Prof Julien Gautrot

Julien Gautrot

Professor in Biomaterials and Biointerfaces

School of Engineering and Materials Science



Research Overview

Bio-interfaces, the interfaces between proteins, cells or tissues and inert materials, are fascinating systems that play key roles in biological and biomedical applications. Research in the Gautrot lab focuses on the design of novel biomaterials and methodologies that allow the study of bio-interfaces and their control for applications in cell-based assays, bio-sensors and regenerative medicine. Our work in the field of biomaterials design is inspired by Nature?s strategies to generate complexity and control function and properties. In particular, we are interested in novel synthetic tools and methodologies allowing the use of Nature's own building blocks, peptide sequences, to confer mechanical, chemical and biological properties to biomaterials. This approach, well suited for design, is appealing as it makes use of the inherent biological 'wiring' that has evolved to control cell and tissue homeostasis: peptide sequences and proteins are the key components that shape biological tissues. In addition, we develop new micro- and nano-patterning techniques to recreate the geometric and hierarchical complexity encountered in cells and tissues (e.g. positioning of organelles, generation of cell polarity and mimicking of tissue architecture and morphogenesis). Key questions that these tools will allow us to address are:

  • How do biological, mechanical and chemical properties of bio-materials (whether synthetic or of natural origin) cross-talk to control cell behaviour and in particular stem cell fate decision?
  • How do cells remodel such materials and how does this impact on cell behaviour and tissue formation?
  • Finally, what is the minimum set of rules or properties required to achieve a desired cell or tissue function?


Publications of specific relevance to Bioengineering Research


Dibble M, Di Cio’ S, Luo P, Balkwill F and Gautrot JE (2023). The impact of pericytes on the stability of microvascular networks in response to nanoparticles. Scientific Reports  vol. 13, (1) 10.1038/s41598-023-31352-x
Neri-Cruz CE, Teixeira FME and Gautrot JE (2023). A guide to functionalisation and bioconjugation strategies to surface-initiated polymer brushes. Chem Commun (Camb)  10.1039/d3cc01082a
Peng L, Nadal C and Gautrot JE (2023). Growth of mesenchymal stem cells at the surface of silicone, mineral and plant-based oils. Biomedical Materials (Bristol)  vol. 18, (3) 10.1088/1748-605X/acbdda
Summan SK, Mayes A, Gunn DA, Gautrot J, Caley M and O'Toole E (2023). 741 The effect of skin ageing-related basement membrane collagen loss on the nucleus. Elsevier  Journal of Investigative Dermatology  vol. 143, (5) s127-s127. 10.1016/j.jid.2023.03.750
Scemama A, Tailor A, Di Cio S, Dibble M, Gautrot J and Biddle A (2023). Development of an in vitro microfluidic model to study the role of microenvironmental cells in oral cancer metastasis. F1000research  vol. 12, 10.12688/f1000research.131810.1
Cervantes-Salguero K, Gutiérrez Fosado YA, Megone W, Gautrot JE and Palma M (2023). Programmed Self-Assembly of DNA Nanosheets with Discrete Single-Molecule Thickness and Interfacial Mechanics: Design, Simulation, and Characterization. Mdpi  Molecules  vol. 28, (9) 10.3390/molecules28093686
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Garrobo-Calleja I, Gautrot J and Balkwill F (2023). Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer. Cancer Research  vol. 83, (7_Supplement) 4576-4576. 10.1158/1538-7445.am2023-4576
Nguyen KDQ, Dejean S, Nottelet B and Gautrot JE (2023). Mechanical Evaluation of Hydrogel-Elastomer Interfaces Generated through Thiol-Ene Coupling. Acs Applied Polymer Materials  vol. 5, (2) 1364-1373. 10.1021/acsapm.2c01878
Peng L, Matellan C, Bosch-Fortea M, Gonzalez-Molina J, Frigerio M, Salentinig S, del Rio Hernandez A and Gautrot JE (2023). Mesenchymal Stem Cells Sense the Toughness of Nanomaterials and Interfaces. Advanced Healthcare Materials  10.1002/adhm.202203297


