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Institute of Bioengineering

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Dr Tina Chowdhury

PhD

Senior Lecturer in Musculoskeletal Science

Department School of Engineering and Materials Science
 Engineering 117, Mile End
Telephone +44 (0)20 7882 7560
Email t.t.chowdhury@qmul.ac.uk
Homepage http://www.sems.qmul.ac.uk/t.t.chowdhury

Research Interests

Our stimulating and vibrant team devoted to cross-disciplinary research provides an exciting environment focused on translational research particularly in the inflammatory joint disease domain. The aim of the mechanotherapy research group is to identify, characterise and clinically implement novel therapeutics that slow down inflammation and repair damage to soft tissues with the vision of restoring normal function. We use multi-disciplinary tools involving engineering/materials/biology and a variety of human tissues to investigate biomechanics and the pro-inflammatory mileau. Tissues include fetal membranes, cartilage and the intervertebral disc. Our research efforts are focused on translational investigation with the aim of delivering novel therapeutics that restore normal function and a healthy ageing phenotype into the clinical arena.

In the last two years, funding from Arthritis Research UK and the AO Foundation has led to substantial success in identifying a novel homeostatic pathway induced by C-type natriuretic peptide (CNP). This protein is found naturally occurring in cartilage tissue and activates natriuretic peptide receptor (Npr2) leading to cGMP/PrkgII signalling. Activation of this homeostatic pathway in response to CNP mediates both reparative and anti-inflammatory effects in diseased cartilage. Our work provides strong evidence that CNP based agents could be used to enhance repair and treat cartilage disorders such as osteoarthritis. In addition, the beneficial effects were enhanced with mechanical loading implicating that both signals (CNP and mechanical loading) act in an anti-inflammatory manner and have protective effects in joint tissues. The next step in the research is to replicate results in a diseased animal model before the benefits can be translated to patients. This is feasible because we are working closely with pharmacologist, Prof Adrian Hobbs (WHRI) and the clinical orthopaedic team led by Mr Manoj Ramachandran at the Royal London Hospital. This multi-disciplinary team makes the work clinically feasible in the next five years. Here is a short video of Dr Nick Peake (scientist funded by Arthritis Research UK) discussing our novel research on the protective effects of CNP in osteoarthritis.

2017

Engels AC, Joyeux L, Van der Merwe J, Jimenez J, Prapanus S, Barrett DW, Connon C, Chowdhury TT, David AL and Deprest J (2017). Tissuepatch is biocompatible and seals iatrogenic membrane defects in a rabbit model. Prenat Diagn  vol. 38, (2) 99-105. 10.1002/pd.5191

Barrett DW, Kethees A, Thrasivoulou C, Mata A, Virasami A, Sebire NJ, Engels AC, Deprest JA, Becker DL, David AL and Chowdhury TT (2017). Trauma induces overexpression of Cx43 in human fetal membrane defects. Prenatal Diagnosis  vol. 37, (9) 899-906. 10.1002/pd.5104

2016

Tilwani RK, Vessillier S, Pingguan-Murphy B, Lee DA, Bader DL and Chowdhury TT (2016). Oxygen tension modulates the effects of TNF? in compressed chondrocytes. Inflamm Res  10.1007/s00011-016-0991-5

Barrett DW, David AL, Thrasivoulou C, Mata A, Becker DL, Engels AC, Deprest JA and CHOWDHURY TT (2016). Connexin 43 is overexpressed in human fetal membrane defects after fetoscopic surgery. Prental Diagnosis  10.1002/pd.4917

2015

Hossain MA, Chowdhury T and Bagul A (2015). Imaging modalities for the in vivo surveillance of mesenchymal stromal cells. J Tissue Eng Regen Med  vol. 9, (11) 1217-1224. 10.1002/term.1907

Peake NJ, Bader DL, Vessillier S, Ramachandran M, Salter DM, Hobbs AJ and Chowdhury TT (2015). C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes. Biochem Biophys Res Commun  vol. 465, (4) 784-789. 10.1016/j.bbrc.2015.08.087

Peake NJ, Pavlov AM, D'Souza A, Pingguan-Murphy B, Sukhorukov GB, Hobbs AJ and CHOWDHURY TT (2015). Controlled Release of C-Type Natriuretic Peptide by Microencapsulation Dampens Proinflammatory Effects Induced by IL-1? in Cartilage Explants. American Chemical Society  Biomacromolecules  10.1021/bm501575w

2014

Chowdhury B, David AL, Thrasivoulou C, Becker DL, Bader DL and Chowdhury TT (2014). Tensile strain increased COX-2 expression and PGE2 release leading to weakening of the human amniotic membrane. Placenta  vol. 35, (12) 1057-1064. 10.1016/j.placenta.2014.09.006

