communications  vol. 48, (85) 10511-10511. 10.1039/c2cc35719d

Colon A, Hoffman TJ, Gebauer J, Dash J, Rigby JH, Arseniyadis S and Cossy J (2012). Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole F. Royal Society of Chemistry (Rsc)  Chemical Communications  vol. 48, (85) 10508-10508. 10.1039/c2cc35721f

2011

Arseniyadis S, Mahesh M, McDaid P, Hampel T, Davey SG and Spivey AC (2011). Studies towards the N-Acylative kinetic resolution of NOBIN. Collection of Czechoslovak Chemical Communications  vol. 76, (10) 1239-1253. 10.1135/cccc2011034

Cossy J, Arseniyadis S and Meyer C (2011). Metathesis in Natural Product Synthesis Strategies, Substrates and Catalysts. John Wiley & Sons 

Dash J, Melillo B, Arseniyadis S and Cossy J (2011). A concise approach towards the synthesis of WS75624 A and WS75624 B via the cross-metathesis of vinyl-functionalized thiazoles. Elsevier Bv  Tetrahedron Letters  vol. 52, (17) 2246-2249. 10.1016/j.tetlet.2011.01.027

2010

ElMarrouni A, Fukuda A, Heras M, Arseniyadis S and Cossy J (2010). Expedient Synthesis of a Stereoisomer of Acremolide B? American Chemical Society (Acs)  The Journal of Organic Chemistry  vol. 75, (24) 8478-8486. 10.1021/jo1017487

ElMarrouni A, Joolakanti SR, Colon A, Heras M, Arseniyadis S and Cossy J (2010). Two Concise Total Syntheses of (-)-Bitungolide F. American Chemical Society (Acs)  Organic Letters  vol. 12, (18) 4074-4077. 10.1021/ol101659y

Hoffman TJ, Kolleth A, Rigby JH, Arseniyadis S and Cossy J (2010). Stereoselective Synthesis of the C1-C11 and C12-C34 Fragments of Mycalolide A. American Chemical Society (Acs)  Organic Letters  vol. 12, (15) 3348-3351. 10.1021/ol101145t

Nicolaou KC, Ortiz A, Zhang H, Dagneau P, Lanver A, Jennings MP, Arseniyadis S, Faraoni R and Lizos DE (2010). Total Synthesis and Structural Revision of Vannusals A and B: Synthesis of the Originally Assigned Structure of Vannusal B. American Chemical Society (Acs)  Journal of The American Chemical Society  vol. 132, (20) 7138-7152. 10.1021/ja100740t

ARSENIYADIS S and Spivey AC (2010). Amine, Alcohol & Phosphine Catalysts for Acyl Transfer Reactions. Asymmetric Organocatalysis  Springer Science & Business Media 

2009

Lebeuf R, Fe¿re¿zou I, Rossier J, Arseniyadis S and Cossy J (2009). Straightforward Synthesis of the Near-Infrared Fluorescent Voltage-Sensitive Dye RH1691 and Analogues Thereof. American Chemical Society (Acs)  Organic Letters  vol. 11, (21) 4822-4825. 10.1021/ol901846g

Hoffman TJ, Dash J, Rigby JH, Arseniyadis S and Cossy J (2009). Enantioselective Organocatalytic Conjugate Reduction of ?-Azole-Containing ?,?-Unsaturated Aldehydes. American Chemical Society (Acs)  Organic Letters  vol. 11, (13) 2756-2759. 10.1021/ol900893e

Cossy J, Bressy C, Bargiggia F, Guyonnet M and Arseniyadis S (2009). One-Pot Hydrosilylation-RCM-Protodesilylation: Application to the Synthesis of ?-Alkenyl ?,?-Unsaturated Lactones. Georg Thieme Verlag Kg  Synlett  vol. 2009, (04) 565-568. 10.1055/s-0028-1087910

2008

Bressy C, Vors J-P, Hillebrand S, Arseniyadis S and Cossy J (2008). Asymmetric Total Synthesis of the Immunosuppressant (-)-Pironetin. Wiley  Angewandte Chemie International Edition  vol. 47, (52) 10137-10140. 10.1002/anie.200802423

Gebauer J, Arseniyadis S and Cossy J (2008). Total Synthesis of Cystothiazole A by Microwave-Assisted Olefin Cross-Metathesis. Wiley  European Journal of Organic Chemistry  vol. 2008, (16) 2701-2704. 10.1002/ejoc.200800203