Kaur A, Gautrot JE, Cavalli G, Watson D, Bickley A, Akutagawa K and Busfield JJC (2022). Kinetic analysis of thiol-ene based cross-linking reaction of polychloroprene rubber. Constitutive Models For Rubber Xii  10.1201/9781003310266-38
Gautrot JE, Chang L, Alexis C, Gutfreund P and Zarbakhsh A (2022). The Architecture of Oligonucleotide-Polycationic Brush Complexes – A Neutron Reflectometry Study. Wiley  Advanced Materials Interfaces  10.1002/admi.202201344
Jones CFE, Di Cio S, Connelly JT and Gautrot JE (2022). Design of an Integrated Microvascularized Human Skin-on-a-Chip Tissue Equivalent Model. Frontiers Media  Frontiers in Bioengineering and Biotechnology  vol. 10, 10.3389/fbioe.2022.915702
Ghorbani S, Shahrokhtash A, Gautrot JE and Sutherland DS (2022). Protein Ligand Nanopattern Size Selects for Cellular Adhesion via Hemidesmosomes over Focal Adhesions. Small Methods  vol. 6, (6) 10.1002/smtd.202200152
Sarmin AM, El Moussaid NE, Suntornnond R, Tyler EJ, Kim YH, Cio SD, Megone WV, Pearce O, Gautrot JE, Dawson J and Connelly JT (2022). Multi-Scale Analysis of the Composition, Structure, and Function of Decellularized Extracellular Matrix for Human Skin and Wound Healing Models. Biomolecules  vol. 12, (6) 10.3390/biom12060837
Kong D, Peng L, Bosch-Fortea M, Chrysanthou A, Alexis CVJM, Matellan C, Zarbakhsh A, Mastroianni G, del Rio Hernandez A and Gautrot JE (2022). Impact of the multiscale viscoelasticity of quasi-2D self-assembled protein networks on stem cell expansion at liquid interfaces. Elsevier  Biomaterials  vol. 284, 10.1016/j.biomaterials.2022.121494
Nguyen NT, Jennings J, Milani AH, Martino CDS, Nguyen LTB, Wu S, Mokhtar MZ, Saunders JM, Gautrot JE, Armes SP and Saunders BR (2022). Highly Stretchable Conductive Covalent Coacervate Gels for Electronic Skin. Biomacromolecules  vol. 23, (3) 1423-1432. 10.1021/acs.biomac.1c01660
Chrysanthou A, Kanso H, Zhong W, Shang L and Gautrot JE (2022). Supercharged Protein Nanosheets for Cell Expansion on Bioemulsions. Acs Applied Materials and Interfaces  10.1021/acsami.2c20188
Chrysanthou A, Bosch-Fortea M and Gautrot JE (2022). Co-Surfactant-Free Bioactive Protein Nanosheets for the Stabilization of Bioemulsions Enabling Adherent Cell Expansion. Biomacromolecules  10.1021/acs.biomac.2c01289


Raynold AAM, Li D, Chang L and Gautrot JE (2021). Competitive binding and molecular crowding regulate the cytoplasmic interactome of non-viral polymeric gene delivery vectors. Nature Communications  vol. 12, (1) 10.1038/s41467-021-26695-w
Peng L and Gautrot JE (2021). Long term expansion profile of mesenchymal stromal cells at protein nanosheet-stabilised bioemulsions for next generation cell culture microcarriers. Elsevier  Materials Today Bio  vol. 12, 100159-100159. 10.1016/j.mtbio.2021.100159
Nguyen KDQ, Crespo-Ribadeneyra M, Picot O, Colak B and Gautrot JE (2021). Ultrafast Photo-Crosslinking of Thiol–Norbornene Opaque Silicone Elastomer Nanocomposites in Air. American Chemical Society  Acs Applied Polymer Materials  10.1021/acsapm.1c00440
Kaur A, Gautrot JE, Cavalli G, Watson D, Bickley A, Akutagawa K and Busfield JJC (2021). Novel crosslinking system for poly-chloroprene rubber to enable recyclability and introduce self-healing. Polymers  vol. 13, (19) 10.3390/polym13193347
Megone W, Kong D, Peng L and Gautrot JE (2021). Extreme reversal in mechanical anisotropy in liquid-liquid interfaces reinforced with self-assembled protein nanosheets. Journal of Colloid and Interface Science  vol. 594, 650-657. 10.1016/j.jcis.2021.03.055
Chang L, Yan H, Chang J and Gautrot JE (2021). Cationic Polymer Brush-Coated Bioglass Nanoparticles for the Design of Bioresorbable RNA Delivery Vectors. Elsevier  European Polymer Journal  110593-110593. 10.1016/j.eurpolymj.2021.110593
Pang X, Li W, Chang L, Gautrot JE, Wang W and Azevedo HS (2021). Hyaluronan (HA) Immobilized on Surfaces via Self-Assembled Monolayers of HA-Binding Peptide Modulates Endothelial Cell Spreading and Migration through Focal Adhesion. American Chemical Society  Acs Applied Materials and Interfaces  vol. 13, (22) 25792-25804. 10.1021/acsami.1c05574
Qu F, Ma X and Gautrot JE (2021). Precise positioning of enzymes within hierarchical polymer nanostructures for switchable bioelectrocatalysis. Elsevier  Biosensors and Bioelectronics  vol. 179, 113045-113045. 10.1016/j.bios.2021.113045
Cozens EJ, Roohpour N and Gautrot JE (2021). Comparative Adhesion of Chemically and Physically Crosslinked Poly(Acrylic Acid)-Based Hydrogels to Soft Tissues. Elsevier  European Polymer Journal  110250-110250. 10.1016/j.eurpolymj.2020.110250
Zhang X, Shi X, Gautrot JE and Peijs T (2021). Nanoengineered electrospun fibers and their biomedical applications: a review. Nanocomposites  vol. 7, (1) 1-34. 10.1080/20550324.2020.1857121
Qu F, Raynold AM and Gautrot JE (2021). Chapter 11: Recent Advances in the Design of Surface-initiated Polymer Brushes for Biomedical Applications. Rsc Soft Matter  10.1039/9781839161124-00264
Megone W, Tang P, Roohpour N and Gautrot JE (2021). Impact of the molecular structure of cationic binders on the rheological and adhesive properties of carboxymethyl cellulose-based coacervate hydrogels. Arkivoc  vol. 2021, (6) 10.24820/ARK.5550190.P011.516