Peake NJ, Hobbs AJ, Pingguan-Murphy B, Salter DM, Berenbaum F and Chowdhury TT (2014). Role of C-type natriuretic peptide signalling in maintaining cartilage and bone function. Osteoarthritis Cartilage  vol. 22, (11) 1800-1807. 10.1016/j.joca.2014.07.018

Peake NJ, Hobbs AJ, Pingguan-Murphy B, Salter DM, Berenbaum F and CHOWDHURY TT (2014). Role of C-type natriuretic peptide signaling in maintaining cartilage and bone function. Elsevier/Science Direct  Osteoarthritis and Cartilage  vol. online edition, 10.1016/j.joca.2014.07.018

Hossain MA, CHOWDHURY TT and Bagul A (2014). Imaging modalities for the in vivo surveillance of mesenchymal stromal cells. Wiley  Journal of Tissue Engineering and Regenerative Medicine  10.1002/term.1907

2013

Parker E, Vessillier S, Pinguaan-Murphy B, Wan Abas WAB, Bader DL and Chowdhury TT (2013). Low oxygen tension increased FN-f induced catabolic activities - response prevented with biomechanical signals. Biomed Central  Arthritis Research and Therapy  vol. 15, (5) R163-R163. 10.1186/ar4346

Peake N, Su N, Ramachandran M, Achan P, Salter DM, Bader DL, Moyes AJ, Hobbs AJ and Chowdhury TT (2013). Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model. Arthritis Research and Therapy  vol. 15, (4) 10.1186/ar4253

Akanji O, Salter DM and Chowdhury TT (2013). Optimisation of quantitative real-time PCR studies in cartilage mechanobiology. Pcr Technology. Current Innovations , Editors: Nolan T and Bustin SA. Crc Pressi Llc 

Hossain MA, Frampton AE, Chowdhury TT and Morsey M (2013). Biological vascular grafts for hemodialysis access. Informa Healthcare  Expert Rev Med Devices  vol. 2, (10) 171-175. 10.1586/erd.12.85

2012

CHOWDHURY TT, Tilwani RK and Bader DL (2012). Biomechanical conditioning enhanced matrix synthesis in nucleus pulposus cells cultured in agarase constructs with TGF?, Editors: Goldsmith EC and Lin SK. Journal Functional Biomaterials  vol. 3, 23-26. 10.3390/jfb3010023

2011

Ramachandran M, Achan P, Salter DM, Bader DL and Chowdhury TT (2011). Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1? in chondrocyte/agarose constructs. Arthritis Research and Therapy  vol. 13, (5) 10.1186/ar3459

Lee DA, Brand J, Salter D, Akanji O-O and Chowdhury TT (2011). Quantification of mRNA using real-time PCR and Western blot analysis of MAPK events in chondrocyte/agarose constructs. Methods Mol Biol  vol. 695, 77-97. 10.1007/978-1-60761-984-0_6

Bader DL, Salter DM and Chowdhury TT (2011). Biomechanical influence of cartilage homeostasis in health and disease. Arthritis  vol. 2011, 10.1155/2011/979032

2010

Chowdhury TT, Schulz RM, Rai SS, Thuemmler CB, Wuestneck N, Bader A and Homandberg GA (2010). Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs. Arthritis Research and Therapy  vol. 12, (3) 10.1186/ar3009

Akanji OO, Sakthithasan P, Salter DM and Chowdhury TT (2010). Dynamic compression alters NF?B activation and I?B-? expression in IL-1?-stimulated chondrocyte/agarose constructs. Inflammation Research  vol. 59, (1) 41-52. 10.1007/s00011-009-0068-9

McGlashan SR, Knight MM, Chowdhury TT, Joshi P, Jensen CG, Kennedy S and Poole CA (2010). Mechanical loading modulates chondrocyte primary cilia incidence and length. Cell Biology International  vol. 34, (5) 441-446. 10.1042/CBI20090094

2009

Raveenthiran SP and Chowdhury TT (2009). Dynamic compression inhibits fibronectin fragment induced iNOS and COX-2 expression in chondrocyte/agarose constructs. Biomechanics and Modeling in Mechanobiology  vol. 8, (4) 273-283. 10.1007/s10237-008-0134-1

2008

Chowdhury TT, Salter DM, Bader DL and Lee DA (2008). Signal transduction pathways involving p38 MAPK, JNK, NF kappa B and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1 beta and dynamic compression. Inflamm Res  vol. 57, (7) 306-313. 10.1007/s00011-007-7126-y

Chowdhury TT, Arghandawi S, Brand J, Akanji OO, Bader DL, Salter DM and Lee DA (2008). Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs. Arthritis Res Ther  vol. 10, (2) 10.1186/ar2389

CHOWDHURY TT, Akanjii OO, Salter DM and Lee DA (2008). Dynamic compression influences IL-1? induced NO and PGE2 release, via alterations in iNOS and COX-2 activity. 5th International Symposium On Mechanobiology of Cartilage and Chondrocyte , Editors: Stoltz JF.