Hoffman TJ, Rigby JH, Arseniyadis S and Cossy J (2008). Synthesis of Vinyl-Functionalized Oxazoles by Olefin Cross-Metathesis. American Chemical Society (Acs)  The Journal of Organic Chemistry  vol. 73, (6) 2400-2403. 10.1021/jo702305g

Arseniyadis S, Mioskowski C, Sabot C, Subhash P and Valleix A (2008). Nonenzymatic Kinetic Resolution of Amines in Ionic Liquids. Georg Thieme Verlag Kg  Synlett  vol. 2008, (2) 268-272. 10.1055/s-2007-1000879

2007

Gebauer J, Arseniyadis S and Cossy J (2007). A Concise Total Synthesis of Melithiazole C? American Chemical Society (Acs)  Organic Letters  vol. 9, (17) 3425-3427. 10.1021/ol701459j

Altmann K-H, Pfeiffer B, Arseniyadis S, Pratt BA and Nicolaou KC (2007). The Chemistry and Biology of Epothilones?The Wheel Keeps Turning. Wiley  Chemmedchem  vol. 2, (4) 396-423. 10.1002/cmdc.200600206

Moïse J, Arseniyadis S and Cossy J (2007). Cross-Metathesis between ?-Methylene-?-butyrolactone and Olefins:? A Dramatic Additive Effect. American Chemical Society (Acs)  Organic Letters  vol. 9, (9) 1695-1698. 10.1021/ol0703940

Dash J, Arseniyadis S and Cossy J (2007). Synthesis of Vinyl-Functionalized Thiazoles by Cross-Metathesis and Tandem Stille Coupling/Cross-Metathesis. Wiley  Advanced Synthesis & Catalysis  vol. 349, (1-2) 152-156. 10.1002/adsc.200600509

2006

Nicolaou KC, Pratt BA, Arseniyadis S, Wartmann M, O'Brate A and Giannakakou P (2006). Molecular Design and Chemical Synthesis of a Highly Potent Epothilone. Wiley  Chemmedchem  vol. 1, (1) 41-44. 10.1002/cmdc.200500056

Spivey AC, Arseniyadis S, Fekner T, Maddaford A and Leese DP (2006). Rapid, room-temperature acylative kinetic resolution of sec-alcohols using atropisomeric 4-aminopyridine/triphenylphosphine catalysis. Elsevier Bv  Tetrahedron  vol. 62, (2-3) 295-301. 10.1016/j.tet.2005.08.124

2005

Arseniyadis S, Subhash PV, Valleix A, Mathew SP, Blackmond DG, Wagner A and Mioskowski C (2005). Tuning the Enantioselective N-Acetylation of Racemic Amines:? A Spectacular Salt Effect. American Chemical Society (Acs)  Journal of The American Chemical Society  vol. 127, (17) 6138-6139. 10.1021/ja051302+

Arseniyadis S, Subhash PV, Valleix A, Wagner A and Mioskowski C (2005). Unprecedented, fully recyclable, solid-supported reagent for the kinetic resolution of racemic amines through enantioselective N-acetylation. Royal Society of Chemistry (Rsc)  Chemical Communications  (26) 3310-3310. 10.1039/b504200c

2004

Spivey AC and Arseniyadis S (2004). Nucleophilic Catalysis by 4-(Dialkylamino)pyridines Revisited?The Search for Optimal Reactivity and Selectivity. Wiley  Angewandte Chemie International Edition  vol. 43, (41) 5436-5441. 10.1002/anie.200460373

Arseniyadis S, Valleix A, Wagner A and Mioskowski C (2004). Kinetic Resolution of Amines: A Highly Enantioselective and Chemoselective Acetylating Agent with a Unique Solvent-Induced Reversal of Stereoselectivity. Wiley  Angewandte Chemie International Edition  vol. 43, (25) 3314-3317. 10.1002/anie.200453956

Arseniyadis S, Wagner A and Mioskowski C (2004). Resin-bound 4-phenyl-1,2-dihydroquinoline (DHQ): a new safety-catch linker for solid-phase organic synthesis (SPOS). Elsevier Bv  Tetrahedron Letters  vol. 45, (10) 2251-2253. 10.1016/j.tetlet.2003.12.161

2002

Arseniyadis S, Wagner A and Mioskowski C (2002). A straightforward preparation of amino?polystyrene resin from Merrifield resin. Elsevier Bv  Tetrahedron Letters  vol. 43, (52) 9717-9719. 10.1016/s0040-4039(02)02192-5

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