You Y, Kobayashi K, Colak B, Luo P, Cozen E, Fields L, Suzuki K and Gautrot J (2020). Engineered cell-degradable poly(2-alkyl-2-oxazoline) hydrogel for epicardial placement of mesenchymal stem cells for myocardial repair. Elsevier  Biomaterials  120356-120356. 10.1016/j.biomaterials.2020.120356
Li D, Xu L, Wang J and Gautrot JE (2020). Responsive Polymer Brush Design and Emerging Applications for Nanotheranostics. Wiley  Advanced Healthcare Materials  10.1002/adhm.202000953
Wu L, Di Cio S, Azevedo HS and Gautrot JE (2020). Photoconfigurable, Cell-Remodelable Disulfide Cross-linked Hyaluronic Acid Hydrogels. American Chemical Society  Biomacromolecules  10.1021/acs.biomac.0c00603
Colak B, Wu L, Cozens EJ and Gautrot JE (2020). Modulation of Thiol-Ene Coupling by the Molecular Environment of Polymer Backbones for Hydrogel Formation and Cell Encapsulation. American Chemical Society  Acs Applied Bio Materials  10.1021/acsabm.0c00908
Zhang X, Megone W, Peijs T and Gautrot JE (2020). Functionalization of electrospun PLA fibers using amphiphilic block copolymers for use in carboxy-methyl-cellulose hydrogel composites. Taylor & Francis Group  Nanocomposites  10.1080/20550324.2020.1784600


Di Cio S, Iskratsch T, Connelly JT and Gautrot JE (2019). Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing. Elsevier  Biomaterials  vol. 232, 10.1016/j.biomaterials.2019.119683
Cozens EJ, Kong D, Roohpour N and Gautrot JE (2019). The physico-chemistry of adhesions of protein resistant and weak polyelectrolyte brushes to cells and tissues. Royal Society of Chemistry  Soft Matter  vol. 16, (2) 505-522. 10.1039/c9sm01403a
Li D, Wu L, Qu F, Ribadeneyra MC, Tu G and Gautrot J (2019). Core-independent approach for polymer brush-functionalised nanomaterials with a fluorescent tag for RNA delivery. Royal Society of Chemistry  Chemical Communications  vol. 55, (94) 14166-14169. 10.1039/c9cc05790k
Crespo M, Santagiuliana G, Picot O, Portale G, Bilotti E and Gautrot JE (2019). A Photoaddressable Liquid Crystalline Phase Transition in Graphene Oxide Nanocomposites. Advanced Functional Materials  vol. 29, (24) 10.1002/adfm.201900738
Crespo M, Santagiuliana G, Picot O, Portale G, Bilotti E and Gautrot JE (2019). Photo?Responsive Graphene: A Photoaddressable Liquid Crystalline Phase Transition in Graphene Oxide Nanocomposites (Adv. Funct. Mater. 24/2019). Advanced Functional Materials  vol. 29, (24) 10.1002/adfm.201970165
Qu F, Li D, Ma X, Chen F and Gautrot JE (2019). A Kinetic Model of Oligonucleotide-Brush Interactions for the Rational Design of Gene Delivery Vectors. Biomacromolecules  vol. 20, (6) 2218-2229. 10.1021/acs.biomac.9b00155
Ahmad N, Colak B, Gibbs MJ, Zhang D-W, Gautrot JE, Watkinson M, Becer CR and Krause S (2019). Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance. Biomacromolecules  vol. 20, (7) 2506-2514. 10.1021/acs.biomac.9b00245
Ahmad N, Colak B, Zhang DW, Gibbs MJ, Watkinson M, Remzi Becer C, Gautrot JE and Krause S (2019). Peptide cross-linked poly (Ethylene glycol) hydrogel films as biosensor coatings for the detection of collagenase. Sensors (Switzerland)  vol. 19, (7) 10.3390/s19071677
GAUTROT JEE (2019). Conformational Dynamics and Responsiveness of Weak and Strong Polyelectrolyte Brushes: Atomistic Simulations of PDMAEMA and PMETAC. American Chemical Society  Langmuir  10.1021/acs.langmuir.8b04268
GAUTROT JEE (2019). Modes of adsorption of polyelectrolytes to model substrates of hydroxyapatite. Elsevier  Journal of Colloid and Interface Science  vol. 543, 237-237. 10.1016/j.jcis.2019.02.063