Chowdhury TT, Akanji OO, Salter DM, Bader DL and Lee DA (2008). Dynamic compression influences interleukin-1 beta-induced nitric oxide and prostaglandin E-2 release by articular chondrocytes via alterations in iNOS and COX-2 expression. Biorheology  vol. 45, (3-4) 257-274. 10.3233/BIR-2008-0474

2007

Campbell JJ, Blain EJ, Chowdhury TT and Knight MM (2007). Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes. Biochemical and Biophysical Research Communications  vol. 361, (2) 329-334. 10.1016/j.bbrc.2007.06.185

2006

Chowdhury TT and Knight MM (2006). Purinergic pathway suppresses the release of NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compression. Journal of Cellular Physiology  vol. 209, (3) 845-853. 10.1002/jcp.20768

Chowdhury TT, Appleby RN, Salter DM, Bader DA and Lee DA (2006). Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes. Biomech Model Mechanobiol  vol. 5, (2-3) 192-201. 10.1007/s10237-006-0032-3

Chowdhury TT, Bader DL and Lee DA (2006). Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes. Biochem Biophys Res Commun  vol. 339, (1) 241-247. 10.1016/j.bbrc.2005.11.016

Chowdhury TT, Bader DL and Lee DA (2006). Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Biorheology  vol. 43, (3,4) 413-429.

CHOWDHURY TT, Bader DL and Lee DA (2006). Dynamic compression counteracts IL-1? induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Mechanobiology: Cartilage and Chondrocyte , Editors: Stoltz JF. Ios Press 

2005

Chowdhury TT, Appleby RN, Salter DA, Bader DL and Lee DA (2005). Integrin mediated mechanotransduction in IL-1 stimulated bovine chondrocytes cultured in agarose constructs. Proceedings of The 2005 Summer Bioengineering Conference  vol. 2005, 545-546.

Chowdhury TT, Bader DL and Lee DA (2005). Dynamic compression counteracts IL-1-induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Proceedings of The 2005 Summer Bioengineering Conference  vol. 2005, 251-252.

Catuogno C, Chowdhury TT, Bader DL and Lee DA (2005). Dynamic compression influences the biochemical response of human mesenchymal stem cells cultured in agarose constructs. European Cells and Materials  vol. 10, (SUPPL.2)

Chowdhury TT, Bader DL and Lee DA (2005). Dynamic compression counteracts IL-1? induced INOS and COX-2 activity by human chondrocytes cultured in agarose constructs. European Cells and Materials  vol. 10, (SUPPL.2)

Sudre L, Cheung F, Kevorkian L, Young DA, Darrah C, Donell ST, Shepstone L, Porter S, Brockbank S, Edwards DR, Parker AE, Clark IM, Boubriak OA, Urban JPG, Cui Z, Tew SR, Li Y, Tweats LM, Hawkins RE, Hardingham TE, Green D, Partridge KA, Leveque I, Mann S, Oreffo ROC, Ball SG and Kie (2005). British society for matrix biology autumn meeting. International Journal of Experimental Pathology  vol. 86, (3) 10.1111/j.0959-9673.2005.00426.x

2004

Chowdhury TT, Salter DM, Bader DL and Lee DA (2004). Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes. Biochem Biophys Res Commun  vol. 318, (4) 873-881. 10.1016/j.bbrc.2004.04.107

Bryant SJ, Chowdhury TT, Lee DA, Bader DL and Anseth KS (2004). Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels. Ann Biomed Eng  vol. 32, (3) 407-417. 10.1023/B:ABME.0000017535.00602.ca

2003

Chowdhury TT, Bader DL and Lee DA (2003). Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs. Osteoarthritis Cartilage  vol. 11, (9) 688-696. 10.1016/S1063-4584(03)00149-3

Chowdhury TT, Bader DL, Shelton JC and Lee DA (2003). Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression. Arch Biochem Biophys  vol. 417, (1) 105-111. 10.1016/S0003-9861(03)00340-0

Chowdhury TT, Shelton JC, Bader DL and LEE DA (2003). Control of mechanotrasduction processes in dynamically stimulated human and bovine chondrocytes cultured in agarose constructs. Internat. J. Artificial Organs  vol. 26, (9) 858-858.

Chowdhury TT, LEE DA, Salter DM, Shelton JC and Bader DL (2003). alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta-stimulated human chondrocyte / agarose constructs and subjected to dynamic compression. Osteoarthritis Cartilage  vol. 11, (Suppl 1) S2-S3.

2001

Chowdhury TT, Bader DL and Lee DA (2001). Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs. Biochem Biophys Res Commun  vol. 285, (5) 1168-1174. 10.1006/bbrc.2001.5311

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