Ahmad N, Colak B, Gibbs MJ, Zhang D-W, Becer CR, Watkinson M, Gautrot JE and Krause S (2018). Collagenase Biosensor Based on the Degradation of Peptide Cross-Linked Poly(Ethylene Glycol) Hydrogel Films. 10.3390/proceedings2130961
Zhang F, An Y, Roohpour N, Barber AH and Gautrot JE (2018). Hydration dependent mechanical performance of denture adhesive hydrogels. Dental Materials  vol. 34, (10) 1440-1448. 10.1016/
Kong D, Peng L, Di Cio S, Novak P and Gautrot JE (2018). Stem Cell Expansion and Fate Decision on Liquid Substrates Are Regulated by Self-Assembled Nanosheets. Acs Nano  vol. 12, (9) 9206-9213. 10.1021/acsnano.8b03865
Tang P, di Cio S, Wang W and E Gautrot J (2018). Surface-Initiated Poly(oligo(2-alkyl-2-oxazoline)methacrylate) Brushes. Langmuir  vol. 34, (34) 10019-10027. 10.1021/acs.langmuir.8b01682
Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018). Erratum: Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions (Developmental cell (2018) 44 3 (326-336.e3) PII: S1534-5807(18)30409-X). Developmental Cell  vol. 45, (5) 10.1016/j.devcel.2018.05.016
Megone W, Roohpour N and Gautrot JE (2018). Impact of surface adhesion and sample heterogeneity on the multiscale mechanical characterisation of soft biomaterials. Sci Rep  vol. 8, (1) 6780-6780. 10.1038/s41598-018-24671-x
Mata A, Azevedo HS, Connelly J and Gautrot J (2018). Bioengineering Complexity and Tuneability in Hydrogels. Hydrogels  10.1201/9781315152226-17
Kong D, Megone W, Nguyen KDQ, Di Cio S, Ramstedt M and Gautrot JE (2018). Protein Nanosheet Mechanics Controls Cell Adhesion and Expansion on Low-Viscosity Liquids. Nano Lett  10.1021/acs.nanolett.7b05339
Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018). Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions. Dev Cell  vol. 44, (3) 326-336.e3. 10.1016/j.devcel.2017.12.024
Li D, Sharili AS, Connelly J and Gautrot JE (2018). Highly Stable RNA Capture by Dense Cationic Polymer Brushes for the Design of Cytocompatible, Serum-Stable SiRNA Delivery Vectors. Biomacromolecules  10.1021/acs.biomac.7b01686
Gill SK, Roohpour N, An Y, Gautrot JE, Topham PD and Tighe BJ (2018). Hydrophobic and hydrophilic effects on water structuring and adhesion in denture adhesives. Wiley  Journal of Biomedical Materials Research Part A  vol. 106, (5) 1355-1362. 10.1002/jbm.a.36341
Colak B, Di Cio S and Gautrot JE (2018). Biofunctionalised Patterned Polymer Brushes via Thiol-Ene Coupling for the Control of Cell Adhesion and the Formation of Cell Arrays. Biomacromolecules  10.1021/acs.biomac.7b01436
Zhang X, Geven MA, Wang X, Qin L, Grijpma DW, Peijs T, Eglin D, Guillaume O and Gautrot JE (2018). A drug eluting poly(Trimethylene carbonate)/ poly(lactic acid)-reinforced nanocomposite for the functional delivery of osteogenic molecules. International Journal of Nanomedicine  vol. 13, 5701-5718. 10.2147/IJN.S163219


Li D and Gautrot JE (2017). Design of Polymer Brushes for Cell Culture and Cellular Delivery. Polymer and Biopolymer Brushes: For Materials Science and Biotechnology  10.1002/9781119455042.ch20
Darshan GH, Kong D, Gautrot J and Vootla S (2017). Physico-chemical characterization of Antheraea mylitta silk mats for wound healing applications. Scientific Reports  vol. 7, (1) 10.1038/s41598-017-10531-7
Krishnamoorthy M, Li D, Sharili AS, Gulin-Sarfraz T, Rosenholm JM and Gautrot JE (2017). The Solution Conformation of Polymer Brushes Determines their Interactions with DNA and Transfection Efficiency. Biomacromolecules  10.1021/acs.biomac.7b01175
Zhang X, Geven MA, Grijpma D, Peijs T and Gautrot JE (2017). Tunable and processable shape memory composites based on degradable polymers. Polymer  10.1016/j.polymer.2017.06.066
Kong D, Nguyen KDQ, Megone W, Peng L and Gautrot JE (2017). The culture of HaCaT cells on liquid substrates is mediated by a mechanically strong liquid–liquid interface. Faraday Discuss.  vol. 204, 367-381. 10.1039/C7FD00091J
Di Cio S, Bøggild TML, Connelly J, Sutherland DS and Gautrot JE (2017). Differential integrin expression regulates cell sensing of the matrix nanoscale geometry. Acta Biomaterialia  vol. 50, 280-292. 10.1016/j.actbio.2016.11.069
Gh D, Kong D, Gautrot J and Vootla SK (2017). Fabrication and Characterization of Conductive Conjugated Polymer-Coated Antheraea mylitta Silk Fibroin Fibers for Biomedical Applications. Macromol Biosci  vol. 17, (7) 10.1002/mabi.201600443
Amabilino D, Bâldea I, Barykina O, Batteas J, Besenius P, Beton P, Bilbao N, Buck M, Chi L, Clarke S, Costantini G, Davidson J, Davies P, De Feyter S, Diaz Fernandez Y, Dwivedi D, Ernst KH, Flood A, Gautrot J, Jabbarzadeh A, Korolkov V, Kühnle A, Lackinger M, Pradier CM and (2017). Preparing macromolecular systems on surfaces: General discussion. Faraday Discussions  vol. 204, 395-418. 10.1039/c7fd90076g


Gautrot JE (2016). Cell Sensing of the Physical Properties of the Microenvironment at Multiple Scales. Mechanobiology: Exploitation For Medical Benefit  10.1002/9781118966174.ch19
Attwood SJ, Cortes E, Haining AW, Robinson B, Li D, Gautrot J and Del Río Hernández A (2016). Adhesive ligand tether length affects the size and length of focal adhesions and influences cell spreading and attachment. Sci Rep  vol. 6, 34334-34334. 10.1038/srep34334
Colak B, Da Silva JCS, Soares TA and Gautrot JE (2016). Impact of the Molecular Environment on Thiol-Ene Coupling For Biofunctionalization and Conjugation. American Chemical Society  Bioconjugate Chemistry  vol. 27, (9) 2111-2123. 10.1021/acs.bioconjchem.6b00349
Nguyen KDQ, Megone WV, Kong D and Gautrot JE (2016). Ultrafast diffusion-controlled thiol-ene based crosslinking of silicone elastomers with tailored mechanical properties for biomedical applications. Polymer Chemistry  vol. 7, (33) 5281-5293. 10.1039/c6py01134a
Zhang X, Geven MA, Grijpma DW, Gautrot JE and Peijs T (2016). “Polymer-polymer composites for the design of strong and tough degradable biomaterials”. Materials Today Communications  vol. 8, 53-63. 10.1016/j.mtcomm.2016.05.001
An Y, Li D, Roohpour N, Gautrot JE and Barber AH (2016). Failure mechanisms in denture adhesives. Elsevier  Dental Materials  vol. 32, (5) 615-623. 10.1016/
Tan KY, Ramstedt M, Colak B, Huck WTS and Gautrot JE (2016). Study of thiol-ene chemistry on polymer brushes and application to surface patterning and protein adsorption. Polymer Chemistry  vol. 7, (4) 979-990. 10.1039/c5py01687h
Di Cio S and Gautrot JE (2016). Cell sensing of physical properties at the nanoscale: Mechanisms and control of cell adhesion and phenotype. Acta Biomaterialia  vol. 30, 26-48. 10.1016/j.actbio.2015.11.027


Di Cio S and Gautrot JE (2015). Cell sensing of physical properties at the nanoscale: Mechanisms and control of cell adhesion and phenotype. Acta Biomaterialia  10.1016/j.actbio.2015.11.027
Eglin D, Alini M, de Bruijn J, Gautrot J, Grijpma DW, Kamer L, Lai Y, Lu S, Peijs T, Peng J, Tang TT, Wang X, Richards RG and Qin L (2015). The RAPIDOS project-European and Chinese collaborative research on biomaterials. J Orthop Translat  vol. 3, (2) 78-84. 10.1016/
Hackett AJ, Malmström J, Molino PJ, Gautrot JE, Zhang H, Higgins MJ, Wallace GG, Williams DE and Travas-Sejdic J (2015). Conductive surfaces with dynamic switching in response to temperature and salt. Journal of Materials Chemistry B  vol. 3, (48) 9285-9294. 10.1039/c5tb02125a


Wang J, Zhou Y, Watkinson M, Gautrot J and Krause S (2014). High-sensitivity light-addressable potentiometric sensors using silicon on sapphire functionalized with self-assembled organic monolayers. Elsevier  Sensors and Actuators B: Chemical  vol. 209, 230-236. 10.1016/j.snb.2014.11.071
Krishnamoorthy M, Hakobyan S, Ramstedt M and GAUTROT JEE (2014). Surface initiated polymer brushes in the biomedical field: Applications in membrane science, biosensing, cell culture, regenerative medicine and antibacterial coatings. American Chemical Society  Chemical Reviews  vol. 114, (21) 10976-11026. 10.1021/cr500252u
Deo DI, Gautrot JE, Sukhorukov GB and Wang W (2014). Biofunctionalization of PEGylated microcapsules for exclusive binding to protein substrates. Biomacromolecules  vol. 15, (7) 2555-2562. 10.1021/bm500412d
Gautrot JE, Malmström J, Sundh M, Margadant C, Sonnenberg A and Sutherland DS (2014). The nanoscale geometrical maturation of focal adhesions controls stem cell differentiation and mechanotransduction. Nano Letters  vol. 14, (7) 3945-3952. 10.1021/nl501248y
Costa P, Gautrot JE and Connelly JT (2014). Directing cell migration using micropatterned and dynamically adhesive polymer brushes. Acta Biomater  vol. 10, (6) 2415-2422. 10.1016/j.actbio.2014.01.029


Tan KY, Lin H, Ramstedt M, Watt FM, Huck WTS and Gautrot JE (2013). Decoupling geometrical and chemical cues directing epidermal stem cell fate on polymer brush-based cell micro-patterns. Integr Biol (Camb)  vol. 5, (6) 899-910. 10.1039/c3ib40026c
GAUTROT JEE, Rzhepishevska O, Hakobyan S, Ruhal R, Barbero D and Ramstedt M (2013). The surface charge of anti-bacterial coatings alters motility and biofilm architecture. Journal of Biomaterials Science: Polymer Edition  vol. 1, (6) 589-602. 10.1039/C3BM00197K


Gautrot JE, Wang C, Liu X, Goldie SJ, Trappmann B, Huck WTS and Watt FM (2012). Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermis. Biomaterials  vol. 33, (21) 5221-5229. 10.1016/j.biomaterials.2012.04.009
Trappmann B, Gautrot JE, Connelly JT, Strange DGT, Li Y, Oyen ML, Cohen Stuart MA, Boehm H, Li B, Vogel V, Spatz JP, Watt FM and Huck WTS (2012). Extracellular-matrix tethering regulates stem-cell fate. Nature Materials  10.1038/nmat3339


Rodriguez-Emmenegger C, Brynda E, Riedel T, Houska M, Šubr V, Alles AB, Hasan E, Gautrot JE and Huck WTS (2011). Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces. Macromol Rapid Commun  vol. 32, (13) 952-957. 10.1002/marc.201100189
Tan KY, Gautrot JE and Huck WTS (2011). Formation of pickering emulsions using ion-specific responsive colloids. Langmuir  vol. 27, (4) 1251-1259. 10.1021/la102904r
Connelly JT, Mishra A, Gautrot JE and Watt FM (2011). Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation. Plos One  vol. 6, (11) 10.1371/journal.pone.0027259
Tan KY, Gautrot JE and Huck WTS (2011). Island brushes to control adhesion of water in oil droplets on planar surfaces. Soft Matter  vol. 7, (15) 7013-7020. 10.1039/c0sm01501f
Strandman S, Gautrot JE and Zhu XX (2011). Recent advances in entropy-driven ring-opening polymerizations. Polymer Chemistry  vol. 2, (4) 791-799. 10.1039/c0py00328j


Connelly JT, Gautrot JE, Trappmann B, Tan DWM, Donati G, Huck WTS and Watt FM (2010). Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nature Cell Biology  vol. 12, (7) 711-718. 10.1038/ncb2074
Gautrot JE, Trappmann B, Oceguera-Yanez F, Connelly J, He X, Watt FM and Huck WTS (2010). Exploiting the superior protein resistance of polymer brushes to control single cell adhesion and polarisation at the micron scale. Biomaterials  vol. 31, (18) 5030-5041. 10.1016/j.biomaterials.2010.02.066
Therien-Aubin H, Gautrot JE, Shao Y, Zhang J and Zhu XX (2010). Shape memory properties of main chain bile acids polymers. Polymer  vol. 51, (1) 22-25. 10.1016/j.polymer.2009.11.027
Gautrot JE, Huck WTS, Welch M and Ramstedt M (2010). Protein-resistant NTA-functionalized polymer brushes for selective and stable immobilization of histidine-tagged proteins. Acs Appl Mater Interfaces  vol. 2, (1) 193-202. 10.1021/am9006484


Gautrot JE and Zhu XX (2009). Shape memory polymers based on naturally-occurring bile acids. Macromolecules  vol. 42, (19) 7324-7331. 10.1021/ma901090r
Trmcic-Cvitas J, Hasan E, Ramstedt M, Li X, Cooper MA, Abell C, Huck WTS and Gautrot JE (2009). Biofunctionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platforms. Biomacromolecules  vol. 10, (10) 2885-2894. 10.1021/bm900706r
Huck WTS, Gautrot J and Watt F (2009). The effects of surface chemistry on epidermal stem cell differentiation. Abstracts of Papers of The American Chemical Society  vol. 237,
Gautrot JE, Zhang J, Shao Y and Zhu XX (2009). New degradable polymers made from natural compounds bile acids by ROMP. Abstracts of Papers of The American Chemical Society  vol. 237,
Hodge P and Gautrot JE (2009). Polymers containing in-chain quinone moieties: synthesis and properties. Polymer International  vol. 58, (3) 261-266. 10.1002/pi.2528
Gautrot JE and Zhu XX (2009). Macrocyclic bile acids: from molecular recognition to degradable biomaterial building blocks. Journal of Materials Chemistry  vol. 19, (32) 5705-5716. 10.1039/b821340b
Gautrot JE, Hodge P, Helliwell M, Raftery J and Cupertino D (2009). Synthesis of electron-accepting polymers containing phenanthra-9,10-quinone units. Journal of Materials Chemistry  vol. 19, (24) 4148-4156. 10.1039/b901853k


Gautrot JE and Zhu XX (2008). High molecular weight bile acid and ricinoleic acid-based copolyesters via entropy-driven ring-opening metathesis polymerisation. Chem Commun (Camb)  (14) 1674-1676. 10.1039/b719021b


Gautrot JE and Hodge P (2007). Poly(dibenzo[a,c]phenazine-2,7-diyl)s - Synthesis and characterisation of a new family of electron-accepting conjugated polymers. Polymer  vol. 48, (24) 7065-7077. 10.1016/j.polymer.2007.09.045
Nguyen BT, Gautrot JE, Nguyen MT and Zhu XX (2007). Silver nanoparticles stabilized by nitrocellulose as low conversion temperature precursors for inkjet-printed electronic circuits. 2007 Nsti Nanotechnology Conference and Trade Show - Nsti Nanotech 2007, Technical Proceedings  vol. 2, 68-71.
Charbonneau C, Gautrot JE, Hébert M-J, Zhu XX and Lerouge S (2007). Chondroitin-4-sulfate: a bioactive macromolecule to foster vascular healing around stent-grafts after endovascular aneurysm repair. Macromol Biosci  vol. 7, (5) 746-752. 10.1002/mabi.200700008
Chen Y, Gautrot JE and Zhu XX (2007). Synthesis and characterization of core-shell microspheres with double thermosensitivity. Langmuir  vol. 23, (3) 1047-1051. 10.1021/la0624945
Chen Y, Gautrot JE and Zhu XX (2007). Synthesis and characterization of core-shell microspheres with double thermosensitivity. Langmuir  vol. 23, (3) 1047-1051. 10.1021/la0624945
Gautrot JE and Zhu XX (2007). Molar mass of main-chain bile acid-based oligo-esters measured by SEC, MALDI-TOF spectrometry and NMR spectroscopy: a comparative study. Anal Chim Acta  vol. 581, (2) 281-286. 10.1016/j.aca.2006.08.020
Gautrot JE, Hodge P, Cupertino D and Helliwell M (2007). 2,6-Diaryl-9,10-anthraquinones as models for electron-accepting polymers. New Journal of Chemistry  vol. 31, (9) 1585-1593. 10.1039/b701257h
Chen Y, Gautrot JE, Li Z and Zhu XX (2007). Preparation and thermo-responsive light diffraction behaviors of soft polymerized crystalline colloidal arrays. Soft Matter  vol. 3, (5) 571-579. 10.1039/b611445h
Nguyen BT, Gautrot JE, Nguyen MT and Zhu XX (2007). Nitrocellulose-stabilized silver nanoparticles as low conversion temperature precursors useful for inkjet printed electronics. Journal of Materials Chemistry  vol. 17, (17) 1725-1730. 10.1039/b616446c


Gautrot JE, Hodge P, Cupertino D and Helliwell M (2006). Experimental evidence for carbonyl-pi electron cloud interactions. New Journal of Chemistry  vol. 30, (12) 1801-1807. 10.1039/b608628d
Gautrot JE and Zhu XX (2006). Main-chain bile acid based degradable elastomers synthesized by entropy-driven ring-opening metathesis polymerization. Angew Chem Int Ed Engl  vol. 45, (41) 6872-6874. 10.1002/anie.200602096
Gautrot JE and Zhu XX (2006). Main?Chain Bile Acid Based Degradable Elastomers Synthesized by Entropy?Driven Ring?Opening Metathesis Polymerization. Angewandte Chemie  vol. 118, (41) 7026-7028. 10.1002/ange.200602096
Nguyen BT, Gautrot JE, Ji C, Brunner P-L, Nguyen MT and Zhu XX (2006). Enhancing the photoluminescence intensity of conjugated polycationic polymers by using quantum dots as antiaggregation reagents. Langmuir  vol. 22, (10) 4799-4803. 10.1021/la053399j
Gautrot JE and Zhu XX (2006). Biodegradable polymers based on bile acids and potential biomedical applications. Journal of Biomaterials Science-Polymer Edition  vol. 17, (10) 1123-1139. 10.1163/156856206778530713


Schroeder R, Majewski LA, Grell M, Maunoury J, Gautrot J, Hodge P and Turner M (2005). Electrode specific electropolymerization of ethylenedioxythiophene: Injection enhancement in organic transistors. Applied Physics Letters  vol. 87, (11) 10.1063/1.2035879


Grants of specific relevance to Bioengineering Research
Engineered Recombinant Strategies to Organogel Design for Food Product Formulations
Gautrot JE and Lee T-Y
Biotechnology and Biological Sciences Research Council (25-09-2022 - 29-09-2026)
Engineered Protein Nanosheets at Liquid-Liquid Interfaces for Stem Cell Expansion, Sorting and Tissue Engineering
EUR1,999,389 European Research Council (01-09-2018 - 31-08-2024)
Design of an organ-on-a-chip model of soft-hard tissue interfaces
Gautrot JE and Da San Martino C
Biotechnology and Biological Sciences Research Council (22-09-2019 - 29-09-2023)
A biophysical model of gum reintegration on enamel
Gautrot JE
£108,279 Biotechnology and Biological Sciences Research Council (30-09-2019 - 29-09-2023)

A 3Rs approach to tumour metastasis: investigating the role of cancer stem cells in metastasis using an in vitro microfluidic model
Biddle AJ, Scemama A and Gautrot JEE
£90,000 National Centre for the Replacement, Refinement and Reduction of Animals in Research (01-10-2019 - 30-09-2022)
Protein Nanosheet-Stabilised Emulsions for Next Generation Biomanufacturing
EUR150,000 European Research Council (01-03-2021 - 31-08-2022)
Design of A Microfluidics Integrated Skin-on-a-Chip Tissue Model
Gautrot JE and Jones CF
Engineering and Physical Sciences Research Council (02-04-2017 - 02-10-2020)
An Ovarian Cancer Model on a Chip
Gautrot JE
£90,000 National Centre for the Replacement Refinement and Reduction of Animals in Research (31-08-2015 - 30-08-2018)
Photo-responsive graphene for anti-corrosive and conductive strong, compliant silicone nanocomposites
Bilotti E and Gautrot JE
£88,336 Engineering and Physical Sciences Research Council (30-09-2015 - 29-09-2016)